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The map label for this gene is thiM [H]

Identifier: 226949525

GI number: 226949525

Start: 2540010

End: 2540807

Strand: Reverse

Name: thiM [H]

Synonym: CLM_2460

Alternate gene names: 226949525

Gene position: 2540807-2540010 (Counterclockwise)

Preceding gene: 226949526

Following gene: 226949524

Centisome position: 61.15

GC content: 31.7

Gene sequence:

>798_bases
TTGCAAATAAGACAGAGTGTTAAATTTAAAAAACCTCTCATTCACTATATTACAAACCCAATTTCAATAAATGATTGTGC
AAATATGATTCTTGCTGTTGGTGCAAAGCCTATTATGGCCGAGCATCCTTTGGAGGTTTCGGAAATTACTTCAATTTCCG
AATCCCTAGGGATTAACCTTGGGAATATAACAGATAATAAAATGAAATCTATGTTGATTTCAGGTAAAATATCCTATGAA
AAGAAGATTCCACAAGTAATTGATCTTGTAGGCGTAGGTTGCAGTAAACTTCGTCTAGATTATGCAAAGAAATTTATTTT
AGAGTGTCATCCAAATGTTATTAAAGGTAATATGTCCGAAATGAAAGCAATCTATGGCATAAAAAGTAGTGCAAAAGGAA
TTGATGTTGGAGCATGTGATATTATAACAGAGCAAAATTTTGATGAAAATATAGAAATGATAAAGAGGTTATCCATGGAA
ACCGGTTCTGTTGTTGCAGCTACAGGAGTAGTGGATATAATAAGCAATGGTACTTATACATATATAATATCAAATGGTTG
TGAAATGCTTTCAATGATAACTGGAACAGGTTGTATGCTTACTGGAATTATAGCAAGTTATATTTCTTCTGGGAATATAC
TAGAAGGTACTGCTCTTGCTATAGTTCTTATGGGAATATGTGGTGAACTTTCTCAGCATGTTAAGGGCACTGGGAGTTTC
AGAAATGAGCTTATAGATAATATTTTTAGTATTTCCGATGATATTATAATAAAAAAAATAAGAATAAATAGTTATTAA

Upstream 100 bases:

>100_bases
TTTCTAGGAGCATTAAGTAGGACAGGTAATCTTGCAAAAATTCAAAGAAGTTTGGGGGCAAAAGTTTATGATAAACCAAG
AGTTAATAATAAACAAATTA

Downstream 100 bases:

>100_bases
TTATGGATACTGGATTTTTATTTTACTATATTTCCAATCTGAATATAGTTAATAGCTAATTTTTGTATAAGTGAAACTAT
AAGAAGCTTTAAATAGTTCA

Product: hydroxyethylthiazole kinase

Products: NA

Alternate protein names: 4-methyl-5-beta-hydroxyethylthiazole kinase 1; TH kinase 1; Thz kinase 1 [H]

Number of amino acids: Translated: 265; Mature: 265

Protein sequence:

>265_residues
MQIRQSVKFKKPLIHYITNPISINDCANMILAVGAKPIMAEHPLEVSEITSISESLGINLGNITDNKMKSMLISGKISYE
KKIPQVIDLVGVGCSKLRLDYAKKFILECHPNVIKGNMSEMKAIYGIKSSAKGIDVGACDIITEQNFDENIEMIKRLSME
TGSVVAATGVVDIISNGTYTYIISNGCEMLSMITGTGCMLTGIIASYISSGNILEGTALAIVLMGICGELSQHVKGTGSF
RNELIDNIFSISDDIIIKKIRINSY

Sequences:

>Translated_265_residues
MQIRQSVKFKKPLIHYITNPISINDCANMILAVGAKPIMAEHPLEVSEITSISESLGINLGNITDNKMKSMLISGKISYE
KKIPQVIDLVGVGCSKLRLDYAKKFILECHPNVIKGNMSEMKAIYGIKSSAKGIDVGACDIITEQNFDENIEMIKRLSME
TGSVVAATGVVDIISNGTYTYIISNGCEMLSMITGTGCMLTGIIASYISSGNILEGTALAIVLMGICGELSQHVKGTGSF
RNELIDNIFSISDDIIIKKIRINSY
>Mature_265_residues
MQIRQSVKFKKPLIHYITNPISINDCANMILAVGAKPIMAEHPLEVSEITSISESLGINLGNITDNKMKSMLISGKISYE
KKIPQVIDLVGVGCSKLRLDYAKKFILECHPNVIKGNMSEMKAIYGIKSSAKGIDVGACDIITEQNFDENIEMIKRLSME
TGSVVAATGVVDIISNGTYTYIISNGCEMLSMITGTGCMLTGIIASYISSGNILEGTALAIVLMGICGELSQHVKGTGSF
RNELIDNIFSISDDIIIKKIRINSY

Specific function: Thiamine biosynthesis. [C]

COG id: COG2145

COG function: function code H; Hydroxyethylthiazole kinase, sugar kinase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Thz kinase family [H]

Homologues:

Organism=Escherichia coli, GI1788421, Length=251, Percent_Identity=29.8804780876494, Blast_Score=121, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6325042, Length=268, Percent_Identity=29.1044776119403, Blast_Score=92, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000417 [H]

Pfam domain/function: PF02110 HK [H]

EC number: =2.7.1.50 [H]

Molecular weight: Translated: 28737; Mature: 28737

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
7.5 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
7.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIRQSVKFKKPLIHYITNPISINDCANMILAVGAKPIMAEHPLEVSEITSISESLGINL
CCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCC
GNITDNKMKSMLISGKISYEKKIPQVIDLVGVGCSKLRLDYAKKFILECHPNVIKGNMSE
CCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHCCCHHH
MKAIYGIKSSAKGIDVGACDIITEQNFDENIEMIKRLSMETGSVVAATGVVDIISNGTYT
HHHHHCCCCCCCCCCCCHHHEEECCCCCHHHHHHHHHCCCCCCEEEHHHHHHHHCCCEEE
YIISNGCEMLSMITGTGCMLTGIIASYISSGNILEGTALAIVLMGICGELSQHVKGTGSF
EEECCCHHHHHHHHCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHH
RNELIDNIFSISDDIIIKKIRINSY
HHHHHHHHHHCCCCCEEEEEEECCC
>Mature Secondary Structure
MQIRQSVKFKKPLIHYITNPISINDCANMILAVGAKPIMAEHPLEVSEITSISESLGINL
CCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCC
GNITDNKMKSMLISGKISYEKKIPQVIDLVGVGCSKLRLDYAKKFILECHPNVIKGNMSE
CCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHCCCHHH
MKAIYGIKSSAKGIDVGACDIITEQNFDENIEMIKRLSMETGSVVAATGVVDIISNGTYT
HHHHHCCCCCCCCCCCCHHHEEECCCCCHHHHHHHHHCCCCCCEEEHHHHHHHHCCCEEE
YIISNGCEMLSMITGTGCMLTGIIASYISSGNILEGTALAIVLMGICGELSQHVKGTGSF
EEECCCHHHHHHHHCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHH
RNELIDNIFSISDDIIIKKIRINSY
HHHHHHHHHHCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA