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The map label for this gene is mtbA [H]

Identifier: 226949515

GI number: 226949515

Start: 2530999

End: 2532069

Strand: Reverse

Name: mtbA [H]

Synonym: CLM_2450

Alternate gene names: 226949515

Gene position: 2532069-2530999 (Counterclockwise)

Preceding gene: 226949516

Following gene: 226949514

Centisome position: 60.94

GC content: 33.61

Gene sequence:

>1071_bases
ATGCATAAAGATGATCAAATGACACCAAATGAACGATTAGCTGCATTTATGACGGGAAAACCTATGGATAGAATCCTTGC
TATGCCAGTTGTTTGCTCCATGTCTGGGCTGGCATTAGGAATGACTCATAAGGAAAAAAGAAGCAGTGCTTTGAATGAAG
CTAAAGCACAGATTGCATGTTATGAAAGATTTGGTAATGATTTAACTGTCATTGAATATGGATTACATGGTGTAGGTATG
GCTCTAGGTACCCAGATGAGTGATCCAGAAGATTCAGTTCCAGCAATTATGAAATATACATTAGATGATTTGAATAATGT
TCATGAATTAGATATGTCAAAATTGGAACTTAAAAAGGATAAGGCATTTCAATTACATATAGAAGCTTGTGATATTTTGA
TTGATAAAGTAGGGAAAGAGGTTCCCACTGGTGTTTTGATATCTGGACCTTTTACCGCCGCTGCAAGCATTTATAAAACA
GAAGATTTATTAAGAGCAACTAGAAAAAATCCTGAAAAGTTACATCAATTGGTTAAATTTTGTACCGAAGGATTAAAAAT
GATTTGCAGAGAGTTTATAAAGACAGGTTCCCTTATTTTGTTATGTGATCCTATTGCATCAGGAACAATTCTTAATCCTA
AAAAATATCTAGAATTTGTTTTGCCATATACAATAGATTTAATGAAAGATATTCATGATGCAAAAGGAACGGTTTGTTAT
CATATTTGTGGGGATACAACCGCAATTGTAGGAGATATGGTGAAATCAGGTTGTGATATGATTAGTGTAGATAATCGAGT
AGATTTGGAATATACAAAACAAGTAGTAGGAGATAAAGTTCCTATTCTTGGCAATGTAGATCCAGTAGGTACGTTAATTT
TAGGCAGTACTAATGATGTAGATTTAGCAGTAAAAAGTTGTATTCAAAAGACATATGATAGCCCTTGTGGATATATTTTA
GCATCAGGATGTGATCTTTCAGGGGGAGTTCCTCTGGAAAATATTGATCAATTTATGACTTCCGCTAGAAAATATGGAAA
GTGGCCATTGAATCCAAATAATTTTCTTTAA

Upstream 100 bases:

>100_bases
TAACAAATATTTATTGGACTAGCTATTATTTAAAGTGATAATCTTAAATAAGTGATGTTAAAATTATCTGAAAAAATAAT
TTATATAGGGAGGCTATTAT

Downstream 100 bases:

>100_bases
AATATAAATCTATTAAAAGACGAAAAATGGAAGAATACAATACTGAACTTTAAAAAAACTATTAAATAAAAATTGTTTTA
AATGAGGTTTTTTAGTATGA

Product: uroporphyrinogen decarboxylase family protein

Products: NA

Alternate protein names: MT2-A; Methylcobamide:CoM methyltransferase II isozyme A [H]

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MHKDDQMTPNERLAAFMTGKPMDRILAMPVVCSMSGLALGMTHKEKRSSALNEAKAQIACYERFGNDLTVIEYGLHGVGM
ALGTQMSDPEDSVPAIMKYTLDDLNNVHELDMSKLELKKDKAFQLHIEACDILIDKVGKEVPTGVLISGPFTAAASIYKT
EDLLRATRKNPEKLHQLVKFCTEGLKMICREFIKTGSLILLCDPIASGTILNPKKYLEFVLPYTIDLMKDIHDAKGTVCY
HICGDTTAIVGDMVKSGCDMISVDNRVDLEYTKQVVGDKVPILGNVDPVGTLILGSTNDVDLAVKSCIQKTYDSPCGYIL
ASGCDLSGGVPLENIDQFMTSARKYGKWPLNPNNFL

Sequences:

>Translated_356_residues
MHKDDQMTPNERLAAFMTGKPMDRILAMPVVCSMSGLALGMTHKEKRSSALNEAKAQIACYERFGNDLTVIEYGLHGVGM
ALGTQMSDPEDSVPAIMKYTLDDLNNVHELDMSKLELKKDKAFQLHIEACDILIDKVGKEVPTGVLISGPFTAAASIYKT
EDLLRATRKNPEKLHQLVKFCTEGLKMICREFIKTGSLILLCDPIASGTILNPKKYLEFVLPYTIDLMKDIHDAKGTVCY
HICGDTTAIVGDMVKSGCDMISVDNRVDLEYTKQVVGDKVPILGNVDPVGTLILGSTNDVDLAVKSCIQKTYDSPCGYIL
ASGCDLSGGVPLENIDQFMTSARKYGKWPLNPNNFL
>Mature_356_residues
MHKDDQMTPNERLAAFMTGKPMDRILAMPVVCSMSGLALGMTHKEKRSSALNEAKAQIACYERFGNDLTVIEYGLHGVGM
ALGTQMSDPEDSVPAIMKYTLDDLNNVHELDMSKLELKKDKAFQLHIEACDILIDKVGKEVPTGVLISGPFTAAASIYKT
EDLLRATRKNPEKLHQLVKFCTEGLKMICREFIKTGSLILLCDPIASGTILNPKKYLEFVLPYTIDLMKDIHDAKGTVCY
HICGDTTAIVGDMVKSGCDMISVDNRVDLEYTKQVVGDKVPILGNVDPVGTLILGSTNDVDLAVKSCIQKTYDSPCGYIL
ASGCDLSGGVPLENIDQFMTSARKYGKWPLNPNNFL

Specific function: Catalyzes the transfer of the methyl group from the methylated corrinoid cofactor of mtmC, mtbC and mttC to coenzyme M [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family. MtbA/mtaA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006360
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: NA

Molecular weight: Translated: 39065; Mature: 39065

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
7.9 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
7.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHKDDQMTPNERLAAFMTGKPMDRILAMPVVCSMSGLALGMTHKEKRSSALNEAKAQIAC
CCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHHHHHH
YERFGNDLTVIEYGLHGVGMALGTQMSDPEDSVPAIMKYTLDDLNNVHELDMSKLELKKD
HHHHCCCEEEEEECCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHCHHHHHHCCC
KAFQLHIEACDILIDKVGKEVPTGVLISGPFTAAASIYKTEDLLRATRKNPEKLHQLVKF
CEEEEEHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
CTEGLKMICREFIKTGSLILLCDPIASGTILNPKKYLEFVLPYTIDLMKDIHDAKGTVCY
HHHHHHHHHHHHHHCCCEEEEECCCCCCCEECHHHHHHHHHHHHHHHHHHHHHCCCCEEE
HICGDTTAIVGDMVKSGCDMISVDNRVDLEYTKQVVGDKVPILGNVDPVGTLILGSTNDV
EECCCHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCH
DLAVKSCIQKTYDSPCGYILASGCDLSGGVPLENIDQFMTSARKYGKWPLNPNNFL
HHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MHKDDQMTPNERLAAFMTGKPMDRILAMPVVCSMSGLALGMTHKEKRSSALNEAKAQIAC
CCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHHHHHH
YERFGNDLTVIEYGLHGVGMALGTQMSDPEDSVPAIMKYTLDDLNNVHELDMSKLELKKD
HHHHCCCEEEEEECCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCHHHHCHHHHHHCCC
KAFQLHIEACDILIDKVGKEVPTGVLISGPFTAAASIYKTEDLLRATRKNPEKLHQLVKF
CEEEEEHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
CTEGLKMICREFIKTGSLILLCDPIASGTILNPKKYLEFVLPYTIDLMKDIHDAKGTVCY
HHHHHHHHHHHHHHCCCEEEEECCCCCCCEECHHHHHHHHHHHHHHHHHHHHHCCCCEEE
HICGDTTAIVGDMVKSGCDMISVDNRVDLEYTKQVVGDKVPILGNVDPVGTLILGSTNDV
EECCCHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCH
DLAVKSCIQKTYDSPCGYILASGCDLSGGVPLENIDQFMTSARKYGKWPLNPNNFL
HHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]