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The map label for this gene is pdxA

Identifier: 226949476

GI number: 226949476

Start: 2491070

End: 2492074

Strand: Reverse

Name: pdxA

Synonym: CLM_2409

Alternate gene names: 226949476

Gene position: 2492074-2491070 (Counterclockwise)

Preceding gene: 226949477

Following gene: 226949475

Centisome position: 59.97

GC content: 32.04

Gene sequence:

>1005_bases
ATGATTAATAATAAACCAATAATAGGAATACCTATAGGAGATCCAGCAGGTGTAGGGCCAGAAATAGTAGTAAAATCATT
AACTGAAGCAGAAGTTTATGAAAAATGTAATCCTATATTAATAGGAGATGCAAAAGTAATTAAACAAGCTATGGGATTCT
GCAATGTTAATTTAAATATAAATTCAATTAAAAAAGCAGATGAGGGTAAGTTTACTTTAGGAACTATAGATTTGATAGAT
TTAAATAATATAGACATCGATGAATTAAAAATAGGTAAGGTTCAAGGTATAGCAGGAAAAGCAGCCTTTGAATATATAAA
AAAATCTGTAGAAATGGCTAAAGAGGGAGAGCTAGATGCTATAGCTACAACTCCAATAAATAAAGAGTCCTTAAGAGAAG
GTAATGTAAATTATATCGGTCATACTGAGATTTTAGCAGATTTAACAGATACAGAAGATCCTCTTACTATGTTTGAAGTT
AGAGGAATGAGGGTATTCTTCTTAACAAGACATGTTTCTTTAAGAAAAGCTTGTGACTTAGTAACTAAAGAAAGAGTATT
AGATTATATAATAAGATGCTCTGAAGCTCTAGAAAAACTAGGAGTAAAGGATGGTAAGATGGCTGTTGCAGGGTTAAATC
CTCATAGTGGAGAACATGGCTTATTTGGAGATGAAGAAATGAAAGCTGTTGTTCCAGCTATAGAGGAAGCTCAAAAAATG
GGATATAAAGTAGAAGGTCCTATAGGAGCAGATTCAGTATTCCATCTAGCTCTTAAGGGAAGATATAATTCAGTATTATC
TTTGTATCATGATCAAGGACATATAGCAACAAAAACATTAGATTTTGAAAGAACTATTGCTGTAACAAATGGAATGCCAA
TACTTAGAACCTCAGTAGATCATGGAACTGCCTTTGATATAGCAGGTACTGGACAAGCTAGTTCTGTAAGTATGGTAGAA
GCTATAATTTTAGCGGCTAAATATTCACCTAAATTTAAAAAATAA

Upstream 100 bases:

>100_bases
AATTGTAAGCAAAGGGGGAATGGTAGGAAAAGAAGATGGAATGGAGTTATGTGTAGATTATTTATTTAAAAATATTAATT
GTGACTAGGGAGGACTAAAT

Downstream 100 bases:

>100_bases
ATTTTATTAATAATTATGATAATTTCTAGGGATTCTTATCTTCACCCAATGAGAGATGAAGATAAGAATCAGCTAGGATA
ATAGATAAGCTGAAATTTTA

Product: 4-hydroxythreonine-4-phosphate dehydrogenase

Products: NA

Alternate protein names: 4-(phosphohydroxy)-L-threonine dehydrogenase

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MINNKPIIGIPIGDPAGVGPEIVVKSLTEAEVYEKCNPILIGDAKVIKQAMGFCNVNLNINSIKKADEGKFTLGTIDLID
LNNIDIDELKIGKVQGIAGKAAFEYIKKSVEMAKEGELDAIATTPINKESLREGNVNYIGHTEILADLTDTEDPLTMFEV
RGMRVFFLTRHVSLRKACDLVTKERVLDYIIRCSEALEKLGVKDGKMAVAGLNPHSGEHGLFGDEEMKAVVPAIEEAQKM
GYKVEGPIGADSVFHLALKGRYNSVLSLYHDQGHIATKTLDFERTIAVTNGMPILRTSVDHGTAFDIAGTGQASSVSMVE
AIILAAKYSPKFKK

Sequences:

>Translated_334_residues
MINNKPIIGIPIGDPAGVGPEIVVKSLTEAEVYEKCNPILIGDAKVIKQAMGFCNVNLNINSIKKADEGKFTLGTIDLID
LNNIDIDELKIGKVQGIAGKAAFEYIKKSVEMAKEGELDAIATTPINKESLREGNVNYIGHTEILADLTDTEDPLTMFEV
RGMRVFFLTRHVSLRKACDLVTKERVLDYIIRCSEALEKLGVKDGKMAVAGLNPHSGEHGLFGDEEMKAVVPAIEEAQKM
GYKVEGPIGADSVFHLALKGRYNSVLSLYHDQGHIATKTLDFERTIAVTNGMPILRTSVDHGTAFDIAGTGQASSVSMVE
AIILAAKYSPKFKK
>Mature_334_residues
MINNKPIIGIPIGDPAGVGPEIVVKSLTEAEVYEKCNPILIGDAKVIKQAMGFCNVNLNINSIKKADEGKFTLGTIDLID
LNNIDIDELKIGKVQGIAGKAAFEYIKKSVEMAKEGELDAIATTPINKESLREGNVNYIGHTEILADLTDTEDPLTMFEV
RGMRVFFLTRHVSLRKACDLVTKERVLDYIIRCSEALEKLGVKDGKMAVAGLNPHSGEHGLFGDEEMKAVVPAIEEAQKM
GYKVEGPIGADSVFHLALKGRYNSVLSLYHDQGHIATKTLDFERTIAVTNGMPILRTSVDHGTAFDIAGTGQASSVSMVE
AIILAAKYSPKFKK

Specific function: Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)

COG id: COG1995

COG function: function code H; Pyridoxal phosphate biosynthesis protein

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pdxA family

Homologues:

Organism=Escherichia coli, GI1786237, Length=329, Percent_Identity=29.1793313069909, Blast_Score=157, Evalue=9e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXA_CLOB1 (A7FVM3)

Other databases:

- EMBL:   CP000726
- RefSeq:   YP_001384460.1
- ProteinModelPortal:   A7FVM3
- SMR:   A7FVM3
- STRING:   A7FVM3
- GeneID:   5395532
- GenomeReviews:   CP000726_GR
- KEGG:   cba:CLB_2147
- eggNOG:   COG1995
- HOGENOM:   HBG451136
- OMA:   PADSVFH
- ProtClustDB:   PRK03743
- BioCyc:   CBOT441770:CLB_2147-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00536
- InterPro:   IPR005255
- TIGRFAMs:   TIGR00557

Pfam domain/function: PF04166 PdxA

EC number: =1.1.1.262

Molecular weight: Translated: 36273; Mature: 36273

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: NA

Important sites: BINDING 141-141 BINDING 142-142 BINDING 278-278 BINDING 296-296

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINNKPIIGIPIGDPAGVGPEIVVKSLTEAEVYEKCNPILIGDAKVIKQAMGFCNVNLNI
CCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHCEEEEEEEH
NSIKKADEGKFTLGTIDLIDLNNIDIDELKIGKVQGIAGKAAFEYIKKSVEMAKEGELDA
HHCCCCCCCCEEEEEEEEEECCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCE
IATTPINKESLREGNVNYIGHTEILADLTDTEDPLTMFEVRGMRVFFLTRHVSLRKACDL
EEECCCCHHHHHCCCCCEEECHHHEEECCCCCCCEEEEEECCEEEEEEEHHHHHHHHHHH
VTKERVLDYIIRCSEALEKLGVKDGKMAVAGLNPHSGEHGLFGDEEMKAVVPAIEEAQKM
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHC
GYKVEGPIGADSVFHLALKGRYNSVLSLYHDQGHIATKTLDFERTIAVTNGMPILRTSVD
CEEEECCCCCCCEEEEEECCCHHHHHHEEECCCCEEEEEECCCEEEEEECCCEEEEEECC
HGTAFDIAGTGQASSVSMVEAIILAAKYSPKFKK
CCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MINNKPIIGIPIGDPAGVGPEIVVKSLTEAEVYEKCNPILIGDAKVIKQAMGFCNVNLNI
CCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHCEEEEEEEH
NSIKKADEGKFTLGTIDLIDLNNIDIDELKIGKVQGIAGKAAFEYIKKSVEMAKEGELDA
HHCCCCCCCCEEEEEEEEEECCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCE
IATTPINKESLREGNVNYIGHTEILADLTDTEDPLTMFEVRGMRVFFLTRHVSLRKACDL
EEECCCCHHHHHCCCCCEEECHHHEEECCCCCCCEEEEEECCEEEEEEEHHHHHHHHHHH
VTKERVLDYIIRCSEALEKLGVKDGKMAVAGLNPHSGEHGLFGDEEMKAVVPAIEEAQKM
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHC
GYKVEGPIGADSVFHLALKGRYNSVLSLYHDQGHIATKTLDFERTIAVTNGMPILRTSVD
CEEEECCCCCCCEEEEEECCCHHHHHHEEECCCCEEEEEECCCEEEEEECCCEEEEEECC
HGTAFDIAGTGQASSVSMVEAIILAAKYSPKFKK
CCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA