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The map label for this gene is hgdA [H]

Identifier: 226949466

GI number: 226949466

Start: 2477449

End: 2478681

Strand: Reverse

Name: hgdA [H]

Synonym: CLM_2399

Alternate gene names: 226949466

Gene position: 2478681-2477449 (Counterclockwise)

Preceding gene: 226949467

Following gene: 226949465

Centisome position: 59.65

GC content: 33.25

Gene sequence:

>1233_bases
ATGGCTGATAAGAAAGAGGTCAAAAAGAATGCAGCAAAAGTGATTAATGGTATATTAGCTAAATCTTATGCAGATGCTTG
GAAGGCAAAAGAAGAAGGAAAACCGGTTGGTTGGTCAACTTCTGTATTCCCACAGGAATTAGTAGAAGTTTTTGGTTTAG
ACGTATTATATCCAGAAAACCAAGCTGCAGGGGTTGCAGCTAAGAAAGAATCTTTATCTCTTTGTGAAGCTGCAGAAAGT
GCTGGATATTCAATTGATTTATGTGCATATGCAAGAACAAATTTTGGACTTTTAGAAAAGGGTGGTTCAGAAAACTTAAA
TATGCCAAAACCTGACTTTATATGCTGCTGTAATAATATTTGTAATCAAGTTATTAAATGGTATGAAAACATTGCAAAGG
AATTAGATATACCATTAATAATGATTGATACTACATTTAATAATGAAGATGAGGTAACAGAAAATAGAATTAAATACCTT
AGAGCTCAATTTGAAGAGGCTATAAAACAACTTGAGAAAATTTCTGGAAAGAAATTTGATCCCAAGAAGTTTGAAGAAGT
TATGAAAATCTCCGCTGAAAACGGTAAGCTTTGGAAATATTCTATGAGTTTACCATCAGGATCTTTCCCATCACCAATGA
ATGGATTTGACTTATTTACCTATATGGCTGTTATCGTATGCTATAGAGGTAAAATAGAAACTACAGAAGCTTTTAAATTA
TTGATTTCTGAATTAGAAGATAATATTAAAAATAAAGCAACTTCCTTTAGAGGAGAAGAGAAATATAGAATTATGATGGA
AGGAATTCCATGCTGGCCATATATAGGCTATAAGATGAGAACTTTAGCAGGCTATGGTGTTAATATGACTGGAAGCGTTT
ACCCCCATGCTTGGGCATTACAGTATGAAGTAAACGATTTAGATGGAATGGCTAAAGCTTACAGTACTATGTTTAATAAT
GTTAACTTAGAAAGAATGTGTAAATACAGAGTAGATTCTTTAATAGATGGAAATTGTGATGGAGCATTCTATCATATGAA
TAGAAGCTGTAAATTGATGAGTTTTATACAATATGAAATGGAAAGACAAGTTTTCGAAAAAACAGGCATACCATATGCGG
GCTTCGATGGAGACCAAGCAGATCCAAGAAACTTTAGTAAGGCTCAGTTTGAAACAAGACTGCAAGGCCTAGTAGAAGTT
ATGGAAGAAAGAAAGAAAGGAGGAAACAAATAA

Upstream 100 bases:

>100_bases
AAATAGAAGAAATGAGAAAAGAAGAGTCAATAAAATAAATTAATGTAAGTTTTTAGATGGAGGGTATAAAAACTTAGATC
GAGAAGGGGGAGGAATATAA

Downstream 100 bases:

>100_bases
TGGATAATATAAAAAATATTTTATCTAAATTAGAGGTAATTGTTAAGAACCCTAAAAAAGTTGTTTCAGATTATAAAGAA
AGAACAGGAAATAAAGTAAT

Product: (R)-2-hydroxyglutaryl-CoA dehydratase subunit alpha family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 410; Mature: 409

Protein sequence:

>410_residues
MADKKEVKKNAAKVINGILAKSYADAWKAKEEGKPVGWSTSVFPQELVEVFGLDVLYPENQAAGVAAKKESLSLCEAAES
AGYSIDLCAYARTNFGLLEKGGSENLNMPKPDFICCCNNICNQVIKWYENIAKELDIPLIMIDTTFNNEDEVTENRIKYL
RAQFEEAIKQLEKISGKKFDPKKFEEVMKISAENGKLWKYSMSLPSGSFPSPMNGFDLFTYMAVIVCYRGKIETTEAFKL
LISELEDNIKNKATSFRGEEKYRIMMEGIPCWPYIGYKMRTLAGYGVNMTGSVYPHAWALQYEVNDLDGMAKAYSTMFNN
VNLERMCKYRVDSLIDGNCDGAFYHMNRSCKLMSFIQYEMERQVFEKTGIPYAGFDGDQADPRNFSKAQFETRLQGLVEV
MEERKKGGNK

Sequences:

>Translated_410_residues
MADKKEVKKNAAKVINGILAKSYADAWKAKEEGKPVGWSTSVFPQELVEVFGLDVLYPENQAAGVAAKKESLSLCEAAES
AGYSIDLCAYARTNFGLLEKGGSENLNMPKPDFICCCNNICNQVIKWYENIAKELDIPLIMIDTTFNNEDEVTENRIKYL
RAQFEEAIKQLEKISGKKFDPKKFEEVMKISAENGKLWKYSMSLPSGSFPSPMNGFDLFTYMAVIVCYRGKIETTEAFKL
LISELEDNIKNKATSFRGEEKYRIMMEGIPCWPYIGYKMRTLAGYGVNMTGSVYPHAWALQYEVNDLDGMAKAYSTMFNN
VNLERMCKYRVDSLIDGNCDGAFYHMNRSCKLMSFIQYEMERQVFEKTGIPYAGFDGDQADPRNFSKAQFETRLQGLVEV
MEERKKGGNK
>Mature_409_residues
ADKKEVKKNAAKVINGILAKSYADAWKAKEEGKPVGWSTSVFPQELVEVFGLDVLYPENQAAGVAAKKESLSLCEAAESA
GYSIDLCAYARTNFGLLEKGGSENLNMPKPDFICCCNNICNQVIKWYENIAKELDIPLIMIDTTFNNEDEVTENRIKYLR
AQFEEAIKQLEKISGKKFDPKKFEEVMKISAENGKLWKYSMSLPSGSFPSPMNGFDLFTYMAVIVCYRGKIETTEAFKLL
ISELEDNIKNKATSFRGEEKYRIMMEGIPCWPYIGYKMRTLAGYGVNMTGSVYPHAWALQYEVNDLDGMAKAYSTMFNNV
NLERMCKYRVDSLIDGNCDGAFYHMNRSCKLMSFIQYEMERQVFEKTGIPYAGFDGDQADPRNFSKAQFETRLQGLVEVM
EERKKGGNK

Specific function: Catalyzes the reversible dehydration of 2- hydroxyglutaryl-CoA to glutaconyl-CoA. This is a key step in the fermentation of glutamate. It is activated by hgdC [H]

COG id: COG1775

COG function: function code E; Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010327 [H]

Pfam domain/function: PF06050 HGD-D [H]

EC number: NA

Molecular weight: Translated: 46538; Mature: 46407

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADKKEVKKNAAKVINGILAKSYADAWKAKEEGKPVGWSTSVFPQELVEVFGLDVLYPEN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCEECCCC
QAAGVAAKKESLSLCEAAESAGYSIDLCAYARTNFGLLEKGGSENLNMPKPDFICCCNNI
CCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHCCCCCCCCCCCCCHHHHHHHHH
CNQVIKWYENIAKELDIPLIMIDTTFNNEDEVTENRIKYLRAQFEEAIKQLEKISGKKFD
HHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PKKFEEVMKISAENGKLWKYSMSLPSGSFPSPMNGFDLFTYMAVIVCYRGKIETTEAFKL
HHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHH
LISELEDNIKNKATSFRGEEKYRIMMEGIPCWPYIGYKMRTLAGYGVNMTGSVYPHAWAL
HHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHHHHCCCCCCCCCCCCCCEEEE
QYEVNDLDGMAKAYSTMFNNVNLERMCKYRVDSLIDGNCDGAFYHMNRSCKLMSFIQYEM
EEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHH
ERQVFEKTGIPYAGFDGDQADPRNFSKAQFETRLQGLVEVMEERKKGGNK
HHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
ADKKEVKKNAAKVINGILAKSYADAWKAKEEGKPVGWSTSVFPQELVEVFGLDVLYPEN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCEECCCC
QAAGVAAKKESLSLCEAAESAGYSIDLCAYARTNFGLLEKGGSENLNMPKPDFICCCNNI
CCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHCCCCCCCCCCCCCHHHHHHHHH
CNQVIKWYENIAKELDIPLIMIDTTFNNEDEVTENRIKYLRAQFEEAIKQLEKISGKKFD
HHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PKKFEEVMKISAENGKLWKYSMSLPSGSFPSPMNGFDLFTYMAVIVCYRGKIETTEAFKL
HHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHH
LISELEDNIKNKATSFRGEEKYRIMMEGIPCWPYIGYKMRTLAGYGVNMTGSVYPHAWAL
HHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHHHHCCCCCCCCCCCCCCEEEE
QYEVNDLDGMAKAYSTMFNNVNLERMCKYRVDSLIDGNCDGAFYHMNRSCKLMSFIQYEM
EEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHH
ERQVFEKTGIPYAGFDGDQADPRNFSKAQFETRLQGLVEVMEERKKGGNK
HHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2659350; 3691501; 8365476; 11106419 [H]