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The map label for this gene is saeR [H]

Identifier: 226949224

GI number: 226949224

Start: 2197093

End: 2197779

Strand: Reverse

Name: saeR [H]

Synonym: CLM_2143

Alternate gene names: 226949224

Gene position: 2197779-2197093 (Counterclockwise)

Preceding gene: 226949225

Following gene: 226949223

Centisome position: 52.89

GC content: 30.42

Gene sequence:

>687_bases
ATGCAGGAAAAAATATTAATAGTAGATGATGAAGATGATATAGTATCTTTTATAAAGGATTATTTTGAGGATCAAGGTTA
CCGCGTTATTACAGCTAGTAATGGTAGAGAAGCTATAGAATACTGTGATAAAGATATAGATATTATTTTACTTGATATAA
TGATGCCTAATATTGATGGTTTTCAGGTTTGCCAAAAGATAAGGGACAAAGTATCCTGTCCTATAATATTTTTAAGTGCT
AGGCAAAGTGAGGTTGATAAAATTAAAGGTCTTTCAGTAGGTGGAGATGATTATATAGTAAAGCCCTTTAGCATAAAAGA
ATTAAAAGCAAGAGTTGAGGCTCATCTTAGAAGAGAAAAAAGAGTTCCTTTAAATAATAGATCTAAGATAATCTTTGGAA
AACTTACTTTAGATCTTAATAGTCGTAAAGTTCATTATGAAGAGGAGGAAATACTTTTTACAGCTAAAGAATTTGATATA
GTAGAACTTTTAGCATTACATCCAGAACAGGTATTTTCTAAAGAACAAATCTATGAAAAAGTTTGGGGATATGATGCAGA
AGGGGATGCAAATACAGTAGCAGAGCATATAAAAAAGATAAGAGCAAAGTTTATAAAAATAAGTGTATCTCTTAATCATA
TAGCTACGGTATGGGGAGTAGGTTATAGATGGGAGAGAAAAAAATGA

Upstream 100 bases:

>100_bases
TTTATATCTAATTTAATTTGTAAAGTATAAAACTTGAAAAATGTTACATTTTAATGTACATGCTATAATATTATTAAAAT
GCAAAAATAGAGGTGTTTAT

Downstream 100 bases:

>100_bases
TGGAAAAAGCATCCTTAAAAACACAAACTATAAGTACTTTTTTATTAATTATATTTTTAAGTATAGTATGTACAATAGCT
ACTCTAGGAACTTATTTATT

Product: DNA-binding response regulator

Products: NA

Alternate protein names: Staphylococcus exoprotein expression protein R [H]

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MQEKILIVDDEDDIVSFIKDYFEDQGYRVITASNGREAIEYCDKDIDIILLDIMMPNIDGFQVCQKIRDKVSCPIIFLSA
RQSEVDKIKGLSVGGDDYIVKPFSIKELKARVEAHLRREKRVPLNNRSKIIFGKLTLDLNSRKVHYEEEEILFTAKEFDI
VELLALHPEQVFSKEQIYEKVWGYDAEGDANTVAEHIKKIRAKFIKISVSLNHIATVWGVGYRWERKK

Sequences:

>Translated_228_residues
MQEKILIVDDEDDIVSFIKDYFEDQGYRVITASNGREAIEYCDKDIDIILLDIMMPNIDGFQVCQKIRDKVSCPIIFLSA
RQSEVDKIKGLSVGGDDYIVKPFSIKELKARVEAHLRREKRVPLNNRSKIIFGKLTLDLNSRKVHYEEEEILFTAKEFDI
VELLALHPEQVFSKEQIYEKVWGYDAEGDANTVAEHIKKIRAKFIKISVSLNHIATVWGVGYRWERKK
>Mature_228_residues
MQEKILIVDDEDDIVSFIKDYFEDQGYRVITASNGREAIEYCDKDIDIILLDIMMPNIDGFQVCQKIRDKVSCPIIFLSA
RQSEVDKIKGLSVGGDDYIVKPFSIKELKARVEAHLRREKRVPLNNRSKIIFGKLTLDLNSRKVHYEEEEILFTAKEFDI
VELLALHPEQVFSKEQIYEKVWGYDAEGDANTVAEHIKKIRAKFIKISVSLNHIATVWGVGYRWERKK

Specific function: Member of the two-component regulatory system saeR/saeS involved in the regulation of staphylococcal virulence factors in a strain-dependent fashion. Probably functions as a transcriptional regulator via a specific DNA-binding domain, recognizing motifs n

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789809, Length=230, Percent_Identity=32.6086956521739, Blast_Score=144, Evalue=4e-36,
Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=35.9090909090909, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1786911, Length=222, Percent_Identity=33.7837837837838, Blast_Score=134, Evalue=4e-33,
Organism=Escherichia coli, GI1786599, Length=231, Percent_Identity=34.1991341991342, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1788394, Length=225, Percent_Identity=34.2222222222222, Blast_Score=131, Evalue=4e-32,
Organism=Escherichia coli, GI1790552, Length=221, Percent_Identity=34.3891402714932, Blast_Score=129, Evalue=1e-31,
Organism=Escherichia coli, GI1790860, Length=224, Percent_Identity=32.1428571428571, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1786784, Length=224, Percent_Identity=34.375, Blast_Score=127, Evalue=5e-31,
Organism=Escherichia coli, GI2367329, Length=224, Percent_Identity=34.375, Blast_Score=118, Evalue=3e-28,
Organism=Escherichia coli, GI1790863, Length=227, Percent_Identity=32.5991189427313, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=31.2217194570136, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1787375, Length=226, Percent_Identity=33.1858407079646, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1787229, Length=230, Percent_Identity=27.8260869565217, Blast_Score=100, Evalue=6e-23,
Organism=Escherichia coli, GI145693140, Length=228, Percent_Identity=28.0701754385965, Blast_Score=91, Evalue=5e-20,
Organism=Escherichia coli, GI1788550, Length=116, Percent_Identity=34.4827586206897, Blast_Score=80, Evalue=9e-17,
Organism=Escherichia coli, GI145693157, Length=119, Percent_Identity=31.0924369747899, Blast_Score=64, Evalue=7e-12,
Organism=Escherichia coli, GI1790437, Length=114, Percent_Identity=28.9473684210526, Blast_Score=64, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26482; Mature: 26482

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQEKILIVDDEDDIVSFIKDYFEDQGYRVITASNGREAIEYCDKDIDIILLDIMMPNIDG
CCCCEEEEECCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHCCCCCCEEEEEEECCCCCH
FQVCQKIRDKVSCPIIFLSARQSEVDKIKGLSVGGDDYIVKPFSIKELKARVEAHLRREK
HHHHHHHHHHCCCCEEEEECCCHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHC
RVPLNNRSKIIFGKLTLDLNSRKVHYEEEEILFTAKEFDIVELLALHPEQVFSKEQIYEK
CCCCCCCCEEEEEEEEEEECCCEEEECCHHEEEEECCCCHHHHHHCCHHHHHHHHHHHHH
VWGYDAEGDANTVAEHIKKIRAKFIKISVSLNHIATVWGVGYRWERKK
HCCCCCCCCHHHHHHHHHHHHHHHEEEEEEHHHHHHHHCCCEEECCCC
>Mature Secondary Structure
MQEKILIVDDEDDIVSFIKDYFEDQGYRVITASNGREAIEYCDKDIDIILLDIMMPNIDG
CCCCEEEEECCHHHHHHHHHHHHCCCEEEEEECCCHHHHHHCCCCCCEEEEEEECCCCCH
FQVCQKIRDKVSCPIIFLSARQSEVDKIKGLSVGGDDYIVKPFSIKELKARVEAHLRREK
HHHHHHHHHHCCCCEEEEECCCHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHC
RVPLNNRSKIIFGKLTLDLNSRKVHYEEEEILFTAKEFDIVELLALHPEQVFSKEQIYEK
CCCCCCCCEEEEEEEEEEECCCEEEECCHHEEEEECCCCHHHHHHCCHHHHHHHHHHHHH
VWGYDAEGDANTVAEHIKKIRAKFIKISVSLNHIATVWGVGYRWERKK
HCCCCCCCCHHHHHHHHHHHHHHHEEEEEEHHHHHHHHCCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA