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The map label for this gene is trkH [H]

Identifier: 226948600

GI number: 226948600

Start: 1546065

End: 1547510

Strand: Direct

Name: trkH [H]

Synonym: CLM_1494

Alternate gene names: 226948600

Gene position: 1546065-1547510 (Clockwise)

Preceding gene: 226948599

Following gene: 226948601

Centisome position: 37.21

GC content: 30.91

Gene sequence:

>1446_bases
ATGAACTACCCAATAGTATTTAAAGTATTAGGAGATGTAATAAAATATGAAGCTTTAGTTATGATATTTCCTCTTATAGC
ATCTTTATATTATGGTGGCAAAGATGCTAATAGTTTTATAATAACTATTGCAATAATGCTGTGTACTGCAGTTATAATGT
CAAATATTAGACCTAAAAATAGAACTTTTTATGCTAAAGAAGGTTTTTTATCTGTTTCTGTTTGTTGGATAGTTATATCT
TTATTTGGAGCGTTACCATTTTATATAAGTGGAGCGATACCTTCCTTTGTAGATTGTATATTTGAAACAGTGTCAGGCTT
TACAACTACGGGAGCTACTATTTTAAAAGAAGTAGAATCTTTACCTAGGGGAATATTGTTTTGGAGAAGCTTTACACATT
GGATAGGTGGTATGGGAATATTAATATTTACATTAGCATTAATGCCTTCTATAGGTGGTACTACAATTCATCTTTTAAAG
GCAGAAAGTCCAGGGCCTACTCCAGGGAAAATTGTTCCAAGGATAAAAGAAACAGCTAAAATAATGTATTTAATATATTT
TGCTATGACTATATTACAAATAAGTTTACTTTTAATTGCAGGGATGGAACCTTATGATGCATTAATACATGCCTTTGGTA
CAGCTGGTACTGGAGGATTTTCCAGTATGAATAGTAGTGTAGGAGCATATAATAATGTATATATAGAAGTTATAATAACA
GTGTTTATGTTATTGTTCGGTGTTAATTTTAATGTATATTTTCAACTAATAGCAGGAAATATTAAACAAGCTTTTAAAAA
TGAAGAAGTGAAATATTATATAGGTATGGTATTGATTGCTATGACAATAATAGCTTTTAATATTAAAGGAATGTATGGGG
GATCTTTAAAGGAAGGTTTTAGGCAATCATCTTTCCAAGTAGCCTCTATTGTAACGACTACAGGTTATGCTACTACTAAT
TTTGATTTGTGGCCAACCCTTAGTAAATCAATATTAGCTTTATTAATGCTTACAGGATGTTGTGCAGGTTCTACCGGTGG
GGGAATTAAAACTGTTCGTATAGTACTTTTGTTTAAAGCTATGAAAAGAGAAATAAGTAAAATTATTCATCCTAGAATGG
TTAATTCAGTAAAACTAGATGGTAAGGTTGTAGAGGATGAAACCATATCGCAGGTTGGATTATTTGTATTTGCCTACGTT
AGTATAATTATAATAGCAGTACTTTTAGTATCTATAGATGGTATGGATATGGAGACCACACTTTCTTCTGTGCTTGCAAC
TATAGGTAATATAGGACCTGGTTTTAAGGTGGTAGGACCTATAGGCAATTTTAATAGCTATTCATCTTTTAGCAAAATAG
TATTTTCATTTTGTATGTTAGCAGGAAGATTAGAGATATATCCAATGCTAGTAATGTTAAGTCCTTCGAGAATGAGAAAA
ATATAA

Upstream 100 bases:

>100_bases
ATGGCGAGGATTCCATAAAAGATGGTGATAATGTCATTATAGTAACGGAAGAAAATAATATAATGGATATTAATAATATA
CTAGAGGGAGGAAACTTAAT

Downstream 100 bases:

>100_bases
TATAGTTTAACTGATAGTAATAGAAAAGTAGCAGATAGATTTAATTTTAAAAGCACAAATATAAAAAATATACTTCATAT
ATCTTACTTATATGTTTATT

Product: Trk system potassium uptake protein TrkH

Products: Proton [Cytoplasm]; K (I) [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MNYPIVFKVLGDVIKYEALVMIFPLIASLYYGGKDANSFIITIAIMLCTAVIMSNIRPKNRTFYAKEGFLSVSVCWIVIS
LFGALPFYISGAIPSFVDCIFETVSGFTTTGATILKEVESLPRGILFWRSFTHWIGGMGILIFTLALMPSIGGTTIHLLK
AESPGPTPGKIVPRIKETAKIMYLIYFAMTILQISLLLIAGMEPYDALIHAFGTAGTGGFSSMNSSVGAYNNVYIEVIIT
VFMLLFGVNFNVYFQLIAGNIKQAFKNEEVKYYIGMVLIAMTIIAFNIKGMYGGSLKEGFRQSSFQVASIVTTTGYATTN
FDLWPTLSKSILALLMLTGCCAGSTGGGIKTVRIVLLFKAMKREISKIIHPRMVNSVKLDGKVVEDETISQVGLFVFAYV
SIIIIAVLLVSIDGMDMETTLSSVLATIGNIGPGFKVVGPIGNFNSYSSFSKIVFSFCMLAGRLEIYPMLVMLSPSRMRK
I

Sequences:

>Translated_481_residues
MNYPIVFKVLGDVIKYEALVMIFPLIASLYYGGKDANSFIITIAIMLCTAVIMSNIRPKNRTFYAKEGFLSVSVCWIVIS
LFGALPFYISGAIPSFVDCIFETVSGFTTTGATILKEVESLPRGILFWRSFTHWIGGMGILIFTLALMPSIGGTTIHLLK
AESPGPTPGKIVPRIKETAKIMYLIYFAMTILQISLLLIAGMEPYDALIHAFGTAGTGGFSSMNSSVGAYNNVYIEVIIT
VFMLLFGVNFNVYFQLIAGNIKQAFKNEEVKYYIGMVLIAMTIIAFNIKGMYGGSLKEGFRQSSFQVASIVTTTGYATTN
FDLWPTLSKSILALLMLTGCCAGSTGGGIKTVRIVLLFKAMKREISKIIHPRMVNSVKLDGKVVEDETISQVGLFVFAYV
SIIIIAVLLVSIDGMDMETTLSSVLATIGNIGPGFKVVGPIGNFNSYSSFSKIVFSFCMLAGRLEIYPMLVMLSPSRMRK
I
>Mature_481_residues
MNYPIVFKVLGDVIKYEALVMIFPLIASLYYGGKDANSFIITIAIMLCTAVIMSNIRPKNRTFYAKEGFLSVSVCWIVIS
LFGALPFYISGAIPSFVDCIFETVSGFTTTGATILKEVESLPRGILFWRSFTHWIGGMGILIFTLALMPSIGGTTIHLLK
AESPGPTPGKIVPRIKETAKIMYLIYFAMTILQISLLLIAGMEPYDALIHAFGTAGTGGFSSMNSSVGAYNNVYIEVIIT
VFMLLFGVNFNVYFQLIAGNIKQAFKNEEVKYYIGMVLIAMTIIAFNIKGMYGGSLKEGFRQSSFQVASIVTTTGYATTN
FDLWPTLSKSILALLMLTGCCAGSTGGGIKTVRIVLLFKAMKREISKIIHPRMVNSVKLDGKVVEDETISQVGLFVFAYV
SIIIIAVLLVSIDGMDMETTLSSVLATIGNIGPGFKVVGPIGNFNSYSSFSKIVFSFCMLAGRLEIYPMLVMLSPSRMRK
I

Specific function: Low-affinity potassium transport system. Interacts with trk system potassium uptake protein trkA. TrkE increases the affinity of the system [H]

COG id: COG0168

COG function: function code P; Trk-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trkH potassium transport family [H]

Homologues:

Organism=Escherichia coli, GI1787626, Length=481, Percent_Identity=33.0561330561331, Blast_Score=259, Evalue=3e-70,
Organism=Escherichia coli, GI48994987, Length=488, Percent_Identity=35.2459016393443, Blast_Score=254, Evalue=6e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003445
- InterPro:   IPR004772 [H]

Pfam domain/function: PF02386 TrkH [H]

EC number: NA

Molecular weight: Translated: 52552; Mature: 52552

Theoretical pI: Translated: 9.47; Mature: 9.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYPIVFKVLGDVIKYEALVMIFPLIASLYYGGKDANSFIITIAIMLCTAVIMSNIRPKN
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
RTFYAKEGFLSVSVCWIVISLFGALPFYISGAIPSFVDCIFETVSGFTTTGATILKEVES
CEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHH
LPRGILFWRSFTHWIGGMGILIFTLALMPSIGGTTIHLLKAESPGPTPGKIVPRIKETAK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHH
IMYLIYFAMTILQISLLLIAGMEPYDALIHAFGTAGTGGFSSMNSSVGAYNNVYIEVIIT
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHCCCCCCCCHHHHHHHHHH
VFMLLFGVNFNVYFQLIAGNIKQAFKNEEVKYYIGMVLIAMTIIAFNIKGMYGGSLKEGF
HHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
RQSSFQVASIVTTTGYATTNFDLWPTLSKSILALLMLTGCCAGSTGGGIKTVRIVLLFKA
HHCCCHHHHHEEECCCEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
MKREISKIIHPRMVNSVKLDGKVVEDETISQVGLFVFAYVSIIIIAVLLVSIDGMDMETT
HHHHHHHHHCHHHHCCEECCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
LSSVLATIGNIGPGFKVVGPIGNFNSYSSFSKIVFSFCMLAGRLEIYPMLVMLSPSRMRK
HHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHEEECHHHHHC
I
C
>Mature Secondary Structure
MNYPIVFKVLGDVIKYEALVMIFPLIASLYYGGKDANSFIITIAIMLCTAVIMSNIRPKN
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
RTFYAKEGFLSVSVCWIVISLFGALPFYISGAIPSFVDCIFETVSGFTTTGATILKEVES
CEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHH
LPRGILFWRSFTHWIGGMGILIFTLALMPSIGGTTIHLLKAESPGPTPGKIVPRIKETAK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHH
IMYLIYFAMTILQISLLLIAGMEPYDALIHAFGTAGTGGFSSMNSSVGAYNNVYIEVIIT
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHCCCCCCCCHHHHHHHHHH
VFMLLFGVNFNVYFQLIAGNIKQAFKNEEVKYYIGMVLIAMTIIAFNIKGMYGGSLKEGF
HHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
RQSSFQVASIVTTTGYATTNFDLWPTLSKSILALLMLTGCCAGSTGGGIKTVRIVLLFKA
HHCCCHHHHHEEECCCEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
MKREISKIIHPRMVNSVKLDGKVVEDETISQVGLFVFAYVSIIIIAVLLVSIDGMDMETT
HHHHHHHHHCHHHHCCEECCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
LSSVLATIGNIGPGFKVVGPIGNFNSYSSFSKIVFSFCMLAGRLEIYPMLVMLSPSRMRK
HHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHEEECHHHHHC
I
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Periplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Periplasm] = Proton [Cytoplasm] + K (I) [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2022616; 9097039; 9278503 [H]