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The map label for this gene is serA [H]

Identifier: 226948399

GI number: 226948399

Start: 1338303

End: 1339247

Strand: Direct

Name: serA [H]

Synonym: CLM_1283

Alternate gene names: 226948399

Gene position: 1338303-1339247 (Clockwise)

Preceding gene: 226948398

Following gene: 226948400

Centisome position: 32.21

GC content: 29.84

Gene sequence:

>945_bases
ATGATAAAAATATTAGTTTCTGATGGAATGGAGCAGAATGCTTTAAATAAATTAAACGAGCAAGGATTTGTAGTATTAGA
TAAACATTTTGAAAAAGAAGAGCTTAAAGAAAAAATAAAGGATTTTGATGCTATTATAATAAGATCAGCTACTAAGGTAG
ATAAGGAAATAATAGATGCAGGTATAAAAGGAAATTTAAAATTAGTTGTAAGAGCAGGAGTTGGACTTGATAATGTGGAT
TTAGAATATGCGAAAGAAAAAGGAGTTAAGGTTTTTAATACACCTAAAGCTAGTAGTGTATCTGTGGCAGAGTTAACTTT
AGGACACATGCTTTGTATAAGTAGATTTATAAATACGGCAAATGTTACTATGCTTCAAGGAAAATGGGAAAAGAAAAAGT
ATAAAGGAACAGAAATATATGGCAAAACATTGGGCCTAATAGGATTTGGAAGAATAGCTAGAGAGGTAGCTAAAAGAGCC
AATGCTTTAGGTATGAATGTAATTTATTATGATATAGCAGGTAAATGTGAAGAATATGAAGAATTTAAATGCTGTACCTT
AGATTATTTATTAAATAATTCAGATTTTATATCTGTGCATATACCTTTCAATAAAGATAGAGGAGCTTTGTTAAAGGAAG
AAGAATTTAATAAAATGAAAGATGGAGTTTATATAATAAATTGTGCTAGAGGTGGAGTAATAGAAGAAGAAGCTCTTTTA
AAAGCTCTTAATAGCGGAAAAGTAACAGCAGCAGCCTTAGATGTATTTGAAAATGAGCCAAAACCAAAGAAAGAACTTAT
AAATCATGAAAGAGTAAGTATAACACCTCATATAGGGGCATCTACTAAAGAAGCGCAGATGAGAATAGGAGAAGAAATAG
TAGATATATTAGATAATTTTTTCAATATAGGAGGAGAAGAACATGACCATATTAAAGTCATTTAG

Upstream 100 bases:

>100_bases
CCGAATTGTAATTGGAAATAAGAATAATTAAAAATAGATTAATTATATTTACGAAGAAAATTAATGGGATTAACCATATA
TATTTGAAAGGGTGAAATTT

Downstream 100 bases:

>100_bases
AGCAATAAGACCTAATAAAGGATTTGATAATAAAATAGCAGCACTACCTTATGATGTAGTTAATACTGATGAAGCTAAAG
AAATAGGGAATAAAAAACCC

Product: D-isomer specific 2-hydroxyacid dehydrogenase family protein

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MIKILVSDGMEQNALNKLNEQGFVVLDKHFEKEELKEKIKDFDAIIIRSATKVDKEIIDAGIKGNLKLVVRAGVGLDNVD
LEYAKEKGVKVFNTPKASSVSVAELTLGHMLCISRFINTANVTMLQGKWEKKKYKGTEIYGKTLGLIGFGRIAREVAKRA
NALGMNVIYYDIAGKCEEYEEFKCCTLDYLLNNSDFISVHIPFNKDRGALLKEEEFNKMKDGVYIINCARGGVIEEEALL
KALNSGKVTAAALDVFENEPKPKKELINHERVSITPHIGASTKEAQMRIGEEIVDILDNFFNIGGEEHDHIKVI

Sequences:

>Translated_314_residues
MIKILVSDGMEQNALNKLNEQGFVVLDKHFEKEELKEKIKDFDAIIIRSATKVDKEIIDAGIKGNLKLVVRAGVGLDNVD
LEYAKEKGVKVFNTPKASSVSVAELTLGHMLCISRFINTANVTMLQGKWEKKKYKGTEIYGKTLGLIGFGRIAREVAKRA
NALGMNVIYYDIAGKCEEYEEFKCCTLDYLLNNSDFISVHIPFNKDRGALLKEEEFNKMKDGVYIINCARGGVIEEEALL
KALNSGKVTAAALDVFENEPKPKKELINHERVSITPHIGASTKEAQMRIGEEIVDILDNFFNIGGEEHDHIKVI
>Mature_314_residues
MIKILVSDGMEQNALNKLNEQGFVVLDKHFEKEELKEKIKDFDAIIIRSATKVDKEIIDAGIKGNLKLVVRAGVGLDNVD
LEYAKEKGVKVFNTPKASSVSVAELTLGHMLCISRFINTANVTMLQGKWEKKKYKGTEIYGKTLGLIGFGRIAREVAKRA
NALGMNVIYYDIAGKCEEYEEFKCCTLDYLLNNSDFISVHIPFNKDRGALLKEEEFNKMKDGVYIINCARGGVIEEEALL
KALNSGKVTAAALDVFENEPKPKKELINHERVSITPHIGASTKEAQMRIGEEIVDILDNFFNIGGEEHDHIKVI

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=294, Percent_Identity=46.9387755102041, Blast_Score=267, Evalue=9e-72,
Organism=Homo sapiens, GI145580575, Length=245, Percent_Identity=35.1020408163265, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI145580578, Length=245, Percent_Identity=35.1020408163265, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI4557499, Length=245, Percent_Identity=35.1020408163265, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI4557497, Length=242, Percent_Identity=33.4710743801653, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI61743967, Length=242, Percent_Identity=33.4710743801653, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI6912396, Length=267, Percent_Identity=31.4606741573034, Blast_Score=124, Evalue=9e-29,
Organism=Escherichia coli, GI1789279, Length=314, Percent_Identity=36.3057324840764, Blast_Score=180, Evalue=1e-46,
Organism=Escherichia coli, GI87082289, Length=240, Percent_Identity=33.3333333333333, Blast_Score=130, Evalue=8e-32,
Organism=Escherichia coli, GI1787645, Length=198, Percent_Identity=33.3333333333333, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1788660, Length=276, Percent_Identity=28.9855072463768, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI87081824, Length=158, Percent_Identity=32.9113924050633, Blast_Score=80, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17532191, Length=296, Percent_Identity=42.5675675675676, Blast_Score=240, Evalue=7e-64,
Organism=Caenorhabditis elegans, GI25147481, Length=255, Percent_Identity=29.4117647058824, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6320925, Length=318, Percent_Identity=36.1635220125786, Blast_Score=213, Evalue=4e-56,
Organism=Saccharomyces cerevisiae, GI6322116, Length=318, Percent_Identity=35.8490566037736, Blast_Score=207, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6324055, Length=300, Percent_Identity=31, Blast_Score=142, Evalue=6e-35,
Organism=Saccharomyces cerevisiae, GI6324964, Length=266, Percent_Identity=29.3233082706767, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6324980, Length=197, Percent_Identity=26.3959390862944, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6325144, Length=181, Percent_Identity=29.8342541436464, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6321253, Length=261, Percent_Identity=25.2873563218391, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19921140, Length=315, Percent_Identity=41.2698412698413, Blast_Score=233, Evalue=1e-61,
Organism=Drosophila melanogaster, GI24585514, Length=263, Percent_Identity=30.7984790874525, Blast_Score=134, Evalue=6e-32,
Organism=Drosophila melanogaster, GI28574282, Length=263, Percent_Identity=30.7984790874525, Blast_Score=134, Evalue=6e-32,
Organism=Drosophila melanogaster, GI28574286, Length=264, Percent_Identity=31.0606060606061, Blast_Score=134, Evalue=7e-32,
Organism=Drosophila melanogaster, GI28574284, Length=263, Percent_Identity=30.7984790874525, Blast_Score=134, Evalue=7e-32,
Organism=Drosophila melanogaster, GI45551003, Length=263, Percent_Identity=30.7984790874525, Blast_Score=134, Evalue=7e-32,
Organism=Drosophila melanogaster, GI45552429, Length=263, Percent_Identity=30.7984790874525, Blast_Score=134, Evalue=9e-32,
Organism=Drosophila melanogaster, GI62472511, Length=210, Percent_Identity=38.5714285714286, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24646446, Length=229, Percent_Identity=37.117903930131, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24646448, Length=229, Percent_Identity=37.117903930131, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24646452, Length=229, Percent_Identity=37.117903930131, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24646450, Length=229, Percent_Identity=37.117903930131, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24585516, Length=298, Percent_Identity=27.8523489932886, Blast_Score=120, Evalue=9e-28,
Organism=Drosophila melanogaster, GI28571528, Length=263, Percent_Identity=32.6996197718631, Blast_Score=113, Evalue=2e-25,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 35095; Mature: 35095

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKILVSDGMEQNALNKLNEQGFVVLDKHFEKEELKEKIKDFDAIIIRSATKVDKEIIDA
CEEEEECCCCCHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHEEEHHHHHHHHHHHHC
GIKGNLKLVVRAGVGLDNVDLEYAKEKGVKVFNTPKASSVSVAELTLGHMLCISRFINTA
CCCCCEEEEEEECCCCCCCCHHHHHHCCCEEEECCCCCCEEHHHHHHHHHHHHHHHHCCC
NVTMLQGKWEKKKYKGTEIYGKTLGLIGFGRIAREVAKRANALGMNVIYYDIAGKCEEYE
CEEEEECCCHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHH
EFKCCTLDYLLNNSDFISVHIPFNKDRGALLKEEEFNKMKDGVYIINCARGGVIEEEALL
HCCEEEEEEEECCCCEEEEEECCCCCCCCCCCHHHHHHHHCCEEEEEECCCCCCHHHHHH
KALNSGKVTAAALDVFENEPKPKKELINHERVSITPHIGASTKEAQMRIGEEIVDILDNF
HHHCCCCEEHHHHHHHCCCCCCHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHH
FNIGGEEHDHIKVI
HHCCCCCCCCEEEC
>Mature Secondary Structure
MIKILVSDGMEQNALNKLNEQGFVVLDKHFEKEELKEKIKDFDAIIIRSATKVDKEIIDA
CEEEEECCCCCHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHEEEHHHHHHHHHHHHC
GIKGNLKLVVRAGVGLDNVDLEYAKEKGVKVFNTPKASSVSVAELTLGHMLCISRFINTA
CCCCCEEEEEEECCCCCCCCHHHHHHCCCEEEECCCCCCEEHHHHHHHHHHHHHHHHCCC
NVTMLQGKWEKKKYKGTEIYGKTLGLIGFGRIAREVAKRANALGMNVIYYDIAGKCEEYE
CEEEEECCCHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHH
EFKCCTLDYLLNNSDFISVHIPFNKDRGALLKEEEFNKMKDGVYIINCARGGVIEEEALL
HCCEEEEEEEECCCCEEEEEECCCCCCCCCCCHHHHHHHHCCEEEEEECCCCCCHHHHHH
KALNSGKVTAAALDVFENEPKPKKELINHERVSITPHIGASTKEAQMRIGEEIVDILDNF
HHHCCCCEEHHHHHHHCCCCCCHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHH
FNIGGEEHDHIKVI
HHCCCCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]