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The map label for this gene is leuS [H]

Identifier: 226947407

GI number: 226947407

Start: 218397

End: 220838

Strand: Reverse

Name: leuS [H]

Synonym: CLM_0234

Alternate gene names: 226947407

Gene position: 220838-218397 (Counterclockwise)

Preceding gene: 226947408

Following gene: 226947405

Centisome position: 5.31

GC content: 31.12

Gene sequence:

>2442_bases
ATGGGAAACTATAGTACTAAAATCGATGAGAAATGGCAAAAAAAATGGGAAGAAAACTCTCTATACAAATTTAATAATGA
AAATTTAGATAAAAAGTTATATGTACTTGAAATGTTTTCTTATCCATCAGGTAGTAAATTACATGCAGGACACTGGTTTA
ACTATGGGCCTGTAGACTCTTGGGCAAGATTTAAAAGAATGCAAGGTTACAATGTTTTTCAACCTATGGGGTTTGATGCT
TTTGGTCTTCCAGCTGAAAACTATGCAATAAAAACTGGTATACATCCAAAGGATTCTACCTTTAAAAATATTGAAACTAT
GGAAACTCAATTAAAAGCCATGGGTGCCATGTTCAACTGGGAAAATGAAGTTATAACTTGTTCACCAGACTACTATAAAT
GGACTCAATGGTTATTTTTAAAACTTTACGAAAAAGGTTTAGCTTATAAAAAGAAAGCACCTGTAAATTGGTGCCCAAGT
TGTAATACTGTTCTTGCTAATGAGCAGGTTTTAGATGGAAAATGTGAAAGATGTGATAGCAATGTTGATAAAAAAAATCT
AGAGCAATGGTTCTTAAAGATAACTGACTATGCTGATGAATTGTTAGAAAAACTCGATGAATTAGATTGGCCTGAAAAAA
CTAAGGCTATGCAAAAACACTGGATCGGAAAATCTGTAGGTGCTGAAGTTGCATTTAATGTAGCAGATTCAGACTTGAGC
TTTAATGTATTTACTACAAGGGTAGATACTTTATTTGGAGTTACTTATGTAGTCTTAGCTCCTGAAAATGATTTAGTAGA
TAAGCTAACTACCCCTGAAAATAAAGCCGAAGTTGAATCATATAAAACTCAAGCTAAAAATCAATCTGATATAGAAAGAC
AATCTATAACTCGAGAAAAAACTGGTGTATTCTCAGGTTCTTATGCCATAAATCCTATAAACGGTAAAAAAGTACCTATA
TGGATAGGAGATTATGTATTAAATACCTATGGAACAGGTTGTGTAATGGCAGTTCCTGCCCATGATGAAAGAGATTTCGC
TTTTGCTACTAAATATAACCTTCCTATAGAAAGAGTTATAGAAGGTGGTGATTCTCTCCCTTATACAGAATATGGTAAAA
TGGTTAATAGTGGAGAATTCGATGGTTTATTTGGAAATAAAGCTAAAGAAGCTGTAATTTCTAAGTTAGAGTCTATGAAT
CTTGGTAGAAAGAAAATAAATTATAGATTAAGAGATTGGCTTGTATCAAGACAAAGATATTGGGGGGCACCTATTCCTAT
AGTTTATTGCGAAAAATGTGGTACAGTAGAAGTTCCTATGGAACAGCTTCCTGTAGAATTACCATATAATGTACAATTCT
CTCCAGATGGAAAATCACCTTTAAGTAAATGTGATGAATTTGTAAATACAACTTGTCCAAAATGTGGTGGTCCAGCTAAA
AGGGAAGCAGATACATTAGACACTTTTGTATGTTCTTCTTGGTATTATCTAAGATATCCAGATAATAAAAACAGTGAAGC
TGCTTTTAATCCTGAATTAATTAATAAAATGCTTCCAGTTGATAAATATGTTGGTGGTCCTGAACATGCTTGCATGCATC
TTTTATATGCTAGATTTATAACTAAAGCTTTAAGAGATATGGGTTATCTAAACTTTGATGAACCATTCTTATCCCTTACT
CACCAAGGATTAATATTAGGACCTGATGGCTTAAAAATGAGTAAATCAAAAGGAAATACTATATCTCCTGATGATTATAT
AAAAGAATTTGGTGCAGATGTATTTAGAATGTATTTAATGTTTGGATTTGATTATACAGAAGGCGGCGCTTGGAGTGACG
ATGCTATAAAATCCATAGGTAAATTTGTAGACAGAGTAGAAAGAATATTAGAAAATGCTAGAGAAGAAATAAAAAATTCT
AAAGATAATAAATCTACTATGGATAAAGATGAGAAAGAATTAAACTACGTAAGGCATCATAGCATTAAATCTATAACTGA
AGATATAGATAAAATGCAGTTCAATACTTCCATAGCAAGATTAATGGAATTTACAAATGCTCTATCTAAATATCTTGGTA
TTGATGCTATTAAAAATGCTTTATTCTTGAGAGAAAGTATAATTGACTTTATAACATTATTAGCACCTTTTGCTCCTCAT
TTTGCTGAAGAACAATGGGAACTTATAGGCATTAATTCTTCCATTTTCAATGAAAAATGGCCTGAATTTGACCCTAAAGC
CCTAATAAAAGATGAAGTTGAAATAGCCGTACAAGTAAATGGGAAAATAAGAGCTAAAATAAATATATCTACTAGTTCAT
CAGAAGATGAAATAAAAGAATCAGCATTAAATAATGAGGATATTAAAAATTCTATAGGTGATAAAGAAATTAAAAAAGTT
ATAGTAATAAAAAATAGATTAGTTAATATAGTTGCTAAATAA

Upstream 100 bases:

>100_bases
TTAGGAGATGAAGGTTTTTTTATTTTATATAAAAATATTTAATTATTATTTTAAATTTTATTTATAAATAATAGTTAATG
AAATAGATAGGAGGATTTTT

Downstream 100 bases:

>100_bases
AATTAAAAAGGCTGTCTGAAGATAAAAATAGATTTAATCTTAACCCGTAAATATAGAAAATACATTTATAAGGCACTTCA
TTTTGCTAAGAAGTTCTTAA

Product: leucyl-tRNA synthetase

Products: NA

Alternate protein names: Leucine--tRNA ligase; LeuRS [H]

Number of amino acids: Translated: 813; Mature: 812

Protein sequence:

>813_residues
MGNYSTKIDEKWQKKWEENSLYKFNNENLDKKLYVLEMFSYPSGSKLHAGHWFNYGPVDSWARFKRMQGYNVFQPMGFDA
FGLPAENYAIKTGIHPKDSTFKNIETMETQLKAMGAMFNWENEVITCSPDYYKWTQWLFLKLYEKGLAYKKKAPVNWCPS
CNTVLANEQVLDGKCERCDSNVDKKNLEQWFLKITDYADELLEKLDELDWPEKTKAMQKHWIGKSVGAEVAFNVADSDLS
FNVFTTRVDTLFGVTYVVLAPENDLVDKLTTPENKAEVESYKTQAKNQSDIERQSITREKTGVFSGSYAINPINGKKVPI
WIGDYVLNTYGTGCVMAVPAHDERDFAFATKYNLPIERVIEGGDSLPYTEYGKMVNSGEFDGLFGNKAKEAVISKLESMN
LGRKKINYRLRDWLVSRQRYWGAPIPIVYCEKCGTVEVPMEQLPVELPYNVQFSPDGKSPLSKCDEFVNTTCPKCGGPAK
READTLDTFVCSSWYYLRYPDNKNSEAAFNPELINKMLPVDKYVGGPEHACMHLLYARFITKALRDMGYLNFDEPFLSLT
HQGLILGPDGLKMSKSKGNTISPDDYIKEFGADVFRMYLMFGFDYTEGGAWSDDAIKSIGKFVDRVERILENAREEIKNS
KDNKSTMDKDEKELNYVRHHSIKSITEDIDKMQFNTSIARLMEFTNALSKYLGIDAIKNALFLRESIIDFITLLAPFAPH
FAEEQWELIGINSSIFNEKWPEFDPKALIKDEVEIAVQVNGKIRAKINISTSSSEDEIKESALNNEDIKNSIGDKEIKKV
IVIKNRLVNIVAK

Sequences:

>Translated_813_residues
MGNYSTKIDEKWQKKWEENSLYKFNNENLDKKLYVLEMFSYPSGSKLHAGHWFNYGPVDSWARFKRMQGYNVFQPMGFDA
FGLPAENYAIKTGIHPKDSTFKNIETMETQLKAMGAMFNWENEVITCSPDYYKWTQWLFLKLYEKGLAYKKKAPVNWCPS
CNTVLANEQVLDGKCERCDSNVDKKNLEQWFLKITDYADELLEKLDELDWPEKTKAMQKHWIGKSVGAEVAFNVADSDLS
FNVFTTRVDTLFGVTYVVLAPENDLVDKLTTPENKAEVESYKTQAKNQSDIERQSITREKTGVFSGSYAINPINGKKVPI
WIGDYVLNTYGTGCVMAVPAHDERDFAFATKYNLPIERVIEGGDSLPYTEYGKMVNSGEFDGLFGNKAKEAVISKLESMN
LGRKKINYRLRDWLVSRQRYWGAPIPIVYCEKCGTVEVPMEQLPVELPYNVQFSPDGKSPLSKCDEFVNTTCPKCGGPAK
READTLDTFVCSSWYYLRYPDNKNSEAAFNPELINKMLPVDKYVGGPEHACMHLLYARFITKALRDMGYLNFDEPFLSLT
HQGLILGPDGLKMSKSKGNTISPDDYIKEFGADVFRMYLMFGFDYTEGGAWSDDAIKSIGKFVDRVERILENAREEIKNS
KDNKSTMDKDEKELNYVRHHSIKSITEDIDKMQFNTSIARLMEFTNALSKYLGIDAIKNALFLRESIIDFITLLAPFAPH
FAEEQWELIGINSSIFNEKWPEFDPKALIKDEVEIAVQVNGKIRAKINISTSSSEDEIKESALNNEDIKNSIGDKEIKKV
IVIKNRLVNIVAK
>Mature_812_residues
GNYSTKIDEKWQKKWEENSLYKFNNENLDKKLYVLEMFSYPSGSKLHAGHWFNYGPVDSWARFKRMQGYNVFQPMGFDAF
GLPAENYAIKTGIHPKDSTFKNIETMETQLKAMGAMFNWENEVITCSPDYYKWTQWLFLKLYEKGLAYKKKAPVNWCPSC
NTVLANEQVLDGKCERCDSNVDKKNLEQWFLKITDYADELLEKLDELDWPEKTKAMQKHWIGKSVGAEVAFNVADSDLSF
NVFTTRVDTLFGVTYVVLAPENDLVDKLTTPENKAEVESYKTQAKNQSDIERQSITREKTGVFSGSYAINPINGKKVPIW
IGDYVLNTYGTGCVMAVPAHDERDFAFATKYNLPIERVIEGGDSLPYTEYGKMVNSGEFDGLFGNKAKEAVISKLESMNL
GRKKINYRLRDWLVSRQRYWGAPIPIVYCEKCGTVEVPMEQLPVELPYNVQFSPDGKSPLSKCDEFVNTTCPKCGGPAKR
EADTLDTFVCSSWYYLRYPDNKNSEAAFNPELINKMLPVDKYVGGPEHACMHLLYARFITKALRDMGYLNFDEPFLSLTH
QGLILGPDGLKMSKSKGNTISPDDYIKEFGADVFRMYLMFGFDYTEGGAWSDDAIKSIGKFVDRVERILENAREEIKNSK
DNKSTMDKDEKELNYVRHHSIKSITEDIDKMQFNTSIARLMEFTNALSKYLGIDAIKNALFLRESIIDFITLLAPFAPHF
AEEQWELIGINSSIFNEKWPEFDPKALIKDEVEIAVQVNGKIRAKINISTSSSEDEIKESALNNEDIKNSIGDKEIKKVI
VIKNRLVNIVAK

Specific function: Unknown

COG id: COG0495

COG function: function code J; Leucyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI7661872, Length=871, Percent_Identity=33.2950631458094, Blast_Score=470, Evalue=1e-132,
Organism=Escherichia coli, GI1786861, Length=858, Percent_Identity=40.9090909090909, Blast_Score=650, Evalue=0.0,
Organism=Escherichia coli, GI2367096, Length=322, Percent_Identity=25.776397515528, Blast_Score=70, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71997517, Length=803, Percent_Identity=28.7671232876712, Blast_Score=311, Evalue=8e-85,
Organism=Caenorhabditis elegans, GI71997510, Length=803, Percent_Identity=28.7671232876712, Blast_Score=311, Evalue=9e-85,
Organism=Caenorhabditis elegans, GI212645227, Length=349, Percent_Identity=28.6532951289398, Blast_Score=127, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6323414, Length=876, Percent_Identity=36.5296803652968, Blast_Score=515, Evalue=1e-147,
Organism=Saccharomyces cerevisiae, GI6321531, Length=374, Percent_Identity=24.331550802139, Blast_Score=91, Evalue=7e-19,
Organism=Drosophila melanogaster, GI21355409, Length=860, Percent_Identity=33.1395348837209, Blast_Score=417, Evalue=1e-116,

Paralogues:

None

Copy number: 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002300
- InterPro:   IPR002302
- InterPro:   IPR014729
- InterPro:   IPR009080
- InterPro:   IPR013155
- InterPro:   IPR009008 [H]

Pfam domain/function: PF08264 Anticodon_1; PF00133 tRNA-synt_1 [H]

EC number: =6.1.1.4 [H]

Molecular weight: Translated: 92951; Mature: 92819

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGNYSTKIDEKWQKKWEENSLYKFNNENLDKKLYVLEMFSYPSGSKLHAGHWFNYGPVDS
CCCCCCCHHHHHHHHHCCCCCEEECCCCCCCEEEEEEEECCCCCCCEECCCCCCCCCHHH
WARFKRMQGYNVFQPMGFDAFGLPAENYAIKTGIHPKDSTFKNIETMETQLKAMGAMFNW
HHHHHHHCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCC
ENEVITCSPDYYKWTQWLFLKLYEKGLAYKKKAPVNWCPSCNTVLANEQVLDGKCERCDS
CCCEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCHHHCCHHHHHCC
NVDKKNLEQWFLKITDYADELLEKLDELDWPEKTKAMQKHWIGKSVGAEVAFNVADSDLS
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHCCCEEEEEEECCCCE
FNVFTTRVDTLFGVTYVVLAPENDLVDKLTTPENKAEVESYKTQAKNQSDIERQSITREK
EEEHHHHHHHHHCCEEEEECCCCHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHH
TGVFSGSYAINPINGKKVPIWIGDYVLNTYGTGCVMAVPAHDERDFAFATKYNLPIERVI
HCCCCCCEEECCCCCCEEEEEECCHHHHCCCCCEEEEECCCCCCCEEEEEECCCCHHHHH
EGGDSLPYTEYGKMVNSGEFDGLFGNKAKEAVISKLESMNLGRKKINYRLRDWLVSRQRY
CCCCCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
WGAPIPIVYCEKCGTVEVPMEQLPVELPYNVQFSPDGKSPLSKCDEFVNTTCPKCGGPAK
CCCCCCEEEECCCCCEECCHHHCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCCCCCCCC
READTLDTFVCSSWYYLRYPDNKNSEAAFNPELINKMLPVDKYVGGPEHACMHLLYARFI
CCHHHHHHHHHCCEEEEECCCCCCCCCCCCHHHHHHHCCHHHHCCCHHHHHHHHHHHHHH
TKALRDMGYLNFDEPFLSLTHQGLILGPDGLKMSKSKGNTISPDDYIKEFGADVFRMYLM
HHHHHHCCCCCCCCHHHHHCCCCEEECCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHH
FGFDYTEGGAWSDDAIKSIGKFVDRVERILENAREEIKNSKDNKSTMDKDEKELNYVRHH
HCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCHHHHHHHHHHH
SIKSITEDIDKMQFNTSIARLMEFTNALSKYLGIDAIKNALFLRESIIDFITLLAPFAPH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHH
FAEEQWELIGINSSIFNEKWPEFDPKALIKDEVEIAVQVNGKIRAKINISTSSSEDEIKE
HHCCCEEEEECCHHHHCCCCCCCCCHHHHCCCEEEEEEECCEEEEEEEECCCCCHHHHHH
SALNNEDIKNSIGDKEIKKVIVIKNRLVNIVAK
HHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GNYSTKIDEKWQKKWEENSLYKFNNENLDKKLYVLEMFSYPSGSKLHAGHWFNYGPVDS
CCCCCCHHHHHHHHHCCCCCEEECCCCCCCEEEEEEEECCCCCCCEECCCCCCCCCHHH
WARFKRMQGYNVFQPMGFDAFGLPAENYAIKTGIHPKDSTFKNIETMETQLKAMGAMFNW
HHHHHHHCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCC
ENEVITCSPDYYKWTQWLFLKLYEKGLAYKKKAPVNWCPSCNTVLANEQVLDGKCERCDS
CCCEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCHHHCCHHHHHCC
NVDKKNLEQWFLKITDYADELLEKLDELDWPEKTKAMQKHWIGKSVGAEVAFNVADSDLS
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHCCCEEEEEEECCCCE
FNVFTTRVDTLFGVTYVVLAPENDLVDKLTTPENKAEVESYKTQAKNQSDIERQSITREK
EEEHHHHHHHHHCCEEEEECCCCHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHH
TGVFSGSYAINPINGKKVPIWIGDYVLNTYGTGCVMAVPAHDERDFAFATKYNLPIERVI
HCCCCCCEEECCCCCCEEEEEECCHHHHCCCCCEEEEECCCCCCCEEEEEECCCCHHHHH
EGGDSLPYTEYGKMVNSGEFDGLFGNKAKEAVISKLESMNLGRKKINYRLRDWLVSRQRY
CCCCCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
WGAPIPIVYCEKCGTVEVPMEQLPVELPYNVQFSPDGKSPLSKCDEFVNTTCPKCGGPAK
CCCCCCEEEECCCCCEECCHHHCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCCCCCCCC
READTLDTFVCSSWYYLRYPDNKNSEAAFNPELINKMLPVDKYVGGPEHACMHLLYARFI
CCHHHHHHHHHCCEEEEECCCCCCCCCCCCHHHHHHHCCHHHHCCCHHHHHHHHHHHHHH
TKALRDMGYLNFDEPFLSLTHQGLILGPDGLKMSKSKGNTISPDDYIKEFGADVFRMYLM
HHHHHHCCCCCCCCHHHHHCCCCEEECCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHH
FGFDYTEGGAWSDDAIKSIGKFVDRVERILENAREEIKNSKDNKSTMDKDEKELNYVRHH
HCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCHHHHHHHHHHH
SIKSITEDIDKMQFNTSIARLMEFTNALSKYLGIDAIKNALFLRESIIDFITLLAPFAPH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHH
FAEEQWELIGINSSIFNEKWPEFDPKALIKDEVEIAVQVNGKIRAKINISTSSSEDEIKE
HHCCCEEEEECCHHHHCCCCCCCCCHHHHCCCEEEEEEECCEEEEEEEECCCCCHHHHHH
SALNNEDIKNSIGDKEIKKVIVIKNRLVNIVAK
HHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA