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The map label for this gene is tmk [H]

Identifier: 226947280

GI number: 226947280

Start: 82428

End: 83123

Strand: Direct

Name: tmk [H]

Synonym: CLM_0097

Alternate gene names: 226947280

Gene position: 82428-83123 (Clockwise)

Preceding gene: 226947279

Following gene: 226947281

Centisome position: 1.98

GC content: 27.16

Gene sequence:

>696_bases
ATGGAAAGAGGTAGGTTAATAGTTATAGAGGGTAGTGATGGAAGTGGTAAAGCTACCCAAACTAAAAAACTTTATGATAA
ATTAGTAACAGAAAATAAGAAAGTTAAAAAAGTAGAATTCCCTAATTATAAAAGTGAATCATCTGCTTTAATAAAGATGT
ACTTAAGTGGAGAATTTGGAAGGAATCCGGATAGTGTAAATCCTTATGCTTCATCTACATTTTATGCGGTAGATAGATTT
GCATCCTATAAAAAAGATTGGGAAGAGTTTTACCTAAAGGGTGGAATTATTATTGCAGATAGATATACTACATCCAATAT
GATACATCAAGCAGCAAAAATAAAAGATGTACAAGCCAAAGATAATTTTTTAAATTGGCTATGGGATTTTGAATTTAGAA
AGTTTAATTTACCTGTACCAGATTGTGTTATATTTTTGGATATGCCTCCTAAATTCAGTAAAATTCTTATGAAAACCAGG
AATAATAAATTTACGGGAGAGAAAGAAAAGGATATACACGAAAATAATTATGAGTATTTATTAGAGTCATATAACAATTC
TAAATATATATCAGAAAAATATGATTGGAATAGAATTGAATGTACTAATAAGGATAAGATTAAAAGTATAGATCAAATAA
ATGATGATATAATTAAAATAATAACACAATATATAGATTTCAGTGAACAAAGGTAA

Upstream 100 bases:

>100_bases
ATGCTATATGTTATTATAAAAATAATGGAATAGATGTATTAGGTTTAAAGGATAATAAGATTCAAATAGTAAAATAATAA
GTATAAATGTGGAGGAAAAA

Downstream 100 bases:

>100_bases
TTATAATTGTAAACTTGTATAAAAAAATATAAAATATAGGTAAGAAACTACAATGTAATATCCTTTAAGGAGGTAATAAT
ATGAAATTAGTTATTGCTAT

Product: putative thymidylate kinase

Products: NA

Alternate protein names: Thymidine monophosphate kinase; dTMP kinase; TMPK [H]

Number of amino acids: Translated: 231; Mature: 231

Protein sequence:

>231_residues
MERGRLIVIEGSDGSGKATQTKKLYDKLVTENKKVKKVEFPNYKSESSALIKMYLSGEFGRNPDSVNPYASSTFYAVDRF
ASYKKDWEEFYLKGGIIIADRYTTSNMIHQAAKIKDVQAKDNFLNWLWDFEFRKFNLPVPDCVIFLDMPPKFSKILMKTR
NNKFTGEKEKDIHENNYEYLLESYNNSKYISEKYDWNRIECTNKDKIKSIDQINDDIIKIITQYIDFSEQR

Sequences:

>Translated_231_residues
MERGRLIVIEGSDGSGKATQTKKLYDKLVTENKKVKKVEFPNYKSESSALIKMYLSGEFGRNPDSVNPYASSTFYAVDRF
ASYKKDWEEFYLKGGIIIADRYTTSNMIHQAAKIKDVQAKDNFLNWLWDFEFRKFNLPVPDCVIFLDMPPKFSKILMKTR
NNKFTGEKEKDIHENNYEYLLESYNNSKYISEKYDWNRIECTNKDKIKSIDQINDDIIKIITQYIDFSEQR
>Mature_231_residues
MERGRLIVIEGSDGSGKATQTKKLYDKLVTENKKVKKVEFPNYKSESSALIKMYLSGEFGRNPDSVNPYASSTFYAVDRF
ASYKKDWEEFYLKGGIIIADRYTTSNMIHQAAKIKDVQAKDNFLNWLWDFEFRKFNLPVPDCVIFLDMPPKFSKILMKTR
NNKFTGEKEKDIHENNYEYLLESYNNSKYISEKYDWNRIECTNKDKIKSIDQINDDIIKIITQYIDFSEQR

Specific function: Catalyzes the reversible phosphorylation of deoxythymidine monophosphate (dTMP) to deoxythymidine diphosphate (dTDP), using ATP as its preferred phosphoryl donor. Situated at the junction of both de novo and salvage pathways of deoxythymidine triphosphate

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018095
- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 27259; Mature: 27259

Theoretical pI: Translated: 8.83; Mature: 8.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERGRLIVIEGSDGSGKATQTKKLYDKLVTENKKVKKVEFPNYKSESSALIKMYLSGEFG
CCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEEEECCCCC
RNPDSVNPYASSTFYAVDRFASYKKDWEEFYLKGGIIIADRYTTSNMIHQAAKIKDVQAK
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCHHH
DNFLNWLWDFEFRKFNLPVPDCVIFLDMPPKFSKILMKTRNNKFTGEKEKDIHENNYEYL
HHHHHHHCCCCEEEECCCCCCEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHH
LESYNNSKYISEKYDWNRIECTNKDKIKSIDQINDDIIKIITQYIDFSEQR
HHHCCCCCEECCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MERGRLIVIEGSDGSGKATQTKKLYDKLVTENKKVKKVEFPNYKSESSALIKMYLSGEFG
CCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEEEECCCCC
RNPDSVNPYASSTFYAVDRFASYKKDWEEFYLKGGIIIADRYTTSNMIHQAAKIKDVQAK
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCHHH
DNFLNWLWDFEFRKFNLPVPDCVIFLDMPPKFSKILMKTRNNKFTGEKEKDIHENNYEYL
HHHHHHHCCCCEEEECCCCCCEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHH
LESYNNSKYISEKYDWNRIECTNKDKIKSIDQINDDIIKIITQYIDFSEQR
HHHCCCCCEECCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036; 11369858; 10666613; 11469859; 11914484; 12454011; 12662932 [H]