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The map label for this gene is serS [H]

Identifier: 226947237

GI number: 226947237

Start: 22539

End: 23819

Strand: Direct

Name: serS [H]

Synonym: CLM_0022

Alternate gene names: 226947237

Gene position: 22539-23819 (Clockwise)

Preceding gene: 226947236

Following gene: 226947241

Centisome position: 0.54

GC content: 29.2

Gene sequence:

>1281_bases
ATGTTAGATTTAAAAAGAATAAGAAATAATTCAAATGAAATAAAAGAAGCATTAAACAATAGAGGAGAAAAGTTTGATGT
AACTGTAATTGATGAAGTTTTAAAATTAGATGAAGAAAGAAGAAATATTTTAGTTAAAGTTGAGGTTTTAAAAAGTAAGA
GAAATAAAGTTTCTTCTGAAGTTCCTAAATTAAAAAAAGAAGGAAAAGATGTATCTAATATAGTAGCTGAAATGAAGAAT
TTATCAGAAGAGATAAAAGGATTTGATGTTACTTTAGCTAAAATAGATGAAAAAATACAATATATAATGCTTAGAATACC
TAATATACCCAACCCACAAGTTCCAGATGGAGAAACAGATGAGGATAATATAGAAATAAGAAATTGGCTGGAACCAACAA
AATTTGATTTTGAACCTAAAGCACATTGGGATATAGGAACAAATTTAAATATTCTTGATTTTGAAAGAGCTGGAAAAGTA
ACAGGATCAAGATTTACTTTTTATAAAGGATTAGGGGCTAGATTAGAAAGAGCAGTAATATCTTATTTTTTAGATACTCA
TACAGAAAAACATGATTATACTGAAATATTACCACCTTATATGGTAAATAGAACAAGTATGATAGGAACAGGACAATTAC
CTAAATTTGAAGAAGACGCTTTTAAAATCTCAGAGGATGATTACTTCTTAATACCAACTGCAGAGGTTCCTGTAACTAAT
TTATATAGAGATGAAATCTTAAAAGGTGATGAATTACCATTAAAACATGTAGCTTATAGTGCTTGTTTTAGATCAGAAGC
AGGTTCAGCAGGTAGAGATACAAGAGGTCTTGTTAGACAACATCAATTTAATAAAGTAGAGCTTGTTAAATTTACAAAAC
CAGAACAATCCTATGAAGAATTGGAAAAATTAACTAATGATGCTGAAACAGTATTAAAAGAGTTGGGTATTCCATATAGA
GTTGTAAGAATATGCAAAGGTGATTTAGGATTTACAGCTGCATTAAAATATGATTTAGAAGTTTGGATGCCAAGTTACAA
TAGATATGTTGAAATATCAAGCTGTAGTAACTTTGAAGACTTCCAAGCAAGACGTGCTAATATAAGATATAAAGAAGATG
CAAAAGCAAAACCACAATATGTTCATACATTAAATGGATCAGGAGTTGCTATTGGAAGAACTGTTGCAGCTATACTTGAA
AACTATCAAAGTGAAGATGGATCAGTTACAATACCAGAAGTGTTAAGACCTTATATGGGAGGAAGAGAAGTAATAAAATA
A

Upstream 100 bases:

>100_bases
GTCCCTTTTATAGGGACGAGGGGCTTTTTTTATTATATTATAAAGCTATAAAATCTGAAGGGAGGAAGTATTTATTGGAT
AATCCAATAAATAAAATATT

Downstream 100 bases:

>100_bases
CTGAATATTATTTGTTATAAAGAATTTATATATATTTAATTTAAAATAAACACTATTAAATTAATTAATTGTGATAAAAT
TTAATAGTGTTTTTATTATT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MLDLKRIRNNSNEIKEALNNRGEKFDVTVIDEVLKLDEERRNILVKVEVLKSKRNKVSSEVPKLKKEGKDVSNIVAEMKN
LSEEIKGFDVTLAKIDEKIQYIMLRIPNIPNPQVPDGETDEDNIEIRNWLEPTKFDFEPKAHWDIGTNLNILDFERAGKV
TGSRFTFYKGLGARLERAVISYFLDTHTEKHDYTEILPPYMVNRTSMIGTGQLPKFEEDAFKISEDDYFLIPTAEVPVTN
LYRDEILKGDELPLKHVAYSACFRSEAGSAGRDTRGLVRQHQFNKVELVKFTKPEQSYEELEKLTNDAETVLKELGIPYR
VVRICKGDLGFTAALKYDLEVWMPSYNRYVEISSCSNFEDFQARRANIRYKEDAKAKPQYVHTLNGSGVAIGRTVAAILE
NYQSEDGSVTIPEVLRPYMGGREVIK

Sequences:

>Translated_426_residues
MLDLKRIRNNSNEIKEALNNRGEKFDVTVIDEVLKLDEERRNILVKVEVLKSKRNKVSSEVPKLKKEGKDVSNIVAEMKN
LSEEIKGFDVTLAKIDEKIQYIMLRIPNIPNPQVPDGETDEDNIEIRNWLEPTKFDFEPKAHWDIGTNLNILDFERAGKV
TGSRFTFYKGLGARLERAVISYFLDTHTEKHDYTEILPPYMVNRTSMIGTGQLPKFEEDAFKISEDDYFLIPTAEVPVTN
LYRDEILKGDELPLKHVAYSACFRSEAGSAGRDTRGLVRQHQFNKVELVKFTKPEQSYEELEKLTNDAETVLKELGIPYR
VVRICKGDLGFTAALKYDLEVWMPSYNRYVEISSCSNFEDFQARRANIRYKEDAKAKPQYVHTLNGSGVAIGRTVAAILE
NYQSEDGSVTIPEVLRPYMGGREVIK
>Mature_426_residues
MLDLKRIRNNSNEIKEALNNRGEKFDVTVIDEVLKLDEERRNILVKVEVLKSKRNKVSSEVPKLKKEGKDVSNIVAEMKN
LSEEIKGFDVTLAKIDEKIQYIMLRIPNIPNPQVPDGETDEDNIEIRNWLEPTKFDFEPKAHWDIGTNLNILDFERAGKV
TGSRFTFYKGLGARLERAVISYFLDTHTEKHDYTEILPPYMVNRTSMIGTGQLPKFEEDAFKISEDDYFLIPTAEVPVTN
LYRDEILKGDELPLKHVAYSACFRSEAGSAGRDTRGLVRQHQFNKVELVKFTKPEQSYEELEKLTNDAETVLKELGIPYR
VVRICKGDLGFTAALKYDLEVWMPSYNRYVEISSCSNFEDFQARRANIRYKEDAKAKPQYVHTLNGSGVAIGRTVAAILE
NYQSEDGSVTIPEVLRPYMGGREVIK

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=470, Percent_Identity=34.6808510638298, Blast_Score=228, Evalue=8e-60,
Organism=Homo sapiens, GI8923421, Length=434, Percent_Identity=28.3410138248848, Blast_Score=192, Evalue=5e-49,
Organism=Homo sapiens, GI225579074, Length=334, Percent_Identity=32.0359281437126, Blast_Score=187, Evalue=1e-47,
Organism=Escherichia coli, GI1787120, Length=432, Percent_Identity=48.1481481481481, Blast_Score=416, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17539260, Length=439, Percent_Identity=33.4851936218679, Blast_Score=206, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI17542084, Length=315, Percent_Identity=31.4285714285714, Blast_Score=138, Evalue=7e-33,
Organism=Saccharomyces cerevisiae, GI6321799, Length=432, Percent_Identity=33.5648148148148, Blast_Score=236, Evalue=4e-63,
Organism=Saccharomyces cerevisiae, GI6320226, Length=411, Percent_Identity=34.7931873479319, Blast_Score=234, Evalue=2e-62,
Organism=Drosophila melanogaster, GI24581334, Length=473, Percent_Identity=33.1923890063425, Blast_Score=207, Evalue=1e-53,
Organism=Drosophila melanogaster, GI17737985, Length=330, Percent_Identity=34.5454545454545, Blast_Score=173, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 48845; Mature: 48845

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDLKRIRNNSNEIKEALNNRGEKFDVTVIDEVLKLDEERRNILVKVEVLKSKRNKVSSE
CCCHHHHHCCHHHHHHHHHCCCCEEEHHHHHHHHHHCHHHCCEEEEEHHHHHHHHHHHHH
VPKLKKEGKDVSNIVAEMKNLSEEIKGFDVTLAKIDEKIQYIMLRIPNIPNPQVPDGETD
HHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHEEEEECCCCCCCCCCCCCCC
EDNIEIRNWLEPTKFDFEPKAHWDIGTNLNILDFERAGKVTGSRFTFYKGLGARLERAVI
CCCCHHHHCCCCCCCCCCCCCCCCCCCCCCEEEHHHCCCCCCCEEEEHHHHHHHHHHHHH
SYFLDTHTEKHDYTEILPPYMVNRTSMIGTGQLPKFEEDAFKISEDDYFLIPTAEVPVTN
HHHHHHCCCCCCHHHHCCCHHHCCCCCCCCCCCCCCCCCCEEECCCCEEEEECCCCCHHH
LYRDEILKGDELPLKHVAYSACFRSEAGSAGRDTRGLVRQHQFNKVELVKFTKPEQSYEE
HHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEEECCCCHHHHH
LEKLTNDAETVLKELGIPYRVVRICKGDLGFTAALKYDLEVWMPSYNRYVEISSCSNFED
HHHHHCHHHHHHHHCCCCCEEHHHHCCCCCEEEEEEEEEEEECCCCCCEEEECCCCCCHH
FQARRANIRYKEDAKAKPQYVHTLNGSGVAIGRTVAAILENYQSEDGSVTIPEVLRPYMG
HHHHHCCCCCCCCCCCCCCEEEEECCCCEEHHHHHHHHHHHHCCCCCCEEHHHHHHHHCC
GREVIK
CHHHCC
>Mature Secondary Structure
MLDLKRIRNNSNEIKEALNNRGEKFDVTVIDEVLKLDEERRNILVKVEVLKSKRNKVSSE
CCCHHHHHCCHHHHHHHHHCCCCEEEHHHHHHHHHHCHHHCCEEEEEHHHHHHHHHHHHH
VPKLKKEGKDVSNIVAEMKNLSEEIKGFDVTLAKIDEKIQYIMLRIPNIPNPQVPDGETD
HHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHEEEEECCCCCCCCCCCCCCC
EDNIEIRNWLEPTKFDFEPKAHWDIGTNLNILDFERAGKVTGSRFTFYKGLGARLERAVI
CCCCHHHHCCCCCCCCCCCCCCCCCCCCCCEEEHHHCCCCCCCEEEEHHHHHHHHHHHHH
SYFLDTHTEKHDYTEILPPYMVNRTSMIGTGQLPKFEEDAFKISEDDYFLIPTAEVPVTN
HHHHHHCCCCCCHHHHCCCHHHCCCCCCCCCCCCCCCCCCEEECCCCEEEEECCCCCHHH
LYRDEILKGDELPLKHVAYSACFRSEAGSAGRDTRGLVRQHQFNKVELVKFTKPEQSYEE
HHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCEEEEEECCCCHHHHH
LEKLTNDAETVLKELGIPYRVVRICKGDLGFTAALKYDLEVWMPSYNRYVEISSCSNFED
HHHHHCHHHHHHHHCCCCCEEHHHHCCCCCEEEEEEEEEEEECCCCCCEEEECCCCCCHH
FQARRANIRYKEDAKAKPQYVHTLNGSGVAIGRTVAAILENYQSEDGSVTIPEVLRPYMG
HHHHHCCCCCCCCCCCCCCEEEEECCCCEEHHHHHHHHHHHHCCCCCCEEHHHHHHHHCC
GREVIK
CHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA