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The map label for this gene is hssS [H]

Identifier: 226225128

GI number: 226225128

Start: 2628956

End: 2630335

Strand: Reverse

Name: hssS [H]

Synonym: Lm4b_02549

Alternate gene names: 226225128

Gene position: 2630335-2628956 (Counterclockwise)

Preceding gene: 226225129

Following gene: 226225127

Centisome position: 90.31

GC content: 40.22

Gene sequence:

>1380_bases
ATGAAATCGTTATATAGTCGAATAGTTGTCACGATGCTTGTCGTCATTATTTCCAGTAGTTTGCTCGGCTTTTTCTTTGC
AAACATTTATTACCAAATAAAATTAAAACCTTTTAACGACGAAAAAACTGCCAAAATAGCGGAGGAAGTCCAACAATTTT
ATGAGTCAAATGCTACGATTTCTTTAAACGAGTACTTGGAAAATGTGGGCGAACTGGGATACGAATTATATTTGACAGAT
GGCGCGGAAAAATCCACTTATTATGGTGGCGCTTTTCGGAAAAAAGATTTACCGGATAAGACAATCAAGCAAGTACTGGA
CGGAGAGACATATCATGGAATTGATTCGTTTGATACAGGCATTTTCATCACAGGCTTTTTTGATAATGATGTGCGAAATA
CCATTGGTGTCCCGGTCCAAGCTGATGGTAAACAACTAGCGCTATTCATACGCCAAGACCCGGAACAACAATTTGGGGAA
CTTCGAATATTTTTCGCGATGATACTTATTTTCACATCCATCATCAGTATTCTGTTGGTTCTTATTAGTGGCAGATATAT
TGTCAAACCTGTCGTGAAGTTGACGAATGCGACGAAAAAAATACGTAAAGGCAATTATGATGTAGCCTTTGAAGTTCGGC
GTAAGGATGAAATTGGGCAGTTGGCAGACTCGTTTACGAAAATGGCTAGTGAACTCAAAAAATCTGAAGCTTCCCGTCAA
GAATTTGTCGCCAATGTTTCTCATGAACTACAATCTCCGCTCACATCCATGCAAGGCTTTGCGAGACTTTTAGGTTCTGG
AACACTAACCGAAAAAGAACAAGCCGAATATTTAACCGTGTTATCAGAGGAGACAACACGTCTATCTTCCTTAACCAAAC
AACTACTCACACTCGCTTCACTTGACCAAGAATCAGAGTTGCGAAAAAAAGAGCCAGTTCACTTAGACGAGCAGTGGCGT
CAATTAATCCAAATGACCGAGTGGAGTTGGCGCGAAAAAGAACTAACAATAAATTTAGACTTAGCAGATGTAAACTATAC
GGGTGATGCTGAATTACTTTATCAAGTGTGGTCCAATTTGTTAACTAATGCGATTAAGTTCACACCACAGGGCGGGAATA
TCAAAGTCCACCTTTATGAAAAAGCGACGTATGTTTTTGTAGAAGTTCAAGATAGCGGTGTCGGCATAGGTAAGGAGGAT
ATGGCCAAGATTTTTGACCGTTTTTATAAAGCTAACGAAAGCCGAACCCGAGAAGAAGGCTCGAGTGGCCTCGGATTATC
CATTTGCCAGAAAATTATCACGCTCCATCACGGCGAAATAACCGTGCAAAGTAGCCCCGAAAAAGGCACGACATTCAAAG
TCAAACTACCAAAAAACTAA

Upstream 100 bases:

>100_bases
ATGTACATATTAAACGATTGCGGGACCATTTTGATGAAGAAAAGGATGGTATTCGAATTGTTACAGTGCGCGGCGTTGGT
TATAAATTGGAGGAGACAAC

Downstream 100 bases:

>100_bases
ATTTGTAAAATCCGATTCACATTCCGTTTACAAAACTTCTTTAAACTAAGGATAAGATCTTAGAAGGAGTTGAACGGAAT
GTTTTTGGCATTAAGAGAAT

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MKSLYSRIVVTMLVVIISSSLLGFFFANIYYQIKLKPFNDEKTAKIAEEVQQFYESNATISLNEYLENVGELGYELYLTD
GAEKSTYYGGAFRKKDLPDKTIKQVLDGETYHGIDSFDTGIFITGFFDNDVRNTIGVPVQADGKQLALFIRQDPEQQFGE
LRIFFAMILIFTSIISILLVLISGRYIVKPVVKLTNATKKIRKGNYDVAFEVRRKDEIGQLADSFTKMASELKKSEASRQ
EFVANVSHELQSPLTSMQGFARLLGSGTLTEKEQAEYLTVLSEETTRLSSLTKQLLTLASLDQESELRKKEPVHLDEQWR
QLIQMTEWSWREKELTINLDLADVNYTGDAELLYQVWSNLLTNAIKFTPQGGNIKVHLYEKATYVFVEVQDSGVGIGKED
MAKIFDRFYKANESRTREEGSSGLGLSICQKIITLHHGEITVQSSPEKGTTFKVKLPKN

Sequences:

>Translated_459_residues
MKSLYSRIVVTMLVVIISSSLLGFFFANIYYQIKLKPFNDEKTAKIAEEVQQFYESNATISLNEYLENVGELGYELYLTD
GAEKSTYYGGAFRKKDLPDKTIKQVLDGETYHGIDSFDTGIFITGFFDNDVRNTIGVPVQADGKQLALFIRQDPEQQFGE
LRIFFAMILIFTSIISILLVLISGRYIVKPVVKLTNATKKIRKGNYDVAFEVRRKDEIGQLADSFTKMASELKKSEASRQ
EFVANVSHELQSPLTSMQGFARLLGSGTLTEKEQAEYLTVLSEETTRLSSLTKQLLTLASLDQESELRKKEPVHLDEQWR
QLIQMTEWSWREKELTINLDLADVNYTGDAELLYQVWSNLLTNAIKFTPQGGNIKVHLYEKATYVFVEVQDSGVGIGKED
MAKIFDRFYKANESRTREEGSSGLGLSICQKIITLHHGEITVQSSPEKGTTFKVKLPKN
>Mature_459_residues
MKSLYSRIVVTMLVVIISSSLLGFFFANIYYQIKLKPFNDEKTAKIAEEVQQFYESNATISLNEYLENVGELGYELYLTD
GAEKSTYYGGAFRKKDLPDKTIKQVLDGETYHGIDSFDTGIFITGFFDNDVRNTIGVPVQADGKQLALFIRQDPEQQFGE
LRIFFAMILIFTSIISILLVLISGRYIVKPVVKLTNATKKIRKGNYDVAFEVRRKDEIGQLADSFTKMASELKKSEASRQ
EFVANVSHELQSPLTSMQGFARLLGSGTLTEKEQAEYLTVLSEETTRLSSLTKQLLTLASLDQESELRKKEPVHLDEQWR
QLIQMTEWSWREKELTINLDLADVNYTGDAELLYQVWSNLLTNAIKFTPQGGNIKVHLYEKATYVFVEVQDSGVGIGKED
MAKIFDRFYKANESRTREEGSSGLGLSICQKIITLHHGEITVQSSPEKGTTFKVKLPKN

Specific function: Member of the two-component regulatory system hssS/hssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. HssS functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=278, Percent_Identity=31.6546762589928, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI1789149, Length=349, Percent_Identity=29.7994269340974, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1786783, Length=401, Percent_Identity=26.4339152119701, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1786600, Length=230, Percent_Identity=30, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI145693157, Length=250, Percent_Identity=31.2, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI1790346, Length=292, Percent_Identity=28.0821917808219, Blast_Score=115, Evalue=9e-27,
Organism=Escherichia coli, GI1790861, Length=308, Percent_Identity=27.9220779220779, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI87082128, Length=314, Percent_Identity=25.796178343949, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI87081816, Length=334, Percent_Identity=25.4491017964072, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1788549, Length=225, Percent_Identity=31.5555555555556, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1788713, Length=239, Percent_Identity=27.1966527196653, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788279, Length=298, Percent_Identity=25.8389261744966, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI48994928, Length=226, Percent_Identity=27.8761061946903, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1787894, Length=303, Percent_Identity=25.7425742574257, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1790436, Length=240, Percent_Identity=29.5833333333333, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1786912, Length=236, Percent_Identity=30.0847457627119, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI1790551, Length=296, Percent_Identity=27.3648648648649, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1789808, Length=294, Percent_Identity=23.469387755102, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1789403, Length=288, Percent_Identity=25.6944444444444, Blast_Score=77, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52038; Mature: 52038

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSLYSRIVVTMLVVIISSSLLGFFFANIYYQIKLKPFNDEKTAKIAEEVQQFYESNATI
CHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEEECCCHHHHHHHHHHHHHHHCCCCE
SLNEYLENVGELGYELYLTDGAEKSTYYGGAFRKKDLPDKTIKQVLDGETYHGIDSFDTG
EHHHHHHHHHCCCEEEEEECCCCCCCEECCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCC
IFITGFFDNDVRNTIGVPVQADGKQLALFIRQDPEQQFGELRIFFAMILIFTSIISILLV
EEEEEEECCCCHHHCCCCEECCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LISGRYIVKPVVKLTNATKKIRKGNYDVAFEVRRKDEIGQLADSFTKMASELKKSEASRQ
HHCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
EFVANVSHELQSPLTSMQGFARLLGSGTLTEKEQAEYLTVLSEETTRLSSLTKQLLTLAS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDQESELRKKEPVHLDEQWRQLIQMTEWSWREKELTINLDLADVNYTGDAELLYQVWSNL
CCCHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHH
LTNAIKFTPQGGNIKVHLYEKATYVFVEVQDSGVGIGKEDMAKIFDRFYKANESRTREEG
HHHHHEECCCCCCEEEEEEECEEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCHHHHHCC
SSGLGLSICQKIITLHHGEITVQSSPEKGTTFKVKLPKN
CCCCCHHHHHHHHHHCCCEEEEECCCCCCCEEEEECCCC
>Mature Secondary Structure
MKSLYSRIVVTMLVVIISSSLLGFFFANIYYQIKLKPFNDEKTAKIAEEVQQFYESNATI
CHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEEECCCHHHHHHHHHHHHHHHCCCCE
SLNEYLENVGELGYELYLTDGAEKSTYYGGAFRKKDLPDKTIKQVLDGETYHGIDSFDTG
EHHHHHHHHHCCCEEEEEECCCCCCCEECCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCC
IFITGFFDNDVRNTIGVPVQADGKQLALFIRQDPEQQFGELRIFFAMILIFTSIISILLV
EEEEEEECCCCHHHCCCCEECCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LISGRYIVKPVVKLTNATKKIRKGNYDVAFEVRRKDEIGQLADSFTKMASELKKSEASRQ
HHCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
EFVANVSHELQSPLTSMQGFARLLGSGTLTEKEQAEYLTVLSEETTRLSSLTKQLLTLAS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDQESELRKKEPVHLDEQWRQLIQMTEWSWREKELTINLDLADVNYTGDAELLYQVWSNL
CCCHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHH
LTNAIKFTPQGGNIKVHLYEKATYVFVEVQDSGVGIGKEDMAKIFDRFYKANESRTREEG
HHHHHEECCCCCCEEEEEEECEEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCHHHHHCC
SSGLGLSICQKIITLHHGEITVQSSPEKGTTFKVKLPKN
CCCCCHHHHHHHHHHCCCEEEEECCCCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA