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The map label for this gene is hssR [H]

Identifier: 226225129

GI number: 226225129

Start: 2630332

End: 2631009

Strand: Reverse

Name: hssR [H]

Synonym: Lm4b_02550

Alternate gene names: 226225129

Gene position: 2631009-2630332 (Counterclockwise)

Preceding gene: 226225130

Following gene: 226225128

Centisome position: 90.33

GC content: 39.97

Gene sequence:

>678_bases
ATGAAACAAATATTAGTAGTAGATGATGATCGGCATATACTTAAACTTGTGGGCCACTATTTGCGTGCAGAAGGCTTCCG
TGTACTTGAGGCAAGCGATGGGGTAGAAGCAGAAAAAATAGTTGAAACAGAGCAAGTTCATTTAGCTGTAATTGATGTGA
TGATGCCCAACATGGATGGTTTTGAACTTTGCAAAAAAATGCGCACAAGTTATCCTGATATCCCTGTTATTATGTTGACA
GCCAAAGATGCGCTGGCGGATAAATCACGCGGTTTTGAAGTGGGAACAGATGATTATGTCACAAAACCCTTTGAACCAGA
AGAGCTAATCTTTCGAATTCGTGCGTTGCTACGGCGTTCTAATCAAGCGAGCGAAGTCAAAATTAATATCGGAAATATTA
CTATCGATCAAAAAAGCTATGGTATAAAAATTGGCAACCAAGAACGAATGATTCCCGTGAAAGAATTTGAGCTTTTATAT
CAGCTAGCAAGCTATCCTGGCCGGATTTTTACTCGAGAAGAATTAATTGAGCGGATTTGGCAACGTGATTATGATGGTAG
TGACCGTACAGTGGATGTACATATTAAACGATTGCGGGACCATTTTGATGAAGAAAAGGATGGTATTCGAATTGTTACAG
TGCGCGGCGTTGGTTATAAATTGGAGGAGACAACATGA

Upstream 100 bases:

>100_bases
TTTATTCGTGGTGATAGGTTAAATGTCTATTCTGGATTTGAACGAATCACGTAAGTTTGATATGATGCAGTAAAATAGGA
CAGTAAGGTGAGCGGTGAAA

Downstream 100 bases:

>100_bases
AATCGTTATATAGTCGAATAGTTGTCACGATGCTTGTCGTCATTATTTCCAGTAGTTTGCTCGGCTTTTTCTTTGCAAAC
ATTTATTACCAAATAAAATT

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MKQILVVDDDRHILKLVGHYLRAEGFRVLEASDGVEAEKIVETEQVHLAVIDVMMPNMDGFELCKKMRTSYPDIPVIMLT
AKDALADKSRGFEVGTDDYVTKPFEPEELIFRIRALLRRSNQASEVKINIGNITIDQKSYGIKIGNQERMIPVKEFELLY
QLASYPGRIFTREELIERIWQRDYDGSDRTVDVHIKRLRDHFDEEKDGIRIVTVRGVGYKLEETT

Sequences:

>Translated_225_residues
MKQILVVDDDRHILKLVGHYLRAEGFRVLEASDGVEAEKIVETEQVHLAVIDVMMPNMDGFELCKKMRTSYPDIPVIMLT
AKDALADKSRGFEVGTDDYVTKPFEPEELIFRIRALLRRSNQASEVKINIGNITIDQKSYGIKIGNQERMIPVKEFELLY
QLASYPGRIFTREELIERIWQRDYDGSDRTVDVHIKRLRDHFDEEKDGIRIVTVRGVGYKLEETT
>Mature_225_residues
MKQILVVDDDRHILKLVGHYLRAEGFRVLEASDGVEAEKIVETEQVHLAVIDVMMPNMDGFELCKKMRTSYPDIPVIMLT
AKDALADKSRGFEVGTDDYVTKPFEPEELIFRIRALLRRSNQASEVKINIGNITIDQKSYGIKIGNQERMIPVKEFELLY
QLASYPGRIFTREELIERIWQRDYDGSDRTVDVHIKRLRDHFDEEKDGIRIVTVRGVGYKLEETT

Specific function: Member of the two-component regulatory system hssS/hssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. Phosphorylated hssR binds to a direct repeat sequence within hrtAB promoter and activates the expression of hrtAB

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=223, Percent_Identity=36.7713004484305, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI1789809, Length=225, Percent_Identity=35.1111111111111, Blast_Score=143, Evalue=1e-35,
Organism=Escherichia coli, GI1790552, Length=219, Percent_Identity=37.4429223744292, Blast_Score=141, Evalue=4e-35,
Organism=Escherichia coli, GI1790860, Length=221, Percent_Identity=34.841628959276, Blast_Score=138, Evalue=3e-34,
Organism=Escherichia coli, GI87082012, Length=219, Percent_Identity=34.2465753424658, Blast_Score=137, Evalue=7e-34,
Organism=Escherichia coli, GI1790863, Length=230, Percent_Identity=33.4782608695652, Blast_Score=133, Evalue=9e-33,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=37.719298245614, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1788394, Length=225, Percent_Identity=33.7777777777778, Blast_Score=129, Evalue=1e-31,
Organism=Escherichia coli, GI1786784, Length=221, Percent_Identity=29.8642533936652, Blast_Score=127, Evalue=7e-31,
Organism=Escherichia coli, GI145693140, Length=232, Percent_Identity=32.3275862068966, Blast_Score=117, Evalue=6e-28,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=31.2217194570136, Blast_Score=114, Evalue=5e-27,
Organism=Escherichia coli, GI1787375, Length=224, Percent_Identity=28.125, Blast_Score=103, Evalue=8e-24,
Organism=Escherichia coli, GI1786911, Length=224, Percent_Identity=27.6785714285714, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1787229, Length=227, Percent_Identity=29.9559471365639, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI145693157, Length=100, Percent_Identity=36, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI1790299, Length=134, Percent_Identity=27.6119402985075, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1788905, Length=171, Percent_Identity=29.2397660818713, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1788550, Length=127, Percent_Identity=27.5590551181102, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1788713, Length=101, Percent_Identity=36.6336633663366, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787487, Length=102, Percent_Identity=29.4117647058824, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI1790437, Length=106, Percent_Identity=33.0188679245283, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26074; Mature: 26074

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQILVVDDDRHILKLVGHYLRAEGFRVLEASDGVEAEKIVETEQVHLAVIDVMMPNMDG
CCEEEEEECCHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHEEEEEECCCCCCH
FELCKKMRTSYPDIPVIMLTAKDALADKSRGFEVGTDDYVTKPFEPEELIFRIRALLRRS
HHHHHHHHCCCCCCCEEEEECCHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
NQASEVKINIGNITIDQKSYGIKIGNQERMIPVKEFELLYQLASYPGRIFTREELIERIW
CCCCEEEEEECEEEECCCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCEECHHHHHHHHH
QRDYDGSDRTVDVHIKRLRDHFDEEKDGIRIVTVRGVGYKLEETT
HCCCCCCCCEEEHHHHHHHHHCCCCCCCEEEEEEECCCEEECCCC
>Mature Secondary Structure
MKQILVVDDDRHILKLVGHYLRAEGFRVLEASDGVEAEKIVETEQVHLAVIDVMMPNMDG
CCEEEEEECCHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHEEEEEECCCCCCH
FELCKKMRTSYPDIPVIMLTAKDALADKSRGFEVGTDDYVTKPFEPEELIFRIRALLRRS
HHHHHHHHCCCCCCCEEEEECCHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
NQASEVKINIGNITIDQKSYGIKIGNQERMIPVKEFELLYQLASYPGRIFTREELIERIW
CCCCEEEEEECEEEECCCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCEECHHHHHHHHH
QRDYDGSDRTVDVHIKRLRDHFDEEKDGIRIVTVRGVGYKLEETT
HCCCCCCCCEEEHHHHHHHHHCCCCCCCEEEEEEECCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA