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The map label for this gene is czcD [H]

Identifier: 226225122

GI number: 226225122

Start: 2623487

End: 2624398

Strand: Reverse

Name: czcD [H]

Synonym: Lm4b_02543

Alternate gene names: 226225122

Gene position: 2624398-2623487 (Counterclockwise)

Preceding gene: 226225123

Following gene: 226225121

Centisome position: 90.1

GC content: 39.36

Gene sequence:

>912_bases
ATGGCACATAACCACGATCATGCTCATGGACACAATCATAATCATGCGCATAATGCCAACAAAAAATCATTATTTATCAG
TTTTATTCTAATTGCTACATTTATGGTAGTCGAAGTTATTGGTGGAATTATGACCAATAGTTTGGCGCTACTTTCTGATG
CGGGGCACATGCTCTCTGACGCCGTGGCGCTAGGTTTAAGTTTAGCTGCATTTAAATTTGGCGAAAAAGCAGCAAGCTCC
GATAAAACATATGGCTATAAAAGATTTGAAATTTTAGCTGCATTTCTTAATGGATTAACGCTCGTTGGGATTTCTGTTTT
TATATTCTATGAAGCGATTGGTCGCTTCTTTGATCCGCCACAAGTAATTGGAGCTGGAATGATGACTATTTCTGTTATCG
GATTGCTTATTAATATTTTGGTCGCTTGGATTTTAATGAAAGGTGACACTAGCGAAAATTTGAATATGCGTAGTGCGTTC
TTGCATGTGCTTGGAGATTTGCTTGGCTCTGTTGGTGCGATTATTGCCGCGTTACTCATTATTTTCCTTGGCTGGAATAT
CGCTGACCCGATTGCGAGTGTTATTGTTGCGGCACTTATCTTAGTTAGTGGTTGGCGTGTACTGAAAGATGCGATTCATA
TTTTGATGGAAGGAAAACCAGCGAATGTCGATACAGAAGAAATCAAAACGTTTTTCCAACAGCAAGACGGTGTGAAAGAA
GTGCATGATTTACATGTATGGGCGATTACTTCGGATTTCAATGCTCTTACAGCTCATTTGACCGTATGCGAAGATGCCGA
CCGAGATAAGATTTTGGCAGATATTGAGCATTATTTGCAAGAAAACTTCTCATTAGAACATAGTACGATTCAACTTGAAG
GAAATCACGCTCACCATCATCACTGCAATTAA

Upstream 100 bases:

>100_bases
AAAATGGAAGTTTTTTTATAAGAATGGTTGCACTTAAAATGTATATATGCTAACATATGCATATAAGGAAATTAGCTACT
TACAGAGGGGAAGTAATCAT

Downstream 100 bases:

>100_bases
TGCCGCTTCATGATATGATTAAAGTATCAATTAGAGGAGTTGGTTTAGATGGAAGAACAAGTTGATTTAGGACATTTTTT
GAAAAAAACTTTTATCGCTG

Product: cation transport protein (efflux)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 303; Mature: 302

Protein sequence:

>303_residues
MAHNHDHAHGHNHNHAHNANKKSLFISFILIATFMVVEVIGGIMTNSLALLSDAGHMLSDAVALGLSLAAFKFGEKAASS
DKTYGYKRFEILAAFLNGLTLVGISVFIFYEAIGRFFDPPQVIGAGMMTISVIGLLINILVAWILMKGDTSENLNMRSAF
LHVLGDLLGSVGAIIAALLIIFLGWNIADPIASVIVAALILVSGWRVLKDAIHILMEGKPANVDTEEIKTFFQQQDGVKE
VHDLHVWAITSDFNALTAHLTVCEDADRDKILADIEHYLQENFSLEHSTIQLEGNHAHHHHCN

Sequences:

>Translated_303_residues
MAHNHDHAHGHNHNHAHNANKKSLFISFILIATFMVVEVIGGIMTNSLALLSDAGHMLSDAVALGLSLAAFKFGEKAASS
DKTYGYKRFEILAAFLNGLTLVGISVFIFYEAIGRFFDPPQVIGAGMMTISVIGLLINILVAWILMKGDTSENLNMRSAF
LHVLGDLLGSVGAIIAALLIIFLGWNIADPIASVIVAALILVSGWRVLKDAIHILMEGKPANVDTEEIKTFFQQQDGVKE
VHDLHVWAITSDFNALTAHLTVCEDADRDKILADIEHYLQENFSLEHSTIQLEGNHAHHHHCN
>Mature_302_residues
AHNHDHAHGHNHNHAHNANKKSLFISFILIATFMVVEVIGGIMTNSLALLSDAGHMLSDAVALGLSLAAFKFGEKAASSD
KTYGYKRFEILAAFLNGLTLVGISVFIFYEAIGRFFDPPQVIGAGMMTISVIGLLINILVAWILMKGDTSENLNMRSAFL
HVLGDLLGSVGAIIAALLIIFLGWNIADPIASVIVAALILVSGWRVLKDAIHILMEGKPANVDTEEIKTFFQQQDGVKEV
HDLHVWAITSDFNALTAHLTVCEDADRDKILADIEHYLQENFSLEHSTIQLEGNHAHHHHCN

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI52352805, Length=319, Percent_Identity=29.153605015674, Blast_Score=155, Evalue=6e-38,
Organism=Homo sapiens, GI21361112, Length=307, Percent_Identity=29.3159609120521, Blast_Score=148, Evalue=5e-36,
Organism=Homo sapiens, GI20070323, Length=324, Percent_Identity=30.2469135802469, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI289803013, Length=270, Percent_Identity=34.4444444444444, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI289803009, Length=270, Percent_Identity=34.4444444444444, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI289803007, Length=270, Percent_Identity=34.4444444444444, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI289803003, Length=270, Percent_Identity=34.4444444444444, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI64762489, Length=278, Percent_Identity=33.8129496402878, Blast_Score=142, Evalue=3e-34,
Organism=Homo sapiens, GI21359890, Length=317, Percent_Identity=28.7066246056782, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI14210520, Length=226, Percent_Identity=29.646017699115, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI222080086, Length=121, Percent_Identity=36.3636363636364, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI40255009, Length=121, Percent_Identity=36.3636363636364, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI52352803, Length=127, Percent_Identity=38.5826771653543, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI52351208, Length=126, Percent_Identity=31.7460317460317, Blast_Score=72, Evalue=6e-13,
Organism=Escherichia coli, GI1786966, Length=285, Percent_Identity=46.6666666666667, Blast_Score=223, Evalue=9e-60,
Organism=Escherichia coli, GI1790349, Length=217, Percent_Identity=22.1198156682028, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI193210990, Length=320, Percent_Identity=30.3125, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17555794, Length=317, Percent_Identity=30.9148264984227, Blast_Score=165, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17555796, Length=301, Percent_Identity=31.2292358803987, Blast_Score=158, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI32564488, Length=307, Percent_Identity=30.9446254071661, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17550442, Length=125, Percent_Identity=33.6, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17550440, Length=125, Percent_Identity=33.6, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6320411, Length=183, Percent_Identity=39.344262295082, Blast_Score=97, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6324892, Length=125, Percent_Identity=34.4, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323899, Length=125, Percent_Identity=35.2, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24583858, Length=323, Percent_Identity=30.030959752322, Blast_Score=148, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24656728, Length=338, Percent_Identity=28.698224852071, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24656724, Length=338, Percent_Identity=28.698224852071, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24656720, Length=338, Percent_Identity=28.698224852071, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24656715, Length=338, Percent_Identity=28.698224852071, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI21357035, Length=338, Percent_Identity=28.698224852071, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24584409, Length=156, Percent_Identity=34.6153846153846, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI28574430, Length=156, Percent_Identity=34.6153846153846, Blast_Score=107, Evalue=7e-24,
Organism=Drosophila melanogaster, GI24645863, Length=131, Percent_Identity=38.1679389312977, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24585900, Length=144, Percent_Identity=32.6388888888889, Blast_Score=88, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24585898, Length=144, Percent_Identity=32.6388888888889, Blast_Score=88, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24585896, Length=144, Percent_Identity=32.6388888888889, Blast_Score=88, Evalue=9e-18,
Organism=Drosophila melanogaster, GI19921672, Length=144, Percent_Identity=32.6388888888889, Blast_Score=88, Evalue=9e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 33155; Mature: 33024

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHNHDHAHGHNHNHAHNANKKSLFISFILIATFMVVEVIGGIMTNSLALLSDAGHMLSD
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVALGLSLAAFKFGEKAASSDKTYGYKRFEILAAFLNGLTLVGISVFIFYEAIGRFFDPP
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
QVIGAGMMTISVIGLLINILVAWILMKGDTSENLNMRSAFLHVLGDLLGSVGAIIAALLI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
IFLGWNIADPIASVIVAALILVSGWRVLKDAIHILMEGKPANVDTEEIKTFFQQQDGVKE
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHH
VHDLHVWAITSDFNALTAHLTVCEDADRDKILADIEHYLQENFSLEHSTIQLEGNHAHHH
HHHEEEEEEECCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCC
HCN
CCC
>Mature Secondary Structure 
AHNHDHAHGHNHNHAHNANKKSLFISFILIATFMVVEVIGGIMTNSLALLSDAGHMLSD
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVALGLSLAAFKFGEKAASSDKTYGYKRFEILAAFLNGLTLVGISVFIFYEAIGRFFDPP
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
QVIGAGMMTISVIGLLINILVAWILMKGDTSENLNMRSAFLHVLGDLLGSVGAIIAALLI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
IFLGWNIADPIASVIVAALILVSGWRVLKDAIHILMEGKPANVDTEEIKTFFQQQDGVKE
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHH
VHDLHVWAITSDFNALTAHLTVCEDADRDKILADIEHYLQENFSLEHSTIQLEGNHAHHH
HHHEEEEEEECCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCC
HCN
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA