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The map label for this gene is thrC

Identifier: 226225094

GI number: 226225094

Start: 2594807

End: 2595862

Strand: Reverse

Name: thrC

Synonym: Lm4b_02515

Alternate gene names: 226225094

Gene position: 2595862-2594807 (Counterclockwise)

Preceding gene: 226225095

Following gene: 226225093

Centisome position: 89.12

GC content: 42.23

Gene sequence:

>1056_bases
ATGTATAAAGGTTTACTAGAAAAATATAAAGAATATCTACCAGTAACTGATAAAACACCAATGATCTCACTTGCGGAAGG
AAATACACCACTTATTCCATTACCGAATTTGTCCAAAGAACTGGGTGTTACTTTATACGGAAAATATGAAGGCTTAAATC
CAACCGGTTCTTTTAAAGACCGTGGAATGGTTATGGCTGTTGCTAAAGCGAAAGAAGAAGGTGCCGAAGCGGTTATTTGT
GCATCCACTGGGAATACTTCTGCTGCGGCTGCGGCATACGCAACACGTGCGGGATTAAAAGCGTACATTGTTATTCCAGA
AGGCAAAGTCGCTCTAGGAAAATTAGCGCAAGCAGTTATGTACGGCGCAGATATTATCTCAATTCAAGGTAATTTTGATG
AAGCGTTAAAATCGGTTCGTGAACTGGCTGAAACAGAAGCAGTAACGCTTGTAAACTCGGTAAATCCTTATCGTTTAGAA
GGTCAAAAAACAGCTGCATTCGAAATTTGTGAGCAATTAGGTTCTGCTCCAGATGTCCTTGCAATCCCAGTAGGTAATGC
CGGAAACATTTCTGCCTACTGGAAAGGGTTTAAAGAGTGGAATGAGGCCAAGGCTTCTGGACTTCCACGGATGCATGGTT
TTGAAGCGGAAGGTGCGGCTGCGATTGTTCAAGGTAAACCGATTGATAATCCGGAAACAATTGCAACGGCGATTCGTATC
GGAAATCCAGCTAGTTGGGAGCTTGCAGAAGCAGCTCGCGATGAATCTGGCGGATATATCCATTCTGTAACAGATGATGA
AATTGTAAATGCGTATAAAAAAATTGCAGCACAAGATGGTGTCTTTATCGAGCCAGGTTCAGCCGCTTCATTAGCTGGTG
TCATCCAACATGTAGCAAATGGAACAATTAAAAAAGGCGAAACAGTAGTTTGTGTCTTTACTGGAAACGGCTTGAAAGAT
CCGGATACTGCGATGAGTGTGCATGAAATTCCAATTTCTCATGTGGATGATATCGAAGCAATGCGCACACATTTACGTTC
AGGAGTGAAAGCTTAA

Upstream 100 bases:

>100_bases
ATTCAACTAGTCAAGCACAATTAGAACAAGCAATCGCTAGGGTCAAAGATGAGCCAGAAATGCAAATGCTCGCAAAATAT
TCCGTTGTGGAGGGTTAAAT

Downstream 100 bases:

>100_bases
TGCGTATTCGTGTACCGGCAACAACGGCCAATCTTGGCCCTGGCTTTGATTCGTGTGGTTTAGCGTTAACGTTATATTTA
ACGCTTGATATTGGAGCGGA

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MYKGLLEKYKEYLPVTDKTPMISLAEGNTPLIPLPNLSKELGVTLYGKYEGLNPTGSFKDRGMVMAVAKAKEEGAEAVIC
ASTGNTSAAAAAYATRAGLKAYIVIPEGKVALGKLAQAVMYGADIISIQGNFDEALKSVRELAETEAVTLVNSVNPYRLE
GQKTAAFEICEQLGSAPDVLAIPVGNAGNISAYWKGFKEWNEAKASGLPRMHGFEAEGAAAIVQGKPIDNPETIATAIRI
GNPASWELAEAARDESGGYIHSVTDDEIVNAYKKIAAQDGVFIEPGSAASLAGVIQHVANGTIKKGETVVCVFTGNGLKD
PDTAMSVHEIPISHVDDIEAMRTHLRSGVKA

Sequences:

>Translated_351_residues
MYKGLLEKYKEYLPVTDKTPMISLAEGNTPLIPLPNLSKELGVTLYGKYEGLNPTGSFKDRGMVMAVAKAKEEGAEAVIC
ASTGNTSAAAAAYATRAGLKAYIVIPEGKVALGKLAQAVMYGADIISIQGNFDEALKSVRELAETEAVTLVNSVNPYRLE
GQKTAAFEICEQLGSAPDVLAIPVGNAGNISAYWKGFKEWNEAKASGLPRMHGFEAEGAAAIVQGKPIDNPETIATAIRI
GNPASWELAEAARDESGGYIHSVTDDEIVNAYKKIAAQDGVFIEPGSAASLAGVIQHVANGTIKKGETVVCVFTGNGLKD
PDTAMSVHEIPISHVDDIEAMRTHLRSGVKA
>Mature_351_residues
MYKGLLEKYKEYLPVTDKTPMISLAEGNTPLIPLPNLSKELGVTLYGKYEGLNPTGSFKDRGMVMAVAKAKEEGAEAVIC
ASTGNTSAAAAAYATRAGLKAYIVIPEGKVALGKLAQAVMYGADIISIQGNFDEALKSVRELAETEAVTLVNSVNPYRLE
GQKTAAFEICEQLGSAPDVLAIPVGNAGNISAYWKGFKEWNEAKASGLPRMHGFEAEGAAAIVQGKPIDNPETIATAIRI
GNPASWELAEAARDESGGYIHSVTDDEIVNAYKKIAAQDGVFIEPGSAASLAGVIQHVANGTIKKGETVVCVFTGNGLKD
PDTAMSVHEIPISHVDDIEAMRTHLRSGVKA

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=317, Percent_Identity=29.9684542586751, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI33469958, Length=277, Percent_Identity=27.7978339350181, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI1790207, Length=319, Percent_Identity=29.4670846394984, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17508781, Length=279, Percent_Identity=29.3906810035842, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322631, Length=292, Percent_Identity=28.7671232876712, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6320930, Length=283, Percent_Identity=28.9752650176678, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 37035; Mature: 37035

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKGLLEKYKEYLPVTDKTPMISLAEGNTPLIPLPNLSKELGVTLYGKYEGLNPTGSFKD
CCHHHHHHHHHHCCCCCCCCEEEEECCCCCEEECCCCHHHCCEEEEEEECCCCCCCCCCC
RGMVMAVAKAKEEGAEAVICASTGNTSAAAAAYATRAGLKAYIVIPEGKVALGKLAQAVM
CCEEEEEEHHHCCCCCEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHH
YGADIISIQGNFDEALKSVRELAETEAVTLVNSVNPYRLEGQKTAAFEICEQLGSAPDVL
HCCEEEEEECCHHHHHHHHHHHHHHHHHHEEECCCCEEECCCCHHHHHHHHHHCCCCCEE
AIPVGNAGNISAYWKGFKEWNEAKASGLPRMHGFEAEGAAAIVQGKPIDNPETIATAIRI
EEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCHHHHEEEEEC
GNPASWELAEAARDESGGYIHSVTDDEIVNAYKKIAAQDGVFIEPGSAASLAGVIQHVAN
CCCCCCHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHC
GTIKKGETVVCVFTGNGLKDPDTAMSVHEIPISHVDDIEAMRTHLRSGVKA
CCCCCCCEEEEEEECCCCCCCHHHCEEECCCCCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MYKGLLEKYKEYLPVTDKTPMISLAEGNTPLIPLPNLSKELGVTLYGKYEGLNPTGSFKD
CCHHHHHHHHHHCCCCCCCCEEEEECCCCCEEECCCCHHHCCEEEEEEECCCCCCCCCCC
RGMVMAVAKAKEEGAEAVICASTGNTSAAAAAYATRAGLKAYIVIPEGKVALGKLAQAVM
CCEEEEEEHHHCCCCCEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHH
YGADIISIQGNFDEALKSVRELAETEAVTLVNSVNPYRLEGQKTAAFEICEQLGSAPDVL
HCCEEEEEECCHHHHHHHHHHHHHHHHHHEEECCCCEEECCCCHHHHHHHHHHCCCCCEE
AIPVGNAGNISAYWKGFKEWNEAKASGLPRMHGFEAEGAAAIVQGKPIDNPETIATAIRI
EEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCHHHHEEEEEC
GNPASWELAEAARDESGGYIHSVTDDEIVNAYKKIAAQDGVFIEPGSAASLAGVIQHVAN
CCCCCCHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHC
GTIKKGETVVCVFTGNGLKDPDTAMSVHEIPISHVDDIEAMRTHLRSGVKA
CCCCCCCEEEEEEECCCCCCCHHHCEEECCCCCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3186450; 8768250 [H]