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The map label for this gene is hom

Identifier: 226225095

GI number: 226225095

Start: 2595865

End: 2597151

Strand: Reverse

Name: hom

Synonym: Lm4b_02516

Alternate gene names: 226225095

Gene position: 2597151-2595865 (Counterclockwise)

Preceding gene: 226225096

Following gene: 226225094

Centisome position: 89.17

GC content: 40.95

Gene sequence:

>1287_bases
GTGGAAGCAAAGTTACAAGTAGGTGTGTTAGGATTTGGAACGGTAGGTAGCGGTGTTATTCATATTTTAGAAGAGCATCA
AGAAAAAATTAGTCAAGTAACTGGATACCATATTTCTGTTAAGAAAGTGCTAGTTCGTGACTTAGAGAAAAATCGCCGTT
ATGAAACAAAAGGTTTTGAACTAACCACCAATCCGTCTGATGTACTGGATGATCCAGAGATTGCTGTTGTTGTCGAGGTT
ATGGGCAGCATCACAACTGCGCGGGAATACATTTTGCAGGCCTTGAAAGCTGGAAAACATGTAGTAACTGCGAATAAGGA
TTTGATTGCGCTACACGGCGACGAATTAGTGGCAGTTGCACAAGCTAATAATTGTGATTTGTTTTATGAAGCGAGCGTTG
CAGGTGGGATTCCGATTTTACGTACAATCGTAAACAGCCTTGCTGCGGATAAAATTCAAAAAGTAATGGGAATCGTCAAC
GGGACGACCAATTTTATGCTAACAAAAATGACGACAGAGAAAAAGTCATACGAAGATGTTTTAGCAGAAGCCCAAGCACT
AGGTTTTGCCGAGTCTGACCCAACGAATGACGTGGACGGAATCGATGCCGCAAGAAAAATGGTTATTATGACAAGACTCG
CATTTGGTATGAATGTGAATTTAGATAATGTAGAAACAAACGGTATTCGCGGGATTTCGCCTGAAGATATCGATGTAGCT
TACCAATTAGGTTATAAAATTAAACTAGTAGGTACGGCGGAAGAAACAAACGGCACAGTTAATGTCAACGTGGGGCCGGT
TTTATTACCAAAGGCTCATCCGCTTGCAGGTGTTAACTATGAAAATAATGCCGTATTTGTAACTGGTGCAGCAGTCGGAG
AAACAATGTTTTACGGACCTGGTGCTGGCGAATTACCAACTGCGACCAGTGTGGTTAGTGATTTAATTACCGTTGCTAAA
AATAGCCGTCTTGGTACGAATGGCAATGCATTTAACAGCTACAAACACGAAACAAAGCATACACCGAAAGAACAAGTTTT
CTCGAAATACTATCTTCGTCTAACAATGGACGATAAAACAGGAACCTTCCTTAAATTGACGCAAATTTTTGCAGAAGCCG
GTGTTGGTTTTGATAAAATTTTGCAACAACCGTATGATGATTTTACGGCGACCGTTGTTATCGTGACACATTCAACTAGT
CAAGCACAATTAGAACAAGCAATCGCTAGGGTCAAAGATGAGCCAGAAATGCAAATGCTCGCAAAATATTCCGTTGTGGA
GGGTTAA

Upstream 100 bases:

>100_bases
TGTGAAGTTGCGTATAATATCACTAATTACTTTTTTTATGAGTAGGTATTAAAAAAGTTAAATTTTCTGTTTTGTTAAAC
AATAATAAGGAGGTTTTCAA

Downstream 100 bases:

>100_bases
ATATGTATAAAGGTTTACTAGAAAAATATAAAGAATATCTACCAGTAACTGATAAAACACCAATGATCTCACTTGCGGAA
GGAAATACACCACTTATTCC

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MEAKLQVGVLGFGTVGSGVIHILEEHQEKISQVTGYHISVKKVLVRDLEKNRRYETKGFELTTNPSDVLDDPEIAVVVEV
MGSITTAREYILQALKAGKHVVTANKDLIALHGDELVAVAQANNCDLFYEASVAGGIPILRTIVNSLAADKIQKVMGIVN
GTTNFMLTKMTTEKKSYEDVLAEAQALGFAESDPTNDVDGIDAARKMVIMTRLAFGMNVNLDNVETNGIRGISPEDIDVA
YQLGYKIKLVGTAEETNGTVNVNVGPVLLPKAHPLAGVNYENNAVFVTGAAVGETMFYGPGAGELPTATSVVSDLITVAK
NSRLGTNGNAFNSYKHETKHTPKEQVFSKYYLRLTMDDKTGTFLKLTQIFAEAGVGFDKILQQPYDDFTATVVIVTHSTS
QAQLEQAIARVKDEPEMQMLAKYSVVEG

Sequences:

>Translated_428_residues
MEAKLQVGVLGFGTVGSGVIHILEEHQEKISQVTGYHISVKKVLVRDLEKNRRYETKGFELTTNPSDVLDDPEIAVVVEV
MGSITTAREYILQALKAGKHVVTANKDLIALHGDELVAVAQANNCDLFYEASVAGGIPILRTIVNSLAADKIQKVMGIVN
GTTNFMLTKMTTEKKSYEDVLAEAQALGFAESDPTNDVDGIDAARKMVIMTRLAFGMNVNLDNVETNGIRGISPEDIDVA
YQLGYKIKLVGTAEETNGTVNVNVGPVLLPKAHPLAGVNYENNAVFVTGAAVGETMFYGPGAGELPTATSVVSDLITVAK
NSRLGTNGNAFNSYKHETKHTPKEQVFSKYYLRLTMDDKTGTFLKLTQIFAEAGVGFDKILQQPYDDFTATVVIVTHSTS
QAQLEQAIARVKDEPEMQMLAKYSVVEG
>Mature_428_residues
MEAKLQVGVLGFGTVGSGVIHILEEHQEKISQVTGYHISVKKVLVRDLEKNRRYETKGFELTTNPSDVLDDPEIAVVVEV
MGSITTAREYILQALKAGKHVVTANKDLIALHGDELVAVAQANNCDLFYEASVAGGIPILRTIVNSLAADKIQKVMGIVN
GTTNFMLTKMTTEKKSYEDVLAEAQALGFAESDPTNDVDGIDAARKMVIMTRLAFGMNVNLDNVETNGIRGISPEDIDVA
YQLGYKIKLVGTAEETNGTVNVNVGPVLLPKAHPLAGVNYENNAVFVTGAAVGETMFYGPGAGELPTATSVVSDLITVAK
NSRLGTNGNAFNSYKHETKHTPKEQVFSKYYLRLTMDDKTGTFLKLTQIFAEAGVGFDKILQQPYDDFTATVVIVTHSTS
QAQLEQAIARVKDEPEMQMLAKYSVVEG

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1790376, Length=371, Percent_Identity=24.7978436657682, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1786183, Length=141, Percent_Identity=31.2056737588652, Blast_Score=72, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6322599, Length=100, Percent_Identity=33, Blast_Score=68, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 46351; Mature: 46351

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEAKLQVGVLGFGTVGSGVIHILEEHQEKISQVTGYHISVKKVLVRDLEKNRRYETKGFE
CCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHCCCEECCCEE
LTTNPSDVLDDPEIAVVVEVMGSITTAREYILQALKAGKHVVTANKDLIALHGDELVAVA
EECCCHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEECCCEEEEE
QANNCDLFYEASVAGGIPILRTIVNSLAADKIQKVMGIVNGTTNFMLTKMTTEKKSYEDV
ECCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHH
LAEAQALGFAESDPTNDVDGIDAARKMVIMTRLAFGMNVNLDNVETNGIRGISPEDIDVA
HHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEE
YQLGYKIKLVGTAEETNGTVNVNVGPVLLPKAHPLAGVNYENNAVFVTGAAVGETMFYGP
EECCEEEEEEEECCCCCCEEEEEECEEECCCCCCCCCCCCCCCEEEEEECCCCCEEEECC
GAGELPTATSVVSDLITVAKNSRLGTNGNAFNSYKHETKHTPKEQVFSKYYLRLTMDDKT
CCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHCCCCHHHHHHEEEEEEEECCCC
GTFLKLTQIFAEAGVGFDKILQQPYDDFTATVVIVTHSTSQAQLEQAIARVKDEPEMQML
CCHHHHHHHHHHHCCCHHHHHCCCCCCCEEEEEEEEECCCHHHHHHHHHHCCCCCHHHHH
AKYSVVEG
HHHHHCCC
>Mature Secondary Structure
MEAKLQVGVLGFGTVGSGVIHILEEHQEKISQVTGYHISVKKVLVRDLEKNRRYETKGFE
CCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHCCCEECCCEE
LTTNPSDVLDDPEIAVVVEVMGSITTAREYILQALKAGKHVVTANKDLIALHGDELVAVA
EECCCHHHCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEECCCEEEEE
QANNCDLFYEASVAGGIPILRTIVNSLAADKIQKVMGIVNGTTNFMLTKMTTEKKSYEDV
ECCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHH
LAEAQALGFAESDPTNDVDGIDAARKMVIMTRLAFGMNVNLDNVETNGIRGISPEDIDVA
HHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEE
YQLGYKIKLVGTAEETNGTVNVNVGPVLLPKAHPLAGVNYENNAVFVTGAAVGETMFYGP
EECCEEEEEEEECCCCCCEEEEEECEEECCCCCCCCCCCCCCCEEEEEECCCCCEEEECC
GAGELPTATSVVSDLITVAKNSRLGTNGNAFNSYKHETKHTPKEQVFSKYYLRLTMDDKT
CCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHCCCCHHHHHHEEEEEEEECCCC
GTFLKLTQIFAEAGVGFDKILQQPYDDFTATVVIVTHSTSQAQLEQAIARVKDEPEMQML
CCHHHHHHHHHHHCCCHHHHHCCCCCCCEEEEEEEEECCCHHHHHHHHHHCCCCCHHHHH
AKYSVVEG
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3139660; 9384377; 3098560 [H]