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The map label for this gene is upp

Identifier: 226225086

GI number: 226225086

Start: 2587431

End: 2588060

Strand: Reverse

Name: upp

Synonym: Lm4b_02507

Alternate gene names: 226225086

Gene position: 2588060-2587431 (Counterclockwise)

Preceding gene: 226225087

Following gene: 226225085

Centisome position: 88.85

GC content: 40.48

Gene sequence:

>630_bases
ATGGCAAATGTACACGTAATTAATCACCCACTAGTCCAACACAAATTAACAATCATTCGAGATAAAAATACGGGAACAAA
AGCATTCCGCGAACTTGTAGATGAAGTCGCTACATTAATGGCGTACGAAATTACACGTGATATGGAACTCGAAGACATCC
AAGTAGAAACACCACTACAAACAACAACTGCGAAAACACTTACTGGTAAAAAATTAGGGATTGTTCCTATTTTAAGAGCT
GGTCTTGGTATGCAAGATGGTATTTTAAAACTTATTCCTGCAGCAAAAGTAGGGCATGTAGGTCTTTATCGTGACCATGA
TACACTAGAACCAGTCGAATATTTTGTAAAACTACCTTCTGACGTAGAAGAACGTCTTTTCATCGTTGTAGATCCAATGC
TTGCAACTGGCGGATCCGCAATTATGGCTATCGATTGCTTGAAAAAACGCGGCGCTCGCAACATGAAATTCATGTGTCTA
GTAGCAGCTCCTGAAGGCGTTAAAGCCCTTCAAGACGCACATCCAGACGTAGAAATCTACGTAGCTGGTTTAGACGAGAA
GTTAGACGAAAATGGTTATATCCGTCCAGGCTTAGGAGATGCTGGCGATAGATTATTCGGAACTAAATAA

Upstream 100 bases:

>100_bases
CCGGTTTTTTTCATGTATAGCAAATTAATCCTTGCACTTGTGTCTTGTTCTGATACAATAAGAGAAGGAAATTTTCAATA
TCAAAGGAGCGAACTAATCG

Downstream 100 bases:

>100_bases
TTAACAATCTCCTCGGTTTAGTGAGATAAGGAATTATAAACAGTGTTGCTTTTTGGCAGACTGGGAAATTTTTTGTCGAA
CTATTTCTGAGGAGTTTTTT

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 209; Mature: 208

Protein sequence:

>209_residues
MANVHVINHPLVQHKLTIIRDKNTGTKAFRELVDEVATLMAYEITRDMELEDIQVETPLQTTTAKTLTGKKLGIVPILRA
GLGMQDGILKLIPAAKVGHVGLYRDHDTLEPVEYFVKLPSDVEERLFIVVDPMLATGGSAIMAIDCLKKRGARNMKFMCL
VAAPEGVKALQDAHPDVEIYVAGLDEKLDENGYIRPGLGDAGDRLFGTK

Sequences:

>Translated_209_residues
MANVHVINHPLVQHKLTIIRDKNTGTKAFRELVDEVATLMAYEITRDMELEDIQVETPLQTTTAKTLTGKKLGIVPILRA
GLGMQDGILKLIPAAKVGHVGLYRDHDTLEPVEYFVKLPSDVEERLFIVVDPMLATGGSAIMAIDCLKKRGARNMKFMCL
VAAPEGVKALQDAHPDVEIYVAGLDEKLDENGYIRPGLGDAGDRLFGTK
>Mature_208_residues
ANVHVINHPLVQHKLTIIRDKNTGTKAFRELVDEVATLMAYEITRDMELEDIQVETPLQTTTAKTLTGKKLGIVPILRAG
LGMQDGILKLIPAAKVGHVGLYRDHDTLEPVEYFVKLPSDVEERLFIVVDPMLATGGSAIMAIDCLKKRGARNMKFMCLV
AAPEGVKALQDAHPDVEIYVAGLDEKLDENGYIRPGLGDAGDRLFGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=202, Percent_Identity=30.1980198019802, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI57863312, Length=202, Percent_Identity=30.1980198019802, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI21450816, Length=165, Percent_Identity=25.4545454545455, Blast_Score=64, Evalue=9e-11,
Organism=Escherichia coli, GI87082118, Length=203, Percent_Identity=54.679802955665, Blast_Score=239, Evalue=7e-65,
Organism=Caenorhabditis elegans, GI17539892, Length=201, Percent_Identity=25.3731343283582, Blast_Score=89, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17539894, Length=201, Percent_Identity=25.3731343283582, Blast_Score=89, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6321920, Length=193, Percent_Identity=38.860103626943, Blast_Score=129, Evalue=4e-31,
Organism=Drosophila melanogaster, GI28573516, Length=206, Percent_Identity=30.5825242718447, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI28573514, Length=206, Percent_Identity=30.5825242718447, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI28573512, Length=206, Percent_Identity=30.5825242718447, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI45550449, Length=206, Percent_Identity=30.5825242718447, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI21358379, Length=175, Percent_Identity=25.1428571428571, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 22945; Mature: 22814

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANVHVINHPLVQHKLTIIRDKNTGTKAFRELVDEVATLMAYEITRDMELEDIQVETPLQ
CCCEEEECCCHHHEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCC
TTTAKTLTGKKLGIVPILRAGLGMQDGILKLIPAAKVGHVGLYRDHDTLEPVEYFVKLPS
HHHHHHCCCCCCCHHHHHHHCCCCCCCHHHHCCCCCCCCEEEECCCCCCCHHHHHHHCCC
DVEERLFIVVDPMLATGGSAIMAIDCLKKRGARNMKFMCLVAAPEGVKALQDAHPDVEIY
CCCCEEEEEECCHHHCCCCEEEHHHHHHHCCCCCCEEEEEEECCCCHHHHHHCCCCEEEE
VAGLDEKLDENGYIRPGLGDAGDRLFGTK
EECCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ANVHVINHPLVQHKLTIIRDKNTGTKAFRELVDEVATLMAYEITRDMELEDIQVETPLQ
CCEEEECCCHHHEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCC
TTTAKTLTGKKLGIVPILRAGLGMQDGILKLIPAAKVGHVGLYRDHDTLEPVEYFVKLPS
HHHHHHCCCCCCCHHHHHHHCCCCCCCHHHHCCCCCCCCEEEECCCCCCCHHHHHHHCCC
DVEERLFIVVDPMLATGGSAIMAIDCLKKRGARNMKFMCLVAAPEGVKALQDAHPDVEIY
CCCCEEEEEECCHHHCCCCEEEHHHHHHHCCCCCCEEEEEEECCCCHHHHHHCCCCEEEE
VAGLDEKLDENGYIRPGLGDAGDRLFGTK
EECCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]