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The map label for this gene is phoP

Identifier: 226225049

GI number: 226225049

Start: 2549572

End: 2550282

Strand: Reverse

Name: phoP

Synonym: Lm4b_02470

Alternate gene names: 226225049

Gene position: 2550282-2549572 (Counterclockwise)

Preceding gene: 226225050

Following gene: 226225048

Centisome position: 87.56

GC content: 36.01

Gene sequence:

>711_bases
TTGGTAAAAATTCTTGTAGTTGATGATGAAGCTTCTATTGTTACGTTACTGCAATTTAACATTGAAAAAGCTGGGTTTGA
TGTGGTAACAGCAGAAGACGGCAGAACCGGATACGAACTCGCTTTGTCCGAAAAACCAGATTTAATTGTGCTTGATTTAA
TGCTTCCTGAGATGGACGGAATCGAAGTAACAAAAAAACTTCGCCAAGATAAAGTAAATGTGCCAATTTTAATGTTAACG
GCAAAAGATGAAGAATTAGATAAAATTATCGGACTGGAACTTGGAGCAGATGACTATATGACTAAACCGTTTAGCCCAAG
AGAAGTAGTTGCAAGAATTAAAGCAATCTTGCGTCGAACAGAAGGAAAAGCCGAAATAATAGAAGAAATAACCGAAGATT
CGGAAGCTACGATATTAATTGGTGATTTGAAAATTTTGCCAGATAGTTATGAAGTGTATTTACAAGATGATTTACTTGAT
TTAACGCCAAAAGAATTTGAGTTATTGCTATTCTTGGCAAATCATCGTGGCAAAGTTTTCTCTAGAGACCAATTGCTCGA
TACTGTCTGGAACTATGATTACGTTGGAGAAACCCGAATTGTAGACGTTCATGTCAGCCATTTGCGCGATAAAATCGAAC
TAGATACAAAACAACCTAAATACATCAAAACAATTCGTGGCTTCGGTTATAAAATGGAGAACGTGAAATAA

Upstream 100 bases:

>100_bases
GTAAAGATAAGATTAATATAAAGGCATTTCTACCCGAAAAAGGTTAATTCATGCTATATTTTAGATAAAAGTGTTACATA
AAGAAGGGATGGGAAGTACG

Downstream 100 bases:

>100_bases
TGAAGAAATTATGGCTGAAAATCGGGTTATCCTTTTTTATCTTATTTTTCGTTGTGATGGTTATTGTTGGCGTTTTTTCC
GGGGAACTAATGAAATCAAC

Product: two-component response phosphate regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 236; Mature: 236

Protein sequence:

>236_residues
MVKILVVDDEASIVTLLQFNIEKAGFDVVTAEDGRTGYELALSEKPDLIVLDLMLPEMDGIEVTKKLRQDKVNVPILMLT
AKDEELDKIIGLELGADDYMTKPFSPREVVARIKAILRRTEGKAEIIEEITEDSEATILIGDLKILPDSYEVYLQDDLLD
LTPKEFELLLFLANHRGKVFSRDQLLDTVWNYDYVGETRIVDVHVSHLRDKIELDTKQPKYIKTIRGFGYKMENVK

Sequences:

>Translated_236_residues
MVKILVVDDEASIVTLLQFNIEKAGFDVVTAEDGRTGYELALSEKPDLIVLDLMLPEMDGIEVTKKLRQDKVNVPILMLT
AKDEELDKIIGLELGADDYMTKPFSPREVVARIKAILRRTEGKAEIIEEITEDSEATILIGDLKILPDSYEVYLQDDLLD
LTPKEFELLLFLANHRGKVFSRDQLLDTVWNYDYVGETRIVDVHVSHLRDKIELDTKQPKYIKTIRGFGYKMENVK
>Mature_236_residues
MVKILVVDDEASIVTLLQFNIEKAGFDVVTAEDGRTGYELALSEKPDLIVLDLMLPEMDGIEVTKKLRQDKVNVPILMLT
AKDEELDKIIGLELGADDYMTKPFSPREVVARIKAILRRTEGKAEIIEEITEDSEATILIGDLKILPDSYEVYLQDDLLD
LTPKEFELLLFLANHRGKVFSRDQLLDTVWNYDYVGETRIVDVHVSHLRDKIELDTKQPKYIKTIRGFGYKMENVK

Specific function: Member of the two-component regulatory system phoP/phoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=231, Percent_Identity=42.4242424242424, Blast_Score=177, Evalue=6e-46,
Organism=Escherichia coli, GI1789809, Length=228, Percent_Identity=40.3508771929825, Blast_Score=174, Evalue=5e-45,
Organism=Escherichia coli, GI1788394, Length=232, Percent_Identity=40.0862068965517, Blast_Score=164, Evalue=4e-42,
Organism=Escherichia coli, GI1786784, Length=232, Percent_Identity=39.6551724137931, Blast_Score=156, Evalue=1e-39,
Organism=Escherichia coli, GI2367329, Length=232, Percent_Identity=40.5172413793103, Blast_Score=152, Evalue=2e-38,
Organism=Escherichia coli, GI1786911, Length=232, Percent_Identity=37.0689655172414, Blast_Score=151, Evalue=4e-38,
Organism=Escherichia coli, GI1790860, Length=232, Percent_Identity=36.2068965517241, Blast_Score=145, Evalue=2e-36,
Organism=Escherichia coli, GI1789402, Length=231, Percent_Identity=35.4978354978355, Blast_Score=138, Evalue=4e-34,
Organism=Escherichia coli, GI1790552, Length=231, Percent_Identity=34.1991341991342, Blast_Score=137, Evalue=5e-34,
Organism=Escherichia coli, GI87082012, Length=235, Percent_Identity=35.3191489361702, Blast_Score=137, Evalue=5e-34,
Organism=Escherichia coli, GI1787375, Length=232, Percent_Identity=33.6206896551724, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1790863, Length=240, Percent_Identity=33.75, Blast_Score=121, Evalue=4e-29,
Organism=Escherichia coli, GI145693140, Length=233, Percent_Identity=35.6223175965665, Blast_Score=117, Evalue=5e-28,
Organism=Escherichia coli, GI1787229, Length=233, Percent_Identity=31.7596566523605, Blast_Score=97, Evalue=6e-22,
Organism=Escherichia coli, GI1788550, Length=102, Percent_Identity=36.2745098039216, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1790299, Length=149, Percent_Identity=26.8456375838926, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1790437, Length=103, Percent_Identity=34.9514563106796, Blast_Score=66, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26986; Mature: 26986

Theoretical pI: Translated: 4.43; Mature: 4.43

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKILVVDDEASIVTLLQFNIEKAGFDVVTAEDGRTGYELALSEKPDLIVLDLMLPEMDG
CEEEEEECCCCCEEEEEEEEHHHCCCEEEEECCCCCCEEEEECCCCCEEEEEEECCCCCC
IEVTKKLRQDKVNVPILMLTAKDEELDKIIGLELGADDYMTKPFSPREVVARIKAILRRT
HHHHHHHHHCCCCCCEEEEEECCHHHHHHHCEEECCCCCCCCCCCHHHHHHHHHHHHHHC
EGKAEIIEEITEDSEATILIGDLKILPDSYEVYLQDDLLDLTPKEFELLLFLANHRGKVF
CCHHHHHHHHCCCCCCEEEEEEEEECCCCEEEEEECCCCCCCCCCEEEEEEEECCCCCEE
SRDQLLDTVWNYDYVGETRIVDVHVSHLRDKIELDTKQPKYIKTIRGFGYKMENVK
CHHHHHHHHCCCCCCCCEEEEEEEHHHHHHHHCCCCCCCHHHHHHHHCCEEECCCC
>Mature Secondary Structure
MVKILVVDDEASIVTLLQFNIEKAGFDVVTAEDGRTGYELALSEKPDLIVLDLMLPEMDG
CEEEEEECCCCCEEEEEEEEHHHCCCEEEEECCCCCCEEEEECCCCCEEEEEEECCCCCC
IEVTKKLRQDKVNVPILMLTAKDEELDKIIGLELGADDYMTKPFSPREVVARIKAILRRT
HHHHHHHHHCCCCCCEEEEEECCHHHHHHHCEEECCCCCCCCCCCHHHHHHHHHHHHHHC
EGKAEIIEEITEDSEATILIGDLKILPDSYEVYLQDDLLDLTPKEFELLLFLANHRGKVF
CCHHHHHHHHCCCCCCEEEEEEEEECCCCEEEEEECCCCCCCCCCEEEEEEEECCCCCEE
SRDQLLDTVWNYDYVGETRIVDVHVSHLRDKIELDTKQPKYIKTIRGFGYKMENVK
CHHHHHHHHCCCCCCCCEEEEEEEHHHHHHHHCCCCCCCHHHHHHHHCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1454550; 3036763; 9387221; 9384377; 8045898; 3142862 [H]