Click here to switch to the map view.

The map label for this gene is pgi

Identifier: 226224917

GI number: 226224917

Start: 2414561

End: 2415913

Strand: Reverse

Name: pgi

Synonym: Lm4b_02337

Alternate gene names: 226224917

Gene position: 2415913-2414561 (Counterclockwise)

Preceding gene: 226224918

Following gene: 226224916

Centisome position: 82.94

GC content: 39.17

Gene sequence:

>1353_bases
ATGACACATATTAAATTTGATTATTCCAAAGCGCTCCGTTTTTTTGAAGAACGCGAACTTGATTATCTTGAACCAGCAGT
AAAAGCAGCTCATGATTCATTACATAATGGTACGGGTGCTGGTAATGACGCACTTGGTTGGATTAACTTACCAACAGATT
ACGACAAAGAAGAATTTGCTCGTATCAAAAAAGCAACAGAAAAAATCCACAGTGATTCTGACGTATTAATCGTTATCGGT
ATCGGTGGTTCTTATCTTGGGGCACGTGCTGCAATCGAAACTTTAAATCATTCCTTCTATAATGTACTTGAAAAAGGTGC
TCGTAAAACACCTCAAGTATTCTTTGCAGGAAATAGCATTAGTTCCTCTTACTTACATGACTTAATTGAAGTAGTTGGCG
ACCGTGACTTCTCTGTTAACGTTATTTCTAAATCCGGAACAACAACAGAGCCAGCAATCGCTTTCCGTGTTTTCAAAGAA
CTTTTAATCAAAAAATATGGCGAAGAAGGCGCGAAAAAACGCATTTACGCTACAACTGATAAAGCAAAAGGCGCTCTAAA
AACATTAGCTGACAATGAAGGCTACGAAACATTTGTTGTTCCAGATGACGTTGGCGGACGTTTCTCTGTTTTAACTGCAG
TAGGTTTACTTCCAATCGCAGTTAGTGGTGTTGATATCGATGCTCTTATGAATGGAGCAGCAGCAGCAAGCAAAGATTTC
GACAAACCTGAACTAAAAAATAACATTGCATACCAATACGCAGCAGCTCGTAACGTTCTTTACCGTAAAGGCAAAGTAAC
AGAACTTCTAATCAGCTATGAACCAGGCTTACAATACTTTAACGAGTGGTGGAAACAATTATTCGGCGAAAGTGAAGGTA
AAGACAAAAAAGGTATTTACCCATCCAGCGCAAACTTCTCCACTGACTTGCACTCTATCGGTCAATATATCCAAGACGGC
CGTCGTAACCTTTTTGAAACAGTTATCAAAGTGGATAAACCACGCCACAACTTAACTATCAATAAAGAAGAGGTAGATCT
AGATGGCTTAAATTATCTTGCTGGCGAAACAGTTGATTTCGTTAACACAAAAGCATTCGAAGGAACACTTCTAGCACATA
CAGACGGCGAAGTTCCAAACTTTGTTGTAGAAGTTCCAGAACTAGATGCATACACTTTCGGTTACCTAGTATACTTCTTT
GAAAAAGCAGTAGCTATCAGCGGTTACCTAAATGGCGTAAATCCATTTGACCAACCAGGCGTAGAAGCATACAAAGCCAA
CATGTTCGCATTACTTGGCAAACCAGGCTTCGAAGACAAAAAAGCAGAATTAGAAAAACGCTTAAACGATTAA

Upstream 100 bases:

>100_bases
TTTCAAAAAGGCTCAAATTTCACAAGGTCAAGCCTTGCTAAAAAGCACTGATTGATATAAAGTTAATAAAGAAACTTTTT
TAAAATTTGGAGGGAAAACA

Downstream 100 bases:

>100_bases
TTTTCACTTCCAAACCTTGGGGCCAATTGCTCCAAGGTTTTTTGTTTGTTTGCGATTTTCTTCCATTGGAGTTACCATAT
AGTTAAACAAAAGGAGGGGA

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI

Number of amino acids: Translated: 450; Mature: 449

Protein sequence:

>450_residues
MTHIKFDYSKALRFFEERELDYLEPAVKAAHDSLHNGTGAGNDALGWINLPTDYDKEEFARIKKATEKIHSDSDVLIVIG
IGGSYLGARAAIETLNHSFYNVLEKGARKTPQVFFAGNSISSSYLHDLIEVVGDRDFSVNVISKSGTTTEPAIAFRVFKE
LLIKKYGEEGAKKRIYATTDKAKGALKTLADNEGYETFVVPDDVGGRFSVLTAVGLLPIAVSGVDIDALMNGAAAASKDF
DKPELKNNIAYQYAAARNVLYRKGKVTELLISYEPGLQYFNEWWKQLFGESEGKDKKGIYPSSANFSTDLHSIGQYIQDG
RRNLFETVIKVDKPRHNLTINKEEVDLDGLNYLAGETVDFVNTKAFEGTLLAHTDGEVPNFVVEVPELDAYTFGYLVYFF
EKAVAISGYLNGVNPFDQPGVEAYKANMFALLGKPGFEDKKAELEKRLND

Sequences:

>Translated_450_residues
MTHIKFDYSKALRFFEERELDYLEPAVKAAHDSLHNGTGAGNDALGWINLPTDYDKEEFARIKKATEKIHSDSDVLIVIG
IGGSYLGARAAIETLNHSFYNVLEKGARKTPQVFFAGNSISSSYLHDLIEVVGDRDFSVNVISKSGTTTEPAIAFRVFKE
LLIKKYGEEGAKKRIYATTDKAKGALKTLADNEGYETFVVPDDVGGRFSVLTAVGLLPIAVSGVDIDALMNGAAAASKDF
DKPELKNNIAYQYAAARNVLYRKGKVTELLISYEPGLQYFNEWWKQLFGESEGKDKKGIYPSSANFSTDLHSIGQYIQDG
RRNLFETVIKVDKPRHNLTINKEEVDLDGLNYLAGETVDFVNTKAFEGTLLAHTDGEVPNFVVEVPELDAYTFGYLVYFF
EKAVAISGYLNGVNPFDQPGVEAYKANMFALLGKPGFEDKKAELEKRLND
>Mature_449_residues
THIKFDYSKALRFFEERELDYLEPAVKAAHDSLHNGTGAGNDALGWINLPTDYDKEEFARIKKATEKIHSDSDVLIVIGI
GGSYLGARAAIETLNHSFYNVLEKGARKTPQVFFAGNSISSSYLHDLIEVVGDRDFSVNVISKSGTTTEPAIAFRVFKEL
LIKKYGEEGAKKRIYATTDKAKGALKTLADNEGYETFVVPDDVGGRFSVLTAVGLLPIAVSGVDIDALMNGAAAASKDFD
KPELKNNIAYQYAAARNVLYRKGKVTELLISYEPGLQYFNEWWKQLFGESEGKDKKGIYPSSANFSTDLHSIGQYIQDGR
RNLFETVIKVDKPRHNLTINKEEVDLDGLNYLAGETVDFVNTKAFEGTLLAHTDGEVPNFVVEVPELDAYTFGYLVYFFE
KAVAISGYLNGVNPFDQPGVEAYKANMFALLGKPGFEDKKAELEKRLND

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family

Homologues:

Organism=Saccharomyces cerevisiae, GI6319673, Length=379, Percent_Identity=25.8575197889182, Blast_Score=73, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PI_LISIN (Q928R6)

Other databases:

- EMBL:   AL596172
- PIR:   AE1740
- RefSeq:   NP_471796.1
- ProteinModelPortal:   Q928R6
- SMR:   Q928R6
- GeneID:   1131258
- GenomeReviews:   AL592022_GR
- KEGG:   lin:lin2466
- GenoList:   LIN2466
- HOGENOM:   HBG615843
- OMA:   YVNDRAY
- ProtClustDB:   PRK14097
- BioCyc:   LINN272626:LIN2466-MONOMER
- BRENDA:   5.3.1.9
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00473
- InterPro:   IPR001672
- InterPro:   IPR018189
- PANTHER:   PTHR11469
- PRINTS:   PR00662

Pfam domain/function: PF00342 PGI

EC number: =5.3.1.9

Molecular weight: Translated: 49895; Mature: 49763

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1; PS00174 P_GLUCOSE_ISOMERASE_2; PS51463 P_GLUCOSE_ISOMERASE_3

Important sites: ACT_SITE 290-290 ACT_SITE 311-311 ACT_SITE 425-425

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
0.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHIKFDYSKALRFFEERELDYLEPAVKAAHDSLHNGTGAGNDALGWINLPTDYDKEEFA
CCCEECCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCHHHHH
RIKKATEKIHSDSDVLIVIGIGGSYLGARAAIETLNHSFYNVLEKGARKTPQVFFAGNSI
HHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCC
SSSYLHDLIEVVGDRDFSVNVISKSGTTTEPAIAFRVFKELLIKKYGEEGAKKRIYATTD
CHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECC
KAKGALKTLADNEGYETFVVPDDVGGRFSVLTAVGLLPIAVSGVDIDALMNGAAAASKDF
HHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCHHHHHCCHHHCCCCC
DKPELKNNIAYQYAAARNVLYRKGKVTELLISYEPGLQYFNEWWKQLFGESEGKDKKGIY
CCCHHHCCHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCC
PSSANFSTDLHSIGQYIQDGRRNLFETVIKVDKPRHNLTINKEEVDLDGLNYLAGETVDF
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECHHHCCCCCCHHHCCCCCHH
VNTKAFEGTLLAHTDGEVPNFVVEVPELDAYTFGYLVYFFEKAVAISGYLNGVNPFDQPG
HCCCCCCCEEEEECCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
VEAYKANMFALLGKPGFEDKKAELEKRLND
HHHHHHCEEEEECCCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
THIKFDYSKALRFFEERELDYLEPAVKAAHDSLHNGTGAGNDALGWINLPTDYDKEEFA
CCEECCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCHHHHH
RIKKATEKIHSDSDVLIVIGIGGSYLGARAAIETLNHSFYNVLEKGARKTPQVFFAGNSI
HHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCC
SSSYLHDLIEVVGDRDFSVNVISKSGTTTEPAIAFRVFKELLIKKYGEEGAKKRIYATTD
CHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECC
KAKGALKTLADNEGYETFVVPDDVGGRFSVLTAVGLLPIAVSGVDIDALMNGAAAASKDF
HHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCHHHHHCCHHHCCCCC
DKPELKNNIAYQYAAARNVLYRKGKVTELLISYEPGLQYFNEWWKQLFGESEGKDKKGIY
CCCHHHCCHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCC
PSSANFSTDLHSIGQYIQDGRRNLFETVIKVDKPRHNLTINKEEVDLDGLNYLAGETVDF
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECHHHCCCCCCHHHCCCCCHH
VNTKAFEGTLLAHTDGEVPNFVVEVPELDAYTFGYLVYFFEKAVAISGYLNGVNPFDQPG
HCCCCCCCEEEEECCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
VEAYKANMFALLGKPGFEDKKAELEKRLND
HHHHHHCEEEEECCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11679669