Click here to switch to the map view.

The map label for this gene is nhaK [H]

Identifier: 226224898

GI number: 226224898

Start: 2383965

End: 2385917

Strand: Reverse

Name: nhaK [H]

Synonym: Lm4b_02317

Alternate gene names: 226224898

Gene position: 2385917-2383965 (Counterclockwise)

Preceding gene: 226224899

Following gene: 226224896

Centisome position: 81.91

GC content: 38.2

Gene sequence:

>1953_bases
ATGGAAATATTTGAACTGATTTTATTAATGTTGAGCGCGGTGTTTTTGTCTAATGTATTAAGCCGATTTTTGCCGGGGAT
TGCAGTGCCTTTAATTCAAGTAATACTAGGGATTATTTTGGCGATTCCGCTTGGGGATCATACGATGGATTTAAATCCGG
AATTATTTTTATTATTATTTATGGCGCCGATTCTTTTTAATGATGGGGCGAGTACGGATAAGAAATCTTTATGGAAAAAT
CGGAAGGCTATTTTGTCATTATCGATTGGGCTAGTGTTTGTAACAGTTGGGGTACTGGGTGCGTTTATTCACTACTTAAT
TCCTGCGATACCTTTTGCCGCGGCGTTTGCGTTAGCTGCGGCACTTGCGCCTACGGATGCTGTTGCGGTGGGGGCGCTGG
CTGAAAAAGTAAGAGTACCCCATAAAATTATGCATATTTTGGAAGGTGAATCGCTTATTAACGATGCTTCCGGACTTGTT
TCGTTCCAGTTTGCTGTGTTGGCGCTTGTAACCGGAACATTCTCATTTATGTCAGCTGGAACAAGCTTTTTGCTTCTTTC
ATTAGGTGGGATTGCGCTTGGAGCTGCCCTTAGTTTACTGAAAATCATGTTAATGCGTGGTTTACGTCAGCTAGGAATCG
AAAATATGACTTCTTTTATGCTGATGGAAATTTTGTTACCATTTTTAATTTTTATGGTAGCCGAAAAAGTTGGAGTAAAT
GGGATTTTAGCAGTAGTTAGTGGCGGAATGGTGCATTCATTTAGTTACAAGGGACTAAATCCTGAAATTGCGCAATTGAA
CTTGCTTTCAAAAAACACGTGGTCTGTTATTATTTTTAGTTTGAATGGTTTGGTATTTATCTTACTAGGGACACAATTAC
CGCAAATTTTGATGACGATTTGGCAAGATGCTAATATTCAAAAAGGTATGCTATTCGTGTATATACTAGGAATCACTTTC
TTACTGCTCGGGCTAAGGTTTTTATGGATCTTGTTTTTCCGCAATTACGAGGAAAATCCGAAAGTGGACTTGGTTAGCAG
ATTGAAAAATACTTTTCTTTATACTGTGGCTGGTGTTCGCGGGACAATTACATTAGTCAGTGCGCTTTCGTTACCTTTTG
TTCTTGGTAATGGGAATGCGTTTCCTGAGCGTGATTTACTTATTTTTATTGCTGCTGGAGTTATTATTACGACGCTACTT
TTGGCCAATTTCACCTTGCCACTTTTTGCAGATAAGAAAGACAAAATTGCGGCGGATCATACGACAGATATTGTACTACT
TCGCGATATTGTGCAGCAATTACAGGCGTATAAAACAGATGAAAATGCAGTGGAAATGAATAAAGTGTTGAATATGTATA
ATAATCGGATTTTCTCTTTGATGGAGCATAAGGAAGTAAATGCTACTGAAAAAGAATTGCGGCGTTTAACACAAGAATGG
CAACTTGAAAATACGAGGAGATTAGTATTTGAACGAAAAATTGATACTGGTGTGGGACTGTCGCATATGATGCGGCTTGG
AAAACGACTCTACGTCCAAACACGAGCAGAGAAGTACCGAGCGAGAATGCGGTATCGTCAGTTATTAAGTCATCGTTTTC
GAGACTTCCGATTTGTGCCTCTTACTTTTGAAGAACGTAGAAAAGAAATTGCTAAACTGCAAAATGAAAACAATTTATTC
GTCATTCAAAAGCTACAAGAACTGGATTCAAATGAGTATAACCCAGAAATCATTTCGCTTTATTTAATGAATTTTGAGCG
AGCATTGGGTCGTGGGAAAAATAAAAAAGAAAGCAATGATGAAGCGCTACAAACAACAATTGACTTAGCTTCACAAATTG
AGCGCGAAACAATTCAACACTACTTTGAAAAAGGTACGATTACGCGGAAAGAAATGAAAGTGTATCGTGATAATTTACTT
GCGATAGAGGCGAATATGCAATTAGAATTTTAA

Upstream 100 bases:

>100_bases
GAGACGGATGTTTCTGAAAAGTTTTTTTGCTAATATGGGAACGGAAGAAATGCCACGCTTCTGACTCAGTGGCACGGATA
CGGGAACGAGGGATGTATTA

Downstream 100 bases:

>100_bases
TAAAAAAGACAGTTAAGCTAATTTTTTAGCCTAGCTGTCTTTTTTTATCATCAAAATAATAAATAATCCGGTCGATAAGT
TCTTTCGTCGTGCTGTCAAA

Product: Na+/H+ antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 650; Mature: 650

Protein sequence:

>650_residues
MEIFELILLMLSAVFLSNVLSRFLPGIAVPLIQVILGIILAIPLGDHTMDLNPELFLLLFMAPILFNDGASTDKKSLWKN
RKAILSLSIGLVFVTVGVLGAFIHYLIPAIPFAAAFALAAALAPTDAVAVGALAEKVRVPHKIMHILEGESLINDASGLV
SFQFAVLALVTGTFSFMSAGTSFLLLSLGGIALGAALSLLKIMLMRGLRQLGIENMTSFMLMEILLPFLIFMVAEKVGVN
GILAVVSGGMVHSFSYKGLNPEIAQLNLLSKNTWSVIIFSLNGLVFILLGTQLPQILMTIWQDANIQKGMLFVYILGITF
LLLGLRFLWILFFRNYEENPKVDLVSRLKNTFLYTVAGVRGTITLVSALSLPFVLGNGNAFPERDLLIFIAAGVIITTLL
LANFTLPLFADKKDKIAADHTTDIVLLRDIVQQLQAYKTDENAVEMNKVLNMYNNRIFSLMEHKEVNATEKELRRLTQEW
QLENTRRLVFERKIDTGVGLSHMMRLGKRLYVQTRAEKYRARMRYRQLLSHRFRDFRFVPLTFEERRKEIAKLQNENNLF
VIQKLQELDSNEYNPEIISLYLMNFERALGRGKNKKESNDEALQTTIDLASQIERETIQHYFEKGTITRKEMKVYRDNLL
AIEANMQLEF

Sequences:

>Translated_650_residues
MEIFELILLMLSAVFLSNVLSRFLPGIAVPLIQVILGIILAIPLGDHTMDLNPELFLLLFMAPILFNDGASTDKKSLWKN
RKAILSLSIGLVFVTVGVLGAFIHYLIPAIPFAAAFALAAALAPTDAVAVGALAEKVRVPHKIMHILEGESLINDASGLV
SFQFAVLALVTGTFSFMSAGTSFLLLSLGGIALGAALSLLKIMLMRGLRQLGIENMTSFMLMEILLPFLIFMVAEKVGVN
GILAVVSGGMVHSFSYKGLNPEIAQLNLLSKNTWSVIIFSLNGLVFILLGTQLPQILMTIWQDANIQKGMLFVYILGITF
LLLGLRFLWILFFRNYEENPKVDLVSRLKNTFLYTVAGVRGTITLVSALSLPFVLGNGNAFPERDLLIFIAAGVIITTLL
LANFTLPLFADKKDKIAADHTTDIVLLRDIVQQLQAYKTDENAVEMNKVLNMYNNRIFSLMEHKEVNATEKELRRLTQEW
QLENTRRLVFERKIDTGVGLSHMMRLGKRLYVQTRAEKYRARMRYRQLLSHRFRDFRFVPLTFEERRKEIAKLQNENNLF
VIQKLQELDSNEYNPEIISLYLMNFERALGRGKNKKESNDEALQTTIDLASQIERETIQHYFEKGTITRKEMKVYRDNLL
AIEANMQLEF
>Mature_650_residues
MEIFELILLMLSAVFLSNVLSRFLPGIAVPLIQVILGIILAIPLGDHTMDLNPELFLLLFMAPILFNDGASTDKKSLWKN
RKAILSLSIGLVFVTVGVLGAFIHYLIPAIPFAAAFALAAALAPTDAVAVGALAEKVRVPHKIMHILEGESLINDASGLV
SFQFAVLALVTGTFSFMSAGTSFLLLSLGGIALGAALSLLKIMLMRGLRQLGIENMTSFMLMEILLPFLIFMVAEKVGVN
GILAVVSGGMVHSFSYKGLNPEIAQLNLLSKNTWSVIIFSLNGLVFILLGTQLPQILMTIWQDANIQKGMLFVYILGITF
LLLGLRFLWILFFRNYEENPKVDLVSRLKNTFLYTVAGVRGTITLVSALSLPFVLGNGNAFPERDLLIFIAAGVIITTLL
LANFTLPLFADKKDKIAADHTTDIVLLRDIVQQLQAYKTDENAVEMNKVLNMYNNRIFSLMEHKEVNATEKELRRLTQEW
QLENTRRLVFERKIDTGVGLSHMMRLGKRLYVQTRAEKYRARMRYRQLLSHRFRDFRFVPLTFEERRKEIAKLQNENNLF
VIQKLQELDSNEYNPEIISLYLMNFERALGRGKNKKESNDEALQTTIDLASQIERETIQHYFEKGTITRKEMKVYRDNLL
AIEANMQLEF

Specific function: Transporter involved in the efflux of sodium, potassium, lithium and rubidium [H]

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. Nhak (TC 2.A.36.3.2) subfamily [H]

Homologues:

Organism=Homo sapiens, GI41872703, Length=488, Percent_Identity=25.2049180327869, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI27734935, Length=267, Percent_Identity=25.0936329588015, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI294997330, Length=272, Percent_Identity=25.7352941176471, Blast_Score=66, Evalue=9e-11,
Organism=Escherichia coli, GI1790501, Length=519, Percent_Identity=36.6088631984586, Blast_Score=263, Evalue=4e-71,
Organism=Caenorhabditis elegans, GI71980847, Length=373, Percent_Identity=20.6434316353887, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI71999817, Length=370, Percent_Identity=23.5135135135135, Blast_Score=65, Evalue=9e-11,
Organism=Drosophila melanogaster, GI281364513, Length=263, Percent_Identity=25.8555133079848, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI221473212, Length=263, Percent_Identity=25.8555133079848, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI221473222, Length=263, Percent_Identity=25.8555133079848, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI221473215, Length=263, Percent_Identity=25.8555133079848, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR018417
- InterPro:   IPR004705
- InterPro:   IPR002014 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 73320; Mature: 73320

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIFELILLMLSAVFLSNVLSRFLPGIAVPLIQVILGIILAIPLGDHTMDLNPELFLLLF
CCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
MAPILFNDGASTDKKSLWKNRKAILSLSIGLVFVTVGVLGAFIHYLIPAIPFAAAFALAA
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALAPTDAVAVGALAEKVRVPHKIMHILEGESLINDASGLVSFQFAVLALVTGTFSFMSAG
HHCCCHHHHHHHHHHHHHCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
TSFLLLSLGGIALGAALSLLKIMLMRGLRQLGIENMTSFMLMEILLPFLIFMVAEKVGVN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GILAVVSGGMVHSFSYKGLNPEIAQLNLLSKNTWSVIIFSLNGLVFILLGTQLPQILMTI
HHHHHHCCCCEEECCCCCCCCCHHHEEEECCCCCEEEEEECCCEEEEEHHHHHHHHHHHH
WQDANIQKGMLFVYILGITFLLLGLRFLWILFFRNYEENPKVDLVSRLKNTFLYTVAGVR
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCH
GTITLVSALSLPFVLGNGNAFPERDLLIFIAAGVIITTLLLANFTLPLFADKKDKIAADH
HHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCC
TTDIVLLRDIVQQLQAYKTDENAVEMNKVLNMYNNRIFSLMEHKEVNATEKELRRLTQEW
CHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
QLENTRRLVFERKIDTGVGLSHMMRLGKRLYVQTRAEKYRARMRYRQLLSHRFRDFRFVP
HHCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEC
LTFEERRKEIAKLQNENNLFVIQKLQELDSNEYNPEIISLYLMNFERALGRGKNKKESND
CCHHHHHHHHHHHCCCCCEEEEHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCH
EALQTTIDLASQIERETIQHYFEKGTITRKEMKVYRDNLLAIEANMQLEF
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCEEEEEECCEECC
>Mature Secondary Structure
MEIFELILLMLSAVFLSNVLSRFLPGIAVPLIQVILGIILAIPLGDHTMDLNPELFLLLF
CCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHH
MAPILFNDGASTDKKSLWKNRKAILSLSIGLVFVTVGVLGAFIHYLIPAIPFAAAFALAA
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALAPTDAVAVGALAEKVRVPHKIMHILEGESLINDASGLVSFQFAVLALVTGTFSFMSAG
HHCCCHHHHHHHHHHHHHCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
TSFLLLSLGGIALGAALSLLKIMLMRGLRQLGIENMTSFMLMEILLPFLIFMVAEKVGVN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GILAVVSGGMVHSFSYKGLNPEIAQLNLLSKNTWSVIIFSLNGLVFILLGTQLPQILMTI
HHHHHHCCCCEEECCCCCCCCCHHHEEEECCCCCEEEEEECCCEEEEEHHHHHHHHHHHH
WQDANIQKGMLFVYILGITFLLLGLRFLWILFFRNYEENPKVDLVSRLKNTFLYTVAGVR
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCH
GTITLVSALSLPFVLGNGNAFPERDLLIFIAAGVIITTLLLANFTLPLFADKKDKIAADH
HHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCC
TTDIVLLRDIVQQLQAYKTDENAVEMNKVLNMYNNRIFSLMEHKEVNATEKELRRLTQEW
CHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
QLENTRRLVFERKIDTGVGLSHMMRLGKRLYVQTRAEKYRARMRYRQLLSHRFRDFRFVP
HHCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEC
LTFEERRKEIAKLQNENNLFVIQKLQELDSNEYNPEIISLYLMNFERALGRGKNKKESND
CCHHHHHHHHHHHCCCCCEEEEHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCH
EALQTTIDLASQIERETIQHYFEKGTITRKEMKVYRDNLLAIEANMQLEF
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCEEEEEECCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA