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The map label for this gene is hemE

Identifier: 226224820

GI number: 226224820

Start: 2307203

End: 2308264

Strand: Reverse

Name: hemE

Synonym: Lm4b_02239

Alternate gene names: 226224820

Gene position: 2308264-2307203 (Counterclockwise)

Preceding gene: 226224822

Following gene: 226224819

Centisome position: 79.25

GC content: 37.85

Gene sequence:

>1062_bases
ATGACAAAAATAACGAATGATTTATTTTTAAAAGCAGCGCGAAAAGAACAAGTTGACCGAATTCCGGTTTGGTATATGAG
ACAAGCAGGGAGATCTCAACCAGAATACCGCAAATTAAAAGAAAAATACTCTCTATTTGAAATTACTCATCAGCCAGAAA
TATGTGCTTACGTAACCAAATTACCAGTAGATCAATATGGTGTTGATGCAGCCATTTTATACAAAGATATTATGACACCA
CTTCCGGGGATGGGAGTAGACGTTGAAATCAAATCTGGTATTGGTCCAGTCATACATAATCCTATTAGATCTTTCCAAGA
TGTAGAAAAACTGACAATGTTCAAACCAGAAATAGAAGTTCCTTATGTCCTAGATACGATAAAATTATTGGCAGATGATA
TGCTAGATGTACCTTTAATTGGCTTTGCAGGTGCACCATTTACTTTGGCTAGCTATATGATAGAAGGTGGTCCATCGAAA
AATTATCACCAAACAAAAAGTTTTATGTATCGCGAGCCAGAAGTTTGGGCAATACTAATGGAAAAACTTGGTCGAATGAC
TGCGAATTATTTAATTGCGCAAATTAATGCGGGCACTTCTGCGGTGCAATTGTTTGATTCTTGGGTAGGGGCACTTAGTC
GAGCTGACTATGCTGAATACATTCGACCAGTAATCGAAATGATTGTTAGAGAAGTGAAAGCAGTTCATCCAACAACCCCA
ATTATTATGCAAGCAGTTGGCGCGAGTCATCTTTTAGCAGAATGGGAAACAATGCCGCTTGATGTTGTTGGCGTCGATTG
GCGTGAAACCATCACAAGTGCTCGGAAAAAAGTTCCAACAAAAGCAATTCAAGGAAATCTGGATCCGTCCACACTTCTTG
CACCAGAGAAATGTTTAAAAGAAGCAAATCGTATTTTGCAAGAAGGCGTACTAGAACCAGGTTATATTTTTAATTTAGGA
CATGGCGTTTTCCCGGAAGTACCACCAGAAATGTTGAAGAAACTAACTAATTACATCCATGAACGTAGCGAAATTCTATT
AAAAAAGGATGATATAAAATGA

Upstream 100 bases:

>100_bases
TTGGTTTTATACAAATTTTCTAGTATCCTTTTATCTGGAGAAGTTATTTATTGTTCTGTTGCCTATTGTGTGTAAATGAA
CAAAGAAGGGAAGCGACTCA

Downstream 100 bases:

>100_bases
CTAAAAAAGTAGGTCTACTTGTAATGGCATACGGGACACCGTACAAAGATGAAGATATTGAACGTTACTATACAGATATT
CGTCATGGTCATAAGCCAAG

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 353; Mature: 352

Protein sequence:

>353_residues
MTKITNDLFLKAARKEQVDRIPVWYMRQAGRSQPEYRKLKEKYSLFEITHQPEICAYVTKLPVDQYGVDAAILYKDIMTP
LPGMGVDVEIKSGIGPVIHNPIRSFQDVEKLTMFKPEIEVPYVLDTIKLLADDMLDVPLIGFAGAPFTLASYMIEGGPSK
NYHQTKSFMYREPEVWAILMEKLGRMTANYLIAQINAGTSAVQLFDSWVGALSRADYAEYIRPVIEMIVREVKAVHPTTP
IIMQAVGASHLLAEWETMPLDVVGVDWRETITSARKKVPTKAIQGNLDPSTLLAPEKCLKEANRILQEGVLEPGYIFNLG
HGVFPEVPPEMLKKLTNYIHERSEILLKKDDIK

Sequences:

>Translated_353_residues
MTKITNDLFLKAARKEQVDRIPVWYMRQAGRSQPEYRKLKEKYSLFEITHQPEICAYVTKLPVDQYGVDAAILYKDIMTP
LPGMGVDVEIKSGIGPVIHNPIRSFQDVEKLTMFKPEIEVPYVLDTIKLLADDMLDVPLIGFAGAPFTLASYMIEGGPSK
NYHQTKSFMYREPEVWAILMEKLGRMTANYLIAQINAGTSAVQLFDSWVGALSRADYAEYIRPVIEMIVREVKAVHPTTP
IIMQAVGASHLLAEWETMPLDVVGVDWRETITSARKKVPTKAIQGNLDPSTLLAPEKCLKEANRILQEGVLEPGYIFNLG
HGVFPEVPPEMLKKLTNYIHERSEILLKKDDIK
>Mature_352_residues
TKITNDLFLKAARKEQVDRIPVWYMRQAGRSQPEYRKLKEKYSLFEITHQPEICAYVTKLPVDQYGVDAAILYKDIMTPL
PGMGVDVEIKSGIGPVIHNPIRSFQDVEKLTMFKPEIEVPYVLDTIKLLADDMLDVPLIGFAGAPFTLASYMIEGGPSKN
YHQTKSFMYREPEVWAILMEKLGRMTANYLIAQINAGTSAVQLFDSWVGALSRADYAEYIRPVIEMIVREVKAVHPTTPI
IMQAVGASHLLAEWETMPLDVVGVDWRETITSARKKVPTKAIQGNLDPSTLLAPEKCLKEANRILQEGVLEPGYIFNLGH
GVFPEVPPEMLKKLTNYIHERSEILLKKDDIK

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=355, Percent_Identity=36.056338028169, Blast_Score=216, Evalue=2e-56,
Organism=Escherichia coli, GI2367337, Length=352, Percent_Identity=37.2159090909091, Blast_Score=238, Evalue=3e-64,
Organism=Saccharomyces cerevisiae, GI6320252, Length=352, Percent_Identity=32.3863636363636, Blast_Score=188, Evalue=1e-48,
Organism=Drosophila melanogaster, GI221330099, Length=345, Percent_Identity=35.0724637681159, Blast_Score=218, Evalue=4e-57,
Organism=Drosophila melanogaster, GI19921920, Length=345, Percent_Identity=35.0724637681159, Blast_Score=218, Evalue=5e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_LISMC (C1KXG7)

Other databases:

- EMBL:   FM242711
- RefSeq:   YP_002758927.1
- GeneID:   7702863
- GenomeReviews:   FM242711_GR
- KEGG:   lmc:Lm4b_02239
- OMA:   AVQLFDS
- ProtClustDB:   PRK00115
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 39919; Mature: 39788

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 46-46 BINDING 76-76 BINDING 152-152 BINDING 207-207 BINDING 321-321

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKITNDLFLKAARKEQVDRIPVWYMRQAGRSQPEYRKLKEKYSLFEITHQPEICAYVTK
CCCCCHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHH
LPVDQYGVDAAILYKDIMTPLPGMGVDVEIKSGIGPVIHNPIRSFQDVEKLTMFKPEIEV
CCCHHHCCCHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
PYVLDTIKLLADDMLDVPLIGFAGAPFTLASYMIEGGPSKNYHQTKSFMYREPEVWAILM
CHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHH
EKLGRMTANYLIAQINAGTSAVQLFDSWVGALSRADYAEYIRPVIEMIVREVKAVHPTTP
HHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCH
IIMQAVGASHLLAEWETMPLDVVGVDWRETITSARKKVPTKAIQGNLDPSTLLAPEKCLK
HHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHCCHHHHCCCCCCHHHCCHHHHHH
EANRILQEGVLEPGYIFNLGHGVFPEVPPEMLKKLTNYIHERSEILLKKDDIK
HHHHHHHHCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TKITNDLFLKAARKEQVDRIPVWYMRQAGRSQPEYRKLKEKYSLFEITHQPEICAYVTK
CCCCHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHH
LPVDQYGVDAAILYKDIMTPLPGMGVDVEIKSGIGPVIHNPIRSFQDVEKLTMFKPEIEV
CCCHHHCCCHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
PYVLDTIKLLADDMLDVPLIGFAGAPFTLASYMIEGGPSKNYHQTKSFMYREPEVWAILM
CHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHH
EKLGRMTANYLIAQINAGTSAVQLFDSWVGALSRADYAEYIRPVIEMIVREVKAVHPTTP
HHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCCH
IIMQAVGASHLLAEWETMPLDVVGVDWRETITSARKKVPTKAIQGNLDPSTLLAPEKCLK
HHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHCCHHHHCCCCCCHHHCCHHHHHH
EANRILQEGVLEPGYIFNLGHGVFPEVPPEMLKKLTNYIHERSEILLKKDDIK
HHHHHHHHCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA