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The map label for this gene is nagA [H]

Identifier: 226224714

GI number: 226224714

Start: 2188064

End: 2189197

Strand: Direct

Name: nagA [H]

Synonym: Lm4b_02130

Alternate gene names: 226224714

Gene position: 2188064-2189197 (Clockwise)

Preceding gene: 226224713

Following gene: 226224715

Centisome position: 75.12

GC content: 39.59

Gene sequence:

>1134_bases
ATGGCCGTTATCAAAAATGTGAAAATTTACAAAGAAAATGAATTAATTGATGCAGCAGTTATTACAGAAGGAAATTTGAT
AAAAGAAGTTTGCTCAACTACTCCTGAAAAGTATTCAGATGAGCCAACTTTTGATGGAAATGGACAGTTGCTAATTCCCG
GAATGATCGACGTTCATATTCATGGGGCAAATAATTATGATATGATGGATGGCTCAACAGAAAGCATCCAAGCTGTTTCG
ATGGCTTGTGCGGAAACCGGATGTACTAGTTTCTTAGTCACCTCGGTTAGTTCTTCTTTTGAAGACTTGATCCAAATGAT
TAAGCAAACTAAAAAAGTCATTGGAAAAGAGAGAGGTGCCAAAATTGCAGGAATTCATTTAGAAGGCCCCTACCTTAATA
TAGAAAAAAAAGGAATGCAAAATCCAGCCTATTTAAGACACCCCGATTTAAAAGAAATGAAAAAGATCTTCGATGAAGCA
GATGGTCTGATAAAAATGGTCACAATTGCTCCAGAATTGCCTGGGGGTATCGAACTCATTGACTTCTTGAAAAAAAGAGG
AGTTGTGGTCGCCATTGCACATTCCAATGCAACTTATGAAGAGGCGCAAAATGCTTTCGAACAAGGAGCAACCCACATCA
CACATTGCTTCAATGCTATGCCAGCCATTCATCACCGGGCACCAGGACTTGTTACAGCAGCCTTGGAAAATAATTCGGTA
AGCGTTCAAGCCATTGTAGACGGTGTCCATCTCCATCCCGGAATCGTGCGCCTTATTCACAAAATTAAAGGACCAGATAA
AATGGTTCTCACAACCGATGCCCTTCAAGCAATGGGAGTTGGCGACGGGGAGTATATTTTTGGCGGTCACCAAGTAACGG
TTAAGGAAGGCATAGCTCGCTTAAAAGACGGGACATTAGCTTCAAGTACCGTGACGATGAATAAATCCTTAAAGTTAAGT
AATGAATTTGGGATTCACTTACAAGACGCTATTCAAATGGCAGCAAGTACGCCGGCAGACATTTTAGGAATGAACAATTT
TGGTCGAATCGAAAAAGGCTATGTCGCTGATTTAGTTTTACTTGATAAAAATTTTGAAGTTCTAACTACATGGATTGATG
GTGAAATATATTAA

Upstream 100 bases:

>100_bases
TTGATGCCGTAATAACAGATCAGCCTTTACCAAAAGATTTAATGCAGTGCCTTATTTCTAAAGAAGTAGAAGTTATATCT
TTGAAAGGATTGTGAAAATA

Downstream 100 bases:

>100_bases
ATCGACTGGATAAATACTTTCAGAGGAGTGGATTATAAAATATGCCATTATTTAAACACGAGGGAACTTACTTTAACTAT
GAAATCCAAGGTGAAGGCAT

Product: N-acetylglucosamine-6-phosphate deacetylase

Products: NA

Alternate protein names: GlcNAc 6-P deacetylase [H]

Number of amino acids: Translated: 377; Mature: 376

Protein sequence:

>377_residues
MAVIKNVKIYKENELIDAAVITEGNLIKEVCSTTPEKYSDEPTFDGNGQLLIPGMIDVHIHGANNYDMMDGSTESIQAVS
MACAETGCTSFLVTSVSSSFEDLIQMIKQTKKVIGKERGAKIAGIHLEGPYLNIEKKGMQNPAYLRHPDLKEMKKIFDEA
DGLIKMVTIAPELPGGIELIDFLKKRGVVVAIAHSNATYEEAQNAFEQGATHITHCFNAMPAIHHRAPGLVTAALENNSV
SVQAIVDGVHLHPGIVRLIHKIKGPDKMVLTTDALQAMGVGDGEYIFGGHQVTVKEGIARLKDGTLASSTVTMNKSLKLS
NEFGIHLQDAIQMAASTPADILGMNNFGRIEKGYVADLVLLDKNFEVLTTWIDGEIY

Sequences:

>Translated_377_residues
MAVIKNVKIYKENELIDAAVITEGNLIKEVCSTTPEKYSDEPTFDGNGQLLIPGMIDVHIHGANNYDMMDGSTESIQAVS
MACAETGCTSFLVTSVSSSFEDLIQMIKQTKKVIGKERGAKIAGIHLEGPYLNIEKKGMQNPAYLRHPDLKEMKKIFDEA
DGLIKMVTIAPELPGGIELIDFLKKRGVVVAIAHSNATYEEAQNAFEQGATHITHCFNAMPAIHHRAPGLVTAALENNSV
SVQAIVDGVHLHPGIVRLIHKIKGPDKMVLTTDALQAMGVGDGEYIFGGHQVTVKEGIARLKDGTLASSTVTMNKSLKLS
NEFGIHLQDAIQMAASTPADILGMNNFGRIEKGYVADLVLLDKNFEVLTTWIDGEIY
>Mature_376_residues
AVIKNVKIYKENELIDAAVITEGNLIKEVCSTTPEKYSDEPTFDGNGQLLIPGMIDVHIHGANNYDMMDGSTESIQAVSM
ACAETGCTSFLVTSVSSSFEDLIQMIKQTKKVIGKERGAKIAGIHLEGPYLNIEKKGMQNPAYLRHPDLKEMKKIFDEAD
GLIKMVTIAPELPGGIELIDFLKKRGVVVAIAHSNATYEEAQNAFEQGATHITHCFNAMPAIHHRAPGLVTAALENNSVS
VQAIVDGVHLHPGIVRLIHKIKGPDKMVLTTDALQAMGVGDGEYIFGGHQVTVKEGIARLKDGTLASSTVTMNKSLKLSN
EFGIHLQDAIQMAASTPADILGMNNFGRIEKGYVADLVLLDKNFEVLTTWIDGEIY

Specific function: N-acetylglucosamine utilization. [C]

COG id: COG1820

COG function: function code G; N-acetylglucosamine-6-phosphate deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nagA family [H]

Homologues:

Organism=Homo sapiens, GI21361513, Length=417, Percent_Identity=29.4964028776978, Blast_Score=165, Evalue=6e-41,
Organism=Homo sapiens, GI224922791, Length=422, Percent_Identity=29.3838862559242, Blast_Score=163, Evalue=2e-40,
Organism=Escherichia coli, GI1786892, Length=385, Percent_Identity=34.025974025974, Blast_Score=201, Evalue=7e-53,
Organism=Caenorhabditis elegans, GI17553768, Length=375, Percent_Identity=30.6666666666667, Blast_Score=147, Evalue=9e-36,
Organism=Drosophila melanogaster, GI19920392, Length=386, Percent_Identity=32.9015544041451, Blast_Score=171, Evalue=5e-43,
Organism=Drosophila melanogaster, GI281361140, Length=400, Percent_Identity=32.5, Blast_Score=170, Evalue=1e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR003764
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.1.25 [H]

Molecular weight: Translated: 40928; Mature: 40796

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVIKNVKIYKENELIDAAVITEGNLIKEVCSTTPEKYSDEPTFDGNGQLLIPGMIDVHI
CCEECCEEEEECCCEEEEEEECCCHHHHHHHCCCCCCCCCCCCCCCCCCEEECCEEEEEE
HGANNYDMMDGSTESIQAVSMACAETGCTSFLVTSVSSSFEDLIQMIKQTKKVIGKERGA
ECCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
KIAGIHLEGPYLNIEKKGMQNPAYLRHPDLKEMKKIFDEADGLIKMVTIAPELPGGIELI
EEEEEEECCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCHHHHH
DFLKKRGVVVAIAHSNATYEEAQNAFEQGATHITHCFNAMPAIHHRAPGLVTAALENNSV
HHHHHCCEEEEEECCCCCHHHHHHHHHHCCHHHHHHHHHCHHHHHCCCCEEEEEECCCCE
SVQAIVDGVHLHPGIVRLIHKIKGPDKMVLTTDALQAMGVGDGEYIFGGHQVTVKEGIAR
EEEEEECCCCCCHHHHHHHHHHCCCCEEEEEHHHHHHHCCCCCCEEECCEEEEHHHHHHH
LKDGTLASSTVTMNKSLKLSNEFGIHLQDAIQMAASTPADILGMNNFGRIEKGYVADLVL
HCCCCCCCEEEEECCCEEECCCCCCCHHHHHHHHHCCCHHHCCCCCCCCCCCCCEEEEEE
LDKNFEVLTTWIDGEIY
ECCCCEEEEEEECCCCC
>Mature Secondary Structure 
AVIKNVKIYKENELIDAAVITEGNLIKEVCSTTPEKYSDEPTFDGNGQLLIPGMIDVHI
CEECCEEEEECCCEEEEEEECCCHHHHHHHCCCCCCCCCCCCCCCCCCEEECCEEEEEE
HGANNYDMMDGSTESIQAVSMACAETGCTSFLVTSVSSSFEDLIQMIKQTKKVIGKERGA
ECCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
KIAGIHLEGPYLNIEKKGMQNPAYLRHPDLKEMKKIFDEADGLIKMVTIAPELPGGIELI
EEEEEEECCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCHHHHH
DFLKKRGVVVAIAHSNATYEEAQNAFEQGATHITHCFNAMPAIHHRAPGLVTAALENNSV
HHHHHCCEEEEEECCCCCHHHHHHHHHHCCHHHHHHHHHCHHHHHCCCCEEEEEECCCCE
SVQAIVDGVHLHPGIVRLIHKIKGPDKMVLTTDALQAMGVGDGEYIFGGHQVTVKEGIAR
EEEEEECCCCCCHHHHHHHHHHCCCCEEEEEHHHHHHHCCCCCCEEECCEEEEHHHHHHH
LKDGTLASSTVTMNKSLKLSNEFGIHLQDAIQMAASTPADILGMNNFGRIEKGYVADLVL
HCCCCCCCEEEEECCCEEECCCCCCCHHHHHHHHHCCCHHHCCCCCCCCCCCCCEEEEEE
LDKNFEVLTTWIDGEIY
ECCCCEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]