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The map label for this gene is nadA

Identifier: 226224622

GI number: 226224622

Start: 2093640

End: 2094740

Strand: Direct

Name: nadA

Synonym: Lm4b_02037

Alternate gene names: 226224622

Gene position: 2093640-2094740 (Clockwise)

Preceding gene: 226224621

Following gene: 226224650

Centisome position: 71.88

GC content: 41.42

Gene sequence:

>1101_bases
ATGAATTTACTAGAAACGGTCGAACAAGATACAATGCCAACTCATTATAAGCAAATGACGCAGGCCGAAATGATTGCTCG
TGTGACGGAAATTAAAGCCCAGCTTGGCGAGAATCTCTTTATTCCCTGTCACCATTATCAAAAAGATGAGGTCGTTCCAT
TTGCCGATGCGATTGGCGATTCCTTACAATTAGCGCAAATTGCTGCACAAAATAAAAAAGCCAAACATATCGTTTTTTGC
GGTGTTCATTTTATGGCAGAAACAGCGGATATGCTTACGACAAGCGAGCAGATTGTTACTTTGCCGGATATGCGCGCTGG
TTGTTCGATGGCAGATATGGCGGACATTCATCAGCTAACAAATGCTTGGCCAAAACTGCAAACCCTTTTCGGCGATACGA
TTTTACCTGTCACTTACATTAATTCCACTGCCGCAATTAAATCCTTCGTCGGTGAACATGGTGGGACTACGGTGACATCT
AGTAACGCAACAAAAATTGTCTCATGGGCGCTCGAACAAAAAGAGCGGATTTTCTTTCTTCCGGATCAACATCTAGGTCG
GAACACTGCGTTCGAACTAGGCATTCCCCTCGAACATATGGCAATTTGGAACCCGATAAAAAATGAACTGGAATATGAGG
GCAATTTGGATGATTGTAAAGTCATTCTTTGGAAAGGCTACTGCTCTGTTCACCAACATTTCACCGTCAAAAATATCGAA
AACATTCGTAAAAACAATCCTAAAATGCGGATTATTGTTCATCCCGAATGCACCCATGAAGTCGTTTCTTTAGCAGATGA
TTCCGGTTCAACGAAAAAAATTGTAACTGAAATAAACAATGCCGCACCTGGCACAGAATGGGCAGTCGGTACCGAAGCCA
ATTTAGTTGGTCGCATTATCCAAGAAAACCCAGATAAAAAAATCGTCTCGCTAAATCCGTTTATGTGCCCATGTATGACC
ATGAATCGAATTGATTTACCACATTTACTCTGGACACTAGAAGCTATCCAAAACGGCGAACAACGAAACCAAATCAAAGT
CGATAAACAGACAACCAAATTTGCCTTAAAAGCCTTAGAAAGAATGCTTCAATTAAGCTAA

Upstream 100 bases:

>100_bases
GTTATAAGGGTTCTGGGGCAAATTACCTTTCTTTAGGCTCCTTAACGCATTCCGTTCGTGCATTTGACATCAGTTTCAAT
AGCAAAGGAGGAATAAAGGC

Downstream 100 bases:

>100_bases
TAAAAAAACGAAAGCAGCAACTGCTTTCGTTTCAGCTCCTTTATAAAAGCTTCTATTTGTCAATCTAAATTTTAATCTGT
AGAACTTACTCGAGCATATG

Product: quinolinate synthetase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 366; Mature: 366

Protein sequence:

>366_residues
MNLLETVEQDTMPTHYKQMTQAEMIARVTEIKAQLGENLFIPCHHYQKDEVVPFADAIGDSLQLAQIAAQNKKAKHIVFC
GVHFMAETADMLTTSEQIVTLPDMRAGCSMADMADIHQLTNAWPKLQTLFGDTILPVTYINSTAAIKSFVGEHGGTTVTS
SNATKIVSWALEQKERIFFLPDQHLGRNTAFELGIPLEHMAIWNPIKNELEYEGNLDDCKVILWKGYCSVHQHFTVKNIE
NIRKNNPKMRIIVHPECTHEVVSLADDSGSTKKIVTEINNAAPGTEWAVGTEANLVGRIIQENPDKKIVSLNPFMCPCMT
MNRIDLPHLLWTLEAIQNGEQRNQIKVDKQTTKFALKALERMLQLS

Sequences:

>Translated_366_residues
MNLLETVEQDTMPTHYKQMTQAEMIARVTEIKAQLGENLFIPCHHYQKDEVVPFADAIGDSLQLAQIAAQNKKAKHIVFC
GVHFMAETADMLTTSEQIVTLPDMRAGCSMADMADIHQLTNAWPKLQTLFGDTILPVTYINSTAAIKSFVGEHGGTTVTS
SNATKIVSWALEQKERIFFLPDQHLGRNTAFELGIPLEHMAIWNPIKNELEYEGNLDDCKVILWKGYCSVHQHFTVKNIE
NIRKNNPKMRIIVHPECTHEVVSLADDSGSTKKIVTEINNAAPGTEWAVGTEANLVGRIIQENPDKKIVSLNPFMCPCMT
MNRIDLPHLLWTLEAIQNGEQRNQIKVDKQTTKFALKALERMLQLS
>Mature_366_residues
MNLLETVEQDTMPTHYKQMTQAEMIARVTEIKAQLGENLFIPCHHYQKDEVVPFADAIGDSLQLAQIAAQNKKAKHIVFC
GVHFMAETADMLTTSEQIVTLPDMRAGCSMADMADIHQLTNAWPKLQTLFGDTILPVTYINSTAAIKSFVGEHGGTTVTS
SNATKIVSWALEQKERIFFLPDQHLGRNTAFELGIPLEHMAIWNPIKNELEYEGNLDDCKVILWKGYCSVHQHFTVKNIE
NIRKNNPKMRIIVHPECTHEVVSLADDSGSTKKIVTEINNAAPGTEWAVGTEANLVGRIIQENPDKKIVSLNPFMCPCMT
MNRIDLPHLLWTLEAIQNGEQRNQIKVDKQTTKFALKALERMLQLS

Specific function: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate [H]

COG id: COG0379

COG function: function code H; Quinolinate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the quinolinate synthase A family. Type 3 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786964, Length=355, Percent_Identity=26.1971830985915, Blast_Score=110, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003473 [H]

Pfam domain/function: PF02445 NadA [H]

EC number: =2.5.1.72 [H]

Molecular weight: Translated: 41162; Mature: 41162

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLLETVEQDTMPTHYKQMTQAEMIARVTEIKAQLGENLFIPCHHYQKDEVVPFADAIGD
CCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHCCC
SLQLAQIAAQNKKAKHIVFCGVHFMAETADMLTTSEQIVTLPDMRAGCSMADMADIHQLT
CHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHCCCCCEEECCCCCCCCCHHHHHHHHHHH
NAWPKLQTLFGDTILPVTYINSTAAIKSFVGEHGGTTVTSSNATKIVSWALEQKERIFFL
HHHHHHHHHHCCCEEEEEECCHHHHHHHHHHCCCCCEEECCCCHHHHHHHHCCCCEEEEC
PDQHLGRNTAFELGIPLEHMAIWNPIKNELEYEGNLDDCKVILWKGYCSVHQHFTVKNIE
CCHHCCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEECHHHHHHCEEHHHHH
NIRKNNPKMRIIVHPECTHEVVSLADDSGSTKKIVTEINNAAPGTEWAVGTEANLVGRII
HHHCCCCEEEEEECCCHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCEECCCCHHHHHHHH
QENPDKKIVSLNPFMCPCMTMNRIDLPHLLWTLEAIQNGEQRNQIKVDKQTTKFALKALE
HCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEECHHHHHHHHHHHH
RMLQLS
HHHCCC
>Mature Secondary Structure
MNLLETVEQDTMPTHYKQMTQAEMIARVTEIKAQLGENLFIPCHHYQKDEVVPFADAIGD
CCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHCCC
SLQLAQIAAQNKKAKHIVFCGVHFMAETADMLTTSEQIVTLPDMRAGCSMADMADIHQLT
CHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHCCCCCEEECCCCCCCCCHHHHHHHHHHH
NAWPKLQTLFGDTILPVTYINSTAAIKSFVGEHGGTTVTSSNATKIVSWALEQKERIFFL
HHHHHHHHHHCCCEEEEEECCHHHHHHHHHHCCCCCEEECCCCHHHHHHHHCCCCEEEEC
PDQHLGRNTAFELGIPLEHMAIWNPIKNELEYEGNLDDCKVILWKGYCSVHQHFTVKNIE
CCHHCCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEECHHHHHHCEEHHHHH
NIRKNNPKMRIIVHPECTHEVVSLADDSGSTKKIVTEINNAAPGTEWAVGTEANLVGRII
HHHCCCCEEEEEECCCHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCEECCCCHHHHHHHH
QENPDKKIVSLNPFMCPCMTMNRIDLPHLLWTLEAIQNGEQRNQIKVDKQTTKFALKALE
HCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEECHHHHHHHHHHHH
RMLQLS
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]