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The map label for this gene is ygcA [C]

Identifier: 226224306

GI number: 226224306

Start: 1752319

End: 1753698

Strand: Reverse

Name: ygcA [C]

Synonym: Lm4b_01717

Alternate gene names: 226224306

Gene position: 1753698-1752319 (Counterclockwise)

Preceding gene: 226224307

Following gene: 226224305

Centisome position: 60.21

GC content: 41.74

Gene sequence:

>1380_bases
ATGAATCAAAATCCAGTAGAAGAAGGACAAAAATTCCCGCTAACTATTCGACGCATGGGAATCAACGGGGAAGGGATCGG
CTACTTTAAAAAAGCAGTTGTATTTGTACCTGGCGCAATTACCGGTGAAGAAGTAGTTGTCGAAGCGGTCAAAGTTCGCG
ATCGTTTCACCGAAGCAAAATTAAATAAAATTCGTAAAAAATCTCCAAACCGAGTTACCGCACCTTGCCCAGTTTACGAG
GCGTGTGGTGGTTGCCAGTTGCAACATGTGGCCTATAGCGCCCAACTTGAACTAAAAAGAGATATTGTTATTCAATCAAT
CGAAAAACATACAAAAATCGATCCAACCAAATTAAAAATCCGCCCAACAATCGGAATGGAAGACCCATGGCGTTACCGTA
ATAAAAGCCAATTCCAAACAAGAATGGTAGGCAGTGGTCAAGTCGAAACAGGCCTTTTCGGTGCCAATTCTCACCAACTT
GTTCCAATTGAAGATTGTATCGTCCAACAACCCGTTACCATCAAAGTAACGAATTTTGTTCGCGACTTACTAGAAAAATA
CGGCGTGCCAATTTATGATGAAAAAGCTGGCAGTGGTATCGTCCGAACTATCGTCGTTCGTACTGGCGTGAAAACCGGCG
AAACACAGCTCGTCTTCATTACAAATAGTAAAAAGTTACCTAAAAAACGCGAAATGCTTGCAGAAATCGAAGCAGCTCTT
CCGGAAGTCACTTCGATTATGCAAAACGTGAATCAAGCAAAATCCTCACTTATTTTCGGTGACGAAACGTTCCTTTTAGC
AGGAAAAGAAAGCATTGAAGAGAAATTAATGGAACTAGAATTCGATCTATCTGCTCGTGCCTTTTTCCAATTAAACCCGT
TCCAAACAGAGCGACTTTATCAAGAAGTCGAAAAAGCACTCGTACTAACAGGCAGTGAAACACTAGTAGATGCTTATTGC
GGTGTTGGAACAATCGGCCAAGCTTTTGCCGGAAAAGTAAAAGAAGTTCGTGGTATGGATATTATTCCAGAATCCATTGA
AGACGCTAAACGAAACGCCGAGAAGAATGGCATCGAAAATGTTTATTATGAAGTTGGGAAAGCAGAAGACGTATTACCAA
AATGGGTAAATGAAGGTTTCCGCCCAGACGCAGTCATCGTTGACCCACCAAGAAGCGGCTGTGACCAAGGCCTAATAAAA
TCATTACTAGATGTGGAAGCAAAACAACTTGTTTATGTATCCTGTAATCCATCCACATTAGCACGTGACTTAGCTTTACT
CGCGAAGAAATATCGCATTCGCTATATGCAACCCGTCGATATGTTCCCGCAAACAGCTCACGTGGAAACCGTAGTACTCT
TGCAGTTAAAAGATAAATAA

Upstream 100 bases:

>100_bases
ATCCTTGTCGATGAAAGTCTTGAAATCATGCCATAAACTACTGACAAGCTGCTGTTTTTTTGTTAGTATTAATGAAGACT
TGGAATGATGGAGGAAAATA

Downstream 100 bases:

>100_bases
AGGACTGGTGGTACATGATTTCAGGATTAAGCCATATCACTTTAATTGTGAAAGATTTGAATAAAACAACTGCTTTCTTA
CAGAATATTTTTAATGCAGA

Product: RNA methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MNQNPVEEGQKFPLTIRRMGINGEGIGYFKKAVVFVPGAITGEEVVVEAVKVRDRFTEAKLNKIRKKSPNRVTAPCPVYE
ACGGCQLQHVAYSAQLELKRDIVIQSIEKHTKIDPTKLKIRPTIGMEDPWRYRNKSQFQTRMVGSGQVETGLFGANSHQL
VPIEDCIVQQPVTIKVTNFVRDLLEKYGVPIYDEKAGSGIVRTIVVRTGVKTGETQLVFITNSKKLPKKREMLAEIEAAL
PEVTSIMQNVNQAKSSLIFGDETFLLAGKESIEEKLMELEFDLSARAFFQLNPFQTERLYQEVEKALVLTGSETLVDAYC
GVGTIGQAFAGKVKEVRGMDIIPESIEDAKRNAEKNGIENVYYEVGKAEDVLPKWVNEGFRPDAVIVDPPRSGCDQGLIK
SLLDVEAKQLVYVSCNPSTLARDLALLAKKYRIRYMQPVDMFPQTAHVETVVLLQLKDK

Sequences:

>Translated_459_residues
MNQNPVEEGQKFPLTIRRMGINGEGIGYFKKAVVFVPGAITGEEVVVEAVKVRDRFTEAKLNKIRKKSPNRVTAPCPVYE
ACGGCQLQHVAYSAQLELKRDIVIQSIEKHTKIDPTKLKIRPTIGMEDPWRYRNKSQFQTRMVGSGQVETGLFGANSHQL
VPIEDCIVQQPVTIKVTNFVRDLLEKYGVPIYDEKAGSGIVRTIVVRTGVKTGETQLVFITNSKKLPKKREMLAEIEAAL
PEVTSIMQNVNQAKSSLIFGDETFLLAGKESIEEKLMELEFDLSARAFFQLNPFQTERLYQEVEKALVLTGSETLVDAYC
GVGTIGQAFAGKVKEVRGMDIIPESIEDAKRNAEKNGIENVYYEVGKAEDVLPKWVNEGFRPDAVIVDPPRSGCDQGLIK
SLLDVEAKQLVYVSCNPSTLARDLALLAKKYRIRYMQPVDMFPQTAHVETVVLLQLKDK
>Mature_459_residues
MNQNPVEEGQKFPLTIRRMGINGEGIGYFKKAVVFVPGAITGEEVVVEAVKVRDRFTEAKLNKIRKKSPNRVTAPCPVYE
ACGGCQLQHVAYSAQLELKRDIVIQSIEKHTKIDPTKLKIRPTIGMEDPWRYRNKSQFQTRMVGSGQVETGLFGANSHQL
VPIEDCIVQQPVTIKVTNFVRDLLEKYGVPIYDEKAGSGIVRTIVVRTGVKTGETQLVFITNSKKLPKKREMLAEIEAAL
PEVTSIMQNVNQAKSSLIFGDETFLLAGKESIEEKLMELEFDLSARAFFQLNPFQTERLYQEVEKALVLTGSETLVDAYC
GVGTIGQAFAGKVKEVRGMDIIPESIEDAKRNAEKNGIENVYYEVGKAEDVLPKWVNEGFRPDAVIVDPPRSGCDQGLIK
SLLDVEAKQLVYVSCNPSTLARDLALLAKKYRIRYMQPVDMFPQTAHVETVVLLQLKDK

Specific function: Could Be A 23s rRNA (Uracil-5-)-Methyltransferase. [C]

COG id: COG2265

COG function: function code J; SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TRAM domain [H]

Homologues:

Organism=Homo sapiens, GI34222389, Length=381, Percent_Identity=27.5590551181102, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI51173878, Length=381, Percent_Identity=27.5590551181102, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI269784680, Length=289, Percent_Identity=28.3737024221453, Blast_Score=106, Evalue=6e-23,
Organism=Homo sapiens, GI269784678, Length=289, Percent_Identity=28.3737024221453, Blast_Score=106, Evalue=6e-23,
Organism=Homo sapiens, GI269784676, Length=289, Percent_Identity=28.3737024221453, Blast_Score=106, Evalue=6e-23,
Organism=Homo sapiens, GI20149688, Length=289, Percent_Identity=28.3737024221453, Blast_Score=106, Evalue=6e-23,
Organism=Escherichia coli, GI1789148, Length=444, Percent_Identity=26.1261261261261, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1787083, Length=384, Percent_Identity=26.5625, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1790403, Length=215, Percent_Identity=30.2325581395349, Blast_Score=76, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71997438, Length=163, Percent_Identity=34.3558282208589, Blast_Score=89, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6322909, Length=432, Percent_Identity=25.462962962963, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24666579, Length=420, Percent_Identity=29.7619047619048, Blast_Score=150, Evalue=3e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016027
- InterPro:   IPR001566
- InterPro:   IPR002792
- InterPro:   IPR010280 [H]

Pfam domain/function: PF01938 TRAM; PF05958 tRNA_U5-meth_tr [H]

EC number: NA

Molecular weight: Translated: 51312; Mature: 51312

Theoretical pI: Translated: 8.02; Mature: 8.02

Prosite motif: PS50926 TRAM ; PS01230 TRMA_1 ; PS01231 TRMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQNPVEEGQKFPLTIRRMGINGEGIGYFKKAVVFVPGAITGEEVVVEAVKVRDRFTEAK
CCCCCCCCCCCCCEEEEEECCCCCCCHHHEEEEEEECCCCCCHHHHHHHHHHHHHHHHHH
LNKIRKKSPNRVTAPCPVYEACGGCQLQHVAYSAQLELKRDIVIQSIEKHTKIDPTKLKI
HHHHHHCCCCCCCCCCCHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
RPTIGMEDPWRYRNKSQFQTRMVGSGQVETGLFGANSHQLVPIEDCIVQQPVTIKVTNFV
EECCCCCCCCCCCCCHHHHHHCCCCCCCCCCEECCCCCCEEEHHHHHHCCCCEEEHHHHH
RDLLEKYGVPIYDEKAGSGIVRTIVVRTGVKTGETQLVFITNSKKLPKKREMLAEIEAAL
HHHHHHCCCCEEECCCCCCCEEEEEECCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHH
PEVTSIMQNVNQAKSSLIFGDETFLLAGKESIEEKLMELEFDLSARAFFQLNPFQTERLY
HHHHHHHHHHHHHHHHEEECCCEEEEECHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHH
QEVEKALVLTGSETLVDAYCGVGTIGQAFAGKVKEVRGMDIIPESIEDAKRNAEKNGIEN
HHHHHHEEECCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHH
VYYEVGKAEDVLPKWVNEGFRPDAVIVDPPRSGCDQGLIKSLLDVEAKQLVYVSCNPSTL
HHHHCCCHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHCCCCCEEEEEECCHHHH
ARDLALLAKKYRIRYMQPVDMFPQTAHVETVVLLQLKDK
HHHHHHHHHHHHHEEECCHHCCCCCCCEEEEEEEEEECC
>Mature Secondary Structure
MNQNPVEEGQKFPLTIRRMGINGEGIGYFKKAVVFVPGAITGEEVVVEAVKVRDRFTEAK
CCCCCCCCCCCCCEEEEEECCCCCCCHHHEEEEEEECCCCCCHHHHHHHHHHHHHHHHHH
LNKIRKKSPNRVTAPCPVYEACGGCQLQHVAYSAQLELKRDIVIQSIEKHTKIDPTKLKI
HHHHHHCCCCCCCCCCCHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
RPTIGMEDPWRYRNKSQFQTRMVGSGQVETGLFGANSHQLVPIEDCIVQQPVTIKVTNFV
EECCCCCCCCCCCCCHHHHHHCCCCCCCCCCEECCCCCCEEEHHHHHHCCCCEEEHHHHH
RDLLEKYGVPIYDEKAGSGIVRTIVVRTGVKTGETQLVFITNSKKLPKKREMLAEIEAAL
HHHHHHCCCCEEECCCCCCCEEEEEECCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHH
PEVTSIMQNVNQAKSSLIFGDETFLLAGKESIEEKLMELEFDLSARAFFQLNPFQTERLY
HHHHHHHHHHHHHHHHEEECCCEEEEECHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHH
QEVEKALVLTGSETLVDAYCGVGTIGQAFAGKVKEVRGMDIIPESIEDAKRNAEKNGIEN
HHHHHHEEECCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHH
VYYEVGKAEDVLPKWVNEGFRPDAVIVDPPRSGCDQGLIKSLLDVEAKQLVYVSCNPSTL
HHHHCCCHHHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHCCCCCEEEEEECCHHHH
ARDLALLAKKYRIRYMQPVDMFPQTAHVETVVLLQLKDK
HHHHHHHHHHHHHEEECCHHCCCCCCCEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]