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The map label for this gene is yfhQ [H]

Identifier: 226224292

GI number: 226224292

Start: 1740253

End: 1741350

Strand: Reverse

Name: yfhQ [H]

Synonym: Lm4b_01703

Alternate gene names: 226224292

Gene position: 1741350-1740253 (Counterclockwise)

Preceding gene: 226224294

Following gene: 226224291

Centisome position: 59.78

GC content: 38.62

Gene sequence:

>1098_bases
ATGAGAAAAATGAAGAGACTAACTTGGGATGAAACAAAGATAACTGCTTTTCAAGAAGCACTCGTTTCCTGGTATGAAGC
GAATAAGCGCGTCTTACCGTGGCGCGAAAATACCGATCCTTACAGAATTTGGGTCTCAGAAATCATGCTTCAACAAACAA
AAGTCGACACAGTAATTCCTTATTTTAATCGCTTTATGACTCAATTTCCGACGATGGAAGATTTTGTCCAAGCGGATGAA
GCGGATATTTTAAAAGCGTGGGAAGGCTTAGGCTATTATTCTCGTGTCAGAAACCTCCAAACAGCCATGAAGCAAGTGAT
GGCCGATTTTTCTGGAGAAGTTCCTACCGACTTAACCACTATTTTATCGCTTAAAGGTGTGGGACCGTATACAGCCGGAG
CTATCTTGAGTATTGCCTACAACCAAGCTGAACCAGCAGTGGATGGCAATGTTATGCGTGTCATCGCCCGCGTTTTAGAA
ATTAGTGAAGACATCATGAAAGTGTCCACCCGGAAAATTTTTGAAGAAGTGTTATATCAACTAATTGACAAAGAAAATCC
AGCCGCTTTCAACCAAGGTTTAATGGAAATTGGTGCGCTTGTTTGTACACCAACAAAACCAATGTGTATGCTTTGTCCGC
TCCAACCGTTTTGCGAAGCGCATAAAAATGGCGTTGAAACGAATTATCCAGTAAAAATAAAAAAAGTGAAAACGAAAACC
AAAGAACTATTAAGCATCATTGTTATTTCAGAGGACGGAAAAATTGCCATAGAGAAACGACCAGAAAATGGTTTGCTTGC
AAATATGTGGCAATTTCCTACTATTGAAATTTCGAAAAAAGAAAATGAGGAAGTAGCTAAACTACAATTTTTACATAATT
ATGGCTTAGACGTTTTACTAGAAGACGAACCAATTGCGCATATCAAACACGTTTTTTCTCATTTAGTATGGAAAATGGAC
ATTCGTGTGGCAAAACTTCAGTCAGCAATTCCAAATGAAAATTGGTATTTTGCAACAGAAGAAGAAATGAAGCGACTTGC
TTTTCCAGTACCATATCAAAAAATGTGGCAAGCGTGGAAAGATTTTAAGGGGGAATAA

Upstream 100 bases:

>100_bases
ATCGGCTTAAGAATGGGTATACTATTTTATTCCCTGTCTACATTATACTACACATCCGGAGCAACACACATTAGAAATCT
ATTAGAATTACGAGGGGAAA

Downstream 100 bases:

>100_bases
CAAATGAATAGAGTGGCATTAGTAACAGGAAGTAGTAGAGGACTTGGAAGAGAAATAGCCATCGCACTTGCAAATGAAGG
CTATGATATCGCTGTTAATT

Product: A/G-specific adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MRKMKRLTWDETKITAFQEALVSWYEANKRVLPWRENTDPYRIWVSEIMLQQTKVDTVIPYFNRFMTQFPTMEDFVQADE
ADILKAWEGLGYYSRVRNLQTAMKQVMADFSGEVPTDLTTILSLKGVGPYTAGAILSIAYNQAEPAVDGNVMRVIARVLE
ISEDIMKVSTRKIFEEVLYQLIDKENPAAFNQGLMEIGALVCTPTKPMCMLCPLQPFCEAHKNGVETNYPVKIKKVKTKT
KELLSIIVISEDGKIAIEKRPENGLLANMWQFPTIEISKKENEEVAKLQFLHNYGLDVLLEDEPIAHIKHVFSHLVWKMD
IRVAKLQSAIPNENWYFATEEEMKRLAFPVPYQKMWQAWKDFKGE

Sequences:

>Translated_365_residues
MRKMKRLTWDETKITAFQEALVSWYEANKRVLPWRENTDPYRIWVSEIMLQQTKVDTVIPYFNRFMTQFPTMEDFVQADE
ADILKAWEGLGYYSRVRNLQTAMKQVMADFSGEVPTDLTTILSLKGVGPYTAGAILSIAYNQAEPAVDGNVMRVIARVLE
ISEDIMKVSTRKIFEEVLYQLIDKENPAAFNQGLMEIGALVCTPTKPMCMLCPLQPFCEAHKNGVETNYPVKIKKVKTKT
KELLSIIVISEDGKIAIEKRPENGLLANMWQFPTIEISKKENEEVAKLQFLHNYGLDVLLEDEPIAHIKHVFSHLVWKMD
IRVAKLQSAIPNENWYFATEEEMKRLAFPVPYQKMWQAWKDFKGE
>Mature_365_residues
MRKMKRLTWDETKITAFQEALVSWYEANKRVLPWRENTDPYRIWVSEIMLQQTKVDTVIPYFNRFMTQFPTMEDFVQADE
ADILKAWEGLGYYSRVRNLQTAMKQVMADFSGEVPTDLTTILSLKGVGPYTAGAILSIAYNQAEPAVDGNVMRVIARVLE
ISEDIMKVSTRKIFEEVLYQLIDKENPAAFNQGLMEIGALVCTPTKPMCMLCPLQPFCEAHKNGVETNYPVKIKKVKTKT
KELLSIIVISEDGKIAIEKRPENGLLANMWQFPTIEISKKENEEVAKLQFLHNYGLDVLLEDEPIAHIKHVFSHLVWKMD
IRVAKLQSAIPNENWYFATEEEMKRLAFPVPYQKMWQAWKDFKGE

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8- oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal effici

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HhH domain [H]

Homologues:

Organism=Homo sapiens, GI190358497, Length=420, Percent_Identity=31.6666666666667, Blast_Score=214, Evalue=8e-56,
Organism=Homo sapiens, GI115298654, Length=419, Percent_Identity=31.7422434367542, Blast_Score=214, Evalue=9e-56,
Organism=Homo sapiens, GI115298652, Length=419, Percent_Identity=31.7422434367542, Blast_Score=214, Evalue=9e-56,
Organism=Homo sapiens, GI115298650, Length=419, Percent_Identity=31.7422434367542, Blast_Score=214, Evalue=9e-56,
Organism=Homo sapiens, GI115298648, Length=420, Percent_Identity=31.6666666666667, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI6912520, Length=420, Percent_Identity=31.6666666666667, Blast_Score=214, Evalue=1e-55,
Organism=Escherichia coli, GI1789331, Length=348, Percent_Identity=34.7701149425287, Blast_Score=210, Evalue=1e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 42214; Mature: 42214

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKMKRLTWDETKITAFQEALVSWYEANKRVLPWRENTDPYRIWVSEIMLQQTKVDTVIP
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
YFNRFMTQFPTMEDFVQADEADILKAWEGLGYYSRVRNLQTAMKQVMADFSGEVPTDLTT
HHHHHHHHCCCHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
ILSLKGVGPYTAGAILSIAYNQAEPAVDGNVMRVIARVLEISEDIMKVSTRKIFEEVLYQ
HHHHCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIDKENPAAFNQGLMEIGALVCTPTKPMCMLCPLQPFCEAHKNGVETNYPVKIKKVKTKT
HHCCCCCHHHHHHHHHHHHEEECCCCCCEEECCCHHHHHHHHCCCCCCCCEEEEHHHHHH
KELLSIIVISEDGKIAIEKRPENGLLANMWQFPTIEISKKENEEVAKLQFLHNYGLDVLL
HHHHEEEEECCCCEEEEEECCCCCCEECCCCCCCEEECCCCCHHHHHHHHHHHCCCEEEE
EDEPIAHIKHVFSHLVWKMDIRVAKLQSAIPNENWYFATEEEMKRLAFPVPYQKMWQAWK
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECHHHHHHHCCCCCHHHHHHHHH
DFKGE
CCCCC
>Mature Secondary Structure
MRKMKRLTWDETKITAFQEALVSWYEANKRVLPWRENTDPYRIWVSEIMLQQTKVDTVIP
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
YFNRFMTQFPTMEDFVQADEADILKAWEGLGYYSRVRNLQTAMKQVMADFSGEVPTDLTT
HHHHHHHHCCCHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
ILSLKGVGPYTAGAILSIAYNQAEPAVDGNVMRVIARVLEISEDIMKVSTRKIFEEVLYQ
HHHHCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIDKENPAAFNQGLMEIGALVCTPTKPMCMLCPLQPFCEAHKNGVETNYPVKIKKVKTKT
HHCCCCCHHHHHHHHHHHHEEECCCCCCEEECCCHHHHHHHHCCCCCCCCEEEEHHHHHH
KELLSIIVISEDGKIAIEKRPENGLLANMWQFPTIEISKKENEEVAKLQFLHNYGLDVLL
HHHHEEEEECCCCEEEEEECCCCCCEECCCCCCCEEECCCCCHHHHHHHHHHHCCCEEEE
EDEPIAHIKHVFSHLVWKMDIRVAKLQSAIPNENWYFATEEEMKRLAFPVPYQKMWQAWK
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECHHHHHHHCCCCCHHHHHHHHH
DFKGE
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8946165; 9384377 [H]