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The map label for this gene is menA [H]

Identifier: 226224280

GI number: 226224280

Start: 1718354

End: 1719292

Strand: Direct

Name: menA [H]

Synonym: Lm4b_01690

Alternate gene names: 226224280

Gene position: 1718354-1719292 (Clockwise)

Preceding gene: 226224274

Following gene: 226224288

Centisome position: 59.0

GC content: 37.91

Gene sequence:

>939_bases
ATGGCTAATGCCTCAAAATCTGCACTTACAAAACAAACTGGATTTCAAAAATGGTGGACATTACTTCGCCCCCATACACT
TGTAGCCTCTTTCGTTCCAGTATTTCTTGGAACATCAGTCGCAATGAGCTACACCAGTTTTCATTTTACACGTTTTATCG
TTATGCTAATTGCTTGTTTCTTTATACAAACATCCGCCAATCTATTCAATGAATATTTTGATTATAAAAAAGGGCAAGAT
GATGAGCACTCGGTAGGAAATGGTGGTGCTATCGTCCGAAATGGTATGCGCCCAGGATTTATTTTATTCCTAGCAATTTT
CTTATACATATTATCAATTCTCGGTGGTGTTTATTTATCCATTGAACTTAATTGGTATGTAGGATTACTTGGCGCAATAT
GTATGCTTGTTGGCTTTCTTTATACGGGAGGACCTTATCCTATTGCTTATACGCCATTTGGTGAAATTATGGCAGGATTC
TTTATGGGGGGAATTATTACTTTCATTTCCTTCTATATTCAAGCAGAATTTATTAGTTCGTTTATCGTATACGTATCGAT
TCCAGTAATGGTGCTCGTTGGTAACTTGCTACTTGCTAATAGTATTCGTGATTTAGTACCTGATAAGAAAAATGGTCGTT
TAACCTTAGCTATCTTGCTAGGTCGCAAATGGGCAACCGTTCTTTTTGCAGCTGCTTTTCTATTCAGTTACGTATTTGAA
ATCGCCCTTATTTTCACACAAGATGCTCCGTGGTGGACGCTTCTGATTTTACTTAGTTTGCCAGAAGCTATTCGCGCCGT
GCGTCGTTTCATCGGCAAAACTTCGCCGATTACAATGGTCCCAGCCATGAAATCCACATCTAAAGCATTAACTATCTTTG
GTATTACATTGGCCCTTGCTTACCTTTTAAGTCTATTATCCAGAAATTTATTCATGTAA

Upstream 100 bases:

>100_bases
TTCTTTCATTTCGTCATTAATTATTGACGTTCTTGCAATATTTCCCTAAAATGAAGGGTAGACATCTGAAACATATGGAA
GTGAAAAAGGAGAGAAAAAC

Downstream 100 bases:

>100_bases
AAAAACTGGTTGTCCTCGTGACAACCAGTTTTTTTATTTAGACCCAATTTGGACTTGCTGTTTATTTTGGGCATATTTCG
CTAATTCTATCGATAAATCA

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MANASKSALTKQTGFQKWWTLLRPHTLVASFVPVFLGTSVAMSYTSFHFTRFIVMLIACFFIQTSANLFNEYFDYKKGQD
DEHSVGNGGAIVRNGMRPGFILFLAIFLYILSILGGVYLSIELNWYVGLLGAICMLVGFLYTGGPYPIAYTPFGEIMAGF
FMGGIITFISFYIQAEFISSFIVYVSIPVMVLVGNLLLANSIRDLVPDKKNGRLTLAILLGRKWATVLFAAAFLFSYVFE
IALIFTQDAPWWTLLILLSLPEAIRAVRRFIGKTSPITMVPAMKSTSKALTIFGITLALAYLLSLLSRNLFM

Sequences:

>Translated_312_residues
MANASKSALTKQTGFQKWWTLLRPHTLVASFVPVFLGTSVAMSYTSFHFTRFIVMLIACFFIQTSANLFNEYFDYKKGQD
DEHSVGNGGAIVRNGMRPGFILFLAIFLYILSILGGVYLSIELNWYVGLLGAICMLVGFLYTGGPYPIAYTPFGEIMAGF
FMGGIITFISFYIQAEFISSFIVYVSIPVMVLVGNLLLANSIRDLVPDKKNGRLTLAILLGRKWATVLFAAAFLFSYVFE
IALIFTQDAPWWTLLILLSLPEAIRAVRRFIGKTSPITMVPAMKSTSKALTIFGITLALAYLLSLLSRNLFM
>Mature_311_residues
ANASKSALTKQTGFQKWWTLLRPHTLVASFVPVFLGTSVAMSYTSFHFTRFIVMLIACFFIQTSANLFNEYFDYKKGQDD
EHSVGNGGAIVRNGMRPGFILFLAIFLYILSILGGVYLSIELNWYVGLLGAICMLVGFLYTGGPYPIAYTPFGEIMAGFF
MGGIITFISFYIQAEFISSFIVYVSIPVMVLVGNLLLANSIRDLVPDKKNGRLTLAILLGRKWATVLFAAAFLFSYVFEI
ALIFTQDAPWWTLLILLSLPEAIRAVRRFIGKTSPITMVPAMKSTSKALTIFGITLALAYLLSLLSRNLFM

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Homo sapiens, GI7019551, Length=316, Percent_Identity=26.8987341772152, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1790365, Length=303, Percent_Identity=26.7326732673267, Blast_Score=97, Evalue=1e-21,
Organism=Drosophila melanogaster, GI17737429, Length=285, Percent_Identity=29.1228070175439, Blast_Score=88, Evalue=8e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 34740; Mature: 34609

Theoretical pI: Translated: 9.88; Mature: 9.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANASKSALTKQTGFQKWWTLLRPHTLVASFVPVFLGTSVAMSYTSFHFTRFIVMLIACF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FIQTSANLFNEYFDYKKGQDDEHSVGNGGAIVRNGMRPGFILFLAIFLYILSILGGVYLS
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHCCEEEE
IELNWYVGLLGAICMLVGFLYTGGPYPIAYTPFGEIMAGFFMGGIITFISFYIQAEFISS
EEHHHHHHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FIVYVSIPVMVLVGNLLLANSIRDLVPDKKNGRLTLAILLGRKWATVLFAAAFLFSYVFE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHH
IALIFTQDAPWWTLLILLSLPEAIRAVRRFIGKTSPITMVPAMKSTSKALTIFGITLALA
HHHHHCCCCCHHHHHHHHHCHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHH
YLLSLLSRNLFM
HHHHHHHHHCCC
>Mature Secondary Structure 
ANASKSALTKQTGFQKWWTLLRPHTLVASFVPVFLGTSVAMSYTSFHFTRFIVMLIACF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FIQTSANLFNEYFDYKKGQDDEHSVGNGGAIVRNGMRPGFILFLAIFLYILSILGGVYLS
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHCCEEEE
IELNWYVGLLGAICMLVGFLYTGGPYPIAYTPFGEIMAGFFMGGIITFISFYIQAEFISS
EEHHHHHHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FIVYVSIPVMVLVGNLLLANSIRDLVPDKKNGRLTLAILLGRKWATVLFAAAFLFSYVFE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHH
IALIFTQDAPWWTLLILLSLPEAIRAVRRFIGKTSPITMVPAMKSTSKALTIFGITLALA
HHHHHCCCCCHHHHHHHHHCHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHH
YLLSLLSRNLFM
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7934828; 9384377 [H]