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The map label for this gene is adcA [H]

Identifier: 226224274

GI number: 226224274

Start: 1711012

End: 1711965

Strand: Direct

Name: adcA [H]

Synonym: Lm4b_01684

Alternate gene names: 226224274

Gene position: 1711012-1711965 (Clockwise)

Preceding gene: 226224273

Following gene: 226224280

Centisome position: 58.74

GC content: 36.37

Gene sequence:

>954_bases
TTGAGAAAAAAGTATCTTATTGCCTTAACTGTACTATTTTCAGCATTACTCATACTTACTGGCTGCTCAGATGAGAGCGA
TAAAAAAGCGACAAAGAGTGATCAATTAACAGTTTATACAACCGTTTACCCTTTGCAGTATTTAACAGAACAAATCGGCG
GTGAGTATGTAGATGTTCATAGCATTTACCCACCAGGTTCTGACGCCCATAGCTTCGAACCCACCCAAAAAGATATGATG
AAAATTGCCGATAGTGATTTATTCTTCTATATCGGACTGGGTATGGAAGGATTTGTGGACAAAGCGGAAAAAACACTCGC
GAATGAACATGTCTCTTTCGTCCCTACCGCTGAAAAATTAGACTTGCCAAAAGATCCAGATGCCGCAGAAGAACATGACC
ACGAAAGCGAAGAAGAACACGAACATGGCGACATTAACCCGCACGTATGGTTAAATCCTGTATACATGGAACAAATGGCA
ACAGTTGTAAAAGATAAATTAATCAAAGAAATGCCCGATCAAAAAGAAACTTTCGAAAAAAATTACCAGGCTGTCGAAAA
AAAATTGAAAAAGCTAGATCAAGATTTCCGCACAGTTACAAAGGAAGCAAAACAAAAAGACTTCGTGACAGCACATGCAG
CCTATAGCTACTGGGAAACAGAATATGGTCTGCACCAAATTCCTATTGCCGGTGTATCAACAAGTGATGAACCTTCTCAA
AAGAAATTAAAATCTATCGTTGAAAAAATCGAAGCAGAGAAAATCCCATATATTATGTTAGAACAAAACACTAACTCAAA
AATAGCAGATGTTATTCAACAAGAAACAAATACAAAAACACTGACACTCCACAATTTAGAAACACTTACGCAAAAAGACT
TAGATCAAAAACGTGATTATCTTTCCATTATGAACGATAATTTAAAAGCATTAAAAGAAGGTCTTAATTATTAA

Upstream 100 bases:

>100_bases
GACAGAATAAGGTATTATCAAATTCGGACTATAAATCGTAATTGCTACGATTCGTATATTATTTAAACAAGAATTATTTC
GATTTAGAGGAGTGAAAAGA

Downstream 100 bases:

>100_bases
AAAGAAAGGCGCTCTGTTTACATAGAGTGCCTTTCTTTTAATTTATTGCGTTGAATTTTTCCAGATGCTGTTTTAGGTAG
CTTTTCGACAATCGTTATTT

Product: ABC transporter/adhesion protein

Products: Zn (II) [Cytoplasm]; ADP; phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 317; Mature: 317

Protein sequence:

>317_residues
MRKKYLIALTVLFSALLILTGCSDESDKKATKSDQLTVYTTVYPLQYLTEQIGGEYVDVHSIYPPGSDAHSFEPTQKDMM
KIADSDLFFYIGLGMEGFVDKAEKTLANEHVSFVPTAEKLDLPKDPDAAEEHDHESEEEHEHGDINPHVWLNPVYMEQMA
TVVKDKLIKEMPDQKETFEKNYQAVEKKLKKLDQDFRTVTKEAKQKDFVTAHAAYSYWETEYGLHQIPIAGVSTSDEPSQ
KKLKSIVEKIEAEKIPYIMLEQNTNSKIADVIQQETNTKTLTLHNLETLTQKDLDQKRDYLSIMNDNLKALKEGLNY

Sequences:

>Translated_317_residues
MRKKYLIALTVLFSALLILTGCSDESDKKATKSDQLTVYTTVYPLQYLTEQIGGEYVDVHSIYPPGSDAHSFEPTQKDMM
KIADSDLFFYIGLGMEGFVDKAEKTLANEHVSFVPTAEKLDLPKDPDAAEEHDHESEEEHEHGDINPHVWLNPVYMEQMA
TVVKDKLIKEMPDQKETFEKNYQAVEKKLKKLDQDFRTVTKEAKQKDFVTAHAAYSYWETEYGLHQIPIAGVSTSDEPSQ
KKLKSIVEKIEAEKIPYIMLEQNTNSKIADVIQQETNTKTLTLHNLETLTQKDLDQKRDYLSIMNDNLKALKEGLNY
>Mature_317_residues
MRKKYLIALTVLFSALLILTGCSDESDKKATKSDQLTVYTTVYPLQYLTEQIGGEYVDVHSIYPPGSDAHSFEPTQKDMM
KIADSDLFFYIGLGMEGFVDKAEKTLANEHVSFVPTAEKLDLPKDPDAAEEHDHESEEEHEHGDINPHVWLNPVYMEQMA
TVVKDKLIKEMPDQKETFEKNYQAVEKKLKKLDQDFRTVTKEAKQKDFVTAHAAYSYWETEYGLHQIPIAGVSTSDEPSQ
KKLKSIVEKIEAEKIPYIMLEQNTNSKIADVIQQETNTKTLTLHNLETLTQKDLDQKRDYLSIMNDNLKALKEGLNY

Specific function: Part of the high-affinity ABC transporter complex AdcABC involved in zinc import (Probable) [H]

COG id: COG0803

COG function: function code P; ABC-type metal ion transport system, periplasmic component/surface adhesin

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 9 family [H]

Homologues:

Organism=Escherichia coli, GI87081990, Length=298, Percent_Identity=21.4765100671141, Blast_Score=93, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006127
- InterPro:   IPR006129
- InterPro:   IPR006128 [H]

Pfam domain/function: PF01297 SBP_bac_9 [H]

EC number: NA

Molecular weight: Translated: 36288; Mature: 36288

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKKYLIALTVLFSALLILTGCSDESDKKATKSDQLTVYTTVYPLQYLTEQIGGEYVDVH
CCCHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCCEEEEEEHHHHHHHHHHHCCCEEEEE
SIYPPGSDAHSFEPTQKDMMKIADSDLFFYIGLGMEGFVDKAEKTLANEHVSFVPTAEKL
ECCCCCCCCCCCCCCHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHCCCEECCCHHHC
DLPKDPDAAEEHDHESEEEHEHGDINPHVWLNPVYMEQMATVVKDKLIKEMPDQKETFEK
CCCCCCCCCHHCCCCCHHHHHCCCCCCCEEECHHHHHHHHHHHHHHHHHHCCCHHHHHHH
NYQAVEKKLKKLDQDFRTVTKEAKQKDFVTAHAAYSYWETEYGLHQIPIAGVSTSDEPSQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCHHH
KKLKSIVEKIEAEKIPYIMLEQNTNSKIADVIQQETNTKTLTLHNLETLTQKDLDQKRDY
HHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHH
LSIMNDNLKALKEGLNY
HHHHHCCHHHHHHHCCC
>Mature Secondary Structure
MRKKYLIALTVLFSALLILTGCSDESDKKATKSDQLTVYTTVYPLQYLTEQIGGEYVDVH
CCCHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCCEEEEEEHHHHHHHHHHHCCCEEEEE
SIYPPGSDAHSFEPTQKDMMKIADSDLFFYIGLGMEGFVDKAEKTLANEHVSFVPTAEKL
ECCCCCCCCCCCCCCHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHCCCEECCCHHHC
DLPKDPDAAEEHDHESEEEHEHGDINPHVWLNPVYMEQMATVVKDKLIKEMPDQKETFEK
CCCCCCCCCHHCCCCCHHHHHCCCCCCCEEECHHHHHHHHHHHHHHHHHHCCCHHHHHHH
NYQAVEKKLKKLDQDFRTVTKEAKQKDFVTAHAAYSYWETEYGLHQIPIAGVSTSDEPSQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCHHH
KKLKSIVEKIEAEKIPYIMLEQNTNSKIADVIQQETNTKTLTLHNLETLTQKDLDQKRDY
HHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHH
LSIMNDNLKALKEGLNY
HHHHHCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Zn (II) [Periplasm]; H2O; ATP [C]

Specific reaction: Zn (II) [Periplasm] + H2O + ATP = Zn (II) [Cytoplasm] + ADP + phosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9274031; 9384377; 9811636 [H]