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The map label for this gene is ytkD [H]

Identifier: 226224272

GI number: 226224272

Start: 1710049

End: 1710522

Strand: Reverse

Name: ytkD [H]

Synonym: Lm4b_01682

Alternate gene names: 226224272

Gene position: 1710522-1710049 (Counterclockwise)

Preceding gene: 226224275

Following gene: 226224271

Centisome position: 58.73

GC content: 39.66

Gene sequence:

>474_bases
TTGTTTATTTATAATGATACACTTGGAAACAAAGTTACAATCTATTTTGAAGCACAGGAAAATAATCCAGACGATGTGCT
CATTATACCTAAAACAGAGGACGGTTGGCTTTTTACCGAACACAAAATTCGTGGGCTTGAATTCCCTGGTGGAAAAGGTG
AACCAGGAGAAACAAATTTAGACGCAGCGAAACGCGAGCTCATGGAAGAGACGGGCGCAATTAGTGATGAACTTCATTTT
GTAGCCGATTATTTGGTCGAATCAGAGGAACGAACGTTTACTAAACGAGTTTATGCGGCGGATGTTATTTCCATTGAATC
ACTAGATGATTACCTTGAAACAAAAGGCCCTGTCATCATTCAAGGGGAGTTAAGTCGATTCATTTTACAACCGGCTTTTA
GCTTTTTTATGCGAGATGCGGGAATGGTCCAAATTGTGCAACAAGCTGAGCGAATCTTAAATGATAAAAACTAG

Upstream 100 bases:

>100_bases
GATTCCTCCGATAAGAATTTTTTTCATTGATTTTCACCCTCTAAATTTCAGCTTACATACAGCTTACCACATTTTTGAAA
AAAGAAAAGGAAGTGAGTTT

Downstream 100 bases:

>100_bases
TCAAATAGGGGCAATCTCTGCTATGATTAAAGAAACTGGAGGTGGGAAAATTGGGTATGCCACTAGAGGTAAACACAATG
ATTGTAACAAAAGGAAAAGA

Product: Nudix hydrolase

Products: NA

Alternate protein names: 8-oxo-dGTPase; dGTP pyrophosphohydrolase [H]

Number of amino acids: Translated: 157; Mature: 157

Protein sequence:

>157_residues
MFIYNDTLGNKVTIYFEAQENNPDDVLIIPKTEDGWLFTEHKIRGLEFPGGKGEPGETNLDAAKRELMEETGAISDELHF
VADYLVESEERTFTKRVYAADVISIESLDDYLETKGPVIIQGELSRFILQPAFSFFMRDAGMVQIVQQAERILNDKN

Sequences:

>Translated_157_residues
MFIYNDTLGNKVTIYFEAQENNPDDVLIIPKTEDGWLFTEHKIRGLEFPGGKGEPGETNLDAAKRELMEETGAISDELHF
VADYLVESEERTFTKRVYAADVISIESLDDYLETKGPVIIQGELSRFILQPAFSFFMRDAGMVQIVQQAERILNDKN
>Mature_157_residues
MFIYNDTLGNKVTIYFEAQENNPDDVLIIPKTEDGWLFTEHKIRGLEFPGGKGEPGETNLDAAKRELMEETGAISDELHF
VADYLVESEERTFTKRVYAADVISIESLDDYLETKGPVIIQGELSRFILQPAFSFFMRDAGMVQIVQQAERILNDKN

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8- oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal effici

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797
- InterPro:   IPR014078 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: NA

Molecular weight: Translated: 17870; Mature: 17870

Theoretical pI: Translated: 4.15; Mature: 4.15

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFIYNDTLGNKVTIYFEAQENNPDDVLIIPKTEDGWLFTEHKIRGLEFPGGKGEPGETNL
CEEECCCCCCEEEEEEEECCCCCCCEEEEECCCCCEEEECCCEEEEECCCCCCCCCCCCH
DAAKRELMEETGAISDELHFVADYLVESEERTFTKRVYAADVISIESLDDYLETKGPVII
HHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
QGELSRFILQPAFSFFMRDAGMVQIVQQAERILNDKN
ECHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MFIYNDTLGNKVTIYFEAQENNPDDVLIIPKTEDGWLFTEHKIRGLEFPGGKGEPGETNL
CEEECCCCCCEEEEEEEECCCCCCCEEEEECCCCCEEEECCCEEEEECCCCCCCCCCCCH
DAAKRELMEETGAISDELHFVADYLVESEERTFTKRVYAADVISIESLDDYLETKGPVII
HHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
QGELSRFILQPAFSFFMRDAGMVQIVQQAERILNDKN
ECHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]