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The map label for this gene is trpC

Identifier: 226224231

GI number: 226224231

Start: 1656323

End: 1657081

Strand: Reverse

Name: trpC

Synonym: Lm4b_01641

Alternate gene names: 226224231

Gene position: 1657081-1656323 (Counterclockwise)

Preceding gene: 226224232

Following gene: 226224230

Centisome position: 56.89

GC content: 40.05

Gene sequence:

>759_bases
ATGACATTTTTAGAAGAAATTTTAGCGCAAAAAGCAGTAGAAGTTGCAGACATGCCCTTAGAAAAAGTAGCCGAAAAACG
GAAAACTTATTCGTTTTATGAATTTTTAAAAGCAAATACCAGCACGATGCAACTTATTGCAGAAGTAAAACGCGCCTCTC
CTTCTAAAGGGGAAATCAATATGGGCGTGAATCCGGTTCTGCAAGCCAAGTCTTATCAAGCTGCGGGTGCAGGAATGATT
TCTGTTTTGACAGATCCTGTTTTTTTCAAAGGCTCGATTGAAGATTTGCGAGAAGTAGCGAAAAATGTCGAAATTCCTGT
ACTATGTAAAGATTTTATTATTAGTGAAAAACAATTGATTCGTGCTCGAAATGCGGGAGCAACGGTTGTATTGCTAATTA
TTTCGGCACTTACAGAAGAGATGCTAATTGCTCTGTTTGAACAAGCTCTGGCGCTTGATTTGGAAGTGTTAGTGGAAGTA
CATGACCAGAAAGAATTAGCTGTTGCTCAAAAAATTGGAGCTAAACTCATTGGTGTGAACAACCGTAATTTGCATACATT
TGAAGTGGATATTGCAGTAAGTGAAAGACTGGCGAGCGATTTCTCGTCGGATGCTTGTTTCATAAGTGAATCAGGTTTTC
GAACAGCTGAAGATGTGGCTCGGGTTAGTCAAAAATATAATGCAGTACTTGTTGGAGAAGCGCTAATGCGAGAAGCGACT
CCAGAAGCAGCGGCGAAAAGTTTGAAGGTGACACGATGA

Upstream 100 bases:

>100_bases
TACAAGAAGGCGTGGATTTAGCAAGAGATTTAATTAGAAGTGGTTTAGCCAAACAAAAATTGGCAGATTTAATTACTTAT
CAAAAAGAGGTGCTAGCAAA

Downstream 100 bases:

>100_bases
TTGTAAAAATTTGTGGATTGAAAAAAGCAGTAGATGTAGCGGCTGCGGTCGATAATGGCGCAGATATGATTGGCTTCGTT
TTCGCAAAAAGTAAACGCCA

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 252; Mature: 251

Protein sequence:

>252_residues
MTFLEEILAQKAVEVADMPLEKVAEKRKTYSFYEFLKANTSTMQLIAEVKRASPSKGEINMGVNPVLQAKSYQAAGAGMI
SVLTDPVFFKGSIEDLREVAKNVEIPVLCKDFIISEKQLIRARNAGATVVLLIISALTEEMLIALFEQALALDLEVLVEV
HDQKELAVAQKIGAKLIGVNNRNLHTFEVDIAVSERLASDFSSDACFISESGFRTAEDVARVSQKYNAVLVGEALMREAT
PEAAAKSLKVTR

Sequences:

>Translated_252_residues
MTFLEEILAQKAVEVADMPLEKVAEKRKTYSFYEFLKANTSTMQLIAEVKRASPSKGEINMGVNPVLQAKSYQAAGAGMI
SVLTDPVFFKGSIEDLREVAKNVEIPVLCKDFIISEKQLIRARNAGATVVLLIISALTEEMLIALFEQALALDLEVLVEV
HDQKELAVAQKIGAKLIGVNNRNLHTFEVDIAVSERLASDFSSDACFISESGFRTAEDVARVSQKYNAVLVGEALMREAT
PEAAAKSLKVTR
>Mature_251_residues
TFLEEILAQKAVEVADMPLEKVAEKRKTYSFYEFLKANTSTMQLIAEVKRASPSKGEINMGVNPVLQAKSYQAAGAGMIS
VLTDPVFFKGSIEDLREVAKNVEIPVLCKDFIISEKQLIRARNAGATVVLLIISALTEEMLIALFEQALALDLEVLVEVH
DQKELAVAQKIGAKLIGVNNRNLHTFEVDIAVSERLASDFSSDACFISESGFRTAEDVARVSQKYNAVLVGEALMREATP
EAAAKSLKVTR

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=251, Percent_Identity=35.8565737051793, Blast_Score=127, Evalue=6e-31,
Organism=Saccharomyces cerevisiae, GI6322638, Length=215, Percent_Identity=42.3255813953488, Blast_Score=153, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_LISMC (C1KVS7)

Other databases:

- EMBL:   FM242711
- RefSeq:   YP_002758338.1
- ProteinModelPortal:   C1KVS7
- SMR:   C1KVS7
- GeneID:   7701613
- GenomeReviews:   FM242711_GR
- KEGG:   lmc:Lm4b_01641
- OMA:   VDLPLLC
- ProtClustDB:   PRK00278
- HAMAP:   MF_00134_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 27595; Mature: 27464

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFLEEILAQKAVEVADMPLEKVAEKRKTYSFYEFLKANTSTMQLIAEVKRASPSKGEIN
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCC
MGVNPVLQAKSYQAAGAGMISVLTDPVFFKGSIEDLREVAKNVEIPVLCKDFIISEKQLI
CCCCHHHHCCCCCCCCCCHHHHHCCCCEECCCHHHHHHHHHCCCCCEEHHHHHHHHHHHH
RARNAGATVVLLIISALTEEMLIALFEQALALDLEVLVEVHDQKELAVAQKIGAKLIGVN
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCEEEECC
NRNLHTFEVDIAVSERLASDFSSDACFISESGFRTAEDVARVSQKYNAVLVGEALMREAT
CCCEEEEEEEHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHCCEEEEHHHHHHHCC
PEAAAKSLKVTR
HHHHHHHCCCCC
>Mature Secondary Structure 
TFLEEILAQKAVEVADMPLEKVAEKRKTYSFYEFLKANTSTMQLIAEVKRASPSKGEIN
CHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCC
MGVNPVLQAKSYQAAGAGMISVLTDPVFFKGSIEDLREVAKNVEIPVLCKDFIISEKQLI
CCCCHHHHCCCCCCCCCCHHHHHCCCCEECCCHHHHHHHHHCCCCCEEHHHHHHHHHHHH
RARNAGATVVLLIISALTEEMLIALFEQALALDLEVLVEVHDQKELAVAQKIGAKLIGVN
HHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCEEEECC
NRNLHTFEVDIAVSERLASDFSSDACFISESGFRTAEDVARVSQKYNAVLVGEALMREAT
CCCEEEEEEEHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHCCEEEEHHHHHHHCC
PEAAAKSLKVTR
HHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA