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The map label for this gene is argD

Identifier: 226224189

GI number: 226224189

Start: 1613291

End: 1614451

Strand: Reverse

Name: argD

Synonym: Lm4b_01599

Alternate gene names: 226224189

Gene position: 1614451-1613291 (Counterclockwise)

Preceding gene: 226224190

Following gene: 226224188

Centisome position: 55.43

GC content: 40.4

Gene sequence:

>1161_bases
ATGAAACATGTTTTTCCAACATACAAAAGGTTTCCTATTGATTTAGTTAACGGTACGGGCACGGTTGTAACAGATAAAAA
TGGTAAAACATATCTCGATTTCACTAGCGGTATCGCAGTTTGTAACCTTGGTCATTGTCCAGCAAATGTTGCAGAAGCAG
TACAACAACAACTAACGAATATTTGGCACACATCGAATTTATATGAATGTGCTTTGCAAGATAGTGTCGCAGAATTAATT
GCAGATGGTAAAGACAGATTAGTTTTCTTTTGTAATAGCGGAACAGAGGCAAATGAAGCAGCGCTCAAATTAGCTAGAAA
ATATACCGGGAAAGAAAAAATAATTACCTTTGAAAAATCTTTCCACGGACGTACTTTTGGTTCGATGTCAGCTACAGCCC
AAGCTAAAATTCATCAAGGGTTCGGGGGACTTGTTCCTGGCTTCACTTACGTCCCTTATAATGACATCGAGGCTTTCCGA
GCAGAAATCGATGAACATACAGCAGCAGTCATGTTAGAAGTAATTCAAGGGGAAGGTGGCGTCATCCCAGCAAATGCAGC
CTTTCTTTTAGAGGTTCAATTGCTTTGCAAAAAAATGGGGGTATTATTAATTATTGATGAGGTGCAGACTGGGCTTGGGC
GAACGGGGACGCTTTATGGATTTGAGCAGATTGGTTTAGAACCAGATATTTTCACTTTAGCAAAAGGGCTTGGAAATGGC
TGGCCGATTGGAGCGATGGTCGGAAAAGCGAATCTAAGTAGTGCTTTTGGGCCAGGAAGTCATGGCTCTACTTTTGGAGG
AAATAAATTGGCCCTTGCGGCGGCTAAAGAGATATTACGAACAATGAAACAAGCGGGATTTTTAGAAGAGGTAAATGCCA
AAGCAGACTATTTTAGATATTTGTTAGAAGTGCATTTAGAGGCGTTGGATAATGTTTCTGTCATTCGTGGTGGAGGATTT
CTGATAGGTATAGAACTTGAAAATACCGCAGAACCAGTTGTAACGGAACTTAGAGATAAAGGATTGCTAATACTAACTGC
GGGGGCTAATGTGCTACGAATCTTACCACCTTTAACCGTCAGTTATGCAGAAATCGATCAAGCCATATATTTATTGAAAA
GTGTTTTGGAAAACCAATTGATTGGGAGTGAAGAGGGATGA

Upstream 100 bases:

>100_bases
CTAGCGCTGCCTTTGCTGCCGAAAACGGTGTCGGAAAAGTTATTATTACAGATTCCCTTAACACTAGCGGAACAAAAATA
AAAAACAAGGTGGCGATTGG

Downstream 100 bases:

>100_bases
CAATGTATGCGAAAAATAATACAGCTGGGAAAGATATGCTCAGTTTGCTTGAATGGAATAAAGAAGAATTGACAGATATT
ATTAAATTAGCTGTTGCAAT

Product: acetylornithine aminotransferase

Products: NA

Alternate protein names: ACOAT [H]

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MKHVFPTYKRFPIDLVNGTGTVVTDKNGKTYLDFTSGIAVCNLGHCPANVAEAVQQQLTNIWHTSNLYECALQDSVAELI
ADGKDRLVFFCNSGTEANEAALKLARKYTGKEKIITFEKSFHGRTFGSMSATAQAKIHQGFGGLVPGFTYVPYNDIEAFR
AEIDEHTAAVMLEVIQGEGGVIPANAAFLLEVQLLCKKMGVLLIIDEVQTGLGRTGTLYGFEQIGLEPDIFTLAKGLGNG
WPIGAMVGKANLSSAFGPGSHGSTFGGNKLALAAAKEILRTMKQAGFLEEVNAKADYFRYLLEVHLEALDNVSVIRGGGF
LIGIELENTAEPVVTELRDKGLLILTAGANVLRILPPLTVSYAEIDQAIYLLKSVLENQLIGSEEG

Sequences:

>Translated_386_residues
MKHVFPTYKRFPIDLVNGTGTVVTDKNGKTYLDFTSGIAVCNLGHCPANVAEAVQQQLTNIWHTSNLYECALQDSVAELI
ADGKDRLVFFCNSGTEANEAALKLARKYTGKEKIITFEKSFHGRTFGSMSATAQAKIHQGFGGLVPGFTYVPYNDIEAFR
AEIDEHTAAVMLEVIQGEGGVIPANAAFLLEVQLLCKKMGVLLIIDEVQTGLGRTGTLYGFEQIGLEPDIFTLAKGLGNG
WPIGAMVGKANLSSAFGPGSHGSTFGGNKLALAAAKEILRTMKQAGFLEEVNAKADYFRYLLEVHLEALDNVSVIRGGGF
LIGIELENTAEPVVTELRDKGLLILTAGANVLRILPPLTVSYAEIDQAIYLLKSVLENQLIGSEEG
>Mature_386_residues
MKHVFPTYKRFPIDLVNGTGTVVTDKNGKTYLDFTSGIAVCNLGHCPANVAEAVQQQLTNIWHTSNLYECALQDSVAELI
ADGKDRLVFFCNSGTEANEAALKLARKYTGKEKIITFEKSFHGRTFGSMSATAQAKIHQGFGGLVPGFTYVPYNDIEAFR
AEIDEHTAAVMLEVIQGEGGVIPANAAFLLEVQLLCKKMGVLLIIDEVQTGLGRTGTLYGFEQIGLEPDIFTLAKGLGNG
WPIGAMVGKANLSSAFGPGSHGSTFGGNKLALAAAKEILRTMKQAGFLEEVNAKADYFRYLLEVHLEALDNVSVIRGGGF
LIGIELENTAEPVVTELRDKGLLILTAGANVLRILPPLTVSYAEIDQAIYLLKSVLENQLIGSEEG

Specific function: Involved In Both The Arginine And Lysine Biosynthetic Pathways. [C]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=386, Percent_Identity=33.6787564766839, Blast_Score=204, Evalue=8e-53,
Organism=Homo sapiens, GI284507298, Length=301, Percent_Identity=35.8803986710963, Blast_Score=175, Evalue=6e-44,
Organism=Homo sapiens, GI13994255, Length=433, Percent_Identity=28.4064665127021, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI37574042, Length=430, Percent_Identity=27.6744186046512, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI24119277, Length=412, Percent_Identity=25.9708737864078, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI226442705, Length=430, Percent_Identity=27.2093023255814, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI226442709, Length=385, Percent_Identity=27.012987012987, Blast_Score=117, Evalue=2e-26,
Organism=Escherichia coli, GI1789759, Length=378, Percent_Identity=42.0634920634921, Blast_Score=274, Evalue=6e-75,
Organism=Escherichia coli, GI1788044, Length=387, Percent_Identity=40.5684754521964, Blast_Score=270, Evalue=2e-73,
Organism=Escherichia coli, GI145693181, Length=393, Percent_Identity=36.6412213740458, Blast_Score=213, Evalue=2e-56,
Organism=Escherichia coli, GI1789016, Length=400, Percent_Identity=34, Blast_Score=210, Evalue=1e-55,
Organism=Escherichia coli, GI1787560, Length=392, Percent_Identity=34.6938775510204, Blast_Score=197, Evalue=1e-51,
Organism=Escherichia coli, GI1786349, Length=298, Percent_Identity=31.2080536912752, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1786991, Length=307, Percent_Identity=26.3843648208469, Blast_Score=97, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI25144271, Length=380, Percent_Identity=35.7894736842105, Blast_Score=211, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI32564660, Length=424, Percent_Identity=31.3679245283019, Blast_Score=191, Evalue=6e-49,
Organism=Caenorhabditis elegans, GI25144274, Length=264, Percent_Identity=37.1212121212121, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI71992977, Length=422, Percent_Identity=27.7251184834123, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI71981843, Length=189, Percent_Identity=31.2169312169312, Blast_Score=90, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17541228, Length=447, Percent_Identity=25.9507829977629, Blast_Score=84, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6324432, Length=397, Percent_Identity=38.0352644836272, Blast_Score=256, Evalue=4e-69,
Organism=Saccharomyces cerevisiae, GI6323470, Length=403, Percent_Identity=31.7617866004963, Blast_Score=183, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6324386, Length=367, Percent_Identity=27.5204359673025, Blast_Score=104, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6321456, Length=374, Percent_Identity=25.9358288770053, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI21357415, Length=384, Percent_Identity=32.8125, Blast_Score=201, Evalue=5e-52,
Organism=Drosophila melanogaster, GI28574759, Length=417, Percent_Identity=29.9760191846523, Blast_Score=181, Evalue=7e-46,
Organism=Drosophila melanogaster, GI161085790, Length=428, Percent_Identity=28.9719626168224, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI21356575, Length=414, Percent_Identity=27.0531400966184, Blast_Score=151, Evalue=7e-37,
Organism=Drosophila melanogaster, GI281366494, Length=302, Percent_Identity=25.4966887417219, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24667139, Length=302, Percent_Identity=25.4966887417219, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24667143, Length=302, Percent_Identity=25.4966887417219, Blast_Score=86, Evalue=5e-17,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.11 [H]

Molecular weight: Translated: 41561; Mature: 41561

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHVFPTYKRFPIDLVNGTGTVVTDKNGKTYLDFTSGIAVCNLGHCPANVAEAVQQQLTN
CCCCCCCHHCCCEEEECCCEEEEECCCCCEEEEECCCEEEEECCCCCHHHHHHHHHHHHH
IWHTSNLYECALQDSVAELIADGKDRLVFFCNSGTEANEAALKLARKYTGKEKIITFEKS
HHCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEECC
FHGRTFGSMSATAQAKIHQGFGGLVPGFTYVPYNDIEAFRAEIDEHTAAVMLEVIQGEGG
CCCCCCCCCCHHHHHHHHCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
VIPANAAFLLEVQLLCKKMGVLLIIDEVQTGLGRTGTLYGFEQIGLEPDIFTLAKGLGNG
EECCCHHHHHHHHHHHHHCCEEEEEECHHHCCCCCCEECCHHHHCCCCCHHHHHHHCCCC
WPIGAMVGKANLSSAFGPGSHGSTFGGNKLALAAAKEILRTMKQAGFLEEVNAKADYFRY
CCHHHEECCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHCCCHHHHCCHHHHHHH
LLEVHLEALDNVSVIRGGGFLIGIELENTAEPVVTELRDKGLLILTAGANVLRILPPLTV
HHHHHHHHHCCEEEEECCCEEEEEEECCCCHHHHHHHCCCCEEEEECCCCEEEECCCCEE
SYAEIDQAIYLLKSVLENQLIGSEEG
HHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKHVFPTYKRFPIDLVNGTGTVVTDKNGKTYLDFTSGIAVCNLGHCPANVAEAVQQQLTN
CCCCCCCHHCCCEEEECCCEEEEECCCCCEEEEECCCEEEEECCCCCHHHHHHHHHHHHH
IWHTSNLYECALQDSVAELIADGKDRLVFFCNSGTEANEAALKLARKYTGKEKIITFEKS
HHCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEECC
FHGRTFGSMSATAQAKIHQGFGGLVPGFTYVPYNDIEAFRAEIDEHTAAVMLEVIQGEGG
CCCCCCCCCCHHHHHHHHCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
VIPANAAFLLEVQLLCKKMGVLLIIDEVQTGLGRTGTLYGFEQIGLEPDIFTLAKGLGNG
EECCCHHHHHHHHHHHHHCCEEEEEECHHHCCCCCCEECCHHHHCCCCCHHHHHHHCCCC
WPIGAMVGKANLSSAFGPGSHGSTFGGNKLALAAAKEILRTMKQAGFLEEVNAKADYFRY
CCHHHEECCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHCCCHHHHCCHHHHHHH
LLEVHLEALDNVSVIRGGGFLIGIELENTAEPVVTELRDKGLLILTAGANVLRILPPLTV
HHHHHHHHHCCEEEEECCCEEEEEEECCCCHHHHHHHCCCCEEEEECCCCEEEECCCCEE
SYAEIDQAIYLLKSVLENQLIGSEEG
HHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA