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The map label for this gene is mutM

Identifier: 226224165

GI number: 226224165

Start: 1584674

End: 1585495

Strand: Reverse

Name: mutM

Synonym: Lm4b_01575

Alternate gene names: 226224165

Gene position: 1585495-1584674 (Counterclockwise)

Preceding gene: 226224166

Following gene: 226224164

Centisome position: 54.43

GC content: 39.9

Gene sequence:

>822_bases
ATGCCAGAAATGCCGGAAGTAGAAAATGTCCGCGCAACTTTACAAGAATTAGTCCCAGGTAAAAAAATAGATCAAGTAAT
TGTTCGTGTTCCAAAAATGATTGTATCAACACCACCCGATGAGTTTGTGCATATGCTTGTCGGGCAAGAAATAGAGGGTG
TACGCCGTCGTGGTAAATTCTTACTTTTTGACTTAACCAACTGTACGATTTTATCGCATTTACGAATGGAAGGTAAATTT
CGGTTAATGGATGAAAAGGAAGAGGTTAGCAAGCATACGCATATTATTTTTCATTTTGAAGATCACACGGAATTGCGTTT
TTTAGATGTGCGAAAATTTGGCACGATGGAAGTAACAAATAAATACGGTGAGGGTGAAACGCGGTCGATTAAAAAGCTTG
GCCCAGAACCGCTGACGCAAGCCTTTACATCAACGGATTTTGCGACTGGTGTAAAAAAAACAAGCCGCGCCATCAAAACG
GCTTTACTTGATCAAAAGTTAGTAGCCGGAGTAGGAAATATTTATGCGGATGAAATTTGTTTTGAAGCAAAAGTGCGCCC
GGAAAGAGCAGCTAACTCACTTTCAGACAAAGAAATCAAACGTATTTTTGAAGCGACGAAAAGTATTATGACTGAAGCTG
TAGCACTTGGTGGCTCCACTGTCAGAACATATGTAAATTCGCAAGGGAAGCTTGGACAATATCAAGATAAATTAAAAGTA
TACGGCAAAACAGACGAACCGTGTGTGGTTTGTGGAACGCCAATTGAAAAAATTAAATTAAACGGACGCGGGACACATTT
TTGCCCGAATTGCCAAAAATAG

Upstream 100 bases:

>100_bases
TGGAAAATGCAGTAGAGCTTTCTGTACCGCTAAAAGTAGATAGCGCATTTGGTGACACTTGGTACGACGCGAAATAAATA
GAGAAACGGGGAGTTTATAT

Downstream 100 bases:

>100_bases
AAAGCGAGCTGAAATCATGGGGAAAACGATTGGATTAACAGGAAGTGTAGCAACAGGGAAATCAACAGTGAGTAACATGA
TTCAGCAAGCGGGTATTCCA

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM [H]

Number of amino acids: Translated: 273; Mature: 272

Protein sequence:

>273_residues
MPEMPEVENVRATLQELVPGKKIDQVIVRVPKMIVSTPPDEFVHMLVGQEIEGVRRRGKFLLFDLTNCTILSHLRMEGKF
RLMDEKEEVSKHTHIIFHFEDHTELRFLDVRKFGTMEVTNKYGEGETRSIKKLGPEPLTQAFTSTDFATGVKKTSRAIKT
ALLDQKLVAGVGNIYADEICFEAKVRPERAANSLSDKEIKRIFEATKSIMTEAVALGGSTVRTYVNSQGKLGQYQDKLKV
YGKTDEPCVVCGTPIEKIKLNGRGTHFCPNCQK

Sequences:

>Translated_273_residues
MPEMPEVENVRATLQELVPGKKIDQVIVRVPKMIVSTPPDEFVHMLVGQEIEGVRRRGKFLLFDLTNCTILSHLRMEGKF
RLMDEKEEVSKHTHIIFHFEDHTELRFLDVRKFGTMEVTNKYGEGETRSIKKLGPEPLTQAFTSTDFATGVKKTSRAIKT
ALLDQKLVAGVGNIYADEICFEAKVRPERAANSLSDKEIKRIFEATKSIMTEAVALGGSTVRTYVNSQGKLGQYQDKLKV
YGKTDEPCVVCGTPIEKIKLNGRGTHFCPNCQK
>Mature_272_residues
PEMPEVENVRATLQELVPGKKIDQVIVRVPKMIVSTPPDEFVHMLVGQEIEGVRRRGKFLLFDLTNCTILSHLRMEGKFR
LMDEKEEVSKHTHIIFHFEDHTELRFLDVRKFGTMEVTNKYGEGETRSIKKLGPEPLTQAFTSTDFATGVKKTSRAIKTA
LLDQKLVAGVGNIYADEICFEAKVRPERAANSLSDKEIKRIFEATKSIMTEAVALGGSTVRTYVNSQGKLGQYQDKLKVY
GKTDEPCVVCGTPIEKIKLNGRGTHFCPNCQK

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger [H]

Homologues:

Organism=Escherichia coli, GI1790066, Length=273, Percent_Identity=37.7289377289377, Blast_Score=186, Evalue=1e-48,
Organism=Escherichia coli, GI1786932, Length=280, Percent_Identity=25.7142857142857, Blast_Score=85, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663 [H]

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS [H]

EC number: =3.2.2.23; =4.2.99.18 [H]

Molecular weight: Translated: 30762; Mature: 30631

Theoretical pI: Translated: 8.79; Mature: 8.79

Prosite motif: PS01242 ZF_FPG_1 ; PS51066 ZF_FPG_2 ; PS51068 FPG_CAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEMPEVENVRATLQELVPGKKIDQVIVRVPKMIVSTPPDEFVHMLVGQEIEGVRRRGKF
CCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCE
LLFDLTNCTILSHLRMEGKFRLMDEKEEVSKHTHIIFHFEDHTELRFLDVRKFGTMEVTN
EEEECCCHHHHHHHHCCCCEEECCCHHHHCCCEEEEEEECCCCCEEEEEHHHCCCEEEHH
KYGEGETRSIKKLGPEPLTQAFTSTDFATGVKKTSRAIKTALLDQKLVAGVGNIYADEIC
CCCCCCHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FEAKVRPERAANSLSDKEIKRIFEATKSIMTEAVALGGSTVRTYVNSQGKLGQYQDKLKV
HHCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHEE
YGKTDEPCVVCGTPIEKIKLNGRGTHFCPNCQK
CCCCCCCEEEECCCHHHEEECCCCCCCCCCCCC
>Mature Secondary Structure 
PEMPEVENVRATLQELVPGKKIDQVIVRVPKMIVSTPPDEFVHMLVGQEIEGVRRRGKF
CCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCE
LLFDLTNCTILSHLRMEGKFRLMDEKEEVSKHTHIIFHFEDHTELRFLDVRKFGTMEVTN
EEEECCCHHHHHHHHCCCCEEECCCHHHHCCCEEEEEEECCCCCEEEEEHHHCCCEEEHH
KYGEGETRSIKKLGPEPLTQAFTSTDFATGVKKTSRAIKTALLDQKLVAGVGNIYADEIC
CCCCCCHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FEAKVRPERAANSLSDKEIKRIFEATKSIMTEAVALGGSTVRTYVNSQGKLGQYQDKLKV
HHCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHEE
YGKTDEPCVVCGTPIEKIKLNGRGTHFCPNCQK
CCCCCCCEEEECCCHHHEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]