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The map label for this gene is hemA

Identifier: 226224158

GI number: 226224158

Start: 1576799

End: 1578106

Strand: Reverse

Name: hemA

Synonym: Lm4b_01568

Alternate gene names: 226224158

Gene position: 1578106-1576799 (Counterclockwise)

Preceding gene: 226224159

Following gene: 226224157

Centisome position: 54.18

GC content: 36.85

Gene sequence:

>1308_bases
ATGTTTATTCTCACCATGGGGCTGAATCATCACACAGCACCAATCGACATCCGCGAAAAATTAGTTTTTAAAGAAAGCGA
AGAAGAAATGGCCTTAGTAACATTACAGCAGGAAAAAAGTATCCTCGAAAATGTTATTATTTCAACGTGCAATCGAACAG
AAATTATTGCGGTTGTTGACCAAATACATACAGGTAGATATTACTTAAAACGCTTTATGGCTAACTGGTTTCAAATGGAT
ATGGAAAAAATCGAACCTTATTTGTTTTTCCATGAAGAATCAGATGCTGTCAATCATTTATATAAAGTAACCGCGGGACT
TGATTCGTTAGTACTGGGAGAAACGCAAATCCTCGGACAAGTAAAACATGCATTCGAAATCGCCAAACAAACGGCTACAA
CAGGTACACTTTTAAATAAACTTTTTCGGGAAGTAGTTACTTTCGCAAAAAAAGTACACCACCATACAAAAATTAATGAA
AATGCTGTGTCTGTCAGTTATGCCGCTGTAGAGGTTGCAAAAAAATTATATGGTTCATTAGACAATAAGAAAATTGTGCT
AGTTGGTGCAGGGGAAATGAGTGAACTCGCTTTGCAAAATCTCGCTGGGAGCGGCATTGCAGATATAACCATCATCAACC
GTACTAAATCTAATGCAGAATTATTAGCAAATCAATTTCAAGCAAAAGTGGGCGCATATGAAAATATGAATGAACATTTG
ATGCTAGCAGACATCGTTCTCGTTTCGACAAGTGCGGCAGAACCTATTATTAAACAAGCTGCTATGCAAGATTTGATGGA
ACAAAAAGCGAGTTCGATGCTTGTAATTGATATCGGTTTACCTCGAAATGTTGAACATGATTGTTCATACATTCCCAATT
TCCATTTATATGACATTGACGATTTGGCAGGGGTTGTTAGCGCGAACTCATTAGAGCGGCAGCGAATCGTTCTGGAACTT
GAAAAAACTATTGAGGCAGAAGTTCGTAACTTTTTCGAGTGGGAAAAGCAACTAGGCGTCGTCCCTGTTATTCGTGCTTT
GCGTGAAAAAGCGTTAGATATGCAAGAAGTTACTATGACTAGTTTAGAAAATAAACTTCCTGGACTAACAGAACGCGAAT
ACATTCAAATTGGAAAACATATGAAAAGCATTATAAACCAAATGCTGAAACAACCTATCTCAGAATTAAAAGAAATGTCT
GTAGAAGAAGATGCAACTACAAGTATTGAACATTTTAAACGTATTTTTGGGTTGAGTGAAACAGATGTTACTGTAATAGA
AAAAGAACAAGCCGAAACGAGGAGTTAA

Upstream 100 bases:

>100_bases
CTCTTTTTTCCGTCTAAATACATAAACGGACTATTTGGTGTACACATCGAAAAGTGGTAGAATGTATTAGAGTTCAATTT
AATTTTAGGAGGATTATCGA

Downstream 100 bases:

>100_bases
CGGATGAAACGGAAAATAATTGTTGGTTCTAGAAGAAGCAAGTTAGCTTTAACTCAGTCTAATTGGGTGATTAACAAGCT
CAAAGAAAATTATCCTGAGT

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR [H]

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MFILTMGLNHHTAPIDIREKLVFKESEEEMALVTLQQEKSILENVIISTCNRTEIIAVVDQIHTGRYYLKRFMANWFQMD
MEKIEPYLFFHEESDAVNHLYKVTAGLDSLVLGETQILGQVKHAFEIAKQTATTGTLLNKLFREVVTFAKKVHHHTKINE
NAVSVSYAAVEVAKKLYGSLDNKKIVLVGAGEMSELALQNLAGSGIADITIINRTKSNAELLANQFQAKVGAYENMNEHL
MLADIVLVSTSAAEPIIKQAAMQDLMEQKASSMLVIDIGLPRNVEHDCSYIPNFHLYDIDDLAGVVSANSLERQRIVLEL
EKTIEAEVRNFFEWEKQLGVVPVIRALREKALDMQEVTMTSLENKLPGLTEREYIQIGKHMKSIINQMLKQPISELKEMS
VEEDATTSIEHFKRIFGLSETDVTVIEKEQAETRS

Sequences:

>Translated_435_residues
MFILTMGLNHHTAPIDIREKLVFKESEEEMALVTLQQEKSILENVIISTCNRTEIIAVVDQIHTGRYYLKRFMANWFQMD
MEKIEPYLFFHEESDAVNHLYKVTAGLDSLVLGETQILGQVKHAFEIAKQTATTGTLLNKLFREVVTFAKKVHHHTKINE
NAVSVSYAAVEVAKKLYGSLDNKKIVLVGAGEMSELALQNLAGSGIADITIINRTKSNAELLANQFQAKVGAYENMNEHL
MLADIVLVSTSAAEPIIKQAAMQDLMEQKASSMLVIDIGLPRNVEHDCSYIPNFHLYDIDDLAGVVSANSLERQRIVLEL
EKTIEAEVRNFFEWEKQLGVVPVIRALREKALDMQEVTMTSLENKLPGLTEREYIQIGKHMKSIINQMLKQPISELKEMS
VEEDATTSIEHFKRIFGLSETDVTVIEKEQAETRS
>Mature_435_residues
MFILTMGLNHHTAPIDIREKLVFKESEEEMALVTLQQEKSILENVIISTCNRTEIIAVVDQIHTGRYYLKRFMANWFQMD
MEKIEPYLFFHEESDAVNHLYKVTAGLDSLVLGETQILGQVKHAFEIAKQTATTGTLLNKLFREVVTFAKKVHHHTKINE
NAVSVSYAAVEVAKKLYGSLDNKKIVLVGAGEMSELALQNLAGSGIADITIINRTKSNAELLANQFQAKVGAYENMNEHL
MLADIVLVSTSAAEPIIKQAAMQDLMEQKASSMLVIDIGLPRNVEHDCSYIPNFHLYDIDDLAGVVSANSLERQRIVLEL
EKTIEAEVRNFFEWEKQLGVVPVIRALREKALDMQEVTMTSLENKLPGLTEREYIQIGKHMKSIINQMLKQPISELKEMS
VEEDATTSIEHFKRIFGLSETDVTVIEKEQAETRS

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) [H]

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family [H]

Homologues:

Organism=Escherichia coli, GI1787461, Length=352, Percent_Identity=35.2272727272727, Blast_Score=224, Evalue=7e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR003462
- InterPro:   IPR018214
- InterPro:   IPR006151 [H]

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH [H]

EC number: =1.2.1.70 [H]

Molecular weight: Translated: 49150; Mature: 49150

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS00747 GLUTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFILTMGLNHHTAPIDIREKLVFKESEEEMALVTLQQEKSILENVIISTCNRTEIIAVVD
CEEEEECCCCCCCCCCHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHCCCCHHHHHHHH
QIHTGRYYLKRFMANWFQMDMEKIEPYLFFHEESDAVNHLYKVTAGLDSLVLGETQILGQ
HHHCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCHHHHHCHHHHHHH
VKHAFEIAKQTATTGTLLNKLFREVVTFAKKVHHHTKINENAVSVSYAAVEVAKKLYGSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCC
DNKKIVLVGAGEMSELALQNLAGSGIADITIINRTKSNAELLANQFQAKVGAYENMNEHL
CCCEEEEEECCCHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCE
MLADIVLVSTSAAEPIIKQAAMQDLMEQKASSMLVIDIGLPRNVEHDCSYIPNFHLYDID
EHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCEEEEHH
DLAGVVSANSLERQRIVLELEKTIEAEVRNFFEWEKQLGVVPVIRALREKALDMQEVTMT
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHH
SLENKLPGLTEREYIQIGKHMKSIINQMLKQPISELKEMSVEEDATTSIEHFKRIFGLSE
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCC
TDVTVIEKEQAETRS
CCEEEEECCHHCCCC
>Mature Secondary Structure
MFILTMGLNHHTAPIDIREKLVFKESEEEMALVTLQQEKSILENVIISTCNRTEIIAVVD
CEEEEECCCCCCCCCCHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHCCCCHHHHHHHH
QIHTGRYYLKRFMANWFQMDMEKIEPYLFFHEESDAVNHLYKVTAGLDSLVLGETQILGQ
HHHCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCHHHHHCHHHHHHH
VKHAFEIAKQTATTGTLLNKLFREVVTFAKKVHHHTKINENAVSVSYAAVEVAKKLYGSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCC
DNKKIVLVGAGEMSELALQNLAGSGIADITIINRTKSNAELLANQFQAKVGAYENMNEHL
CCCEEEEEECCCHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCE
MLADIVLVSTSAAEPIIKQAAMQDLMEQKASSMLVIDIGLPRNVEHDCSYIPNFHLYDID
EHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCEEEEHH
DLAGVVSANSLERQRIVLELEKTIEAEVRNFFEWEKQLGVVPVIRALREKALDMQEVTMT
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHH
SLENKLPGLTEREYIQIGKHMKSIINQMLKQPISELKEMSVEEDATTSIEHFKRIFGLSE
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCC
TDVTVIEKEQAETRS
CCEEEEECCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA