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The map label for this gene is hemC

Identifier: 226224157

GI number: 226224157

Start: 1575866

End: 1576795

Strand: Reverse

Name: hemC

Synonym: Lm4b_01567

Alternate gene names: 226224157

Gene position: 1576795-1575866 (Counterclockwise)

Preceding gene: 226224158

Following gene: 226224156

Centisome position: 54.14

GC content: 38.17

Gene sequence:

>930_bases
ATGAAACGGAAAATAATTGTTGGTTCTAGAAGAAGCAAGTTAGCTTTAACTCAGTCTAATTGGGTGATTAACAAGCTCAA
AGAAAATTATCCTGAGTTCGATTTTGAGATAAAAGAAATTGTTACAAAAGGGGACCGTATTTTAGATGTAACACTTAGCA
AAGTAGGCGGAAAAGGTCTATTTGTATCCGAAGTGGAGCAGGCTTTAAGTGATGAAGTGATTGATTTTGCGGTACATAGC
ATGAAAGATGTTCCATCAAGTTTGAAAGAAGGGTTAATTATTGGCGCGATTCCAAAACGTGAATCGCCATTAGATTGCTT
CGTTTTCAATCGAGTGAATTCTCTAGATGAGTTACCACAAGGCTCGGTCATTGGTACAAGTAGCCTCCGTAGAGCGGCAC
AACTTCTAAAACATCGACCTGATTTTGTGATTAAACCGATTCGAGGCAATATCGATACACGTCTTCAAAAATTACATGCA
GAAAATTTTGATGCAATTATCTTAGCAAAAGCTGGGTTAGCTCGTATGGGTTGGTTAGAAAATACTACGTTAAAACTAGA
AGACATCCCACCAGAATTATGTTTGCCAGCTGTTGGACAAGGTGCACTTGCTATCGAGTGTCGCGAAAGTGATCAACAAA
TCCGCGATATGTTAACTTCTATTCATCACGAAGAAACTGGAATTTGTGTAGAAGCAGAACGTGTTTTCTTGAAAAAATTA
AATGGTGGCTGTGAAATTCCGATTGCCGGCTTTGCTACAAGAGCTAATGAAGTCGTTCATTTTAAAGGTTTAGTTGGTAA
TGCGGATGGTTCCATCATTCTTGCATCCGAACAAGCTGGTGCAAATCCAAGTGAAATTGGAAATAAAGTAGCAGAAGATT
TGCTAAGTGAAGGTGCAGATACTATTATCAAAGAACTGAGAAATATATGA

Upstream 100 bases:

>100_bases
TGCAACTACAAGTATTGAACATTTTAAACGTATTTTTGGGTTGAGTGAAACAGATGTTACTGTAATAGAAAAAGAACAAG
CCGAAACGAGGAGTTAACGG

Downstream 100 bases:

>100_bases
GTAAAAAAGTTGTTTTAACAAGAGAAGCGAATAAAAACAAACCATGGCAAACCTATTTTTCGCAAAATGGTTTTGAAGTG
ACGTCAATCCCGCTGATTAA

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MKRKIIVGSRRSKLALTQSNWVINKLKENYPEFDFEIKEIVTKGDRILDVTLSKVGGKGLFVSEVEQALSDEVIDFAVHS
MKDVPSSLKEGLIIGAIPKRESPLDCFVFNRVNSLDELPQGSVIGTSSLRRAAQLLKHRPDFVIKPIRGNIDTRLQKLHA
ENFDAIILAKAGLARMGWLENTTLKLEDIPPELCLPAVGQGALAIECRESDQQIRDMLTSIHHEETGICVEAERVFLKKL
NGGCEIPIAGFATRANEVVHFKGLVGNADGSIILASEQAGANPSEIGNKVAEDLLSEGADTIIKELRNI

Sequences:

>Translated_309_residues
MKRKIIVGSRRSKLALTQSNWVINKLKENYPEFDFEIKEIVTKGDRILDVTLSKVGGKGLFVSEVEQALSDEVIDFAVHS
MKDVPSSLKEGLIIGAIPKRESPLDCFVFNRVNSLDELPQGSVIGTSSLRRAAQLLKHRPDFVIKPIRGNIDTRLQKLHA
ENFDAIILAKAGLARMGWLENTTLKLEDIPPELCLPAVGQGALAIECRESDQQIRDMLTSIHHEETGICVEAERVFLKKL
NGGCEIPIAGFATRANEVVHFKGLVGNADGSIILASEQAGANPSEIGNKVAEDLLSEGADTIIKELRNI
>Mature_309_residues
MKRKIIVGSRRSKLALTQSNWVINKLKENYPEFDFEIKEIVTKGDRILDVTLSKVGGKGLFVSEVEQALSDEVIDFAVHS
MKDVPSSLKEGLIIGAIPKRESPLDCFVFNRVNSLDELPQGSVIGTSSLRRAAQLLKHRPDFVIKPIRGNIDTRLQKLHA
ENFDAIILAKAGLARMGWLENTTLKLEDIPPELCLPAVGQGALAIECRESDQQIRDMLTSIHHEETGICVEAERVFLKKL
NGGCEIPIAGFATRANEVVHFKGLVGNADGSIILASEQAGANPSEIGNKVAEDLLSEGADTIIKELRNI

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=273, Percent_Identity=47.2527472527472, Blast_Score=234, Evalue=8e-62,
Organism=Homo sapiens, GI66933009, Length=273, Percent_Identity=47.2527472527472, Blast_Score=234, Evalue=8e-62,
Organism=Escherichia coli, GI48994974, Length=304, Percent_Identity=47.3684210526316, Blast_Score=272, Evalue=2e-74,
Organism=Saccharomyces cerevisiae, GI6319996, Length=318, Percent_Identity=37.4213836477987, Blast_Score=196, Evalue=6e-51,
Organism=Drosophila melanogaster, GI20130425, Length=282, Percent_Identity=45.0354609929078, Blast_Score=221, Evalue=6e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 33897; Mature: 33897

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRKIIVGSRRSKLALTQSNWVINKLKENYPEFDFEIKEIVTKGDRILDVTLSKVGGKGL
CCCEEEECCCCCEEEEECCCHHHHHHHHCCCCCCHHHHHHHHCCCEEEEEEHHHCCCCCE
FVSEVEQALSDEVIDFAVHSMKDVPSSLKEGLIIGAIPKRESPLDCFVFNRVNSLDELPQ
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCEEEHHHHHHHHHCCC
GSVIGTSSLRRAAQLLKHRPDFVIKPIRGNIDTRLQKLHAENFDAIILAKAGLARMGWLE
CCEECHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHCCCCEEEEECCCHHHHCCCC
NTTLKLEDIPPELCLPAVGQGALAIECRESDQQIRDMLTSIHHEETGICVEAERVFLKKL
CCEEEEECCCHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHH
NGGCEIPIAGFATRANEVVHFKGLVGNADGSIILASEQAGANPSEIGNKVAEDLLSEGAD
CCCCCCCCCHHHHCCCCEEEEEEEEECCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCHH
TIIKELRNI
HHHHHHHCC
>Mature Secondary Structure
MKRKIIVGSRRSKLALTQSNWVINKLKENYPEFDFEIKEIVTKGDRILDVTLSKVGGKGL
CCCEEEECCCCCEEEEECCCHHHHHHHHCCCCCCHHHHHHHHCCCEEEEEEHHHCCCCCE
FVSEVEQALSDEVIDFAVHSMKDVPSSLKEGLIIGAIPKRESPLDCFVFNRVNSLDELPQ
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCEEEHHHHHHHHHCCC
GSVIGTSSLRRAAQLLKHRPDFVIKPIRGNIDTRLQKLHAENFDAIILAKAGLARMGWLE
CCEECHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHCCCCEEEEECCCHHHHCCCC
NTTLKLEDIPPELCLPAVGQGALAIECRESDQQIRDMLTSIHHEETGICVEAERVFLKKL
CCEEEEECCCHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHH
NGGCEIPIAGFATRANEVVHFKGLVGNADGSIILASEQAGANPSEIGNKVAEDLLSEGAD
CCCCCCCCCHHHHCCCCEEEEEEEEECCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCHH
TIIKELRNI
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA