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The map label for this gene is ldh2 [H]

Identifier: 226224135

GI number: 226224135

Start: 1552848

End: 1553783

Strand: Reverse

Name: ldh2 [H]

Synonym: Lm4b_01544

Alternate gene names: 226224135

Gene position: 1553783-1552848 (Counterclockwise)

Preceding gene: 226224136

Following gene: 226224134

Centisome position: 53.35

GC content: 40.81

Gene sequence:

>936_bases
ATGAAACCGCGTAAAGTAATGATAATTGGAGCTGGAAATGTAGGAACAGCTGCAGCACACGCATTTGTTAATCAAAAATT
TGTGGAAGAGTTAATTCTTGTAGATTTAAATAAAGAACGTGTAGAAGGGAATCGGAAAGACTTGGCTGATGCAGCTGCAT
TTATGCCCGGTAAAATGGATATTACTGTTCGTGATGCGAGCGATTGTGCAGATGTAGATATCGCTGTAATCACTGTAACT
GCTGGTCCTTTAAAAGAAGGACAAACTCGTTTAGACGAACTGAGAAGTACTTCAAGAATCGTTTCAAGCATTGTGCCCGA
GATGATGAAAGGCGGGTTTAATGGTATTTTCTTAATCGCGACGAATCCGTGTGATATCATCACATACCAAGTGTGGAAAT
TGTCCGGTTTACCAAGAGAACGAGTACTCGGAACGGGGGTATGGCTTGATACAACAAGGTTACGCCGTTTACTCGCAGAA
AAACTAGATATTGCTGCTCAAAGTATCGATGCTTTTATCCTTGGTGAGCACGGAGATTCTCAATTCCCCGTGTGGTCCCA
TTCATCTATTTATGGTAAACCAGTGAATGAATATAGTGTGGAAAAACTAGGCGAGGCACTAGATTTGAAACAAATAGGTG
AAACTGCTCGGGATACTGGTTTTGAAATCTACCACCAAAAAGGCTGCACAGAATACGGCATAGGTGGTACGATTGTCGAG
ATTTGTCGCCATATATTTAGTGGGAGCCAGCGTGCTTTAACGGTGTCTTGTGTGCTCGATGGCGAATACGGAGAAAGTGG
TCTAGCTATCGGAGTTCCAGCCGTTTTAAGTCAAAATGGTGTAAAAGAAATCATCTCTTTAAAATTAGATGAGAAAGAAA
AAGAAGCATTTGCGAATTCTGTGGCGGTTATTAAAAAAAGTATTCAATCTATTTAA

Upstream 100 bases:

>100_bases
AGAAGTTTATACGAACGCAGAGATAAATTAAGTCAACACACCCCTTTTTCGGACAATTTGAATAGGGGTGTTTTATATGA
ATCACTAGGAGGAAGAAAAT

Downstream 100 bases:

>100_bases
GGTGTCAATAATATTATTATGTAAACTAAATAAGCGTTTCTTTTATAAACAAAAACTAGTACAGACGTTCCGTTTTATGC
TATCATATAATGTATGACGT

Product: L-lactate dehydrogenase

Products: NA

Alternate protein names: L-LDH 2 [H]

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MKPRKVMIIGAGNVGTAAAHAFVNQKFVEELILVDLNKERVEGNRKDLADAAAFMPGKMDITVRDASDCADVDIAVITVT
AGPLKEGQTRLDELRSTSRIVSSIVPEMMKGGFNGIFLIATNPCDIITYQVWKLSGLPRERVLGTGVWLDTTRLRRLLAE
KLDIAAQSIDAFILGEHGDSQFPVWSHSSIYGKPVNEYSVEKLGEALDLKQIGETARDTGFEIYHQKGCTEYGIGGTIVE
ICRHIFSGSQRALTVSCVLDGEYGESGLAIGVPAVLSQNGVKEIISLKLDEKEKEAFANSVAVIKKSIQSI

Sequences:

>Translated_311_residues
MKPRKVMIIGAGNVGTAAAHAFVNQKFVEELILVDLNKERVEGNRKDLADAAAFMPGKMDITVRDASDCADVDIAVITVT
AGPLKEGQTRLDELRSTSRIVSSIVPEMMKGGFNGIFLIATNPCDIITYQVWKLSGLPRERVLGTGVWLDTTRLRRLLAE
KLDIAAQSIDAFILGEHGDSQFPVWSHSSIYGKPVNEYSVEKLGEALDLKQIGETARDTGFEIYHQKGCTEYGIGGTIVE
ICRHIFSGSQRALTVSCVLDGEYGESGLAIGVPAVLSQNGVKEIISLKLDEKEKEAFANSVAVIKKSIQSI
>Mature_311_residues
MKPRKVMIIGAGNVGTAAAHAFVNQKFVEELILVDLNKERVEGNRKDLADAAAFMPGKMDITVRDASDCADVDIAVITVT
AGPLKEGQTRLDELRSTSRIVSSIVPEMMKGGFNGIFLIATNPCDIITYQVWKLSGLPRERVLGTGVWLDTTRLRRLLAE
KLDIAAQSIDAFILGEHGDSQFPVWSHSSIYGKPVNEYSVEKLGEALDLKQIGETARDTGFEIYHQKGCTEYGIGGTIVE
ICRHIFSGSQRALTVSCVLDGEYGESGLAIGVPAVLSQNGVKEIISLKLDEKEKEAFANSVAVIKKSIQSI

Specific function: Unknown

COG id: COG0039

COG function: function code C; Malate/lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH/MDH superfamily. LDH family [H]

Homologues:

Organism=Homo sapiens, GI47059044, Length=301, Percent_Identity=32.890365448505, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI221136809, Length=301, Percent_Identity=32.890365448505, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI291575128, Length=313, Percent_Identity=32.5878594249201, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI4557032, Length=313, Percent_Identity=32.5878594249201, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI9257228, Length=300, Percent_Identity=33.6666666666667, Blast_Score=171, Evalue=8e-43,
Organism=Homo sapiens, GI4504973, Length=300, Percent_Identity=33.6666666666667, Blast_Score=171, Evalue=8e-43,
Organism=Homo sapiens, GI5031857, Length=312, Percent_Identity=31.0897435897436, Blast_Score=170, Evalue=1e-42,
Organism=Homo sapiens, GI260099723, Length=313, Percent_Identity=30.9904153354633, Blast_Score=170, Evalue=1e-42,
Organism=Homo sapiens, GI15082234, Length=301, Percent_Identity=32.890365448505, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI260099725, Length=189, Percent_Identity=35.4497354497354, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI260099727, Length=188, Percent_Identity=35.6382978723404, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI207028494, Length=229, Percent_Identity=31.8777292576419, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI103472011, Length=289, Percent_Identity=25.6055363321799, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI103472015, Length=183, Percent_Identity=28.4153005464481, Blast_Score=90, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17535107, Length=296, Percent_Identity=34.4594594594595, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI17136226, Length=306, Percent_Identity=32.3529411764706, Blast_Score=170, Evalue=1e-42,
Organism=Drosophila melanogaster, GI45550422, Length=309, Percent_Identity=27.831715210356, Blast_Score=156, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001557
- InterPro:   IPR011304
- InterPro:   IPR018177
- InterPro:   IPR022383
- InterPro:   IPR001236
- InterPro:   IPR015955
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02866 Ldh_1_C; PF00056 Ldh_1_N [H]

EC number: =1.1.1.27 [H]

Molecular weight: Translated: 33783; Mature: 33783

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS00064 L_LDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPRKVMIIGAGNVGTAAAHAFVNQKFVEELILVDLNKERVEGNRKDLADAAAFMPGKMD
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHCCCCEE
ITVRDASDCADVDIAVITVTAGPLKEGQTRLDELRSTSRIVSSIVPEMMKGGFNGIFLIA
EEEECCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
TNPCDIITYQVWKLSGLPRERVLGTGVWLDTTRLRRLLAEKLDIAAQSIDAFILGEHGDS
CCCCCEEEEEEEEECCCCHHHHEECCCEECHHHHHHHHHHHHHHHHHHCCEEEEECCCCC
QFPVWSHSSIYGKPVNEYSVEKLGEALDLKQIGETARDTGFEIYHQKGCTEYGIGGTIVE
CCCCCCCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHCCEEEEHHCCCCCCCCCHHHHH
ICRHIFSGSQRALTVSCVLDGEYGESGLAIGVPAVLSQNGVKEIISLKLDEKEKEAFANS
HHHHHHCCCCCEEEEEEEEECCCCCCCCEECCHHHHCCCCHHHHHHHHCCCHHHHHHHHH
VAVIKKSIQSI
HHHHHHHHHCC
>Mature Secondary Structure
MKPRKVMIIGAGNVGTAAAHAFVNQKFVEELILVDLNKERVEGNRKDLADAAAFMPGKMD
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHCCCCEE
ITVRDASDCADVDIAVITVTAGPLKEGQTRLDELRSTSRIVSSIVPEMMKGGFNGIFLIA
EEEECCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
TNPCDIITYQVWKLSGLPRERVLGTGVWLDTTRLRRLLAEKLDIAAQSIDAFILGEHGDS
CCCCCEEEEEEEEECCCCHHHHEECCCEECHHHHHHHHHHHHHHHHHHCCEEEEECCCCC
QFPVWSHSSIYGKPVNEYSVEKLGEALDLKQIGETARDTGFEIYHQKGCTEYGIGGTIVE
CCCCCCCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHCCEEEEHHCCCCCCCCCHHHHH
ICRHIFSGSQRALTVSCVLDGEYGESGLAIGVPAVLSQNGVKEIISLKLDEKEKEAFANS
HHHHHHCCCCCEEEEEEEEECCCCCCCCEECCHHHHCCCCHHHHHHHHCCCHHHHHHHHH
VAVIKKSIQSI
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]