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The map label for this gene is cymR [H]

Identifier: 226224116

GI number: 226224116

Start: 1531732

End: 1532154

Strand: Direct

Name: cymR [H]

Synonym: Lm4b_01525

Alternate gene names: 226224116

Gene position: 1531732-1532154 (Clockwise)

Preceding gene: 226224109

Following gene: 226224117

Centisome position: 52.59

GC content: 41.61

Gene sequence:

>423_bases
ATGAAGATTACAACAAAAGGTCGCTATGGCCTAACAATAACACTTGAACTCGCAAAAAGAATTGGTGATGGCCCAATTTC
TCTTCGTAGTATCGCCCAAGATAAAAATTTATCGGAACATTATTTAGAGCAGTTAATCGGTCCCCTTCGTAATGCAGGAA
TTGTTAAAAGTATCCGCGGGGCTCATGGTGGCTACGTTTTGAACGGCGATCCTGAAAAAATTACTGCAGGTGACATCATC
CGCACACTGGAAGGCCCGATTGTACTTGTCGAAAGTATGGAAGATGAAGAAGCTGCTCAGCGTGAATTATGGACACGAAT
GCGCAATGCTGTCCGTGACGTGTTAGATCAAACAACACTTGCTGACTTATTAAAACATTCTACGGATGCTGAACTATCGG
ATGGTTACATGTTTTATATTTAA

Upstream 100 bases:

>100_bases
TCTGTGCGTTCACCCACTTGTTTCCTTTGCCTTCTTTCTGTAATTCCGATATAATAGATGCGGTATAAGCGGTTTTGAAA
TTACTGGAGGTTAAATAAAA

Downstream 100 bases:

>100_bases
TGAAAAAAGCCTATTTTCGAATAGGCTTTTTATCTGCCATCGAAACGGAAAATACAGTCTATTATTATCTGATTATTCCG
AAATAAACATCAAAAGCAAA

Product: hypothetical protein

Products: NA

Alternate protein names: Cysteine metabolism repressor [H]

Number of amino acids: Translated: 140; Mature: 140

Protein sequence:

>140_residues
MKITTKGRYGLTITLELAKRIGDGPISLRSIAQDKNLSEHYLEQLIGPLRNAGIVKSIRGAHGGYVLNGDPEKITAGDII
RTLEGPIVLVESMEDEEAAQRELWTRMRNAVRDVLDQTTLADLLKHSTDAELSDGYMFYI

Sequences:

>Translated_140_residues
MKITTKGRYGLTITLELAKRIGDGPISLRSIAQDKNLSEHYLEQLIGPLRNAGIVKSIRGAHGGYVLNGDPEKITAGDII
RTLEGPIVLVESMEDEEAAQRELWTRMRNAVRDVLDQTTLADLLKHSTDAELSDGYMFYI
>Mature_140_residues
MKITTKGRYGLTITLELAKRIGDGPISLRSIAQDKNLSEHYLEQLIGPLRNAGIVKSIRGAHGGYVLNGDPEKITAGDII
RTLEGPIVLVESMEDEEAAQRELWTRMRNAVRDVLDQTTLADLLKHSTDAELSDGYMFYI

Specific function: Master repressor of cysteine metabolism in B.subtilis. Controls the expression of genes involved either in cysteine synthesis from sulfide (cysK), sulfonates (ssu), or methionine (mccAB) or in cystine uptake (tcyP). Activity of CymR is positively regulate

COG id: COG1959

COG function: function code K; Predicted transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH rrf2-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788880, Length=132, Percent_Identity=30.3030303030303, Blast_Score=72, Evalue=2e-14,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000944 [H]

Pfam domain/function: PF02082 Rrf2 [H]

EC number: NA

Molecular weight: Translated: 15554; Mature: 15554

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS01332 UPF0074

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKITTKGRYGLTITLELAKRIGDGPISLRSIAQDKNLSEHYLEQLIGPLRNAGIVKSIRG
CCCCCCCCCCEEEEHHHHHHCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHCC
AHGGYVLNGDPEKITAGDIIRTLEGPIVLVESMEDEEAAQRELWTRMRNAVRDVLDQTTL
CCCCEEECCCCCCCCHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ADLLKHSTDAELSDGYMFYI
HHHHHCCCCCCCCCCEEEEC
>Mature Secondary Structure
MKITTKGRYGLTITLELAKRIGDGPISLRSIAQDKNLSEHYLEQLIGPLRNAGIVKSIRG
CCCCCCCCCCEEEEHHHHHHCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHCC
AHGGYVLNGDPEKITAGDIIRTLEGPIVLVESMEDEEAAQRELWTRMRNAVRDVLDQTTL
CCCCEEECCCCCCCCHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ADLLKHSTDAELSDGYMFYI
HHHHHCCCCCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]