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The map label for this gene is aroE [H]

Identifier: 226224091

GI number: 226224091

Start: 1505234

End: 1506055

Strand: Reverse

Name: aroE [H]

Synonym: Lm4b_01500

Alternate gene names: 226224091

Gene position: 1506055-1505234 (Counterclockwise)

Preceding gene: 226224092

Following gene: 226224090

Centisome position: 51.71

GC content: 37.35

Gene sequence:

>822_bases
TTGGAAAAATATGTTGTTATCGGAAATCCTATTCGTCACTCGTTATCACCAGCTATGCAAAATCGGATTTTCCAAGAACT
TGGAATGAATGCGGAGTATAACTCTGTTTTAATAGAAGAAGACGCTTTTGAAACAGAAATCAAAAAATTAATGGATTCTG
GAGTGCGTGGATTTAATATTACAACACCATTTAAAGAGCGTATTTTACCATTTTTAGATGAATTAGAGGATCTTGCAGCA
GCTTCTGGCGCAGTGAATACTGTGCTAAAAAAAGAGGACAAATGGTACGGATTTAATACAGATGGCAAAGGCTACTTAGA
AGGATTAGAAGAAATCCGCTCAATTACAGAAGATGATTCTATTTTAATTACCGGTGCGGGTGGCGCAAGCAAGGCAATTT
ACCTAGCGCTTTCCACTCACACGGATGCTAAAATAACCGTTACTAATCGTACAACGGAAAAAGCGATAGAAATGACGAAA
GATAATGAAAATCATCACGCCGTCACACTAGAAGAAGCAGAAAAACAACTGGCTGATTTTACGATTATCATTCAAACAAC
ATCTATCGGTTTAGAAGCTTCCAAAAACAAAAGCCCAATTTCGCTGGCTAATGTAAAAAAAGGAACGATTTGTTCTGATA
TTATTTATAATCCAGCCGAAACAGCCTTTTTGAAAGAAGCAAAGAAAAATGGAGCTATTACCCAAAATGGCTTACCGATG
TTTGTTAATCAAGGGGCACTTGCCTTTGAAATATGGACTGGGATAAAACCAGAGCGATCACTGATGAAAGAAGCAGTACT
CGAACAATTAGGAGGAAACTAA

Upstream 100 bases:

>100_bases
ACAATTCCAGAAGGCGGCGCGAAAGTTACTGCGTGGGTTCCTGAAGGCGTGAGCGCAACTATCCGGACATCACTCGTTTA
AAACGAAGGAGGCCTGTCAT

Downstream 100 bases:

>100_bases
TGTTAACAGCTACACAAAAACGTTTTTTAAGAAAAGAAGCGCATAATATCCAACCTATTTTCCAAGTAGGAAAAGGAAGC
GTATTACCAAACTTAATTAT

Product: shikimate 5-dehydrogenase (AroD)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 273; Mature: 273

Protein sequence:

>273_residues
MEKYVVIGNPIRHSLSPAMQNRIFQELGMNAEYNSVLIEEDAFETEIKKLMDSGVRGFNITTPFKERILPFLDELEDLAA
ASGAVNTVLKKEDKWYGFNTDGKGYLEGLEEIRSITEDDSILITGAGGASKAIYLALSTHTDAKITVTNRTTEKAIEMTK
DNENHHAVTLEEAEKQLADFTIIIQTTSIGLEASKNKSPISLANVKKGTICSDIIYNPAETAFLKEAKKNGAITQNGLPM
FVNQGALAFEIWTGIKPERSLMKEAVLEQLGGN

Sequences:

>Translated_273_residues
MEKYVVIGNPIRHSLSPAMQNRIFQELGMNAEYNSVLIEEDAFETEIKKLMDSGVRGFNITTPFKERILPFLDELEDLAA
ASGAVNTVLKKEDKWYGFNTDGKGYLEGLEEIRSITEDDSILITGAGGASKAIYLALSTHTDAKITVTNRTTEKAIEMTK
DNENHHAVTLEEAEKQLADFTIIIQTTSIGLEASKNKSPISLANVKKGTICSDIIYNPAETAFLKEAKKNGAITQNGLPM
FVNQGALAFEIWTGIKPERSLMKEAVLEQLGGN
>Mature_273_residues
MEKYVVIGNPIRHSLSPAMQNRIFQELGMNAEYNSVLIEEDAFETEIKKLMDSGVRGFNITTPFKERILPFLDELEDLAA
ASGAVNTVLKKEDKWYGFNTDGKGYLEGLEEIRSITEDDSILITGAGGASKAIYLALSTHTDAKITVTNRTTEKAIEMTK
DNENHHAVTLEEAEKQLADFTIIIQTTSIGLEASKNKSPISLANVKKGTICSDIIYNPAETAFLKEAKKNGAITQNGLPM
FVNQGALAFEIWTGIKPERSLMKEAVLEQLGGN

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1789675, Length=275, Percent_Identity=37.0909090909091, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI1787983, Length=267, Percent_Identity=31.8352059925094, Blast_Score=129, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6320332, Length=295, Percent_Identity=29.8305084745763, Blast_Score=81, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151 [H]

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N [H]

EC number: =1.1.1.25 [H]

Molecular weight: Translated: 30018; Mature: 30018

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKYVVIGNPIRHSLSPAMQNRIFQELGMNAEYNSVLIEEDAFETEIKKLMDSGVRGFNI
CCCEEEECCCHHHHCCHHHHHHHHHHHCCCCCCCEEEEECHHHHHHHHHHHHCCCCCCCC
TTPFKERILPFLDELEDLAAASGAVNTVLKKEDKWYGFNTDGKGYLEGLEEIRSITEDDS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCC
ILITGAGGASKAIYLALSTHTDAKITVTNRTTEKAIEMTKDNENHHAVTLEEAEKQLADF
EEEEECCCCCCEEEEEEECCCCEEEEEECCCHHHHHHHHCCCCCCEEEEHHHHHHHHHCE
TIIIQTTSIGLEASKNKSPISLANVKKGTICSDIIYNPAETAFLKEAKKNGAITQNGLPM
EEEEEEEECCEECCCCCCCEEEECCCCCCCHHHHHCCCHHHHHHHHHHHCCCEECCCCCE
FVNQGALAFEIWTGIKPERSLMKEAVLEQLGGN
EEECCCEEEEEECCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MEKYVVIGNPIRHSLSPAMQNRIFQELGMNAEYNSVLIEEDAFETEIKKLMDSGVRGFNI
CCCEEEECCCHHHHCCHHHHHHHHHHHCCCCCCCEEEEECHHHHHHHHHHHHCCCCCCCC
TTPFKERILPFLDELEDLAAASGAVNTVLKKEDKWYGFNTDGKGYLEGLEEIRSITEDDS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCC
ILITGAGGASKAIYLALSTHTDAKITVTNRTTEKAIEMTKDNENHHAVTLEEAEKQLADF
EEEEECCCCCCEEEEEEECCCCEEEEEECCCHHHHHHHHCCCCCCEEEEHHHHHHHHHCE
TIIIQTTSIGLEASKNKSPISLANVKKGTICSDIIYNPAETAFLKEAKKNGAITQNGLPM
EEEEEEEECCEECCCCCCCEEEECCCCCCCHHHHHCCCHHHHHHHHHHHCCCEECCCCCE
FVNQGALAFEIWTGIKPERSLMKEAVLEQLGGN
EEECCCEEEEEECCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA