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The map label for this gene is era

Identifier: 226224063

GI number: 226224063

Start: 1479591

End: 1480496

Strand: Reverse

Name: era

Synonym: Lm4b_01472

Alternate gene names: 226224063

Gene position: 1480496-1479591 (Counterclockwise)

Preceding gene: 226224064

Following gene: 226224061

Centisome position: 50.83

GC content: 34.11

Gene sequence:

>906_bases
ATGAGTGAACCATTTAAATCAGGATTTGTAGCTATAGTTGGGCGGCCTAACGTTGGGAAATCAACTTTATTAAATCACAT
CATTGGCCAAAAAATTGCCATTATGAGTGATAAAGCTCAAACAACAAGAAATAAAGTACAAGGTGTTTATACAACAGATG
AATCACAAATTATTTTTATTGATACACCAGGTATACATAAACCAAAGCATAAATTAGGCGATTTCATGGTGAAGATTGCG
CTAAATACGTTCCAAGAAGTAGACTTAATTTATTTCGTAATCGACGCATCTACCGGATTTGGACGCGGAGATGAATTTAT
TATTGAAAAACTTAAAAACGTACAAACACCTGTTTTTCTTTTGATTAATAAGATTGATTTAATTGCTCCAGAAGATTTAT
TCAAGTTAATTGAACAGTACCGCGATTTGATGGACTTTGATGAGATTATTCCTATTTCAGCACTTCAAGGAAATAACGTG
CCTAACTTACTAGAACAAACGAATGCTAACTTAGAAATCGGACCAATGTATTATCCAAAAGATCAAATCACGGACCATCC
TGAGCGTTTCATCATCTCGGAGTTAATTCGTGAACAGGTTTTACAATTAACACGAGAAGAAGTTCCACATTCTGTAGCAG
TGGTTATTGAAGGAATTGAAAAAAACCCTAAAACAGAAAAACTTACAATCAATGCTACAATTATTGTAGAAAGAAGCACG
CAAAAAGGAATTATTATTGGTAAACAAGGTCAAATGCTAAAACAAATTGGTATGCGTGCTAGAAAAGAAATTGAACGCTT
ACTCGGCTCCAAAGTCTTCTTAGAAATTTGGGTAAAAGTTCAAAAAAACTGGCGCGATAAAGAGCATTATTTGCAAGATT
ATGGTTTCGACCGCGAAGAGTATTAA

Upstream 100 bases:

>100_bases
CGCCAGATATGCCAGTAATATTAACAAACTTAACAGGGAAAACAGCGACGGTAACGGTGAAAGAACTTTTACCAGGCGCA
TTCACATCGGAGGATATGTT

Downstream 100 bases:

>100_bases
AAAAGCATCTGGCGCACAATTGGGTTTGTGCGCCAGATGCTTTTAATTATTCTTTATTTGTAGTCCAGCTATAGTTATCA
TATTCTACATCATATGGTCC

Product: GTP-binding protein Era

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 301; Mature: 300

Protein sequence:

>301_residues
MSEPFKSGFVAIVGRPNVGKSTLLNHIIGQKIAIMSDKAQTTRNKVQGVYTTDESQIIFIDTPGIHKPKHKLGDFMVKIA
LNTFQEVDLIYFVIDASTGFGRGDEFIIEKLKNVQTPVFLLINKIDLIAPEDLFKLIEQYRDLMDFDEIIPISALQGNNV
PNLLEQTNANLEIGPMYYPKDQITDHPERFIISELIREQVLQLTREEVPHSVAVVIEGIEKNPKTEKLTINATIIVERST
QKGIIIGKQGQMLKQIGMRARKEIERLLGSKVFLEIWVKVQKNWRDKEHYLQDYGFDREEY

Sequences:

>Translated_301_residues
MSEPFKSGFVAIVGRPNVGKSTLLNHIIGQKIAIMSDKAQTTRNKVQGVYTTDESQIIFIDTPGIHKPKHKLGDFMVKIA
LNTFQEVDLIYFVIDASTGFGRGDEFIIEKLKNVQTPVFLLINKIDLIAPEDLFKLIEQYRDLMDFDEIIPISALQGNNV
PNLLEQTNANLEIGPMYYPKDQITDHPERFIISELIREQVLQLTREEVPHSVAVVIEGIEKNPKTEKLTINATIIVERST
QKGIIIGKQGQMLKQIGMRARKEIERLLGSKVFLEIWVKVQKNWRDKEHYLQDYGFDREEY
>Mature_300_residues
SEPFKSGFVAIVGRPNVGKSTLLNHIIGQKIAIMSDKAQTTRNKVQGVYTTDESQIIFIDTPGIHKPKHKLGDFMVKIAL
NTFQEVDLIYFVIDASTGFGRGDEFIIEKLKNVQTPVFLLINKIDLIAPEDLFKLIEQYRDLMDFDEIIPISALQGNNVP
NLLEQTNANLEIGPMYYPKDQITDHPERFIISELIREQVLQLTREEVPHSVAVVIEGIEKNPKTEKLTINATIIVERSTQ
KGIIIGKQGQMLKQIGMRARKEIERLLGSKVFLEIWVKVQKNWRDKEHYLQDYGFDREEY

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism [H]

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain [H]

Homologues:

Organism=Homo sapiens, GI24307899, Length=323, Percent_Identity=25.077399380805, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1788919, Length=292, Percent_Identity=40.7534246575342, Blast_Score=223, Evalue=1e-59,
Organism=Escherichia coli, GI87082120, Length=157, Percent_Identity=35.031847133758, Blast_Score=94, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24646434, Length=310, Percent_Identity=26.7741935483871, Blast_Score=103, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005662
- InterPro:   IPR006073
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 34524; Mature: 34392

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS50823 KH_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEPFKSGFVAIVGRPNVGKSTLLNHIIGQKIAIMSDKAQTTRNKVQGVYTTDESQIIFI
CCCCCCCCCEEEEECCCCCHHHHHHHHHCCEEEEECCHHHHHHHHCCEEEECCCCEEEEE
DTPGIHKPKHKLGDFMVKIALNTFQEVDLIYFVIDASTGFGRGDEFIIEKLKNVQTPVFL
ECCCCCCCHHHHHHHHHHHHHHHHHHCEEEEEEEECCCCCCCCHHHHHHHHHCCCCCHHH
LINKIDLIAPEDLFKLIEQYRDLMDFDEIIPISALQGNNVPNLLEQTNANLEIGPMYYPK
EEHHHHCCCHHHHHHHHHHHHHHHCHHHHCCCEECCCCCCCHHHHHCCCCEEECCEECCC
DQITDHPERFIISELIREQVLQLTREEVPHSVAVVIEGIEKNPKTEKLTINATIIVERST
HHCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCEEEEEEEEEEEECC
QKGIIIGKQGQMLKQIGMRARKEIERLLGSKVFLEIWVKVQKNWRDKEHYLQDYGFDREE
CCCEEECCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCC
Y
C
>Mature Secondary Structure 
SEPFKSGFVAIVGRPNVGKSTLLNHIIGQKIAIMSDKAQTTRNKVQGVYTTDESQIIFI
CCCCCCCCEEEEECCCCCHHHHHHHHHCCEEEEECCHHHHHHHHCCEEEECCCCEEEEE
DTPGIHKPKHKLGDFMVKIALNTFQEVDLIYFVIDASTGFGRGDEFIIEKLKNVQTPVFL
ECCCCCCCHHHHHHHHHHHHHHHHHHCEEEEEEEECCCCCCCCHHHHHHHHHCCCCCHHH
LINKIDLIAPEDLFKLIEQYRDLMDFDEIIPISALQGNNVPNLLEQTNANLEIGPMYYPK
EEHHHHCCCHHHHHHHHHHHHHHHCHHHHCCCEECCCCCCCHHHHHCCCCEEECCEECCC
DQITDHPERFIISELIREQVLQLTREEVPHSVAVVIEGIEKNPKTEKLTINATIIVERST
HHCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCEEEEEEEEEEEECC
QKGIIIGKQGQMLKQIGMRARKEIERLLGSKVFLEIWVKVQKNWRDKEHYLQDYGFDREE
CCCEEECCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCC
Y
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]