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The map label for this gene is prsA1 [H]

Identifier: 226224045

GI number: 226224045

Start: 1460742

End: 1461626

Strand: Reverse

Name: prsA1 [H]

Synonym: Lm4b_01454

Alternate gene names: 226224045

Gene position: 1461626-1460742 (Counterclockwise)

Preceding gene: 226224046

Following gene: 226224040

Centisome position: 50.18

GC content: 33.33

Gene sequence:

>885_bases
TTGACAAAATTAAAAAAAGTGATGATTTCCGTAATAGCAGCTACATTACTACTACTCGCTGGTTGTGGAAGCAGTGCTGT
TGTTAAAACAGATGCAGGAAGTGTCACACAAGATGAGCTTTACGAAGCGATGAAAACGACTTATGGAAATGAGGTCGTGC
AACAACTTACTTTCAAAAAAATCTTAGAAGATAAATACACCGTAACAGAAAAAGAAGTAAATGCAGAATACAAGAAATAT
GAAGAACAATACGGTGACTCATTTGAATCAACGTTATCCTCTAATAATTTAACAAAAACTTCTTTCAAAGAAAATTTAGA
GTATAATTTACTTGTTCAAAAAGCAACAGAAGCAAACATGAATGTAAGTGAAAGCAAGCTAAAAACCTACTACAAAACTT
GGGAACCAGATATTACTGTGCGCCATATTTTAGTAGACGATGAAGCTACAGCGAAAGAAATTCAAACGAAATTAAAAAAT
GGTGAAAAATTCACTGATTTAGCTAAAGAATATTCTACAGATACAGCAACTAGTACAAATGGTGGGCTTTTAGATCCATT
TGGTCCCGGTGAAATGGACGAAACATTTGAAAAAGCAGCCTATGCATTAGAAAATAAAGATGATGTAAGTGGCATTGTGA
AATCTACCTACGGATATCACTTGATCCAATTAGTGAAGAAAACAGAAAAAGGCACTTACGCTAAAGAAAAAGCAAACGTA
AAAGCCGCATATATTGAATCTCAATTAACCACAGAAAATATGACAGCTGCACTCAAAAAAGAGTTAAAAGCTGCTAATAT
TGATATTAAAGATAGTGATTTAAAAGATGCATTTGCAGATTACACAAGTACATCTTCAACAAGTTCCACAACAACATCTA
ACTAA

Upstream 100 bases:

>100_bases
TTATGCGTAATGTTCACAGTTATTTCATATTTGTTTCTTATTCTGGACACTTTTTATCGCTAAAGTAAGAAGTAGCCGAA
AGACGAAGGAGAGGAACAGT

Downstream 100 bases:

>100_bases
TATTACTTCGGATCCACCTATACAAAAAGCCCTTTACTGGTTTTGATTCCCGTCAAAAACACACTCCAGTAAAGGGCTTT
TCTATGCAAATAAACGAATC

Product: protein secretion PrsA (post-translocation molecular chaperone)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MTKLKKVMISVIAATLLLLAGCGSSAVVKTDAGSVTQDELYEAMKTTYGNEVVQQLTFKKILEDKYTVTEKEVNAEYKKY
EEQYGDSFESTLSSNNLTKTSFKENLEYNLLVQKATEANMNVSESKLKTYYKTWEPDITVRHILVDDEATAKEIQTKLKN
GEKFTDLAKEYSTDTATSTNGGLLDPFGPGEMDETFEKAAYALENKDDVSGIVKSTYGYHLIQLVKKTEKGTYAKEKANV
KAAYIESQLTTENMTAALKKELKAANIDIKDSDLKDAFADYTSTSSTSSTTTSN

Sequences:

>Translated_294_residues
MTKLKKVMISVIAATLLLLAGCGSSAVVKTDAGSVTQDELYEAMKTTYGNEVVQQLTFKKILEDKYTVTEKEVNAEYKKY
EEQYGDSFESTLSSNNLTKTSFKENLEYNLLVQKATEANMNVSESKLKTYYKTWEPDITVRHILVDDEATAKEIQTKLKN
GEKFTDLAKEYSTDTATSTNGGLLDPFGPGEMDETFEKAAYALENKDDVSGIVKSTYGYHLIQLVKKTEKGTYAKEKANV
KAAYIESQLTTENMTAALKKELKAANIDIKDSDLKDAFADYTSTSSTSSTTTSN
>Mature_293_residues
TKLKKVMISVIAATLLLLAGCGSSAVVKTDAGSVTQDELYEAMKTTYGNEVVQQLTFKKILEDKYTVTEKEVNAEYKKYE
EQYGDSFESTLSSNNLTKTSFKENLEYNLLVQKATEANMNVSESKLKTYYKTWEPDITVRHILVDDEATAKEIQTKLKNG
EKFTDLAKEYSTDTATSTNGGLLDPFGPGEMDETFEKAAYALENKDDVSGIVKSTYGYHLIQLVKKTEKGTYAKEKANVK
AAYIESQLTTENMTAALKKELKAANIDIKDSDLKDAFADYTSTSSTSSTTTSN

Specific function: Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins [H]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

None

Paralogues:

None

Copy number: 400 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023059
- InterPro:   IPR000297 [H]

Pfam domain/function: PF00639 Rotamase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 32600; Mature: 32469

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKLKKVMISVIAATLLLLAGCGSSAVVKTDAGSVTQDELYEAMKTTYGNEVVQQLTFKK
CCHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ILEDKYTVTEKEVNAEYKKYEEQYGDSFESTLSSNNLTKTSFKENLEYNLLVQKATEANM
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHCCCEEEEEEEHHCCCC
NVSESKLKTYYKTWEPDITVRHILVDDEATAKEIQTKLKNGEKFTDLAKEYSTDTATSTN
CCHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCC
GGLLDPFGPGEMDETFEKAAYALENKDDVSGIVKSTYGYHLIQLVKKTEKGTYAKEKANV
CCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCC
KAAYIESQLTTENMTAALKKELKAANIDIKDSDLKDAFADYTSTSSTSSTTTSN
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
TKLKKVMISVIAATLLLLAGCGSSAVVKTDAGSVTQDELYEAMKTTYGNEVVQQLTFKK
CHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ILEDKYTVTEKEVNAEYKKYEEQYGDSFESTLSSNNLTKTSFKENLEYNLLVQKATEANM
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHCCCEEEEEEEHHCCCC
NVSESKLKTYYKTWEPDITVRHILVDDEATAKEIQTKLKNGEKFTDLAKEYSTDTATSTN
CCHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCC
GGLLDPFGPGEMDETFEKAAYALENKDDVSGIVKSTYGYHLIQLVKKTEKGTYAKEKANV
CCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCC
KAAYIESQLTTENMTAALKKELKAANIDIKDSDLKDAFADYTSTSSTSSTTTSN
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]