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The map label for this gene is lisR

Identifier: 226223978

GI number: 226223978

Start: 1386256

End: 1386936

Strand: Direct

Name: lisR

Synonym: Lm4b_01386

Alternate gene names: 226223978

Gene position: 1386256-1386936 (Clockwise)

Preceding gene: 226223977

Following gene: 226223979

Centisome position: 47.59

GC content: 39.21

Gene sequence:

>681_bases
ATGAATAGAATATTAATCGTAGAAGATGAAAAAAACTTAGCACGCTTTATCGAACTCGAATTACAACATGAAAATTATGA
AACAGCGGTTGCTAATGATGGACGTGCTGGACTAGAACTCGCACTTAATGAAGAATGGGATGCTATTTTACTCGATCTAA
TGTTGCCGCATTTAAACGGTGTAGAAGTTTGTCGTCGTGTACGCCAAGTGAAACAAACACCCATTATTATGATAACCGCA
CGTGACTCAGTTATCGATCGTGTATCCGGACTGGATCACGGAGCAGATGATTACATCGTCAAACCCTTCGCTATTGAAGA
ATTACTTGCGCGCCTTCGCTCGCTATTGCGTCGGGTGGAAAATGCAGAACAATCTGCTAAACAAACAACGCTACAGTATC
GTAATCTAATTGTTGAAAAGGAAAATCGCATTGTCAAACGCGACGAAGAAATCATTGACTTAACAAAACGAGAGTATGAA
CTTTTACTTACGTTAATGGAAAATGTTAATATCGTTCTTACGCGGGAAGTGTTACTCAATAAAGTATGGGGTTATGAAAC
AGAAGTAGAAACAAATGTAGTGGATGTGTACGTTCGTTACTTACGAAATAAAATTGATCATCCTGACGAAGAAAGTTATA
TCCAAACAGTTCGCGGGACAGGGTATGTGATGCGTACATGA

Upstream 100 bases:

>100_bases
AATATCTATTTATGCGCTGTTATTAGTTGTTTTTGAGCTAAAGTTCGTTACAATAGTAATAGGAATATAGTGTAATGACC
GAAAGAGAGGGTTAGGCCAA

Downstream 100 bases:

>100_bases
CGACAAGCCCATTTTCCTTAAAAAGTCGTTCTTTGAAATTCAAATGGACTTTTGGAGCTAGTGCAGCTATTTTTCTAACT
TTTTTCTTATTTTCCTATGC

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 226; Mature: 226

Protein sequence:

>226_residues
MNRILIVEDEKNLARFIELELQHENYETAVANDGRAGLELALNEEWDAILLDLMLPHLNGVEVCRRVRQVKQTPIIMITA
RDSVIDRVSGLDHGADDYIVKPFAIEELLARLRSLLRRVENAEQSAKQTTLQYRNLIVEKENRIVKRDEEIIDLTKREYE
LLLTLMENVNIVLTREVLLNKVWGYETEVETNVVDVYVRYLRNKIDHPDEESYIQTVRGTGYVMRT

Sequences:

>Translated_226_residues
MNRILIVEDEKNLARFIELELQHENYETAVANDGRAGLELALNEEWDAILLDLMLPHLNGVEVCRRVRQVKQTPIIMITA
RDSVIDRVSGLDHGADDYIVKPFAIEELLARLRSLLRRVENAEQSAKQTTLQYRNLIVEKENRIVKRDEEIIDLTKREYE
LLLTLMENVNIVLTREVLLNKVWGYETEVETNVVDVYVRYLRNKIDHPDEESYIQTVRGTGYVMRT
>Mature_226_residues
MNRILIVEDEKNLARFIELELQHENYETAVANDGRAGLELALNEEWDAILLDLMLPHLNGVEVCRRVRQVKQTPIIMITA
RDSVIDRVSGLDHGADDYIVKPFAIEELLARLRSLLRRVENAEQSAKQTTLQYRNLIVEKENRIVKRDEEIIDLTKREYE
LLLTLMENVNIVLTREVLLNKVWGYETEVETNVVDVYVRYLRNKIDHPDEESYIQTVRGTGYVMRT

Specific function: Member of the two-component regulatory system ArlS/ArlR [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=41.3636363636364, Blast_Score=179, Evalue=2e-46,
Organism=Escherichia coli, GI1786784, Length=223, Percent_Identity=39.9103139013453, Blast_Score=162, Evalue=2e-41,
Organism=Escherichia coli, GI1786599, Length=228, Percent_Identity=36.8421052631579, Blast_Score=145, Evalue=2e-36,
Organism=Escherichia coli, GI1786911, Length=223, Percent_Identity=36.7713004484305, Blast_Score=144, Evalue=7e-36,
Organism=Escherichia coli, GI1789402, Length=223, Percent_Identity=35.8744394618834, Blast_Score=139, Evalue=1e-34,
Organism=Escherichia coli, GI1790552, Length=223, Percent_Identity=38.5650224215247, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI2367329, Length=229, Percent_Identity=37.117903930131, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1788394, Length=221, Percent_Identity=36.1990950226244, Blast_Score=134, Evalue=6e-33,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=34.8017621145374, Blast_Score=130, Evalue=9e-32,
Organism=Escherichia coli, GI1790860, Length=225, Percent_Identity=34.2222222222222, Blast_Score=120, Evalue=8e-29,
Organism=Escherichia coli, GI1787229, Length=227, Percent_Identity=33.4801762114537, Blast_Score=118, Evalue=3e-28,
Organism=Escherichia coli, GI1787375, Length=224, Percent_Identity=33.4821428571429, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1790863, Length=225, Percent_Identity=30.6666666666667, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI145693140, Length=233, Percent_Identity=30.0429184549356, Blast_Score=97, Evalue=8e-22,
Organism=Escherichia coli, GI1788550, Length=145, Percent_Identity=32.4137931034483, Blast_Score=83, Evalue=2e-17,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26420; Mature: 26420

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRILIVEDEKNLARFIELELQHENYETAVANDGRAGLELALNEEWDAILLDLMLPHLNG
CCCEEEEECCHHHHHHHHHEECCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCH
VEVCRRVRQVKQTPIIMITARDSVIDRVSGLDHGADDYIVKPFAIEELLARLRSLLRRVE
HHHHHHHHHHHCCCEEEEEECHHHHHHHHCCCCCCCCCEECHHHHHHHHHHHHHHHHHHH
NAEQSAKQTTLQYRNLIVEKENRIVKRDEEIIDLTKREYELLLTLMENVNIVLTREVLLN
HHHHHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHH
KVWGYETEVETNVVDVYVRYLRNKIDHPDEESYIQTVRGTGYVMRT
HHCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEEC
>Mature Secondary Structure
MNRILIVEDEKNLARFIELELQHENYETAVANDGRAGLELALNEEWDAILLDLMLPHLNG
CCCEEEEECCHHHHHHHHHEECCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCH
VEVCRRVRQVKQTPIIMITARDSVIDRVSGLDHGADDYIVKPFAIEELLARLRSLLRRVE
HHHHHHHHHHHCCCEEEEEECHHHHHHHHCCCCCCCCCEECHHHHHHHHHHHHHHHHHHH
NAEQSAKQTTLQYRNLIVEKENRIVKRDEEIIDLTKREYELLLTLMENVNIVLTREVLLN
HHHHHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHH
KVWGYETEVETNVVDVYVRYLRNKIDHPDEESYIQTVRGTGYVMRT
HHCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA