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The map label for this gene is xseA

Identifier: 226223962

GI number: 226223962

Start: 1368069

End: 1369421

Strand: Direct

Name: xseA

Synonym: Lm4b_01369

Alternate gene names: 226223962

Gene position: 1368069-1369421 (Clockwise)

Preceding gene: 226223961

Following gene: 226223963

Centisome position: 46.97

GC content: 38.95

Gene sequence:

>1353_bases
ATGGAGCAAGATAAATATTTGACGGTAGCAGCAATAACCAAATATATCGAAAAAAAGTTTGAAGTAGATCCCTACATGAA
GCAAGTTTTTGTGCGCGGTGAAATTTCTAATTTAAAACAACCAGCGAGTGGACATCTATATTTTACGGTAAAAGATGAAT
TTGCGATGCTTCGTTCTGTCATGTTTCACAAAGCAGTTCAAAAAATTGGTTTTGTCCCAGAAGATGGTATGAATGTCCTT
ATCACAGGACGAATTGGCGTATTTACAAAAGCTGGTCGCTATCAGTTCTATGCAGAACATATGGAACCAGATGGTGTCGG
AGCGCTTTATATTCAATTAGAGCAATTAAAATCGCAATTGGAAAAGGAAGGGCTTTTTGCGGAAACGCATAAAAAAGTGC
TTCCTTCTTTCCCGTCTAAAGTCGCTGTCGTTACGTCCAAAACTGGTGCAGCTGTTCGTGATATACTAACCACCATTCAT
CGAAGAATGCCTTCTGTGGAAGTGATTGTTTATCCAACTATTGTTCAAGGGGAGAAAGCGGCTCAAAAAATTGTCGAAAA
CATTGGCAAGATTAATCAGCGAAATGATATTGATGTTATGATTATTGGGCGTGGTGGTGGTTCGCTTGAAGAACTATGGG
CTTTTAATGAAGAACCTGTTGTTCGAGCAGTATATGATTCCGATGTACCTGTAATTTCAGCGGTCGGACATGAAACTGAT
TTTGCGTTAAGTGATTTTTCTGCAGATGTACGAGCCGCAACGCCAACTGCGGCGGCAGAACTTGCTGTTCCAGATTATCG
CGATTTAGAAGAACGATTAGCAGAACGTAAATACCGTTTGCTCGCAGTCACCAGACAAGCATTAGAAAGAAAAGAACGGT
CACTAGAGCAACTTAAACAACACTTGATTTTAAATGGTCCGAAACATCAATTAGAACAGCAAATGGAACGTACAGATTAT
TTTTCCGAACGATTAAATAATGCTTTTTCTAAACAAATATTTGTTAAGCAAACAGTTTTTGACCGATTAAATGATCGGCT
ACATTATTACCATCCGAATAAAGAAATTGAACTACAAAAAGAACAGATGGCACTACGACTTCAAGCATTAGAAAAAGCGA
TGAAACAACTTTTGAAAGACAAACAACAATCTTTCTTTCGGCAAATAGATGCGCTAGAACATCTGAGCCCTCTTTCTTTA
TTGAAACGAGGATTTGGTGTAACGTATAAAGAGAATATGCTGGTTAAATCAGTGCAGGAGCTTGAAGTCGGCGATAATAT
CCAAGTGAAAATGCAAGGCGGACAGATAGAGGCACTCATTACCGCGAAGGAGGAAGATATAAGTGGCAACTAA

Upstream 100 bases:

>100_bases
AGGTGGCGTTGGCCCGATGACAATCACAATGCTACTTGCGAACACATTAAAAGCAGCAAAACGCATTTGGAAAATGAATT
GATTAATTGGATGTGAAATG

Downstream 100 bases:

>100_bases
AAAGAAAACTTTTGAAGAAGCAATTGCAGAATTAGAAACAATCGTAGAAGCACTCGAAAATGGTAGTGCCTCACTTGAAG
ATTCTCTCGATATGTACCAA

Product: exodeoxyribonuclease VII large subunit

Products: NA

Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit [H]

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MEQDKYLTVAAITKYIEKKFEVDPYMKQVFVRGEISNLKQPASGHLYFTVKDEFAMLRSVMFHKAVQKIGFVPEDGMNVL
ITGRIGVFTKAGRYQFYAEHMEPDGVGALYIQLEQLKSQLEKEGLFAETHKKVLPSFPSKVAVVTSKTGAAVRDILTTIH
RRMPSVEVIVYPTIVQGEKAAQKIVENIGKINQRNDIDVMIIGRGGGSLEELWAFNEEPVVRAVYDSDVPVISAVGHETD
FALSDFSADVRAATPTAAAELAVPDYRDLEERLAERKYRLLAVTRQALERKERSLEQLKQHLILNGPKHQLEQQMERTDY
FSERLNNAFSKQIFVKQTVFDRLNDRLHYYHPNKEIELQKEQMALRLQALEKAMKQLLKDKQQSFFRQIDALEHLSPLSL
LKRGFGVTYKENMLVKSVQELEVGDNIQVKMQGGQIEALITAKEEDISGN

Sequences:

>Translated_450_residues
MEQDKYLTVAAITKYIEKKFEVDPYMKQVFVRGEISNLKQPASGHLYFTVKDEFAMLRSVMFHKAVQKIGFVPEDGMNVL
ITGRIGVFTKAGRYQFYAEHMEPDGVGALYIQLEQLKSQLEKEGLFAETHKKVLPSFPSKVAVVTSKTGAAVRDILTTIH
RRMPSVEVIVYPTIVQGEKAAQKIVENIGKINQRNDIDVMIIGRGGGSLEELWAFNEEPVVRAVYDSDVPVISAVGHETD
FALSDFSADVRAATPTAAAELAVPDYRDLEERLAERKYRLLAVTRQALERKERSLEQLKQHLILNGPKHQLEQQMERTDY
FSERLNNAFSKQIFVKQTVFDRLNDRLHYYHPNKEIELQKEQMALRLQALEKAMKQLLKDKQQSFFRQIDALEHLSPLSL
LKRGFGVTYKENMLVKSVQELEVGDNIQVKMQGGQIEALITAKEEDISGN
>Mature_450_residues
MEQDKYLTVAAITKYIEKKFEVDPYMKQVFVRGEISNLKQPASGHLYFTVKDEFAMLRSVMFHKAVQKIGFVPEDGMNVL
ITGRIGVFTKAGRYQFYAEHMEPDGVGALYIQLEQLKSQLEKEGLFAETHKKVLPSFPSKVAVVTSKTGAAVRDILTTIH
RRMPSVEVIVYPTIVQGEKAAQKIVENIGKINQRNDIDVMIIGRGGGSLEELWAFNEEPVVRAVYDSDVPVISAVGHETD
FALSDFSADVRAATPTAAAELAVPDYRDLEERLAERKYRLLAVTRQALERKERSLEQLKQHLILNGPKHQLEQQMERTDY
FSERLNNAFSKQIFVKQTVFDRLNDRLHYYHPNKEIELQKEQMALRLQALEKAMKQLLKDKQQSFFRQIDALEHLSPLSL
LKRGFGVTYKENMLVKSVQELEVGDNIQVKMQGGQIEALITAKEEDISGN

Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides [H]

COG id: COG1570

COG function: function code L; Exonuclease VII, large subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xseA family [H]

Homologues:

Organism=Escherichia coli, GI1788856, Length=418, Percent_Identity=39.9521531100478, Blast_Score=301, Evalue=6e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003753
- InterPro:   IPR020579
- InterPro:   IPR004365 [H]

Pfam domain/function: PF02601 Exonuc_VII_L; PF01336 tRNA_anti [H]

EC number: =3.1.11.6 [H]

Molecular weight: Translated: 51292; Mature: 51292

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQDKYLTVAAITKYIEKKFEVDPYMKQVFVRGEISNLKQPASGHLYFTVKDEFAMLRSV
CCCCCEEHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHCCCCCCCEEEEEECHHHHHHHHH
MFHKAVQKIGFVPEDGMNVLITGRIGVFTKAGRYQFYAEHMEPDGVGALYIQLEQLKSQL
HHHHHHHHHCCCCCCCCEEEEECCCEEEEECCCEEEEHHCCCCCCCEEEEEEHHHHHHHH
EKEGLFAETHKKVLPSFPSKVAVVTSKTGAAVRDILTTIHRRMPSVEVIVYPTIVQGEKA
HHCCCHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCEEEEEEEEEECCHHH
AQKIVENIGKINQRNDIDVMIIGRGGGSLEELWAFNEEPVVRAVYDSDVPVISAVGHETD
HHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHCCCCCCEEEEEECCCCCEEEECCCCCC
FALSDFSADVRAATPTAAAELAVPDYRDLEERLAERKYRLLAVTRQALERKERSLEQLKQ
CCHHHCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HLILNGPKHQLEQQMERTDYFSERLNNAFSKQIFVKQTVFDRLNDRLHYYHPNKEIELQK
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCEEECH
EQMALRLQALEKAMKQLLKDKQQSFFRQIDALEHLSPLSLLKRGFGVTYKENMLVKSVQE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHH
LEVGDNIQVKMQGGQIEALITAKEEDISGN
HCCCCCEEEEEECCEEEEEEEECCCCCCCC
>Mature Secondary Structure
MEQDKYLTVAAITKYIEKKFEVDPYMKQVFVRGEISNLKQPASGHLYFTVKDEFAMLRSV
CCCCCEEHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHCCCCCCCEEEEEECHHHHHHHHH
MFHKAVQKIGFVPEDGMNVLITGRIGVFTKAGRYQFYAEHMEPDGVGALYIQLEQLKSQL
HHHHHHHHHCCCCCCCCEEEEECCCEEEEECCCEEEEHHCCCCCCCEEEEEEHHHHHHHH
EKEGLFAETHKKVLPSFPSKVAVVTSKTGAAVRDILTTIHRRMPSVEVIVYPTIVQGEKA
HHCCCHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCEEEEEEEEEECCHHH
AQKIVENIGKINQRNDIDVMIIGRGGGSLEELWAFNEEPVVRAVYDSDVPVISAVGHETD
HHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHCCCCCCEEEEEECCCCCEEEECCCCCC
FALSDFSADVRAATPTAAAELAVPDYRDLEERLAERKYRLLAVTRQALERKERSLEQLKQ
CCHHHCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HLILNGPKHQLEQQMERTDYFSERLNNAFSKQIFVKQTVFDRLNDRLHYYHPNKEIELQK
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCEEECH
EQMALRLQALEKAMKQLLKDKQQSFFRQIDALEHLSPLSLLKRGFGVTYKENMLVKSVQE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHH
LEVGDNIQVKMQGGQIEALITAKEEDISGN
HCCCCCEEEEEECCEEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]