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The map label for this gene is gluP [H]

Identifier: 226223938

GI number: 226223938

Start: 1348357

End: 1349895

Strand: Direct

Name: gluP [H]

Synonym: Lm4b_01345

Alternate gene names: 226223938

Gene position: 1348357-1349895 (Clockwise)

Preceding gene: 226223937

Following gene: 226223939

Centisome position: 46.29

GC content: 36.13

Gene sequence:

>1539_bases
TTGAGCTTCCAAGAACAATATGTCTTCTGGCGCCTAACTAATTATTTCTTGGGTGTTGAAAAATACCGTTTAATCCATCT
TCACGAGGAGAAACAAGAACTTTGGTTGGAAAATACAAGCCAGAAAAAAAGACCAGTCATCCGTATACAGATGAAAGAAT
TAAGTTGGGCTAATGTGGTGGAACGCGATGTGACACACACTTTACACGTTACCGAAAATCTTCGTAAGCAAATGGGGCGC
TTGAAATTGCCTCTTGTGAATATTTATATAACACCATTTGAACCAATGGGTGATATTTCGCCTTTTTTTGGGCAGTCAAT
TGCTTCTCCAAATGAAAAAGTGAAATTAGAAAATATTTTACTCGCGAACGAACAAATGAGAGATCATCTAGACACACTCG
TTAAAACTTTAGAATTACCAGAAGAAGCATTTGTTCTTCCAAATGAAATAACGAAAGAGCTAGTAGCAAAAGAACGAGAG
CAAGTAATCTCGTATATTACTACTAAAGTAAATGAAGAACAAAAAGTTGCTAGGAATTCAAAACCAATAGTTACGTATAC
GTTCATTGGTCTTTTGGTTGTAGCGTTTTTGTGGCTTTCTTTCCAAGGTGGAACTACCAATTCATTTAACTTAATTAAAT
GGGGCGGGAAATTCAACCCACTTATATATGCTGGGGAATGGTGGCGCTTTATTTCACCGATTTTTCTTCATAGTGGATTA
ATGCATTTAGCTTCCAATGCAGTTATGCTTTATATTGTAGGTGCTTGGGCAGAGCGTATTTATGGTAAATGGCGATATGT
TCTAATTCTTCTCTTAGGAGGAATATGCGGAAACATAGCCAGTTTTGCATTAAATATGAATTTATCTGTTGGTGCAAGTA
CTGCAGTATTTGCAGTAATGGGCGCGTTACTTTATTTGGTTGTTTTAAAACCAAATCTTTATGCAAAAACAATTGGCGTC
AGTATCGCGTCACTTGTCGCAATTAATTTGTTAATTGATGTATTTTCTAGCCAGATTGATATTGCTGGACATATTGGTGG
TCTTGTAGGTGGTTTCTTGCTTGCCGGAGCATTATCGTTACCAAAACAATTTTTCCATTGGCGACGACTTGCATATGGCA
TTTCACTTTTTGGTGTAGCTGTTTTATTTTTGTATTTTGGCTACCAAAAAGGAGAACAACCATATGATCCGATGCAGGCT
AATGTAGCAGTACAACAATACCTTCAAGAACAAAATAAAAAAGAAGCAACCAAGATTACCGATAATTTAATTTCTAGCGG
AAGTGCTGACGGCTATTCATATACGTATGCTGCATCTATCGCTTTACAAGATAAGCAAATAGACAAAGCAGAAACAATGG
CTAAAGAAGCAATTAATATCGACAAAGACATCCCAGAAGCTCATTATTATTTATCTGTTTGCTATAGAGTAAAAGGCGAT
ATGCCAAATGCAATTAAAGAAGCGAACAGCGCTAGAGAGTTATCAAGCAATCCATTTTTTGATTCTTATTACGATGAGTT
AGAAAAAATCAAAGAATAA

Upstream 100 bases:

>100_bases
AAGGAAAAATAATTCTATAGAAAATAGGGTGGATTGTTTACAACACCCTTTTTTTTGCGTATAGTAGTAAATATAATTTG
TAATGAAAGCAGGGAATTTT

Downstream 100 bases:

>100_bases
GAGGTTTTTAATGTGAAAACAGTTTATGATGTTGCCCAATTACTAAGAAAGCATGGCATTATTGTTTATTTAGGAAAACG
ACAATATGACATCGAAATGA

Product: hypothetical protein

Products: NA

Alternate protein names: Intramembrane serine protease [H]

Number of amino acids: Translated: 512; Mature: 511

Protein sequence:

>512_residues
MSFQEQYVFWRLTNYFLGVEKYRLIHLHEEKQELWLENTSQKKRPVIRIQMKELSWANVVERDVTHTLHVTENLRKQMGR
LKLPLVNIYITPFEPMGDISPFFGQSIASPNEKVKLENILLANEQMRDHLDTLVKTLELPEEAFVLPNEITKELVAKERE
QVISYITTKVNEEQKVARNSKPIVTYTFIGLLVVAFLWLSFQGGTTNSFNLIKWGGKFNPLIYAGEWWRFISPIFLHSGL
MHLASNAVMLYIVGAWAERIYGKWRYVLILLLGGICGNIASFALNMNLSVGASTAVFAVMGALLYLVVLKPNLYAKTIGV
SIASLVAINLLIDVFSSQIDIAGHIGGLVGGFLLAGALSLPKQFFHWRRLAYGISLFGVAVLFLYFGYQKGEQPYDPMQA
NVAVQQYLQEQNKKEATKITDNLISSGSADGYSYTYAASIALQDKQIDKAETMAKEAINIDKDIPEAHYYLSVCYRVKGD
MPNAIKEANSARELSSNPFFDSYYDELEKIKE

Sequences:

>Translated_512_residues
MSFQEQYVFWRLTNYFLGVEKYRLIHLHEEKQELWLENTSQKKRPVIRIQMKELSWANVVERDVTHTLHVTENLRKQMGR
LKLPLVNIYITPFEPMGDISPFFGQSIASPNEKVKLENILLANEQMRDHLDTLVKTLELPEEAFVLPNEITKELVAKERE
QVISYITTKVNEEQKVARNSKPIVTYTFIGLLVVAFLWLSFQGGTTNSFNLIKWGGKFNPLIYAGEWWRFISPIFLHSGL
MHLASNAVMLYIVGAWAERIYGKWRYVLILLLGGICGNIASFALNMNLSVGASTAVFAVMGALLYLVVLKPNLYAKTIGV
SIASLVAINLLIDVFSSQIDIAGHIGGLVGGFLLAGALSLPKQFFHWRRLAYGISLFGVAVLFLYFGYQKGEQPYDPMQA
NVAVQQYLQEQNKKEATKITDNLISSGSADGYSYTYAASIALQDKQIDKAETMAKEAINIDKDIPEAHYYLSVCYRVKGD
MPNAIKEANSARELSSNPFFDSYYDELEKIKE
>Mature_511_residues
SFQEQYVFWRLTNYFLGVEKYRLIHLHEEKQELWLENTSQKKRPVIRIQMKELSWANVVERDVTHTLHVTENLRKQMGRL
KLPLVNIYITPFEPMGDISPFFGQSIASPNEKVKLENILLANEQMRDHLDTLVKTLELPEEAFVLPNEITKELVAKEREQ
VISYITTKVNEEQKVARNSKPIVTYTFIGLLVVAFLWLSFQGGTTNSFNLIKWGGKFNPLIYAGEWWRFISPIFLHSGLM
HLASNAVMLYIVGAWAERIYGKWRYVLILLLGGICGNIASFALNMNLSVGASTAVFAVMGALLYLVVLKPNLYAKTIGVS
IASLVAINLLIDVFSSQIDIAGHIGGLVGGFLLAGALSLPKQFFHWRRLAYGISLFGVAVLFLYFGYQKGEQPYDPMQAN
VAVQQYLQEQNKKEATKITDNLISSGSADGYSYTYAASIALQDKQIDKAETMAKEAINIDKDIPEAHYYLSVCYRVKGDM
PNAIKEANSARELSSNPFFDSYYDELEKIKE

Specific function: Rhomboid-type serine protease that catalyzes intramembrane proteolysis. Important for normal cell division and sporulation. May act as a glucose exporter [H]

COG id: COG0705

COG function: function code R; Uncharacterized membrane protein (homolog of Drosophila rhomboid)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 2 TPR repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002610
- InterPro:   IPR022764
- InterPro:   IPR001440
- InterPro:   IPR013026
- InterPro:   IPR011990
- InterPro:   IPR019734 [H]

Pfam domain/function: PF01694 Rhomboid; PF00515 TPR_1 [H]

EC number: =3.4.21.105 [H]

Molecular weight: Translated: 58035; Mature: 57904

Theoretical pI: Translated: 7.36; Mature: 7.36

Prosite motif: PS50293 TPR_REGION

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFQEQYVFWRLTNYFLGVEKYRLIHLHEEKQELWLENTSQKKRPVIRIQMKELSWANVV
CCCCHHHHHHHHHHHHHCHHHEEEEEEECHHHHHHHCCCCCCCCCEEEEEEHHCCHHHHH
ERDVTHTLHVTENLRKQMGRLKLPLVNIYITPFEPMGDISPFFGQSIASPNEKVKLENIL
HHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCHHHHHHHCCCCCCEEHHHHH
LANEQMRDHLDTLVKTLELPEEAFVLPNEITKELVAKEREQVISYITTKVNEEQKVARNS
HHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCC
KPIVTYTFIGLLVVAFLWLSFQGGTTNSFNLIKWGGKFNPLIYAGEWWRFISPIFLHSGL
CCEEHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCEEECCCHHHHHHHHHHHHHH
MHLASNAVMLYIVGAWAERIYGKWRYVLILLLGGICGNIASFALNMNLSVGASTAVFAVM
HHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHH
GALLYLVVLKPNLYAKTIGVSIASLVAINLLIDVFSSQIDIAGHIGGLVGGFLLAGALSL
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
PKQFFHWRRLAYGISLFGVAVLFLYFGYQKGEQPYDPMQANVAVQQYLQEQNKKEATKIT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
DNLISSGSADGYSYTYAASIALQDKQIDKAETMAKEAINIDKDIPEAHYYLSVCYRVKGD
HHHHHCCCCCCCEEEEEEEEEECCHHCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCC
MPNAIKEANSARELSSNPFFDSYYDELEKIKE
CCHHHHHCCHHHHCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
SFQEQYVFWRLTNYFLGVEKYRLIHLHEEKQELWLENTSQKKRPVIRIQMKELSWANVV
CCCHHHHHHHHHHHHHCHHHEEEEEEECHHHHHHHCCCCCCCCCEEEEEEHHCCHHHHH
ERDVTHTLHVTENLRKQMGRLKLPLVNIYITPFEPMGDISPFFGQSIASPNEKVKLENIL
HHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCHHHHHHHCCCCCCEEHHHHH
LANEQMRDHLDTLVKTLELPEEAFVLPNEITKELVAKEREQVISYITTKVNEEQKVARNS
HHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCC
KPIVTYTFIGLLVVAFLWLSFQGGTTNSFNLIKWGGKFNPLIYAGEWWRFISPIFLHSGL
CCEEHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCEEECCCHHHHHHHHHHHHHH
MHLASNAVMLYIVGAWAERIYGKWRYVLILLLGGICGNIASFALNMNLSVGASTAVFAVM
HHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHH
GALLYLVVLKPNLYAKTIGVSIASLVAINLLIDVFSSQIDIAGHIGGLVGGFLLAGALSL
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
PKQFFHWRRLAYGISLFGVAVLFLYFGYQKGEQPYDPMQANVAVQQYLQEQNKKEATKIT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
DNLISSGSADGYSYTYAASIALQDKQIDKAETMAKEAINIDKDIPEAHYYLSVCYRVKGD
HHHHHCCCCCCCEEEEEEEEEECCHHCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCC
MPNAIKEANSARELSSNPFFDSYYDELEKIKE
CCHHHHHCCHHHHCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]