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The map label for this gene is clpX

Identifier: 226223871

GI number: 226223871

Start: 1278030

End: 1279289

Strand: Direct

Name: clpX

Synonym: Lm4b_01278

Alternate gene names: 226223871

Gene position: 1278030-1279289 (Clockwise)

Preceding gene: 226223870

Following gene: 226223872

Centisome position: 43.88

GC content: 37.14

Gene sequence:

>1260_bases
TTGTTTAAATTTAACGACGAAAAAGGCCAACTTAAATGCTCCTTTTGCGGAAAGACTCAAGATCAAGTACGTAAATTAGT
GGCCGGTCCAGGTGTTTATATTTGTGATGAATGTATCGAGCTTTGTAATGAAATTATTGAAGAAGAGCTAGGTATTTCTG
AATTTGTTGATTTTGGTGAAGTACCAAAACCTCAAGAAATCCGTCATATATTAAGTGACTATGTTATTGGTCAAGAACGT
GCTAAAAAAGCACTTGCTGTAGCAGTTTACAATCACTACAAACGTATTAATTCCAATGAAACGAAAGAAGATGAAGTAGA
ACTTTCGAAAAGTAACATTTGTCTAATTGGTCCAACTGGTAGTGGTAAAACACTTCTTGCTCAAACATTAGCGCGAATTC
TCAATGTTCCATTTGCTATTGCAGATGCGACTTCACTTACAGAAGCTGGTTACGTTGGGGAAGATGTAGAAAATATTCTT
CTTAAACTGATTCAATCAGCAGATTACGATGTGGAAAAAGCCGAAAAAGGTATTATCTATATTGACGAAATTGACAAAGT
TGCTCGCAAATCCGAAAACCCATCTATTACTAGAGACGTTTCCGGTGAAGGCGTACAACAAGCGCTACTGAAAATTTTGG
AAGGTACTGTCGCAAGCGTTCCTCCTCAAGGCGGTAGAAAACATCCTCATCAAGAGTTAATTCAAATTGATACAGGAAAT
ATTCTATTTATCGTTGGTGGAGCTTTTGATGGAATCGAACAAATCGTTAAAAATCGAATGGGTGAAAAAGTCATTGGCTT
TGGCACAGATAATGCGAAATTAAAAGATGATGAAACTTATTTATCTCGCGTTGTTCCAGAAGATTTACTGAAATTCGGTT
TAATTCCTGAATTTATCGGCCGTTTACCGGTTATAGCAACGCTTGAACAATTAGATGAAGCTGCGCTTGTTTCCATTTTG
ACAGAACCGAAGAATGCTTTAGTAAAACAATACAAACGTATGTTAGAGCTTGATGATGTAGAACTTGAATTCGAACCAAC
TGCTCTAATTGAAATTGCGAAAGAAGCGATTGAACGCAAAACCGGAGCGCGTGGTCTTCGTTCGATTATCGAACAGATTA
TGCTTGAAGTGATGTTCGAAATTCCTTCTCGTGATGACATTACGAAGTGTATAATTACTGAAAAAGCAGCTCGTGGTGAA
GAAGAACCGCAACTGCAATTAGAAGATGGTTCTATTATTCCAATTAAAACATCTGCATGA

Upstream 100 bases:

>100_bases
GATGATTGGCATTTCTAATAAACAAATGATATTATTAACACACATAGGAGATGAAAAAATCGCCTATAAGCAACATACCT
ATGCGAAGGGGTGAAATATT

Downstream 100 bases:

>100_bases
TTAGAATGCGCGTCGTAATTGGCGCGCATTTTTTCTATCAAACCAGCTTGTTTTACTGTAATATCTGACTTGTTTCGTGC
TATACTTTATTAATATTAAT

Product: ATP-dependent protease ATP-binding subunit ClpX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MFKFNDEKGQLKCSFCGKTQDQVRKLVAGPGVYICDECIELCNEIIEEELGISEFVDFGEVPKPQEIRHILSDYVIGQER
AKKALAVAVYNHYKRINSNETKEDEVELSKSNICLIGPTGSGKTLLAQTLARILNVPFAIADATSLTEAGYVGEDVENIL
LKLIQSADYDVEKAEKGIIYIDEIDKVARKSENPSITRDVSGEGVQQALLKILEGTVASVPPQGGRKHPHQELIQIDTGN
ILFIVGGAFDGIEQIVKNRMGEKVIGFGTDNAKLKDDETYLSRVVPEDLLKFGLIPEFIGRLPVIATLEQLDEAALVSIL
TEPKNALVKQYKRMLELDDVELEFEPTALIEIAKEAIERKTGARGLRSIIEQIMLEVMFEIPSRDDITKCIITEKAARGE
EEPQLQLEDGSIIPIKTSA

Sequences:

>Translated_419_residues
MFKFNDEKGQLKCSFCGKTQDQVRKLVAGPGVYICDECIELCNEIIEEELGISEFVDFGEVPKPQEIRHILSDYVIGQER
AKKALAVAVYNHYKRINSNETKEDEVELSKSNICLIGPTGSGKTLLAQTLARILNVPFAIADATSLTEAGYVGEDVENIL
LKLIQSADYDVEKAEKGIIYIDEIDKVARKSENPSITRDVSGEGVQQALLKILEGTVASVPPQGGRKHPHQELIQIDTGN
ILFIVGGAFDGIEQIVKNRMGEKVIGFGTDNAKLKDDETYLSRVVPEDLLKFGLIPEFIGRLPVIATLEQLDEAALVSIL
TEPKNALVKQYKRMLELDDVELEFEPTALIEIAKEAIERKTGARGLRSIIEQIMLEVMFEIPSRDDITKCIITEKAARGE
EEPQLQLEDGSIIPIKTSA
>Mature_419_residues
MFKFNDEKGQLKCSFCGKTQDQVRKLVAGPGVYICDECIELCNEIIEEELGISEFVDFGEVPKPQEIRHILSDYVIGQER
AKKALAVAVYNHYKRINSNETKEDEVELSKSNICLIGPTGSGKTLLAQTLARILNVPFAIADATSLTEAGYVGEDVENIL
LKLIQSADYDVEKAEKGIIYIDEIDKVARKSENPSITRDVSGEGVQQALLKILEGTVASVPPQGGRKHPHQELIQIDTGN
ILFIVGGAFDGIEQIVKNRMGEKVIGFGTDNAKLKDDETYLSRVVPEDLLKFGLIPEFIGRLPVIATLEQLDEAALVSIL
TEPKNALVKQYKRMLELDDVELEFEPTALIEIAKEAIERKTGARGLRSIIEQIMLEVMFEIPSRDDITKCIITEKAARGE
EEPQLQLEDGSIIPIKTSA

Specific function: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP [H]

COG id: COG1219

COG function: function code O; ATP-dependent protease Clp, ATPase subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family [H]

Homologues:

Organism=Homo sapiens, GI7242140, Length=331, Percent_Identity=48.036253776435, Blast_Score=308, Evalue=5e-84,
Organism=Escherichia coli, GI1786642, Length=410, Percent_Identity=62.1951219512195, Blast_Score=511, Evalue=1e-146,
Organism=Escherichia coli, GI1790366, Length=104, Percent_Identity=43.2692307692308, Blast_Score=92, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI71982908, Length=339, Percent_Identity=44.8377581120944, Blast_Score=284, Evalue=6e-77,
Organism=Caenorhabditis elegans, GI71982905, Length=339, Percent_Identity=44.8377581120944, Blast_Score=283, Evalue=1e-76,
Organism=Caenorhabditis elegans, GI71988663, Length=400, Percent_Identity=39.75, Blast_Score=263, Evalue=1e-70,
Organism=Caenorhabditis elegans, GI71988660, Length=254, Percent_Identity=39.7637795275591, Blast_Score=173, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6319704, Length=437, Percent_Identity=36.3844393592677, Blast_Score=254, Evalue=2e-68,
Organism=Drosophila melanogaster, GI24648291, Length=325, Percent_Identity=47.3846153846154, Blast_Score=297, Evalue=8e-81,
Organism=Drosophila melanogaster, GI24648289, Length=325, Percent_Identity=47.3846153846154, Blast_Score=297, Evalue=1e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR019489
- InterPro:   IPR004487
- InterPro:   IPR010603 [H]

Pfam domain/function: PF07724 AAA_2; PF10431 ClpB_D2-small; PF06689 zf-C4_ClpX [H]

EC number: NA

Molecular weight: Translated: 46399; Mature: 46399

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKFNDEKGQLKCSFCGKTQDQVRKLVAGPGVYICDECIELCNEIIEEELGISEFVDFGE
CCCCCCCCCCEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHCCC
VPKPQEIRHILSDYVIGQERAKKALAVAVYNHYKRINSNETKEDEVELSKSNICLIGPTG
CCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCEEEEECCC
SGKTLLAQTLARILNVPFAIADATSLTEAGYVGEDVENILLKLIQSADYDVEKAEKGIIY
CCHHHHHHHHHHHHCCCHHHHCCHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHCCCEEE
IDEIDKVARKSENPSITRDVSGEGVQQALLKILEGTVASVPPQGGRKHPHQELIQIDTGN
EHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCHHHCCCCCCCCCCCHHHHEEECCCC
ILFIVGGAFDGIEQIVKNRMGEKVIGFGTDNAKLKDDETYLSRVVPEDLLKFGLIPEFIG
EEEEECCCHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHCHHHHHHHCCCHHHHC
RLPVIATLEQLDEAALVSILTEPKNALVKQYKRMLELDDVELEFEPTALIEIAKEAIERK
CCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHH
TGARGLRSIIEQIMLEVMFEIPSRDDITKCIITEKAARGEEEPQLQLEDGSIIPIKTSA
HCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCEEECCCCEEEEECCC
>Mature Secondary Structure
MFKFNDEKGQLKCSFCGKTQDQVRKLVAGPGVYICDECIELCNEIIEEELGISEFVDFGE
CCCCCCCCCCEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHCCC
VPKPQEIRHILSDYVIGQERAKKALAVAVYNHYKRINSNETKEDEVELSKSNICLIGPTG
CCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCEEEEECCC
SGKTLLAQTLARILNVPFAIADATSLTEAGYVGEDVENILLKLIQSADYDVEKAEKGIIY
CCHHHHHHHHHHHHCCCHHHHCCHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHCCCEEE
IDEIDKVARKSENPSITRDVSGEGVQQALLKILEGTVASVPPQGGRKHPHQELIQIDTGN
EHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCHHHCCCCCCCCCCCHHHHEEECCCC
ILFIVGGAFDGIEQIVKNRMGEKVIGFGTDNAKLKDDETYLSRVVPEDLLKFGLIPEFIG
EEEEECCCHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHCHHHHHHHCCCHHHHC
RLPVIATLEQLDEAALVSILTEPKNALVKQYKRMLELDDVELEFEPTALIEIAKEAIERK
CCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHH
TGARGLRSIIEQIMLEVMFEIPSRDDITKCIITEKAARGEEEPQLQLEDGSIIPIKTSA
HCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCEEECCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]