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The map label for this gene is pbpC [H]

Identifier: 226223072

GI number: 226223072

Start: 479119

End: 481155

Strand: Reverse

Name: pbpC [H]

Synonym: Lm4b_00468

Alternate gene names: 226223072

Gene position: 481155-479119 (Counterclockwise)

Preceding gene: 226223075

Following gene: 226223070

Centisome position: 16.52

GC content: 40.99

Gene sequence:

>2037_bases
ATGGCTAGTTATGGTGGGAAAAAGAGGAATAACAAAAAAGCAATTATCATTGGAAGCATTGCCGCTGTTGTCGTCCTCGC
AGGCATTGCCATTTACTTTTTCATTCAAAATCAACACAAAGATGAAAAAAATGCTTTAGCAGCCGCAGAAACTTTTACAT
CAAATATCGCTAAAGAAAAGTACGACAAGTTGGGAAGTAGCGTCTCAAGTGAATCCTTGAAAAAAGTCGAATTTACAAAG
AAAGAAATGGAAGATAAGTATCAAGCTGTTTACGACGGGATTGGCGCAAAAGATATTAAAGTAAAAAATCTAAAATCTGT
CTATGATGACAAAGAAAACAAATTCAACTTAACATACGAACTAGAAATGCGGACTAGCCTCGGGAAACTCGCTACACAAA
AATACAAAACGACTATTTCCAAGCAAGATGATGACTGGAAAATCGACTGGAAACCAGCTCTCATTTTCCCCGGAATGGTG
AAAACAGATAAGGTGCGCATCACGGAAGACGAAGTAGAGCGTGGTCAAATAGTGGACAGAAATGGTAATCCACTCGCGAC
TACTGGTCAATTTGCCGAAGCTGGTGTAGTGCCTTCGAAGCTTGGTGAAGGCGACGAGAAAGTGAAAAACATTGCGGATA
TTAGCAAAAAACTAGAAGTCTCCACTGATTACATCAACAAACAGCTCGATCAAAAATGGGTCCAAGCAGATAGCTTCGTT
CCTTTAGTTACATTGAATAAAGATAATCTACCTGAGGCTACTGGACTTACGTATGCTCAAAAAGAAATGAGGACGTACCC
ATTAAATGAAGCAACCTCGCATTTGATTGGCTATGTCGGTGAAGTTAGCGCCGAAGACATTGAAAAAAATCCAAAACTCA
GCGTTGGCGATGTCATTGGGAAAAGTGGCTTAGAACGTTACTATGACAAACAACTGCGCGGTAAAAATGGTGGCGCAATT
AAAATCATCAATGACCAAACCAAGCAAGAAGATACTTTACAAAAAATCGATAAAAAAGATGGCGAAGAAATTAAACTAAC
GATTGATGCAGCCGTTCAGAAGAAAGCTTTTGATAGCCTCGGTTCCGAAACTGGCGCTGTGACCATGATTAATCCGACAA
ATGGCGAACTATTAGCGTTAGTGAGCACCCCTTCTTATGATGCCAACCAAATGGTGCTCGGGATCACTTCCGAAGATTAC
GCAAAATATAATGACGACAAACGCCTACCTTTCCTAGCAAGATACGCAAATCGTTACGCACCAGGCTCTACCTTTAAAAC
AATTACAGCCACAATTGGGCTGGACACTGGCGTTACAAAACCCGACAAAGTCCGTGAAATTTCTGGCTTACAGTGGCAAA
AAGATGCTTCATGGGGCAAGTATTTTGTCACTCGTGTCCATGATGTTCCAAAAGTAAATATGACGGATGCGCTTGTGCAC
TCTGATAACATTTACTTCGCTCAAGAAGGTCTAGAAATCGGCAAAGATAAACTAACTGCTGGCTTGAAAAAATTCGATTT
TGATAAGGAATATAACTTACCTTTCACAATGAAACCAGCACAAATTTCGAATGATGGGCTGAACTCGGAAATATTACTAG
CTGACACATCTTACGGACAAGGTGAATTACTGATGTCGCCAATTCAACAAGCGATTGCATACTCGGCCATTGCAAGCGAC
GGAAAAATGCCTTATCCAAAACTAGATACAAAAGAAAAAGCTGGCAAGGAAACACAAGCAACCGAAGCCGCTTCTGCCAA
CCAAGTCAAAGCAGCTTTAGTCAAAACTGTTTCTGATCCAGCTGGTACAGCACACGCCCTACAAATCCAAGGTCATAGTA
TCGCAGCCAAAACCGGTACAGCCGAACTAAAAGAAAAACAAGGCGAAGATGGCCTTGAAAATGGTTTTGTTTACGCCTTC
GATGCCGACAATCCCAATTACCTCATGGTAGGAATGATTGAAAACGTCAAAGGTCGCGGTGGTAGCGGACTTGTAATTGA
TAAGCTAAAACCAGTTATTGAAAGTATGTATAAATAA

Upstream 100 bases:

>100_bases
AATATGTCGGGCAAATCTAAAGTTTTCTTTAATTTTTTCAACTTTTTTAGAAGTGTTTGGTATAATTAATTGAATATAAC
ATGAAATTAAGGGGTGTATT

Downstream 100 bases:

>100_bases
AAAAGAGCCATTCTGTTCGCGAACAGAATGGCTCTTTTTTGTTAACTTTCATGGGTTAATTCAGTAATTTCTCCTTTTGT
ATTAAAACGAACAACTAAAA

Product: D-alanyl-D-alanine carboxypeptidase

Products: NA

Alternate protein names: PBP 3; PSPB20; Penicillin-binding protein C [H]

Number of amino acids: Translated: 678; Mature: 677

Protein sequence:

>678_residues
MASYGGKKRNNKKAIIIGSIAAVVVLAGIAIYFFIQNQHKDEKNALAAAETFTSNIAKEKYDKLGSSVSSESLKKVEFTK
KEMEDKYQAVYDGIGAKDIKVKNLKSVYDDKENKFNLTYELEMRTSLGKLATQKYKTTISKQDDDWKIDWKPALIFPGMV
KTDKVRITEDEVERGQIVDRNGNPLATTGQFAEAGVVPSKLGEGDEKVKNIADISKKLEVSTDYINKQLDQKWVQADSFV
PLVTLNKDNLPEATGLTYAQKEMRTYPLNEATSHLIGYVGEVSAEDIEKNPKLSVGDVIGKSGLERYYDKQLRGKNGGAI
KIINDQTKQEDTLQKIDKKDGEEIKLTIDAAVQKKAFDSLGSETGAVTMINPTNGELLALVSTPSYDANQMVLGITSEDY
AKYNDDKRLPFLARYANRYAPGSTFKTITATIGLDTGVTKPDKVREISGLQWQKDASWGKYFVTRVHDVPKVNMTDALVH
SDNIYFAQEGLEIGKDKLTAGLKKFDFDKEYNLPFTMKPAQISNDGLNSEILLADTSYGQGELLMSPIQQAIAYSAIASD
GKMPYPKLDTKEKAGKETQATEAASANQVKAALVKTVSDPAGTAHALQIQGHSIAAKTGTAELKEKQGEDGLENGFVYAF
DADNPNYLMVGMIENVKGRGGSGLVIDKLKPVIESMYK

Sequences:

>Translated_678_residues
MASYGGKKRNNKKAIIIGSIAAVVVLAGIAIYFFIQNQHKDEKNALAAAETFTSNIAKEKYDKLGSSVSSESLKKVEFTK
KEMEDKYQAVYDGIGAKDIKVKNLKSVYDDKENKFNLTYELEMRTSLGKLATQKYKTTISKQDDDWKIDWKPALIFPGMV
KTDKVRITEDEVERGQIVDRNGNPLATTGQFAEAGVVPSKLGEGDEKVKNIADISKKLEVSTDYINKQLDQKWVQADSFV
PLVTLNKDNLPEATGLTYAQKEMRTYPLNEATSHLIGYVGEVSAEDIEKNPKLSVGDVIGKSGLERYYDKQLRGKNGGAI
KIINDQTKQEDTLQKIDKKDGEEIKLTIDAAVQKKAFDSLGSETGAVTMINPTNGELLALVSTPSYDANQMVLGITSEDY
AKYNDDKRLPFLARYANRYAPGSTFKTITATIGLDTGVTKPDKVREISGLQWQKDASWGKYFVTRVHDVPKVNMTDALVH
SDNIYFAQEGLEIGKDKLTAGLKKFDFDKEYNLPFTMKPAQISNDGLNSEILLADTSYGQGELLMSPIQQAIAYSAIASD
GKMPYPKLDTKEKAGKETQATEAASANQVKAALVKTVSDPAGTAHALQIQGHSIAAKTGTAELKEKQGEDGLENGFVYAF
DADNPNYLMVGMIENVKGRGGSGLVIDKLKPVIESMYK
>Mature_677_residues
ASYGGKKRNNKKAIIIGSIAAVVVLAGIAIYFFIQNQHKDEKNALAAAETFTSNIAKEKYDKLGSSVSSESLKKVEFTKK
EMEDKYQAVYDGIGAKDIKVKNLKSVYDDKENKFNLTYELEMRTSLGKLATQKYKTTISKQDDDWKIDWKPALIFPGMVK
TDKVRITEDEVERGQIVDRNGNPLATTGQFAEAGVVPSKLGEGDEKVKNIADISKKLEVSTDYINKQLDQKWVQADSFVP
LVTLNKDNLPEATGLTYAQKEMRTYPLNEATSHLIGYVGEVSAEDIEKNPKLSVGDVIGKSGLERYYDKQLRGKNGGAIK
IINDQTKQEDTLQKIDKKDGEEIKLTIDAAVQKKAFDSLGSETGAVTMINPTNGELLALVSTPSYDANQMVLGITSEDYA
KYNDDKRLPFLARYANRYAPGSTFKTITATIGLDTGVTKPDKVREISGLQWQKDASWGKYFVTRVHDVPKVNMTDALVHS
DNIYFAQEGLEIGKDKLTAGLKKFDFDKEYNLPFTMKPAQISNDGLNSEILLADTSYGQGELLMSPIQQAIAYSAIASDG
KMPYPKLDTKEKAGKETQATEAASANQVKAALVKTVSDPAGTAHALQIQGHSIAAKTGTAELKEKQGEDGLENGFVYAFD
ADNPNYLMVGMIENVKGRGGSGLVIDKLKPVIESMYK

Specific function: Cell Wall Formation; Pbp-2 Is Responsible For The Determination Of The Rod Shape Of The Cell. Its Synthesize Cross- Linked Peptidoglycan From The Lipid Intermediates. [C]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=559, Percent_Identity=26.2969588550984, Blast_Score=145, Evalue=8e-36,
Organism=Escherichia coli, GI1786272, Length=492, Percent_Identity=24.7967479674797, Blast_Score=99, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR007887
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF05223 MecA_N; PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 74540; Mature: 74409

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASYGGKKRNNKKAIIIGSIAAVVVLAGIAIYFFIQNQHKDEKNALAAAETFTSNIAKEK
CCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHH
YDKLGSSVSSESLKKVEFTKKEMEDKYQAVYDGIGAKDIKVKNLKSVYDDKENKFNLTYE
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHCCCCCCEEEEEE
LEMRTSLGKLATQKYKTTISKQDDDWKIDWKPALIFPGMVKTDKVRITEDEVERGQIVDR
EEEHHHHHHHHHHHHHHHCCCCCCCEEEEEECEEEECCCCCCCEEEEEHHHHCCCEEECC
NGNPLATTGQFAEAGVVPSKLGEGDEKVKNIADISKKLEVSTDYINKQLDQKWVQADSFV
CCCCCCCCCCHHHCCCCHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCE
PLVTLNKDNLPEATGLTYAQKEMRTYPLNEATSHLIGYVGEVSAEDIEKNPKLSVGDVIG
EEEEECCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHCCCCCCCHHHHHH
KSGLERYYDKQLRGKNGGAIKIINDQTKQEDTLQKIDKKDGEEIKLTIDAAVQKKAFDSL
HHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHC
GSETGAVTMINPTNGELLALVSTPSYDANQMVLGITSEDYAKYNDDKRLPFLARYANRYA
CCCCCEEEEEECCCCCEEEEEECCCCCCCCEEEEECCHHHHHCCCCCCCHHHHHHHHHCC
PGSTFKTITATIGLDTGVTKPDKVREISGLQWQKDASWGKYFVTRVHDVPKVNMTDALVH
CCCCEEEEEEEEECCCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHEEE
SDNIYFAQEGLEIGKDKLTAGLKKFDFDKEYNLPFTMKPAQISNDGLNSEILLADTSYGQ
CCCEEEECCCCHHCHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCCEEEEEECCCCC
GELLMSPIQQAIAYSAIASDGKMPYPKLDTKEKAGKETQATEAASANQVKAALVKTVSDP
CHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCHHHHHHCCHHHHHHHHHHHHCCC
AGTAHALQIQGHSIAAKTGTAELKEKQGEDGLENGFVYAFDADNPNYLMVGMIENVKGRG
CCCEEEEEECCCEEEECCCCHHHHHHCCCCCCCCCEEEEEECCCCCEEEEEEEECCCCCC
GSGLVIDKLKPVIESMYK
CCCEEHHHHHHHHHHHCC
>Mature Secondary Structure 
ASYGGKKRNNKKAIIIGSIAAVVVLAGIAIYFFIQNQHKDEKNALAAAETFTSNIAKEK
CCCCCCCCCCCCEEEEEHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHH
YDKLGSSVSSESLKKVEFTKKEMEDKYQAVYDGIGAKDIKVKNLKSVYDDKENKFNLTYE
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHCCCCCCEEEEEE
LEMRTSLGKLATQKYKTTISKQDDDWKIDWKPALIFPGMVKTDKVRITEDEVERGQIVDR
EEEHHHHHHHHHHHHHHHCCCCCCCEEEEEECEEEECCCCCCCEEEEEHHHHCCCEEECC
NGNPLATTGQFAEAGVVPSKLGEGDEKVKNIADISKKLEVSTDYINKQLDQKWVQADSFV
CCCCCCCCCCHHHCCCCHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCE
PLVTLNKDNLPEATGLTYAQKEMRTYPLNEATSHLIGYVGEVSAEDIEKNPKLSVGDVIG
EEEEECCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHCCCCCCCHHHHHH
KSGLERYYDKQLRGKNGGAIKIINDQTKQEDTLQKIDKKDGEEIKLTIDAAVQKKAFDSL
HHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHC
GSETGAVTMINPTNGELLALVSTPSYDANQMVLGITSEDYAKYNDDKRLPFLARYANRYA
CCCCCEEEEEECCCCCEEEEEECCCCCCCCEEEEECCHHHHHCCCCCCCHHHHHHHHHCC
PGSTFKTITATIGLDTGVTKPDKVREISGLQWQKDASWGKYFVTRVHDVPKVNMTDALVH
CCCCEEEEEEEEECCCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHEEE
SDNIYFAQEGLEIGKDKLTAGLKKFDFDKEYNLPFTMKPAQISNDGLNSEILLADTSYGQ
CCCEEEECCCCHHCHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCCEEEEEECCCCC
GELLMSPIQQAIAYSAIASDGKMPYPKLDTKEKAGKETQATEAASANQVKAALVKTVSDP
CHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCHHHHHHCCHHHHHHHHHHHHCCC
AGTAHALQIQGHSIAAKTGTAELKEKQGEDGLENGFVYAFDADNPNYLMVGMIENVKGRG
CCCEEEEEECCCEEEECCCCHHHHHHCCCCCCCCCEEEEEECCCCCEEEEEEEECCCCCC
GSGLVIDKLKPVIESMYK
CCCEEHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377; 3145906 [H]