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The map label for this gene is tkt [H]

Identifier: 226222968

GI number: 226222968

Start: 371202

End: 373199

Strand: Reverse

Name: tkt [H]

Synonym: Lm4b_00360

Alternate gene names: 226222968

Gene position: 373199-371202 (Counterclockwise)

Preceding gene: 226222969

Following gene: 226222956

Centisome position: 12.81

GC content: 47.05

Gene sequence:

>1998_bases
ATGAGCAGAATTGATGAACAAATGGTTAACTCGATTCGCGTATTATCAATGGATATGATTGAAAAAGCGAACTCCGGCCA
TCCCGGTTTGCCGATGGGAGCCGCACCAATGGCTTTCTCGCTTTGGAAAAATCATTTAAAATTCAATCCAGAACACCCAA
CTTGGTTTAACCGCGATCGCTTCGTTTTGTCAGCTGGTCACGGTTCGGCAATGCTTTATAGTTTGCTACATCTATTTGGT
TATGATTTACCAATGAGCGAGCTGAAAAACTTCCGCCAAACTGGTAGTAAAACGCCCGGTCATCCTGAATTCGGTCATAC
GGTTGGTGTCGATGCAACTACCGGTCCACTTGGTCAAGGTTTCGCAATGGGAGTTGGGATGGCGATGGCCGAGGCTCACC
TTGGCGCCAAATTTAACCAACCTGAATTCCCGGTTGTTGACCATAATACCTACGTGCTATGCGGAGACGGCTGTTTGATG
GAAGGCATTTCCTACGAAGCCGCATCCCTTGCTGGTCATTTAAAACTGGGAAAATTAGTTGTTTTATATGATTCGAATGA
TATCTCACTGGATGGCGATTTAAACGAGTCTTTTTCAGAAGACATCGAACTCAGATTCCGAGCAGCCGGTTGGCAAACGC
TACGTGTGGACGACGGAAATGACTTAGATGCGCTTGATGCAGCAATCCATCTCGCAAAAACCGAGAAATCCCGCCCTACT
TTAATCGAAGTGAAAACGGTCATCGGTTACGGTAGCCCTGGTAAAGCCGGAAAATCGGCGGCACACGGCTCCCCACTTGG
CGAAAAAGAACTCAAACTTGCAAAAGAAGCTTACGATTGGCAAATGCCACCTTTTGAATTACCAAAAACTGTCGAAAATC
AGAAAGAATTTTATCATTCTAAAGGTCGCGCGAGTGAAAGCAGCTGGCTCCGGACATTCAATGCTTACAAACAAAAATTT
CCAGCACTCGCAGAAAGTTTGCAACAATTAATGGATGATAATTTGGATACGGATTGGGATGCAGAACTTCCTGTCTTCGA
TGAAAATGCGGACAAAGCCGTTGCAACCCGTGAAGTATCAGGAATTGTTCTACAAGAATTGGAGAAAAAACTGCCTAACC
TATTTGGTGGCGCGGCCGATTTGGCCTCCTCCAATAAAACCCATTTAAAAGCTAGCGAACGGTTTGCTCCAGGTAACTAT
GCCGCCAAAAATATCTCATTCGGCGTCCGCGAGTTCGCAATGGGAGCAGCAGTCAACGGAATGACGCTTCACGGCGGTGT
TCAAGCTTTCGGCGCAACCTTCTTCGTATTCTCGGATTATCTACGTTCCGCGATTCGTTCAGCAGCTTTAATGGGCATTC
CATCCACTTTCATCATGACCCATGATTCCATCGCAGTCGGTGAAGACGGTCCAACGCACGAACCAATCGAGCATCTCGCA
TCCTTCCGCGCCATGCCGGGACTTCACGTCATCCGACCAGCTGACGGCAACGAAACCGTTGAAGCATACCGCTATGCCTT
TACTCAAAAAGAACAACCAACCATGCTCGTTCTTAGCCGCCAAAACCTGCCAATTTTACCAAATAGCGCAGCAAAAGCGC
AAACCGGACTTGCAAAAGGTGCTTACATCTTAGCCGATTCCCCGCTTGATAAACTAGATATTATCTTACTCGCTTCTGGA
TCCGAAGTACACCTAATGACAGCTGTCAGAGATAATCTCGCTAAAAAAGGCTTCGGAGCACGCGTAGTCAGCATGCCAAG
CTTTGATTTATTCGACAAACAAAGCCCCGAATATAAAGAGTCCGTTTTACCAAAAGCAGTGAAAAATCGCTTCGCCGCAG
AAATGGGCGCATCATACGGCTGGCACAAATACCTCGGCGACACAGGCCAAATCCTCGCGATTGATTCGTTTGGTATGTCT
GGCCCGGGAGATGAGCTAGCAAGACGATTTGGCTTTACTGTAGAGAACTTGACGGAGCTTGCGTTGAAGCAGTTGTAG

Upstream 100 bases:

>100_bases
AGCCTTTTCCCGAAACTTTGGTCTCATCCTTTGACTGATAAAGGTATTGAAGGATTTTTAAAAGATTGGGAAGCGTTCAG
TCAGAAAGAAGGCAATTAAT

Downstream 100 bases:

>100_bases
GTATGGAATAAACTTTTTAACAGTAACCAATCAAGTACTCGGGCATAAAAAAGCAGGCATTCTCTATTTAGAAAGAAGAG
AATGCCTGTATTTATTTGAC

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 665; Mature: 664

Protein sequence:

>665_residues
MSRIDEQMVNSIRVLSMDMIEKANSGHPGLPMGAAPMAFSLWKNHLKFNPEHPTWFNRDRFVLSAGHGSAMLYSLLHLFG
YDLPMSELKNFRQTGSKTPGHPEFGHTVGVDATTGPLGQGFAMGVGMAMAEAHLGAKFNQPEFPVVDHNTYVLCGDGCLM
EGISYEAASLAGHLKLGKLVVLYDSNDISLDGDLNESFSEDIELRFRAAGWQTLRVDDGNDLDALDAAIHLAKTEKSRPT
LIEVKTVIGYGSPGKAGKSAAHGSPLGEKELKLAKEAYDWQMPPFELPKTVENQKEFYHSKGRASESSWLRTFNAYKQKF
PALAESLQQLMDDNLDTDWDAELPVFDENADKAVATREVSGIVLQELEKKLPNLFGGAADLASSNKTHLKASERFAPGNY
AAKNISFGVREFAMGAAVNGMTLHGGVQAFGATFFVFSDYLRSAIRSAALMGIPSTFIMTHDSIAVGEDGPTHEPIEHLA
SFRAMPGLHVIRPADGNETVEAYRYAFTQKEQPTMLVLSRQNLPILPNSAAKAQTGLAKGAYILADSPLDKLDIILLASG
SEVHLMTAVRDNLAKKGFGARVVSMPSFDLFDKQSPEYKESVLPKAVKNRFAAEMGASYGWHKYLGDTGQILAIDSFGMS
GPGDELARRFGFTVENLTELALKQL

Sequences:

>Translated_665_residues
MSRIDEQMVNSIRVLSMDMIEKANSGHPGLPMGAAPMAFSLWKNHLKFNPEHPTWFNRDRFVLSAGHGSAMLYSLLHLFG
YDLPMSELKNFRQTGSKTPGHPEFGHTVGVDATTGPLGQGFAMGVGMAMAEAHLGAKFNQPEFPVVDHNTYVLCGDGCLM
EGISYEAASLAGHLKLGKLVVLYDSNDISLDGDLNESFSEDIELRFRAAGWQTLRVDDGNDLDALDAAIHLAKTEKSRPT
LIEVKTVIGYGSPGKAGKSAAHGSPLGEKELKLAKEAYDWQMPPFELPKTVENQKEFYHSKGRASESSWLRTFNAYKQKF
PALAESLQQLMDDNLDTDWDAELPVFDENADKAVATREVSGIVLQELEKKLPNLFGGAADLASSNKTHLKASERFAPGNY
AAKNISFGVREFAMGAAVNGMTLHGGVQAFGATFFVFSDYLRSAIRSAALMGIPSTFIMTHDSIAVGEDGPTHEPIEHLA
SFRAMPGLHVIRPADGNETVEAYRYAFTQKEQPTMLVLSRQNLPILPNSAAKAQTGLAKGAYILADSPLDKLDIILLASG
SEVHLMTAVRDNLAKKGFGARVVSMPSFDLFDKQSPEYKESVLPKAVKNRFAAEMGASYGWHKYLGDTGQILAIDSFGMS
GPGDELARRFGFTVENLTELALKQL
>Mature_664_residues
SRIDEQMVNSIRVLSMDMIEKANSGHPGLPMGAAPMAFSLWKNHLKFNPEHPTWFNRDRFVLSAGHGSAMLYSLLHLFGY
DLPMSELKNFRQTGSKTPGHPEFGHTVGVDATTGPLGQGFAMGVGMAMAEAHLGAKFNQPEFPVVDHNTYVLCGDGCLME
GISYEAASLAGHLKLGKLVVLYDSNDISLDGDLNESFSEDIELRFRAAGWQTLRVDDGNDLDALDAAIHLAKTEKSRPTL
IEVKTVIGYGSPGKAGKSAAHGSPLGEKELKLAKEAYDWQMPPFELPKTVENQKEFYHSKGRASESSWLRTFNAYKQKFP
ALAESLQQLMDDNLDTDWDAELPVFDENADKAVATREVSGIVLQELEKKLPNLFGGAADLASSNKTHLKASERFAPGNYA
AKNISFGVREFAMGAAVNGMTLHGGVQAFGATFFVFSDYLRSAIRSAALMGIPSTFIMTHDSIAVGEDGPTHEPIEHLAS
FRAMPGLHVIRPADGNETVEAYRYAFTQKEQPTMLVLSRQNLPILPNSAAKAQTGLAKGAYILADSPLDKLDIILLASGS
EVHLMTAVRDNLAKKGFGARVVSMPSFDLFDKQSPEYKESVLPKAVKNRFAAEMGASYGWHKYLGDTGQILAIDSFGMSG
PGDELARRFGFTVENLTELALKQL

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=589, Percent_Identity=27.3344651952462, Blast_Score=149, Evalue=1e-35,
Organism=Homo sapiens, GI4507521, Length=589, Percent_Identity=27.3344651952462, Blast_Score=149, Evalue=1e-35,
Organism=Homo sapiens, GI133778974, Length=581, Percent_Identity=26.8502581755594, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI225637461, Length=512, Percent_Identity=24.8046875, Blast_Score=105, Evalue=2e-22,
Organism=Homo sapiens, GI225637459, Length=512, Percent_Identity=24.8046875, Blast_Score=105, Evalue=2e-22,
Organism=Homo sapiens, GI225637463, Length=512, Percent_Identity=24.8046875, Blast_Score=105, Evalue=2e-22,
Organism=Escherichia coli, GI48994911, Length=667, Percent_Identity=47.0764617691154, Blast_Score=615, Evalue=1e-177,
Organism=Escherichia coli, GI1788808, Length=676, Percent_Identity=48.9644970414201, Blast_Score=614, Evalue=1e-177,
Organism=Caenorhabditis elegans, GI17539652, Length=669, Percent_Identity=27.3542600896861, Blast_Score=157, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6325331, Length=671, Percent_Identity=46.795827123696, Blast_Score=580, Evalue=1e-166,
Organism=Saccharomyces cerevisiae, GI6319593, Length=677, Percent_Identity=44.3131462333826, Blast_Score=546, Evalue=1e-156,
Organism=Drosophila melanogaster, GI45551847, Length=585, Percent_Identity=27.1794871794872, Blast_Score=171, Evalue=2e-42,
Organism=Drosophila melanogaster, GI45550715, Length=585, Percent_Identity=27.1794871794872, Blast_Score=171, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24645119, Length=550, Percent_Identity=27.6363636363636, Blast_Score=158, Evalue=9e-39,
Organism=Drosophila melanogaster, GI24666278, Length=588, Percent_Identity=26.8707482993197, Blast_Score=154, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 72490; Mature: 72359

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS00018 EF_HAND_1 ; PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRIDEQMVNSIRVLSMDMIEKANSGHPGLPMGAAPMAFSLWKNHLKFNPEHPTWFNRDR
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCE
FVLSAGHGSAMLYSLLHLFGYDLPMSELKNFRQTGSKTPGHPEFGHTVGVDATTGPLGQG
EEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCEECCCCCCCCCCCC
FAMGVGMAMAEAHLGAKFNQPEFPVVDHNTYVLCGDGCLMEGISYEAASLAGHLKLGKLV
HHHHHHHHHHHHHHCCCCCCCCCCEECCCEEEEECCCHHHCCCCHHHHHHHCCEEECCEE
VLYDSNDISLDGDLNESFSEDIELRFRAAGWQTLRVDDGNDLDALDAAIHLAKTEKSRPT
EEECCCCEEECCCCCCCCCCCEEEEEEECCEEEEEECCCCCHHHHHHHHHHHHCCCCCCC
LIEVKTVIGYGSPGKAGKSAAHGSPLGEKELKLAKEAYDWQMPPFELPKTVENQKEFYHS
EEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
KGRASESSWLRTFNAYKQKFPALAESLQQLMDDNLDTDWDAELPVFDENADKAVATREVS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCCHHHHHHHH
GIVLQELEKKLPNLFGGAADLASSNKTHLKASERFAPGNYAAKNISFGVREFAMGAAVNG
HHHHHHHHHHHHHHHCCHHHHCCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCC
MTLHGGVQAFGATFFVFSDYLRSAIRSAALMGIPSTFIMTHDSIAVGEDGPTHEPIEHLA
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEECCCCCCHHHHHHHH
SFRAMPGLHVIRPADGNETVEAYRYAFTQKEQPTMLVLSRQNLPILPNSAAKAQTGLAKG
HHHCCCCCEEEECCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHHCCCCC
AYILADSPLDKLDIILLASGSEVHLMTAVRDNLAKKGFGARVVSMPSFDLFDKQSPEYKE
EEEEECCCCCCEEEEEEECCCCEEEHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCHHHH
SVLPKAVKNRFAAEMGASYGWHKYLGDTGQILAIDSFGMSGPGDELARRFGFTVENLTEL
HHHHHHHHHHHHHHHCCCCCHHHHCCCCCCEEEEECCCCCCCHHHHHHHHCCCHHHHHHH
ALKQL
HHHCC
>Mature Secondary Structure 
SRIDEQMVNSIRVLSMDMIEKANSGHPGLPMGAAPMAFSLWKNHLKFNPEHPTWFNRDR
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCE
FVLSAGHGSAMLYSLLHLFGYDLPMSELKNFRQTGSKTPGHPEFGHTVGVDATTGPLGQG
EEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCEECCCCCCCCCCCC
FAMGVGMAMAEAHLGAKFNQPEFPVVDHNTYVLCGDGCLMEGISYEAASLAGHLKLGKLV
HHHHHHHHHHHHHHCCCCCCCCCCEECCCEEEEECCCHHHCCCCHHHHHHHCCEEECCEE
VLYDSNDISLDGDLNESFSEDIELRFRAAGWQTLRVDDGNDLDALDAAIHLAKTEKSRPT
EEECCCCEEECCCCCCCCCCCEEEEEEECCEEEEEECCCCCHHHHHHHHHHHHCCCCCCC
LIEVKTVIGYGSPGKAGKSAAHGSPLGEKELKLAKEAYDWQMPPFELPKTVENQKEFYHS
EEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
KGRASESSWLRTFNAYKQKFPALAESLQQLMDDNLDTDWDAELPVFDENADKAVATREVS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCCHHHHHHHH
GIVLQELEKKLPNLFGGAADLASSNKTHLKASERFAPGNYAAKNISFGVREFAMGAAVNG
HHHHHHHHHHHHHHHCCHHHHCCCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCC
MTLHGGVQAFGATFFVFSDYLRSAIRSAALMGIPSTFIMTHDSIAVGEDGPTHEPIEHLA
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEECCCCCCHHHHHHHH
SFRAMPGLHVIRPADGNETVEAYRYAFTQKEQPTMLVLSRQNLPILPNSAAKAQTGLAKG
HHHCCCCCEEEECCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHHCCCCC
AYILADSPLDKLDIILLASGSEVHLMTAVRDNLAKKGFGARVVSMPSFDLFDKQSPEYKE
EEEEECCCCCCEEEEEEECCCCEEEHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCHHHH
SVLPKAVKNRFAAEMGASYGWHKYLGDTGQILAIDSFGMSGPGDELARRFGFTVENLTEL
HHHHHHHHHHHHHHHCCCCCHHHHCCCCCCEEEEECCCCCCCHHHHHHHHCCCHHHHHHH
ALKQL
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]