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The map label for this gene is comEC [H]

Identifier: 226222911

GI number: 226222911

Start: 305657

End: 306499

Strand: Reverse

Name: comEC [H]

Synonym: Lm4b_00303

Alternate gene names: 226222911

Gene position: 306499-305657 (Counterclockwise)

Preceding gene: 226222912

Following gene: 226222910

Centisome position: 10.52

GC content: 37.13

Gene sequence:

>843_bases
ATGAAAAAAGGGATTCTAAACGTATTATTAGTTTTTGCTTTAATTGCGGGGCTTTCCGTACCAAGTTCTATGCAAGTTGA
AGCTGCTGCACCAACTATAAAAGTGCATTTTATTGATGTTGGTCAAGGAGATGCCATTTATATCAAAGCACCTAGTGGAG
AAGATATTTTAATTGATGCAGGTAACAAAGGTAAAGGGAAAACTGTTGTAAATTATTTAAAAAAATTAAAAGTAAAAGAT
ATTGAGATAATGATTGCTTCTCATTCAGATGCGGATAACATTGGTGGATTACCAGAAGTCATGAATAATATCAAGGTAAA
AAGCCTTTATGCACCAAAATCCACAAACACAACAGCCGCTTACAAAAATTTTGTGAACACGGCGAAAAAGAAAAAACTAA
CCATTAAAACCGCAAAAGCAGGCGTAAAACTCCCTGTCAAAGGAGTAAATGCGCAGTTTGTTGGTCCTGTTAAAACTTAC
GGAAAAACAGATCGAAACAACTGGAGTGCTGTTCTCCACGTCGCATATAAGAAAAACACCTTCCTTTTCACAGGAGATGC
GCAAACAAAAGCAGAAAACGATATGATTAAGGCAAAGAAAACCTTACGAGCTGACGTGTTAAAAGTAAGTACACAAGGTT
CCAAAGCTGCAACAAGCAAAGCGTTTGTCAATGTCGTTAAACCAAAATACGCCATTATTAGCGTTGGGAAAAATGGATAT
GGCCACCCCACTTCACAAACCGTTAACACATTGACAAAAGCAAAAGCGAAAGTTTATCGAACAGATCGTAATAAAACCGT
CGTTGTAACAGGCAACGGCTCCAGTTATTCTATCGGAAAATAA

Upstream 100 bases:

>100_bases
AATGTCAAAGCAGCAGCAGATCATCTTACTGACACGAATGAAGCAGATGGGGTTTACAAATTTCTAAAAGAATTCATTTC
ATAAGAGAAGAGGAAAAGGG

Downstream 100 bases:

>100_bases
TTTATGCTTATACGAAAAGCCAATAATAAAGATACGACTTTATTATTGGCTTTTTCCAACTATGCGTATTGGTTAACCTT
TCTGAGTTAGAAATAACTCA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MKKGILNVLLVFALIAGLSVPSSMQVEAAAPTIKVHFIDVGQGDAIYIKAPSGEDILIDAGNKGKGKTVVNYLKKLKVKD
IEIMIASHSDADNIGGLPEVMNNIKVKSLYAPKSTNTTAAYKNFVNTAKKKKLTIKTAKAGVKLPVKGVNAQFVGPVKTY
GKTDRNNWSAVLHVAYKKNTFLFTGDAQTKAENDMIKAKKTLRADVLKVSTQGSKAATSKAFVNVVKPKYAIISVGKNGY
GHPTSQTVNTLTKAKAKVYRTDRNKTVVVTGNGSSYSIGK

Sequences:

>Translated_280_residues
MKKGILNVLLVFALIAGLSVPSSMQVEAAAPTIKVHFIDVGQGDAIYIKAPSGEDILIDAGNKGKGKTVVNYLKKLKVKD
IEIMIASHSDADNIGGLPEVMNNIKVKSLYAPKSTNTTAAYKNFVNTAKKKKLTIKTAKAGVKLPVKGVNAQFVGPVKTY
GKTDRNNWSAVLHVAYKKNTFLFTGDAQTKAENDMIKAKKTLRADVLKVSTQGSKAATSKAFVNVVKPKYAIISVGKNGY
GHPTSQTVNTLTKAKAKVYRTDRNKTVVVTGNGSSYSIGK
>Mature_280_residues
MKKGILNVLLVFALIAGLSVPSSMQVEAAAPTIKVHFIDVGQGDAIYIKAPSGEDILIDAGNKGKGKTVVNYLKKLKVKD
IEIMIASHSDADNIGGLPEVMNNIKVKSLYAPKSTNTTAAYKNFVNTAKKKKLTIKTAKAGVKLPVKGVNAQFVGPVKTY
GKTDRNNWSAVLHVAYKKNTFLFTGDAQTKAENDMIKAKKTLRADVLKVSTQGSKAATSKAFVNVVKPKYAIISVGKNGY
GHPTSQTVNTLTKAKAKVYRTDRNKTVVVTGNGSSYSIGK

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: COG2333

COG function: function code R; Predicted hydrolase (metallo-beta-lactamase superfamily)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 29973; Mature: 29973

Theoretical pI: Translated: 10.75; Mature: 10.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKGILNVLLVFALIAGLSVPSSMQVEAAAPTIKVHFIDVGQGDAIYIKAPSGEDILIDA
CCCHHHHHHHHHHHHHHCCCCCCCEEEECCCEEEEEEEEECCCCEEEEECCCCCEEEEEC
GNKGKGKTVVNYLKKLKVKDIEIMIASHSDADNIGGLPEVMNNIKVKSLYAPKSTNTTAA
CCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCCCCCHHHHHHCCEEEEEECCCCCCCHHH
YKNFVNTAKKKKLTIKTAKAGVKLPVKGVNAQFVGPVKTYGKTDRNNWSAVLHVAYKKNT
HHHHHHHHHHCEEEEEEECCCEEEEEECCCEEEECCHHHCCCCCCCCCEEEEEEEEECCE
FLFTGDAQTKAENDMIKAKKTLRADVLKVSTQGSKAATSKAFVNVVKPKYAIISVGKNGY
EEEECCCCCCCHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHCCCCEEEEEECCCCC
GHPTSQTVNTLTKAKAKVYRTDRNKTVVVTGNGSSYSIGK
CCCCHHHHHHHHHHHHHEEEECCCCEEEEEECCCCCCCCC
>Mature Secondary Structure
MKKGILNVLLVFALIAGLSVPSSMQVEAAAPTIKVHFIDVGQGDAIYIKAPSGEDILIDA
CCCHHHHHHHHHHHHHHCCCCCCCEEEECCCEEEEEEEEECCCCEEEEECCCCCEEEEEC
GNKGKGKTVVNYLKKLKVKDIEIMIASHSDADNIGGLPEVMNNIKVKSLYAPKSTNTTAA
CCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCCCCCHHHHHHCCEEEEEECCCCCCCHHH
YKNFVNTAKKKKLTIKTAKAGVKLPVKGVNAQFVGPVKTYGKTDRNNWSAVLHVAYKKNT
HHHHHHHHHHCEEEEEEECCCEEEEEECCCEEEECCHHHCCCCCCCCCEEEEEEEEECCE
FLFTGDAQTKAENDMIKAKKTLRADVLKVSTQGSKAATSKAFVNVVKPKYAIISVGKNGY
EEEECCCCCCCHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHCCCCEEEEEECCCCC
GHPTSQTVNTLTKAKAKVYRTDRNKTVVVTGNGSSYSIGK
CCCCHHHHHHHHHHHHHEEEECCCCEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]