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The map label for this gene is yabD [H]

Identifier: 226222814

GI number: 226222814

Start: 186325

End: 187098

Strand: Direct

Name: yabD [H]

Synonym: Lm4b_00182

Alternate gene names: 226222814

Gene position: 186325-187098 (Clockwise)

Preceding gene: 226222813

Following gene: 226222815

Centisome position: 6.4

GC content: 39.41

Gene sequence:

>774_bases
TTGCTATTTGATACGCATGTACACCTCAATGACGAGGCTTTTGATGATGATATAGAAGAAGTAATAAAACGCGCACAGGA
AAACGATGTGACTCGCATGGCCGTGGTGGGCTTTAATAAAGAAACAATTGACCGAGCGCTTGAATTAGCCGAGAAATATG
ATTTTATCTCATTAATCGTCGGCTGGCATCCCACAGACGCTATTACCTTCACAGATGAAGATTTAGAATGGCTCCGCGAT
TTAGCACTTACACACCCGAAAGTAGTTGCTTTAGGCGAAATGGGCTTAGATTATCACTGGGATACTTCGCCAAAAGAAAC
GCAATTTGAGGTTTTTAGAAAACAAATCCGTTTAGCGAAAGAAGTGAATTTACCGATAGTTATTCACAACCGCGAAGCAA
CAGAAGATGTTGTTCGTATTTTGCAAGAAGAGCACGCTGAAGAAGTAGGTGGAATTATGCATTGCTTTGGTGAAACTGTC
GAAGTAATGGAAGCATGTCTAGCGATGAATTTTTACATTTCATTCGGAGGAACAGTCACTTTTAAAAACGCAAAATTACC
AAAAATTGCAGCTCAAGCTATACCAATTGACCGTTTATTAATTGAAACTGACGCGCCGTATCTCGCTCCAACCCCAAATC
GCGGAAAAAGAAATGAACCCGGATACGTCAAGTTAGTTGCCGAAAAAATTGCAGAACTGAAAGAAATGAAATATAGTGAA
ATCGCTACGCACTCAACAGAAAACGCAAAAAAACTATTTAAAATAAAAGATTGA

Upstream 100 bases:

>100_bases
GTAAATCTCAGGAAAGCCACCAATTGCTAGGTGGCTTTTTTTGTATGCATCAAAAATTATAGTATAATAGAAGGAAATGA
TTTTATTAGGAGGAATTCTC

Downstream 100 bases:

>100_bases
TTGTAACACAATTGTAATATAAGGGCCAGTCTGTAACCCAATCTTAAGCTTCACGGAGATAAAAATGATGACTGGGACAA
AAACCCTTATTTTATGCCTA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 257; Mature: 257

Protein sequence:

>257_residues
MLFDTHVHLNDEAFDDDIEEVIKRAQENDVTRMAVVGFNKETIDRALELAEKYDFISLIVGWHPTDAITFTDEDLEWLRD
LALTHPKVVALGEMGLDYHWDTSPKETQFEVFRKQIRLAKEVNLPIVIHNREATEDVVRILQEEHAEEVGGIMHCFGETV
EVMEACLAMNFYISFGGTVTFKNAKLPKIAAQAIPIDRLLIETDAPYLAPTPNRGKRNEPGYVKLVAEKIAELKEMKYSE
IATHSTENAKKLFKIKD

Sequences:

>Translated_257_residues
MLFDTHVHLNDEAFDDDIEEVIKRAQENDVTRMAVVGFNKETIDRALELAEKYDFISLIVGWHPTDAITFTDEDLEWLRD
LALTHPKVVALGEMGLDYHWDTSPKETQFEVFRKQIRLAKEVNLPIVIHNREATEDVVRILQEEHAEEVGGIMHCFGETV
EVMEACLAMNFYISFGGTVTFKNAKLPKIAAQAIPIDRLLIETDAPYLAPTPNRGKRNEPGYVKLVAEKIAELKEMKYSE
IATHSTENAKKLFKIKD
>Mature_257_residues
MLFDTHVHLNDEAFDDDIEEVIKRAQENDVTRMAVVGFNKETIDRALELAEKYDFISLIVGWHPTDAITFTDEDLEWLRD
LALTHPKVVALGEMGLDYHWDTSPKETQFEVFRKQIRLAKEVNLPIVIHNREATEDVVRILQEEHAEEVGGIMHCFGETV
EVMEACLAMNFYISFGGTVTFKNAKLPKIAAQAIPIDRLLIETDAPYLAPTPNRGKRNEPGYVKLVAEKIAELKEMKYSE
IATHSTENAKKLFKIKD

Specific function: Unknown

COG id: COG0084

COG function: function code L; Mg-dependent DNase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tatD DNase family [H]

Homologues:

Organism=Homo sapiens, GI226061853, Length=270, Percent_Identity=31.8518518518519, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI110349734, Length=265, Percent_Identity=31.6981132075472, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI110349730, Length=265, Percent_Identity=31.3207547169811, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI14042943, Length=266, Percent_Identity=30.4511278195489, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI226061614, Length=254, Percent_Identity=30.3149606299213, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI225903424, Length=210, Percent_Identity=32.8571428571429, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI226061595, Length=227, Percent_Identity=30.8370044052863, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI225903439, Length=247, Percent_Identity=29.5546558704453, Blast_Score=100, Evalue=1e-21,
Organism=Escherichia coli, GI1787342, Length=258, Percent_Identity=39.922480620155, Blast_Score=185, Evalue=3e-48,
Organism=Escherichia coli, GI48994985, Length=259, Percent_Identity=33.5907335907336, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI87082439, Length=255, Percent_Identity=30.9803921568627, Blast_Score=123, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17559024, Length=281, Percent_Identity=33.0960854092527, Blast_Score=148, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17565396, Length=234, Percent_Identity=34.6153846153846, Blast_Score=100, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI71980746, Length=262, Percent_Identity=25.5725190839695, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17543026, Length=182, Percent_Identity=34.0659340659341, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24648690, Length=286, Percent_Identity=29.7202797202797, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI221330018, Length=273, Percent_Identity=30.7692307692308, Blast_Score=100, Evalue=7e-22,
Organism=Drosophila melanogaster, GI24586117, Length=273, Percent_Identity=30.7692307692308, Blast_Score=100, Evalue=8e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015992
- InterPro:   IPR001130
- InterPro:   IPR018228
- InterPro:   IPR012278
- InterPro:   IPR015991 [H]

Pfam domain/function: PF01026 TatD_DNase [H]

EC number: 3.1.21.-

Molecular weight: Translated: 29343; Mature: 29343

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS01137 TATD_1 ; PS01090 TATD_2 ; PS01091 TATD_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFDTHVHLNDEAFDDDIEEVIKRAQENDVTRMAVVGFNKETIDRALELAEKYDFISLIV
CEEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHCCEEEEEE
GWHPTDAITFTDEDLEWLRDLALTHPKVVALGEMGLDYHWDTSPKETQFEVFRKQIRLAK
ECCCCCEEEECCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHH
EVNLPIVIHNREATEDVVRILQEEHAEEVGGIMHCFGETVEVMEACLAMNFYISFGGTVT
HCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCEEE
FKNAKLPKIAAQAIPIDRLLIETDAPYLAPTPNRGKRNEPGYVKLVAEKIAELKEMKYSE
ECCCCCCHHHHHHCCHHHEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
IATHSTENAKKLFKIKD
HHHCCCCCHHHHEEECC
>Mature Secondary Structure
MLFDTHVHLNDEAFDDDIEEVIKRAQENDVTRMAVVGFNKETIDRALELAEKYDFISLIV
CEEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHCCEEEEEE
GWHPTDAITFTDEDLEWLRDLALTHPKVVALGEMGLDYHWDTSPKETQFEVFRKQIRLAK
ECCCCCEEEECCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHH
EVNLPIVIHNREATEDVVRILQEEHAEEVGGIMHCFGETVEVMEACLAMNFYISFGGTVT
HCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCEEE
FKNAKLPKIAAQAIPIDRLLIETDAPYLAPTPNRGKRNEPGYVKLVAEKIAELKEMKYSE
ECCCCCCHHHHHHCCHHHEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
IATHSTENAKKLFKIKD
HHHCCCCCHHHHEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377 [H]