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The map label for this gene is malL [H]

Identifier: 226222813

GI number: 226222813

Start: 184567

End: 186228

Strand: Direct

Name: malL [H]

Synonym: Lm4b_00181

Alternate gene names: 226222813

Gene position: 184567-186228 (Clockwise)

Preceding gene: 226222812

Following gene: 226222814

Centisome position: 6.34

GC content: 37.97

Gene sequence:

>1662_bases
ATGAAAGAAAAAGATTGGTGGAAAAAAAGCGTAGTGTACCAAATCTATCCAAAGAGTTTTAATGATTCGAATGGTGATGG
AGTTGGTGATATTCAAGGAATTATCGAGAAATTAGATTATTTAAAAGAGCTAGGTGTGGACGTTATCTGGTTGTCCCCAG
TATACGATTCGCCTCAAGATGACAATGGTTACGATATTCGCGATTATCAAAAAATTTACGAAGAGTATGGAGATATGGCG
ACTTTTGATCAATTACTTCAAGGTTTACACGACCGCGAAATGAAACTTGTAATGGATCTTGTTGTTAACCATACTTCTGA
TGAACACAAGTGGTTTGAGGAATCCAGAAAATCCAAAGACAACCCGTACAGAGATTACTATTTCTGGCGCGAGGAAAACG
AAATCAATAACTGGGGCTCGATTTTCAGCGGTCCAGCATGGGAATTGGACGAAAAAACAGGTGAGTACTATTTACACCTG
TTCTCCAAAAAACAACCTGATTTAAACTGGGAAAACCCTAAATTACGCCAAGATGTATATAATATGATGAAATTCTGGCT
AGATAAAGGCATTGATGGCTTCCGCATGGACGTAATTAATTTTATTTCCAAAAATACTGATTTCCCAGATGGTCCAGTAC
CAGATGGTCAAATTTATGGCGATGCTGGCAATGATTTTTGTAATGGACCGCGGATTCATGAGTTCTTGCAAGAAATGAAC
CAAGAAGTTACTTCTAAATACGATGTGATGACTGTTGGCGAAATGCCTGGTGCTAGTACAACCGACGCGCAAATTTACAC
GAATCCAGCAAATAATGAAGTCGATATGATTTTTACATTTGAACATATGAACTTAGATTCCGATGGCGACAATAAATGGG
ATCTAAAACCAATCTACTTACCAGATTTAAAAGAAAATATGTCTGAATGGCAAGTGGCGCTTCAAGAAAACGGTTGGAAT
AGCTTATATTGGAATAATCATGACCAACCGCGTATCGTTTCTCGTTTTGGGAATGACAATCGTTTCCGTGTTCGTTCAGC
GAAAATGCTTGCAACTTGTTTGCATATGATGAAAGGAACGCCATATATTTATCAAGGTGAAGAAATTGGGATGACAAATG
TTCATTTTGAAACGCTAGATGATTACCGTGATATCGAAACGCTAAACATGTACAAAGAGCGTAAGGAGCAAGGACACAGC
CATGAAAGCATCATGCAGTCGATTTACACAAAAGGCCGTGACAATGCGAGAACGCCGTACCAGTGGGATAATAGCGAGAA
TGCTGGCTTCACAACCGGAACGCCTTGGCTTAAAGTCAACCCGCGCTATACAGAAATCAACAACGAAGAAGCGCTGAAAA
ACCCAGATTCCATTTTCTACTACTACCAAAATCTTATTAAGTTACGAAAAACGACTGAAATCATCACAACTGGTAATTAT
CGTTTGTTATTACCTAAAGATGAAGCGATTTTCGCATATGAACGCTACACAGAAAATGAAAAATTAGTGGTTTTATGTAA
TTTCACAGAAGAAGAACAAGTTATTTCTGATGAAAACATTTTGAACGAAATCCAAAAAGGTTCCGTGCTTGTAAACAATG
TTCCTAATATTATAGAAGGAACTTTACGACCTTACGAAGCAATCGTTTATCAAATCAAGTAA

Upstream 100 bases:

>100_bases
TGCTACCCATCAAGGTGAAGCAAACTTGCAACATAAAGTAACTACTATACAAGTTTTTGGAGAAAAAACAGACAAAATTA
CAAGGGCGGGAATTTAATCT

Downstream 100 bases:

>100_bases
ATCTCAGGAAAGCCACCAATTGCTAGGTGGCTTTTTTTGTATGCATCAAAAATTATAGTATAATAGAAGGAAATGATTTT
ATTAGGAGGAATTCTCTTGC

Product: oligo-1,6-glucosidase

Products: NA

Alternate protein names: Dextrin 6-alpha-D-glucanohydrolase; Oligosaccharide alpha-1,6-glucosidase; Sucrase-isomaltase; Isomaltase [H]

Number of amino acids: Translated: 553; Mature: 553

Protein sequence:

>553_residues
MKEKDWWKKSVVYQIYPKSFNDSNGDGVGDIQGIIEKLDYLKELGVDVIWLSPVYDSPQDDNGYDIRDYQKIYEEYGDMA
TFDQLLQGLHDREMKLVMDLVVNHTSDEHKWFEESRKSKDNPYRDYYFWREENEINNWGSIFSGPAWELDEKTGEYYLHL
FSKKQPDLNWENPKLRQDVYNMMKFWLDKGIDGFRMDVINFISKNTDFPDGPVPDGQIYGDAGNDFCNGPRIHEFLQEMN
QEVTSKYDVMTVGEMPGASTTDAQIYTNPANNEVDMIFTFEHMNLDSDGDNKWDLKPIYLPDLKENMSEWQVALQENGWN
SLYWNNHDQPRIVSRFGNDNRFRVRSAKMLATCLHMMKGTPYIYQGEEIGMTNVHFETLDDYRDIETLNMYKERKEQGHS
HESIMQSIYTKGRDNARTPYQWDNSENAGFTTGTPWLKVNPRYTEINNEEALKNPDSIFYYYQNLIKLRKTTEIITTGNY
RLLLPKDEAIFAYERYTENEKLVVLCNFTEEEQVISDENILNEIQKGSVLVNNVPNIIEGTLRPYEAIVYQIK

Sequences:

>Translated_553_residues
MKEKDWWKKSVVYQIYPKSFNDSNGDGVGDIQGIIEKLDYLKELGVDVIWLSPVYDSPQDDNGYDIRDYQKIYEEYGDMA
TFDQLLQGLHDREMKLVMDLVVNHTSDEHKWFEESRKSKDNPYRDYYFWREENEINNWGSIFSGPAWELDEKTGEYYLHL
FSKKQPDLNWENPKLRQDVYNMMKFWLDKGIDGFRMDVINFISKNTDFPDGPVPDGQIYGDAGNDFCNGPRIHEFLQEMN
QEVTSKYDVMTVGEMPGASTTDAQIYTNPANNEVDMIFTFEHMNLDSDGDNKWDLKPIYLPDLKENMSEWQVALQENGWN
SLYWNNHDQPRIVSRFGNDNRFRVRSAKMLATCLHMMKGTPYIYQGEEIGMTNVHFETLDDYRDIETLNMYKERKEQGHS
HESIMQSIYTKGRDNARTPYQWDNSENAGFTTGTPWLKVNPRYTEINNEEALKNPDSIFYYYQNLIKLRKTTEIITTGNY
RLLLPKDEAIFAYERYTENEKLVVLCNFTEEEQVISDENILNEIQKGSVLVNNVPNIIEGTLRPYEAIVYQIK
>Mature_553_residues
MKEKDWWKKSVVYQIYPKSFNDSNGDGVGDIQGIIEKLDYLKELGVDVIWLSPVYDSPQDDNGYDIRDYQKIYEEYGDMA
TFDQLLQGLHDREMKLVMDLVVNHTSDEHKWFEESRKSKDNPYRDYYFWREENEINNWGSIFSGPAWELDEKTGEYYLHL
FSKKQPDLNWENPKLRQDVYNMMKFWLDKGIDGFRMDVINFISKNTDFPDGPVPDGQIYGDAGNDFCNGPRIHEFLQEMN
QEVTSKYDVMTVGEMPGASTTDAQIYTNPANNEVDMIFTFEHMNLDSDGDNKWDLKPIYLPDLKENMSEWQVALQENGWN
SLYWNNHDQPRIVSRFGNDNRFRVRSAKMLATCLHMMKGTPYIYQGEEIGMTNVHFETLDDYRDIETLNMYKERKEQGHS
HESIMQSIYTKGRDNARTPYQWDNSENAGFTTGTPWLKVNPRYTEINNEEALKNPDSIFYYYQNLIKLRKTTEIITTGNY
RLLLPKDEAIFAYERYTENEKLVVLCNFTEEEQVISDENILNEIQKGSVLVNNVPNIIEGTLRPYEAIVYQIK

Specific function: Unknown

COG id: COG0366

COG function: function code G; Glycosidases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyl hydrolase 13 family [H]

Homologues:

Organism=Homo sapiens, GI187423904, Length=534, Percent_Identity=30.3370786516854, Blast_Score=251, Evalue=2e-66,
Organism=Escherichia coli, GI1790687, Length=550, Percent_Identity=45.2727272727273, Blast_Score=517, Evalue=1e-148,
Organism=Escherichia coli, GI1786604, Length=363, Percent_Identity=24.5179063360882, Blast_Score=93, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI25147709, Length=523, Percent_Identity=25.6214149139579, Blast_Score=138, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI32565753, Length=216, Percent_Identity=31.0185185185185, Blast_Score=114, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6321726, Length=586, Percent_Identity=40.4436860068259, Blast_Score=414, Evalue=1e-116,
Organism=Saccharomyces cerevisiae, GI6322245, Length=576, Percent_Identity=38.5416666666667, Blast_Score=410, Evalue=1e-115,
Organism=Saccharomyces cerevisiae, GI6324416, Length=586, Percent_Identity=39.9317406143345, Blast_Score=399, Evalue=1e-112,
Organism=Saccharomyces cerevisiae, GI6322241, Length=586, Percent_Identity=39.9317406143345, Blast_Score=399, Evalue=1e-112,
Organism=Saccharomyces cerevisiae, GI6322021, Length=586, Percent_Identity=39.9317406143345, Blast_Score=399, Evalue=1e-112,
Organism=Saccharomyces cerevisiae, GI6319776, Length=580, Percent_Identity=37.2413793103448, Blast_Score=365, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6321731, Length=580, Percent_Identity=37.0689655172414, Blast_Score=363, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24583747, Length=559, Percent_Identity=34.1681574239714, Blast_Score=292, Evalue=4e-79,
Organism=Drosophila melanogaster, GI24583749, Length=559, Percent_Identity=34.1681574239714, Blast_Score=292, Evalue=4e-79,
Organism=Drosophila melanogaster, GI221330053, Length=587, Percent_Identity=32.7086882453152, Blast_Score=281, Evalue=9e-76,
Organism=Drosophila melanogaster, GI24586593, Length=586, Percent_Identity=32.0819112627986, Blast_Score=281, Evalue=9e-76,
Organism=Drosophila melanogaster, GI24583745, Length=562, Percent_Identity=33.4519572953737, Blast_Score=274, Evalue=9e-74,
Organism=Drosophila melanogaster, GI45549022, Length=542, Percent_Identity=30.8118081180812, Blast_Score=258, Evalue=6e-69,
Organism=Drosophila melanogaster, GI24586599, Length=545, Percent_Identity=31.1926605504587, Blast_Score=256, Evalue=2e-68,
Organism=Drosophila melanogaster, GI24586597, Length=539, Percent_Identity=32.0964749536178, Blast_Score=254, Evalue=1e-67,
Organism=Drosophila melanogaster, GI24586587, Length=534, Percent_Identity=30.7116104868914, Blast_Score=246, Evalue=4e-65,
Organism=Drosophila melanogaster, GI24586589, Length=567, Percent_Identity=31.7460317460317, Blast_Score=241, Evalue=9e-64,
Organism=Drosophila melanogaster, GI24586591, Length=518, Percent_Identity=31.8532818532818, Blast_Score=237, Evalue=2e-62,
Organism=Drosophila melanogaster, GI281360393, Length=531, Percent_Identity=29.0018832391714, Blast_Score=202, Evalue=6e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013780
- InterPro:   IPR006047
- InterPro:   IPR006589
- InterPro:   IPR017853
- InterPro:   IPR013781 [H]

Pfam domain/function: PF00128 Alpha-amylase [H]

EC number: =3.2.1.10 [H]

Molecular weight: Translated: 65138; Mature: 65138

Theoretical pI: Translated: 4.43; Mature: 4.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEKDWWKKSVVYQIYPKSFNDSNGDGVGDIQGIIEKLDYLKELGVDVIWLSPVYDSPQD
CCCHHHHHHCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCC
DNGYDIRDYQKIYEEYGDMATFDQLLQGLHDREMKLVMDLVVNHTSDEHKWFEESRKSKD
CCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCC
NPYRDYYFWREENEINNWGSIFSGPAWELDEKTGEYYLHLFSKKQPDLNWENPKLRQDVY
CCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHH
NMMKFWLDKGIDGFRMDVINFISKNTDFPDGPVPDGQIYGDAGNDFCNGPRIHEFLQEMN
HHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHH
QEVTSKYDVMTVGEMPGASTTDAQIYTNPANNEVDMIFTFEHMNLDSDGDNKWDLKPIYL
HHHHCCCCEEEECCCCCCCCCCCEEEECCCCCCEEEEEEEEECCCCCCCCCCCCCCEEEC
PDLKENMSEWQVALQENGWNSLYWNNHDQPRIVSRFGNDNRFRVRSAKMLATCLHMMKGT
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCCCEEEEHHHHHHHHHHHHHCCC
PYIYQGEEIGMTNVHFETLDDYRDIETLNMYKERKEQGHSHESIMQSIYTKGRDNARTPY
CEEEECCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCC
QWDNSENAGFTTGTPWLKVNPRYTEINNEEALKNPDSIFYYYQNLIKLRKTTEIITTGNY
CCCCCCCCCCCCCCCEEEECCCEEECCCHHHHCCCCHHHHHHHHHHHHHHHHEEEEECCE
RLLLPKDEAIFAYERYTENEKLVVLCNFTEEEQVISDENILNEIQKGSVLVNNVPNIIEG
EEEECCCCEEEEEHEECCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCEEECCCCHHHHH
TLRPYEAIVYQIK
CCCCCEEEEEECC
>Mature Secondary Structure
MKEKDWWKKSVVYQIYPKSFNDSNGDGVGDIQGIIEKLDYLKELGVDVIWLSPVYDSPQD
CCCHHHHHHCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCC
DNGYDIRDYQKIYEEYGDMATFDQLLQGLHDREMKLVMDLVVNHTSDEHKWFEESRKSKD
CCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCC
NPYRDYYFWREENEINNWGSIFSGPAWELDEKTGEYYLHLFSKKQPDLNWENPKLRQDVY
CCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHH
NMMKFWLDKGIDGFRMDVINFISKNTDFPDGPVPDGQIYGDAGNDFCNGPRIHEFLQEMN
HHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHH
QEVTSKYDVMTVGEMPGASTTDAQIYTNPANNEVDMIFTFEHMNLDSDGDNKWDLKPIYL
HHHHCCCCEEEECCCCCCCCCCCEEEECCCCCCEEEEEEEEECCCCCCCCCCCCCCEEEC
PDLKENMSEWQVALQENGWNSLYWNNHDQPRIVSRFGNDNRFRVRSAKMLATCLHMMKGT
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCCCEEEEHHHHHHHHHHHHHCCC
PYIYQGEEIGMTNVHFETLDDYRDIETLNMYKERKEQGHSHESIMQSIYTKGRDNARTPY
CEEEECCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCC
QWDNSENAGFTTGTPWLKVNPRYTEINNEEALKNPDSIFYYYQNLIKLRKTTEIITTGNY
CCCCCCCCCCCCCCCEEEECCCEEECCCHHHHCCCCHHHHHHHHHHHHHHHHEEEEECCE
RLLLPKDEAIFAYERYTENEKLVVLCNFTEEEQVISDENILNEIQKGSVLVNNVPNIIEG
EEEECCCCEEEEEHEECCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCEEECCCCHHHHH
TLRPYEAIVYQIK
CCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2120057; 8370659; 9193006 [H]