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The map label for this gene is era [H]

Identifier: 225861144

GI number: 225861144

Start: 1176655

End: 1177554

Strand: Reverse

Name: era [H]

Synonym: SPT_1234

Alternate gene names: 225861144

Gene position: 1177554-1176655 (Counterclockwise)

Preceding gene: 225861145

Following gene: 225861143

Centisome position: 55.75

GC content: 43.78

Gene sequence:

>900_bases
ATGACTTTTAAATCAGGCTTTGTAGCCATTTTAGGACGTCCCAATGTTGGGAAGTCAACCTTTTTAAATCACGTTATGGG
GCAAAAGATTGCCATCATGAGTGACAAGGCGCAGACAACGCGCAATAAAATCATGGGAATTTACACGACTGATAAGGAGC
AAATTGTCTTTATCGACACACCAGGGATTCACAAACCTAAAACAGCTCTCGGAGATTTCATGGTTGAGTCTGCCTACAGT
ACCCTTCGCGAAGTGGACACTGTTCTTTTCATGGTGCCTGCTGATGAAGCGCGTGGTAAGGGGGACGATATGATTATTGA
GCGTCTCAAGGCTGCCAAGGTTCCTGTGATTTTGGTGGTGAATAAAATCGATAAGGTTCATCCAGACCAGCTCTTGTCTC
AGATTGATGACTTCCGTAATCAAATGGACTTTAAGGAAATTGTTCCAATCTCAGCCCTTCAGGGAAATAACGTGTCTCGT
CTAGTGGATATTTTGAGTGAAAATCTGGATGAAGGTTTCCAATATTTCCCGTCTGATCAAATCACAGACCATCCAGAACG
TTTCTTGGTTTCAGAAATGGTTCGCGAGAAAGTCTTGCATCTAACTCGTGAAGAGATTCCGCATTCTGTAGCAGTAGTTG
TTGACTCTATGAAACGAGACGAAGAGACAGACAAGGTTCACATCCGTGCAACCATCATGGTCGAGCGCGATAGCCAAAAA
GGGATTATCATCGGTAAAGGTGGCGCTATGCTTAAGAAAATCGGTAGCATGGCCCGTCGTGATATCGAACTCATGCTAGG
AGACAAGGTCTTCCTAGAAACCTGGGTCAAGGTCAAGAAAAACTGGCGCGATAAAAAGCTAGATTTGGCTGACTTTGGCT
ATAATGAAAGAGAATACTAA

Upstream 100 bases:

>100_bases
GGCGCGGTATTAGTGGTTTCTCTTTTCGCAGCCTTAACAGGTGCATTGATTTTTCTCCCACGAATCTGGGATTTATTATT
TTAAACAGTAAGAGGAAATT

Downstream 100 bases:

>100_bases
GTAGAGGTAGGCTCATGCCTGCTTCTTGTTTTTACAGAAGGAGGACTTATGCCTGAATTACCTGAGGTTGAAACCGTTTG
TCGTGGCTTAGAAAAATTGA

Product: GTP-binding protein Era

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 299; Mature: 298

Protein sequence:

>299_residues
MTFKSGFVAILGRPNVGKSTFLNHVMGQKIAIMSDKAQTTRNKIMGIYTTDKEQIVFIDTPGIHKPKTALGDFMVESAYS
TLREVDTVLFMVPADEARGKGDDMIIERLKAAKVPVILVVNKIDKVHPDQLLSQIDDFRNQMDFKEIVPISALQGNNVSR
LVDILSENLDEGFQYFPSDQITDHPERFLVSEMVREKVLHLTREEIPHSVAVVVDSMKRDEETDKVHIRATIMVERDSQK
GIIIGKGGAMLKKIGSMARRDIELMLGDKVFLETWVKVKKNWRDKKLDLADFGYNEREY

Sequences:

>Translated_299_residues
MTFKSGFVAILGRPNVGKSTFLNHVMGQKIAIMSDKAQTTRNKIMGIYTTDKEQIVFIDTPGIHKPKTALGDFMVESAYS
TLREVDTVLFMVPADEARGKGDDMIIERLKAAKVPVILVVNKIDKVHPDQLLSQIDDFRNQMDFKEIVPISALQGNNVSR
LVDILSENLDEGFQYFPSDQITDHPERFLVSEMVREKVLHLTREEIPHSVAVVVDSMKRDEETDKVHIRATIMVERDSQK
GIIIGKGGAMLKKIGSMARRDIELMLGDKVFLETWVKVKKNWRDKKLDLADFGYNEREY
>Mature_298_residues
TFKSGFVAILGRPNVGKSTFLNHVMGQKIAIMSDKAQTTRNKIMGIYTTDKEQIVFIDTPGIHKPKTALGDFMVESAYST
LREVDTVLFMVPADEARGKGDDMIIERLKAAKVPVILVVNKIDKVHPDQLLSQIDDFRNQMDFKEIVPISALQGNNVSRL
VDILSENLDEGFQYFPSDQITDHPERFLVSEMVREKVLHLTREEIPHSVAVVVDSMKRDEETDKVHIRATIMVERDSQKG
IIIGKGGAMLKKIGSMARRDIELMLGDKVFLETWVKVKKNWRDKKLDLADFGYNEREY

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism [H]

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain [H]

Homologues:

Organism=Homo sapiens, GI24307899, Length=305, Percent_Identity=24.2622950819672, Blast_Score=79, Evalue=4e-15,
Organism=Escherichia coli, GI1788919, Length=293, Percent_Identity=43.6860068259386, Blast_Score=235, Evalue=2e-63,
Organism=Escherichia coli, GI87082120, Length=156, Percent_Identity=34.6153846153846, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI2367268, Length=181, Percent_Identity=29.8342541436464, Blast_Score=64, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24646434, Length=308, Percent_Identity=27.5974025974026, Blast_Score=100, Evalue=9e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005662
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 34011; Mature: 33880

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: PS50823 KH_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFKSGFVAILGRPNVGKSTFLNHVMGQKIAIMSDKAQTTRNKIMGIYTTDKEQIVFIDT
CCCCCCEEEEEECCCCCHHHHHHHHHCCEEEEECCHHHHHHHHEEEEEECCCCEEEEEEC
PGIHKPKTALGDFMVESAYSTLREVDTVLFMVPADEARGKGDDMIIERLKAAKVPVILVV
CCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEECHHCCCCCHHHHHHHHHHCCCCEEEEE
NKIDKVHPDQLLSQIDDFRNQMDFKEIVPISALQGNNVSRLVDILSENLDEGFQYFPSDQ
CCCCCCCHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
ITDHPERFLVSEMVREKVLHLTREEIPHSVAVVVDSMKRDEETDKVHIRATIMVERDSQK
CCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEEEEEEEEECCCC
GIIIGKGGAMLKKIGSMARRDIELMLGDKVFLETWVKVKKNWRDKKLDLADFGYNEREY
CEEEECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCC
>Mature Secondary Structure 
TFKSGFVAILGRPNVGKSTFLNHVMGQKIAIMSDKAQTTRNKIMGIYTTDKEQIVFIDT
CCCCCEEEEEECCCCCHHHHHHHHHCCEEEEECCHHHHHHHHEEEEEECCCCEEEEEEC
PGIHKPKTALGDFMVESAYSTLREVDTVLFMVPADEARGKGDDMIIERLKAAKVPVILVV
CCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEECHHCCCCCHHHHHHHHHHCCCCEEEEE
NKIDKVHPDQLLSQIDDFRNQMDFKEIVPISALQGNNVSRLVDILSENLDEGFQYFPSDQ
CCCCCCCHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
ITDHPERFLVSEMVREKVLHLTREEIPHSVAVVVDSMKRDEETDKVHIRATIMVERDSQK
CCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEEEEEEEEECCCC
GIIIGKGGAMLKKIGSMARRDIELMLGDKVFLETWVKVKKNWRDKKLDLADFGYNEREY
CEEEECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA