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The map label for this gene is mutM [H]

Identifier: 225861143

GI number: 225861143

Start: 1175782

End: 1176606

Strand: Reverse

Name: mutM [H]

Synonym: SPT_1233

Alternate gene names: 225861143

Gene position: 1176606-1175782 (Counterclockwise)

Preceding gene: 225861144

Following gene: 225861142

Centisome position: 55.71

GC content: 44.24

Gene sequence:

>825_bases
ATGCCTGAATTACCTGAGGTTGAAACCGTTTGTCGTGGCTTAGAAAAATTGATTATAGGAAAGAAGATTTCGAGTATAGA
AATTCGCTACCCCAAGATGATTAAGACGGATTTGGAAGAGTTTCAAAGGGAATTGCCTAGTCAGATTATCGAGTCAATGG
GACGTCGTGGAAAATATTTGCTTTTTTATCTGACAGACAAGGTCTTGATTTCCCATTTGCGGATGGAGGGCAAGTATTTT
TACTATCCAGACCAAGGACCTGAACGCAAGCATGCCCATGTTTTCTTTCATTTTGAAGATGGTGGCACGCTTGTTTATGA
GGATGTTCGCAAGTTTGGAACCATGGAACTCTTGGTGCCTGACCTTTTAGACGCCTACTTTATTTCTAAAAAATTAGGTC
CTGAACCAAGCGAACAAGACTTTGATTTACAGGTCTTTCAATCTGCCCTTGCCAAGTCCAAAAAGCCTATCAAATCCCAT
CTCCTAGACCAGACCTTGGTAGCTGGACTTGGCAATATCTATGTGGATGAGGTTCTCTGGCGAGCTCAGGTTCATCCAGC
TAGACCTTCCCAGACTTTGACAGCAGAAGAAGCGACTGCCATTCATGACCAGACCATTGCTGTTTTGGGCCAGGCTGTTG
AAAAAGGTGGCTCCACCATTCGGACTTATACCAATGCCTTTGGGGAAGATGGAAGCATGCAGGACTTTCATCAGGTCTAT
GATAAGACTGGTCAAGAATGTGTACGCTGTGGTACCATCATTGAGAAAATTCAACTAGGCGGACGAGGCACCCACTTTTG
TCCAAACTGTCAAAGGAGGGACTGA

Upstream 100 bases:

>100_bases
CGATAAAAAGCTAGATTTGGCTGACTTTGGCTATAATGAAAGAGAATACTAAGTAGAGGTAGGCTCATGCCTGCTTCTTG
TTTTTACAGAAGGAGGACTT

Downstream 100 bases:

>100_bases
TGAGAAAAATCATCGGAATCACTGGGGGAATTGCCTCTGGTAAGTCAACTGTGACAAATTTTCTAAGACAGCAAGGCTTT
CAAGTAGTGGATGCCGACGC

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM [H]

Number of amino acids: Translated: 274; Mature: 273

Protein sequence:

>274_residues
MPELPEVETVCRGLEKLIIGKKISSIEIRYPKMIKTDLEEFQRELPSQIIESMGRRGKYLLFYLTDKVLISHLRMEGKYF
YYPDQGPERKHAHVFFHFEDGGTLVYEDVRKFGTMELLVPDLLDAYFISKKLGPEPSEQDFDLQVFQSALAKSKKPIKSH
LLDQTLVAGLGNIYVDEVLWRAQVHPARPSQTLTAEEATAIHDQTIAVLGQAVEKGGSTIRTYTNAFGEDGSMQDFHQVY
DKTGQECVRCGTIIEKIQLGGRGTHFCPNCQRRD

Sequences:

>Translated_274_residues
MPELPEVETVCRGLEKLIIGKKISSIEIRYPKMIKTDLEEFQRELPSQIIESMGRRGKYLLFYLTDKVLISHLRMEGKYF
YYPDQGPERKHAHVFFHFEDGGTLVYEDVRKFGTMELLVPDLLDAYFISKKLGPEPSEQDFDLQVFQSALAKSKKPIKSH
LLDQTLVAGLGNIYVDEVLWRAQVHPARPSQTLTAEEATAIHDQTIAVLGQAVEKGGSTIRTYTNAFGEDGSMQDFHQVY
DKTGQECVRCGTIIEKIQLGGRGTHFCPNCQRRD
>Mature_273_residues
PELPEVETVCRGLEKLIIGKKISSIEIRYPKMIKTDLEEFQRELPSQIIESMGRRGKYLLFYLTDKVLISHLRMEGKYFY
YPDQGPERKHAHVFFHFEDGGTLVYEDVRKFGTMELLVPDLLDAYFISKKLGPEPSEQDFDLQVFQSALAKSKKPIKSHL
LDQTLVAGLGNIYVDEVLWRAQVHPARPSQTLTAEEATAIHDQTIAVLGQAVEKGGSTIRTYTNAFGEDGSMQDFHQVYD
KTGQECVRCGTIIEKIQLGGRGTHFCPNCQRRD

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger [H]

Homologues:

Organism=Escherichia coli, GI1790066, Length=272, Percent_Identity=36.7647058823529, Blast_Score=169, Evalue=2e-43,
Organism=Escherichia coli, GI1786932, Length=278, Percent_Identity=26.6187050359712, Blast_Score=96, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663 [H]

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS [H]

EC number: =3.2.2.23; =4.2.99.18 [H]

Molecular weight: Translated: 31188; Mature: 31057

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS01242 ZF_FPG_1 ; PS51066 ZF_FPG_2 ; PS51068 FPG_CAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVETVCRGLEKLIIGKKISSIEIRYPKMIKTDLEEFQRELPSQIIESMGRRGKYL
CCCCCCHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
LFYLTDKVLISHLRMEGKYFYYPDQGPERKHAHVFFHFEDGGTLVYEDVRKFGTMELLVP
EEEEHHHHHHHHHHHCCCEEECCCCCCCCCCEEEEEEECCCCEEHHHHHHHHCCHHHHHH
DLLDAYFISKKLGPEPSEQDFDLQVFQSALAKSKKPIKSHLLDQTLVAGLGNIYVDEVLW
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RAQVHPARPSQTLTAEEATAIHDQTIAVLGQAVEKGGSTIRTYTNAFGEDGSMQDFHQVY
HHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHCCCCCCHHHHHHHH
DKTGQECVRCGTIIEKIQLGGRGTHFCPNCQRRD
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PELPEVETVCRGLEKLIIGKKISSIEIRYPKMIKTDLEEFQRELPSQIIESMGRRGKYL
CCCCCHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
LFYLTDKVLISHLRMEGKYFYYPDQGPERKHAHVFFHFEDGGTLVYEDVRKFGTMELLVP
EEEEHHHHHHHHHHHCCCEEECCCCCCCCCCEEEEEEECCCCEEHHHHHHHHCCHHHHHH
DLLDAYFISKKLGPEPSEQDFDLQVFQSALAKSKKPIKSHLLDQTLVAGLGNIYVDEVLW
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RAQVHPARPSQTLTAEEATAIHDQTIAVLGQAVEKGGSTIRTYTNAFGEDGSMQDFHQVY
HHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHCCCCCCHHHHHHHH
DKTGQECVRCGTIIEKIQLGGRGTHFCPNCQRRD
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11463916 [H]