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The map label for this gene is gpo [H]

Identifier: 225860353

GI number: 225860353

Start: 326148

End: 326624

Strand: Reverse

Name: gpo [H]

Synonym: SPT_0363

Alternate gene names: 225860353

Gene position: 326624-326148 (Counterclockwise)

Preceding gene: 225860355

Following gene: 225860341

Centisome position: 15.46

GC content: 42.35

Gene sequence:

>477_bases
ATGACTTCACTTTATGATTTTTCCGTTTTGAACCAAAACAACCAAGCAACTCCCTTGGATAGCTATCGTGGCAAAGTTCT
CTTGATTGTCAACACTACTACTGGATGTGGTTTAATGCCCCAGTACCAGGGACTTCAAGAACTCTATGAACGCTATCAAG
ATCAGGGCTTCGAAATATTGGATTTCCCTTGCAATCAGTTTATGGGACAAGCACCCGGCAGCGCAGAGGAAATCAACGCC
TTCTGTAGCCTACATTTTCAAACCACCTTCCCACGTTTTGCCAAGATTAAGGTCAACGGTAAGGAAGCAGACCCTCTCTA
TGTCTGGTTAAAAGACCATAAATCTGGCCCACTAGGAAAACGAATCGAATGGAATTTCGCTAAGTTTCTCATTAGTCGTG
ATGGGCAAGTCTTTGAACGCTTTTCTTCAAAAACAGACCCAAAACAAATTGAAGAGGCGATACAAACTCTACTATAA

Upstream 100 bases:

>100_bases
TTTCTATCATATTGAGGGCTTATTCTTCAACAATATCTTCCATCCGACTCGACGAAAAAAGTAAAAACTGTTACAATGTA
GAAAAAGAAAAGAGGCCCTC

Downstream 100 bases:

>100_bases
TTCACAATCTCACTATGATTAGGTTTCCTTTAACCTGATGAATAGTGAGATTTTTTGATTGGCTTTGACTTAAATAGAAA
AACACCCCATGATATGAAAC

Product: peroxiredoxin Hyr1 (hydrogen peroxide resistanceprotein 1) (oxidant receptor peroxidase 1) (glutathione peroxidase 3)(phospholipid hydroperoxide glutathione peroxidase 3) (phgpx3)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 158; Mature: 157

Protein sequence:

>158_residues
MTSLYDFSVLNQNNQATPLDSYRGKVLLIVNTTTGCGLMPQYQGLQELYERYQDQGFEILDFPCNQFMGQAPGSAEEINA
FCSLHFQTTFPRFAKIKVNGKEADPLYVWLKDHKSGPLGKRIEWNFAKFLISRDGQVFERFSSKTDPKQIEEAIQTLL

Sequences:

>Translated_158_residues
MTSLYDFSVLNQNNQATPLDSYRGKVLLIVNTTTGCGLMPQYQGLQELYERYQDQGFEILDFPCNQFMGQAPGSAEEINA
FCSLHFQTTFPRFAKIKVNGKEADPLYVWLKDHKSGPLGKRIEWNFAKFLISRDGQVFERFSSKTDPKQIEEAIQTLL
>Mature_157_residues
TSLYDFSVLNQNNQATPLDSYRGKVLLIVNTTTGCGLMPQYQGLQELYERYQDQGFEILDFPCNQFMGQAPGSAEEINAF
CSLHFQTTFPRFAKIKVNGKEADPLYVWLKDHKSGPLGKRIEWNFAKFLISRDGQVFERFSSKTDPKQIEEAIQTLL

Specific function: Not Essential For B12 Transport; However, It Is An Auxiliary Component Of The Transport System. [C]

COG id: COG0386

COG function: function code O; Glutathione peroxidase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutathione peroxidase family [H]

Homologues:

Organism=Homo sapiens, GI75709200, Length=153, Percent_Identity=40.5228758169935, Blast_Score=114, Evalue=4e-26,
Organism=Homo sapiens, GI90903240, Length=155, Percent_Identity=40, Blast_Score=113, Evalue=6e-26,
Organism=Homo sapiens, GI15618997, Length=156, Percent_Identity=35.2564102564103, Blast_Score=103, Evalue=5e-23,
Organism=Homo sapiens, GI192455698, Length=159, Percent_Identity=33.9622641509434, Blast_Score=101, Evalue=3e-22,
Organism=Homo sapiens, GI90903238, Length=130, Percent_Identity=41.5384615384615, Blast_Score=98, Evalue=3e-21,
Organism=Homo sapiens, GI4557629, Length=177, Percent_Identity=32.7683615819209, Blast_Score=81, Evalue=5e-16,
Organism=Homo sapiens, GI41406084, Length=182, Percent_Identity=32.4175824175824, Blast_Score=77, Evalue=5e-15,
Organism=Homo sapiens, GI32967607, Length=181, Percent_Identity=29.8342541436464, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI6006001, Length=177, Percent_Identity=31.0734463276836, Blast_Score=71, Evalue=4e-13,
Organism=Homo sapiens, GI33186887, Length=154, Percent_Identity=32.4675324675325, Blast_Score=66, Evalue=1e-11,
Organism=Escherichia coli, GI1788003, Length=178, Percent_Identity=37.6404494382022, Blast_Score=126, Evalue=9e-31,
Organism=Caenorhabditis elegans, GI17506887, Length=159, Percent_Identity=45.2830188679245, Blast_Score=145, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI17535473, Length=159, Percent_Identity=44.6540880503145, Blast_Score=139, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI193210707, Length=161, Percent_Identity=39.7515527950311, Blast_Score=121, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI71993584, Length=157, Percent_Identity=34.3949044585987, Blast_Score=109, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI193209493, Length=167, Percent_Identity=34.7305389221557, Blast_Score=90, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17550320, Length=167, Percent_Identity=34.7305389221557, Blast_Score=88, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71999642, Length=76, Percent_Identity=40.7894736842105, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322228, Length=159, Percent_Identity=50.314465408805, Blast_Score=171, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6319721, Length=158, Percent_Identity=50.6329113924051, Blast_Score=169, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6322826, Length=159, Percent_Identity=43.3962264150943, Blast_Score=141, Evalue=5e-35,
Organism=Drosophila melanogaster, GI24656767, Length=160, Percent_Identity=40.625, Blast_Score=126, Evalue=8e-30,
Organism=Drosophila melanogaster, GI24656777, Length=160, Percent_Identity=40.625, Blast_Score=126, Evalue=8e-30,
Organism=Drosophila melanogaster, GI24656772, Length=160, Percent_Identity=40.625, Blast_Score=125, Evalue=9e-30,
Organism=Drosophila melanogaster, GI85726443, Length=158, Percent_Identity=40.5063291139241, Blast_Score=119, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000889
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00255 GSHPx [H]

EC number: =1.11.1.9 [H]

Molecular weight: Translated: 18100; Mature: 17969

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS00763 GLUTATHIONE_PEROXID_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSLYDFSVLNQNNQATPLDSYRGKVLLIVNTTTGCGLMPQYQGLQELYERYQDQGFEIL
CCCCCCCCEECCCCCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCEEE
DFPCNQFMGQAPGSAEEINAFCSLHFQTTFPRFAKIKVNGKEADPLYVWLKDHKSGPLGK
ECCHHHHHCCCCCCHHHHHHHHEEEEECCCCCEEEEEECCCCCCEEEEEEECCCCCCCCC
RIEWNFAKFLISRDGQVFERFSSKTDPKQIEEAIQTLL
CEEHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHHHC
>Mature Secondary Structure 
TSLYDFSVLNQNNQATPLDSYRGKVLLIVNTTTGCGLMPQYQGLQELYERYQDQGFEIL
CCCCCCCEECCCCCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCEEE
DFPCNQFMGQAPGSAEEINAFCSLHFQTTFPRFAKIKVNGKEADPLYVWLKDHKSGPLGK
ECCHHHHHCCCCCCHHHHHHHHEEEEECCCCCEEEEEECCCCCCEEEEEEECCCCCCCCC
RIEWNFAKFLISRDGQVFERFSSKTDPKQIEEAIQTLL
CEEHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]