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The map label for this gene is uxuA

Identifier: 225859884

GI number: 225859884

Start: 2046541

End: 2047641

Strand: Reverse

Name: uxuA

Synonym: SP70585_2237

Alternate gene names: 225859884

Gene position: 2047641-2046541 (Counterclockwise)

Preceding gene: 225859885

Following gene: 225859883

Centisome position: 93.73

GC content: 43.42

Gene sequence:

>1101_bases
ATGAAAATGTCATTTCGATGGTATGGAAAAAAAGACCCTGTGACACTTGAAGAGATTAAAGCAATTCCTGGCATGCAGGG
AATTGTGACAGCTGTCTACGATGTGCCAGTAGGTCAGGCTTGGCCTTTGGAAAATATTCTTGAGTTGAAACAAATGGTGG
AAGAGGCAGGTTTAGAGATTACAGTTATTGAGTCCATTCCTGTCCATGAAGATATCAAACAAGGCAAACCAAACCGTGAT
GAGCTGATTGAAAACTATAAAACATCTATTCGTAATGTCGGAGCGGCAGGAATTCCAGTTGTATGCTACAACTTCATGCC
TGTATTTGACTGGACACGTTCGGACTTGCATCATCCTCTTCCAGATGGTTCAACTTCCCTAGCCTTTCTGAAATCTGATT
TAGCTGGTGTTGATCCTGTGGCAGATGACTTGAACTTGCCGGGTTGGGATTCATCTTATTCCAAGGAAGAAATGAAGAAC
GTTATTGAAAATTATCGTCAGAATATTTCTGAGGAAGATTTATGGGCAAACTTGGAGTATTTCATCAAGGCGATTATGCC
AACGGCTGAGGAAGCAGGAGTGAAAATGGCGATTCACCCAGATGATCCTCCGTATGGAATTTTTGGATTGCCACGTATCA
TTACTGGTCAAGAAGCTGTTGAACGCTTTTTGAATCTCTATGACTCAGAACATAATGGAATTACCATGTGTGTCGGTTCC
TATGCTTCTGATCCGAAAAATGATGTCCTCGCCATGACAGAATATGCTCTCAAACGCAACCGTATCAATTTTATGCACAC
TCGTAATGTGACGGCAGGGGCTTGGGGCTTCCAAGAAACTGCACACTTGTCACAGTCTGGCGATATTGATATGAATGGAG
TAGTTAAACTCTTGGTGGACTATGATTGGCAAGGAGCTTTGCGACCAGACCATGGTCGACGTATCTGGGGAGACCAAACT
AAGACACCTGGCTATGGTTTGTATGACCGTGCACTCGGTGCGACCTATTTTAACGGTCTCTACGAAGCGAATATGCGAGC
GGCAGGTAAGACACCAGATTTTGGAATTAAAGTAAAAACAGTTGGGAATAAGGAGGGCTAG

Upstream 100 bases:

>100_bases
GAGGAAGTGCCTGAGGACTATGATCGCCTAGGTCAGTTTGTAGAAGCAATATCTTACTACAATGCCAAAGAGTTTTTTGA
ACAATAAAGGAGAGTAAATC

Downstream 100 bases:

>100_bases
TTATGACACGTGTTATTGAATTTAAAGACAAGGTTGTTGTTATTACCGGAGCTGGAGGCGTTCTTTGTGGTTATTTGGCA
AAAGAATTTGCGAAGGCTGG

Product: mannonate dehydratase

Products: NA

Alternate protein names: D-mannonate hydrolase

Number of amino acids: Translated: 366; Mature: 366

Protein sequence:

>366_residues
MKMSFRWYGKKDPVTLEEIKAIPGMQGIVTAVYDVPVGQAWPLENILELKQMVEEAGLEITVIESIPVHEDIKQGKPNRD
ELIENYKTSIRNVGAAGIPVVCYNFMPVFDWTRSDLHHPLPDGSTSLAFLKSDLAGVDPVADDLNLPGWDSSYSKEEMKN
VIENYRQNISEEDLWANLEYFIKAIMPTAEEAGVKMAIHPDDPPYGIFGLPRIITGQEAVERFLNLYDSEHNGITMCVGS
YASDPKNDVLAMTEYALKRNRINFMHTRNVTAGAWGFQETAHLSQSGDIDMNGVVKLLVDYDWQGALRPDHGRRIWGDQT
KTPGYGLYDRALGATYFNGLYEANMRAAGKTPDFGIKVKTVGNKEG

Sequences:

>Translated_366_residues
MKMSFRWYGKKDPVTLEEIKAIPGMQGIVTAVYDVPVGQAWPLENILELKQMVEEAGLEITVIESIPVHEDIKQGKPNRD
ELIENYKTSIRNVGAAGIPVVCYNFMPVFDWTRSDLHHPLPDGSTSLAFLKSDLAGVDPVADDLNLPGWDSSYSKEEMKN
VIENYRQNISEEDLWANLEYFIKAIMPTAEEAGVKMAIHPDDPPYGIFGLPRIITGQEAVERFLNLYDSEHNGITMCVGS
YASDPKNDVLAMTEYALKRNRINFMHTRNVTAGAWGFQETAHLSQSGDIDMNGVVKLLVDYDWQGALRPDHGRRIWGDQT
KTPGYGLYDRALGATYFNGLYEANMRAAGKTPDFGIKVKTVGNKEG
>Mature_366_residues
MKMSFRWYGKKDPVTLEEIKAIPGMQGIVTAVYDVPVGQAWPLENILELKQMVEEAGLEITVIESIPVHEDIKQGKPNRD
ELIENYKTSIRNVGAAGIPVVCYNFMPVFDWTRSDLHHPLPDGSTSLAFLKSDLAGVDPVADDLNLPGWDSSYSKEEMKN
VIENYRQNISEEDLWANLEYFIKAIMPTAEEAGVKMAIHPDDPPYGIFGLPRIITGQEAVERFLNLYDSEHNGITMCVGS
YASDPKNDVLAMTEYALKRNRINFMHTRNVTAGAWGFQETAHLSQSGDIDMNGVVKLLVDYDWQGALRPDHGRRIWGDQT
KTPGYGLYDRALGATYFNGLYEANMRAAGKTPDFGIKVKTVGNKEG

Specific function: Hexuronate conversion to KDG. [C]

COG id: COG1312

COG function: function code G; D-mannonate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannonate dehydratase family

Homologues:

Organism=Escherichia coli, GI1790778, Length=397, Percent_Identity=36.5239294710327, Blast_Score=248, Evalue=5e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UXUA_STRP7 (C1CAV6)

Other databases:

- EMBL:   CP000918
- RefSeq:   YP_002741394.1
- ProteinModelPortal:   C1CAV6
- EnsemblBacteria:   EBSTRT00000073207
- GeneID:   7683489
- GenomeReviews:   CP000918_GR
- KEGG:   snm:SP70585_2237
- GeneTree:   EBGT00050000026584
- ProtClustDB:   PRK03906
- BioCyc:   SPNE488221:SP70585_2237-MONOMER
- HAMAP:   MF_00106
- InterPro:   IPR004628
- InterPro:   IPR013022
- Gene3D:   G3DSA:3.20.20.150
- PIRSF:   PIRSF016049
- TIGRFAMs:   TIGR00695

Pfam domain/function: PF03786 UxuA; SSF51658 Xyl_isomerase-like_TIM-brl

EC number: =4.2.1.8

Molecular weight: Translated: 40941; Mature: 40941

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMSFRWYGKKDPVTLEEIKAIPGMQGIVTAVYDVPVGQAWPLENILELKQMVEEAGLEI
CCCCEEECCCCCCCCHHHHHHCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEE
TVIESIPVHEDIKQGKPNRDELIENYKTSIRNVGAAGIPVVCYNFMPVFDWTRSDLHHPL
EEEECCCCHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHCCCHHHCCCCC
PDGSTSLAFLKSDLAGVDPVADDLNLPGWDSSYSKEEMKNVIENYRQNISEEDLWANLEY
CCCCCHHHHHHHHHCCCCCCHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHH
FIKAIMPTAEEAGVKMAIHPDDPPYGIFGLPRIITGQEAVERFLNLYDSEHNGITMCVGS
HHHHHCCCHHHCCEEEEECCCCCCCCCCCCCHHCCCHHHHHHHHHHHCCCCCCEEEEECC
YASDPKNDVLAMTEYALKRNRINFMHTRNVTAGAWGFQETAHLSQSGDIDMNGVVKLLVD
CCCCCCCCHHHHHHHHHHHCCEEEEEECCCCCCCCCCHHHHHCCCCCCCCCCCEEEEEEE
YDWQGALRPDHGRRIWGDQTKTPGYGLYDRALGATYFNGLYEANMRAAGKTPDFGIKVKT
CCCCCCCCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEE
VGNKEG
CCCCCC
>Mature Secondary Structure
MKMSFRWYGKKDPVTLEEIKAIPGMQGIVTAVYDVPVGQAWPLENILELKQMVEEAGLEI
CCCCEEECCCCCCCCHHHHHHCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEE
TVIESIPVHEDIKQGKPNRDELIENYKTSIRNVGAAGIPVVCYNFMPVFDWTRSDLHHPL
EEEECCCCHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHCCCHHHCCCCC
PDGSTSLAFLKSDLAGVDPVADDLNLPGWDSSYSKEEMKNVIENYRQNISEEDLWANLEY
CCCCCHHHHHHHHHCCCCCCHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHH
FIKAIMPTAEEAGVKMAIHPDDPPYGIFGLPRIITGQEAVERFLNLYDSEHNGITMCVGS
HHHHHCCCHHHCCEEEEECCCCCCCCCCCCCHHCCCHHHHHHHHHHHCCCCCCEEEEECC
YASDPKNDVLAMTEYALKRNRINFMHTRNVTAGAWGFQETAHLSQSGDIDMNGVVKLLVD
CCCCCCCCHHHHHHHHHHHCCEEEEEECCCCCCCCCCHHHHHCCCCCCCCCCCEEEEEEE
YDWQGALRPDHGRRIWGDQTKTPGYGLYDRALGATYFNGLYEANMRAAGKTPDFGIKVKT
CCCCCCCCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEE
VGNKEG
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA